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Prevalence and risk factors of acute-on-chronic liver failure in a single center from Argentina

World Journal of Hepatology 2016年第34期8卷 1529-1534页

作者： cristian Dominguez Eugenia Romero Jorgelina Graciano Jose Luis Fernandez Luis Viola Division of Gastroenterology Sanatorio Guemes Centro Integral de Gastroenterología

AIMTo study the prevalence, characteristics, risk factors and mortality at 28 d of acute-on-chronic liver failure (ACLF). METHODSA total of 100 cirrhotic patients admitted to our hospital for more than one day were included during the period between June 2013 and December 2015. We used the European Association for the Study of the Liver-Chronic Liver Failure-Consortium diagnostic criteria for ACLF, considering it as the acute decompensation of cirrhosis associated with the presence of one or more organ failure. For the diagnosis of organic failure the Chronic Liver Failure-Sequential Organ Failure Assessment score was used. Our population was divided into patients with and without ACLF. Clinical characteristics, presence of precipitating events, potential risk factors for developing ACLF and causes of mortality were analyzed. Mortality at 28 d was evaluated. RESULTSTwenty-nine patients (29%) developed ACLF criteria. Alcoholism, detected in 58 patients (58%), was the major etiological agent of cirrhosis. Bacterial infections were recognized as a precipitating event in 41.3% of cases and gastrointestinal bleeding in 27.5%. No precipitating event was identifiable in 27.5% of patients with ACLF. Comparing patients with and without ACLF, statistically significant risk factors were: Child Pugh score 10.2 ± 2.1 vs 8.4 ± 1.6 (P ˂ 0.0001), MELD score 20.7 ± 8.5 vs 12.3 ± 4 (P ˂ 0.0001), presence of ascites 27 (93%) vs 43 (60.5%) (P = 0.001), leukocytosis 15300 ± 8033 per cubic millimeter vs 10770 ± 5601 per cubic millimeter (P ˂ 0.0001), and high plasma levels of C reactive protein values 50.9 ± 46.4 mg/L vs 28.6 ± 23.4 mg/L (P ˂ 0.0019). Mortality rate was 62% (18 patients) vs 5.6% (4 patients), respectively (P CONCLUSIONWe observed that the ACLF is a frequent entity in this group of patients and has a significantly higher mortality rate.

关键词： Acute-on-chronic liver failure Acute liver decompensation Cirrhosis Ascites Mortality

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Morphology, flight performance, and water crossing tendencies of Afro-Palearctic raptors during migration

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Current Zoology 2015年第6期61卷 951-958页

作者： Nicolantonio AGOSTINI Michele PANUCCIO cristian PASQUARETTA MEDRAPTORS (Mediterranean Raptor Migration Network) Via Mario Fioretti 18 00152 Rome Italy University of Pavia Department of Earth and Environmental Sciences Via Ferrata 9 27100 Pavia (PV) Italy Universit6 de Strasbourg IPHC 23 rue Becquerel 67087 Strasbourg France CNRS UMR7178 67037 Strasbourg France

Raptors primarily use soaring-gliding flight which exploits thermals and ridge lifts over land to reduce energetic costs However during migration, these birds often have to cross water surfaces where thermal currents are weak; during these times, birds mainly use flapping （powered） flight which increases energy consumption and mortality risk. As a result, some species have evolved strategies to reduce the amount of time spent over water by taking extensive detours over land. In this paper, we con- ducted a meta-analysis of water-crossing tendencies in Afro-Palearctic migrating raptors in relation to their morphology, their flight performance, and their phylogenetic relationships. In particular, we considered the aspect ratio （calculated as the wing span squared divided by wing area）, the energetic cost of powered flight, and the maximum water crossing length regularly performed by adult birds. Our results suggest that energy consumption during powered flight predominately affects the ability of raptors to fly over water surfaces

关键词： Water crossing Aspect ratio Powered flight Migration Raptors Wing tip

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THz plasmonics and electronics in germanene nanostrips

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Journal of Semiconductors 2023年第10期44卷 37-49页

