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Early diagnosis of pancreatic cancer: Shedding light on an unresolved challenge

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World Journal of Clinical Cases 2024年第14期12卷 2463-2465页

作者： cristian Lindner Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile

Diagnosing early-stage pancreatic cancer(PC)remains a clinical ***,studying novel imaging aspects that could enhance the diagnostic accuracy of malignant pancreatic precursor lesions is *** article aims to un-derscore the promising role of emerging imaging aspects that may facilitate the earlier diagnosis of PC,thereby improving its management and prognosis.

关键词： Pancreatic cancer Pancreatic intraepithelial neoplasm High-grade pancreatic intraepithelial neoplasm Pancreatic ducts Cancer Early diagnosis

Contributing to the prediction of prognosis for treated hepatocellular carcinoma: Imaging aspects that sculpt the future

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3377-3380页

作者： cristian Lindner Department of Radiology Faculty of MedicineUniversity of ConcepcionConcepcion 4030000BiobíoChile Department of Radiology Hospital Regional Guillermo Grant BenaventeConcepcion 4030000BiobíoChile

A novel nomogram model to predict the prognosis of hepatocellular carcinoma(HCC)treated with radiofrequency ablation and transarterial chemoembolization was recently published in the World Journal of Gastrointestinal *** model includes clinical and laboratory factors,but emerging imaging aspects,partic-ularly from magnetic resonance imaging(MRI)and radiomics,could enhance the predictive accuracy *** MRI and deep learning radiomics models significantly improve prognostic predictions for the treatment of ***-corporating advanced imaging features,such as peritumoral hypointensity and radiomics scores,alongside clinical factors,can refine prognostic models,