作者： Talia Tene Marco Guevara Gabriela Tubon-Usca Oswaldo Villacrés Cáceres Gabriel Moreano cristian Vacacela Gomez Stefano Bellucci Department of Chemistry Universidad Técnica Particular de Loja110160 LojaEcuador UNICARIBE Research Center University of CalabriaI-87036 RendeCSItaly Grupo de Investigación en Materiales Avanzados(GIMA) Facultad de CienciasEscuela Superior Politécnica de Chimborazo(ESPOCH)RiobambaEcuador Facultad de Ciencias Escuela Superior Politécnica de Chimborazo(ESPOCH)RiobambaEcuador Faculty of Mechanical Engineering Escuela Superior Politécnica de Chimborazo(ESPOCH)Riobamba 060155Ecuador INFN-Laboratori Nazionali di Frascati Via E.Fermi 54I-00044 FrascatiItaly

Germanene nanostrips(GeNSs)have garnered significant attention in modern semiconductor technology due to their exceptional physical characteristics,positioning them as promising candidates for a wide range of *** exhibit a two-dimensional(buckled)honeycomb-like lattice,which is similar to germanene but with controllable *** modeling of GeNSs is essential for developing appropriate synthesis methods as it enables understanding and controlling the growth process of these ***,one can adjust the strip width,which in turn can tune the bandgap and plasmonic response of the material to meet specific device *** this study,the objective is to investigate the electronic behav-ior and THz plasmon features of GeNSs(≥100 nm wide).A semi-analytical model based on the charge-carrier velocity of free-standing germanene is utilized for this *** charge-carrier velocity of freestanding germanene is determined through the GW approximation(V_(F)=0.702×10^(6)m·s^(−1)).Within the width range of 100 to 500 nm,GeNSs exhibit narrow bandgaps,typi-cally measuring only a few ***,upon analysis,it was found that the bandgaps of the investigated GeNSs ranged between 29 and 6 *** well,these nanostrips exhibit√q-like plasmon dispersions,with their connected plasmonic fre-quency(≤30 THz)capable of being manipulated by varying parameters such as strip width,excitation plasmon angle,and sam-ple *** manipulations can lead to frequency variations,either increasing or decreasing,as well as shifts towards larger momentum *** outcomes of our study serve as a foundational motivation for future experiments,and further con-firmation is needed to validate the reported results.

关键词： nanostrips carrier velocity germanene plasmonics electronics

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The RSA Cryptographic Protocol Is Not Secure

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Applied Mathematics 2013年第12期4卷 1635-1636页

作者： cristian Dumitrescu Kitchener Canada

In this article I describe a randomized algorithm based on random walks with two absorbing barriers that solves the satisfiability problem (known to be NP complete) with arbitrary high probability. As a consequence of... 详细信息

关键词： The Satisfiability Problem Hamming Distance Random Walk with Two Absorbing Barriers

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Plant triterpenoid saponins function as susceptibility factors to promote the pathogenicity of Botrytis cinerea

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Molecular Plant 2024年第7期17卷 1073-1089页

作者： Francisco J.Escaray Amelia Felipo-Benavent cristian J.Antonelli Begona Balaguer Maria Pilar Lopez-Gresa Pablo Vera Instituto de Biologia Molecular y Celular de Plantas Universidad Politecnica de Valencia-C.S.l.CCiudad Politecnica de la InnovacionEdificio 8Eacceso GIngeniero Fausto Elios/n46022ValenciaSpain

The gray mold fungus Botrytis cinerea is a necrotrophic pathogen that causes diseases in hundreds of plant species,including high-value *** polyxenous nature and pathogenic success are due to its ability to perceive host signals in its *** this study,we found that laticifer cells of Euphorbia lathyris are a source of susceptibility factors required by *** to cause ***,poor-in-latex(pil)mutants,which lack laticifer cells,show full resistance to this pathogen,whereas lot-of-latex mutants,which produce more laticifer cells,are *** S factors are triterpenoid saponins,which are widely distributed natural products of vast structural *** downregulation of laticifer-specific oxydosqualene cyclase genes,which encode the first committed step enzymes for triterpene and,therefore,saponin biosynthesis,conferred disease resistance to ***,the Medicago truncatula Iha-1 mutant,compromised in triterpenoid saponin biosynthesis,showed enhanced ***,the application of different purified triterpenoid saponins pharmacologically complemented the diseaseresistant phenotype ofpil and hla-1 mutants and enhanced disease susceptibility in different plant *** found that triterpenoid saponins function as plant cues that signal transcriptional reprogramming in ***,leading to a change in its growth habit and infection strategy,culminating in the abundant formation of infection cushions,the multicellular appressoria apparatus dedicated to plant penetration and biomass destruction in *** together,these results provide an explanation for how plant triterpenoid saponins function as disease susceptibility factors to promote *** pathogenicity.

关键词： Euphorbia lathyris laticifer cell latex appressorium infection cushion necrotrophic fungi

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Water-soluble hollow nanocrystals from self-assembly of AIEEactive Pt(II)metallomesogens

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Nano Research 2021年第1期14卷 245-254页

作者： cristian Cuerva Javier Fernandez-Lodeiro Mercedes Cano Jose Luis Capelo-Martinez Carlos Lodeiro BIOSCOPE Research Group LAQV@REQUIMTE Chemistry DepartmentNOVA School of Science and TechnologyNOVA University Lisbon2829-516 CaparicaPortugal PROTEOMASS Scientific Society Rua dos InventoresMadam ParqueCaparica Campus2829-516 CaparicaPortugal Department of Inorganic Chemistry Complutense University of MadridCiudad Universitaria28040 MadridSpain

Luminescent hollow micro-and nanocrystals have been successfully obtained taking advantage of the self-assembly behavior and the aggregation-induced emission enhancement properties of several bispyrazolate Pt(II)metallomesogens decorated with four terminal alkyl ***-in-water droplets have been used to confine the Pt(II)compounds and drive them to be self-assembled via intermolecular Pt…Pt interactions into spherical aggregates of about 200 or 50 *** of the oil phase generates highly-stable aqueous dispersions of nanocrystals that emit a bright orange light as a result of the existence of^(3)MMLCT excited *** methods and conditions have been tested for studying the effect of several parameters such as the temperature and the stirring speed in the final particle size and in the polydispersity ***,the micro-and nanocrystals are able to entrap hydrophobic drugs between the alkyl chains of the compounds,forming stable dispersions of drug-loaded capsules in *** droplet method is applied in the area of metallomesogens for the first time to synthesize self-assembled Pt(II)nanocapsules,which opens a new field of study that could allow the use of these liquid crystal materials in biomedical applications.

关键词： R(II)metallomesogens self-assembly luminescent nanomaterials droplets nanocapsules

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Emerging and multifaceted potential contributions of polyphenols in the management of type 2 diabetes mellitus

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World Journal of Diabetes 2024年第2期15卷 154-169页

作者： Ileana González cristian Lindner Ivan Schneider Erik Diaz Miguel Angel Morales Armando Rojas Biomedical Research Laboratories Faculty of MedicineCatholic University of MauleTalca 34600000Chile Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile Centre of Primary Attention South Metropolitan Health ServiceSantiago 3830000Chile Faculty of Medicine Catholic University of MauleTalca 3460000Chile Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Type 2 diabetes mellitus(T2DM)is recognized as a serious public health concern with a considerable impact on human life,long-term health expenditures,and substantial health *** this context,the use of dietary polyphenols to prevent and manage T2DM is widely *** dietary compounds exert their beneficial effects through several actions,including the protection of pancreatic islet β-cell,the antioxidant capacities of these molecules,their effects on insulin secretion and actions,the regulation of intestinal microbiota,and their contribution to ameliorate diabetic complications,particularly those of vascular *** the present review,we intend to highlight these multifaceted actions and the molecular mechanisms by which these plant-derived secondary metabolites exert their beneficial effects on type 2 diabetes patients.

关键词： Polyphenols Antioxidants Oxidative stress Type 2 diabetes mellitus Health benefits

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Adsorption of Copper from an Ammonia-Thiosulfate Media Using DOWEX 550A Ion Exchange Resin

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International Journal of Nonferrous Metallurgy 2016年第4期5卷 33-44页

作者： cristian Vargas Patricio Navarro Departamento de Ingeniería Metalúrgica Universidad de Santiago de Chile Santiago Chile

The study of copper adsorption onto ion exchange resins of anionic type is part of the gold recovery from ammonia-thiosulfate solutions, where copper is the main impurity of the system because it acts as a catalyst of gold dissolution reaction. A study is made of the adsorption and desorption of copper in the form of the complex in an ammonia-thiosulfate media on an ion exchange resin, DOWEX 550A, classified as a strong base, which in its inner structure has a quaternary amine functional group. In the studied pH range copper adsorption increased with increasing pH, while the presence of thiosulfate decreased it, the same as the ammonia content, due to the greater presence of cuprotetramine, . Elution of the copper complexes from the resin was more efficient with sulfite than with perchlorate.

关键词： Adsorption Desorption Copper Ion Exchange Resin Ammonia-Thiosulfate

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Geomorphologic map of the 1st Mutnaya River,Southeastern Kamchatka,Russia

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Journal of Mountain Science 2017年第12期14卷 2373-2390页

作者： gheorghe romanescu sergey chalov cristian constantin stoleriu alin mihu-pintilie silvia eleonora angileri yulia kuznetsova mariaelena cama michael maerker alexandru ioan cuza university of iasi faculty of geography and geologydepartment of geographylasi 700505 Romania lomonosov moscow state university faculty of geographyMoscow 119234Russia alexandru ioan cuza university of iasi interdisciplinary research department–field science700505Romania universitàdegli studi di palermo department of earth and marine sciencesPalerm 90133italy tübingen university department for geographyTubingen 72074Germany universitàdegli studi di pavia department of earth and environmental sciencesPavia 90133Italy heidelberg academy of sciences and humanities Heidelberg 69117Germany

The Kamchatka Peninsula - situated in the Pacific ＂Ring of Fire＂ - has 29 active and over 4oo extinct volcanoes. Since it is situated in the northeastern extremity of Russia, in subarctic climate, the volcanic landforms are overprinted by the 446 glaciers. This research focuses on the ltMutnaya catchment which drains the southern slopes of two active volcanoes： Avachinsky and Koryaksky. Those volcanoes are a permanent threat for the cities of Petropavlovsk and Elizovo, which are the 2 of 3 cities of the peninsula. Hence, most of the studies carriedout in the area dealt with the natural hazards and only few focus on landscape evolution. Thus, the purpose of this study was to elaborate a cartographic approach which integrates classic geomorphology with state of the art GIS and remote sensing techniques. As result, different landforms and related processes have been analysed and included geomorphologic map of the in the first general ltMutnaya catchment.

关键词： Geomorphologieal mapping AdvancedLand Observation Satellite (ALOS) Digital SurfaceModel (DSM) GIS Terrain analysis Glacio-volcanism Landform modelling Processes and forms

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Convergence of the turkey gut microbiota following cohabitation under commercial settings

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Journal of Animal Science and Biotechnology 2021年第4期12卷 1635-1644页

作者： Elizabeth A.Miller Brittanie Winfield Bonnie P.Weber cristian Flores-Figueroa Jeannette Munoz-Aguayo Jared Huisinga Timothy J.Johnson Department of Veterinary and Biomedical Sciences University of MinnesotaSaint PaulMNUSA University of Minnesota Mid-Central Research and Outreach CenterWillmarMNUSA Science Innovations WillmarMNUSA

Background:Microbiota development is a critical aspect of turkey poult maturation,and the succession of microbes in the turkey gut has been shown to correlate with poult *** purpose of this study was to determine the fate of the microbiota in turkey poults after movement of birds first raised in an isolated hatch brood system into a more traditional commercial brood facility with pre-existing *** poults were first divided into groups raised in conventional brood pens from day-of-hatch and those raised in an experimental hatch brood *** 11 days of growth,hatch brood birds were moved into pens within the conventional brood barn and monitored for an additional 18 *** of both hatch brood and conventional pen birds was performed at multiple timepoints throughout the study,and cecal content was used to analyze the bacterial microbiota using 16S rRNA gene amplicon ***:Alpha diversity tended to be higher in samples from conventional pen birds compared to those from hatch brood birds prior to the day 11 move,but the difference between systems was not observed *** beta diversity metrics,bacterial community succession appeared delayed in the hatch brood system birds pre-move,but post-move community composition quickly converged with that of the conventional pen *** was validated through assessment of significantly different genera between hatch brood system and conventional pen birds,where numbers of significantly different taxa quickly decreased following the *** key taxa previously associated with poult performance were delayed in their appearance and relative abundance in hatch brood ***:Overall,this study demonstrates that the use of isolated hatch brood systems has an impact on the poult gut microbiota,but its impact is resolved quickly once the birds are introduced into a conventional brood ***,the benefits of pathogen reduction with hatch brood systems may out

关键词： Brood Gut Hatch Microbiota Poult Succession Turkey

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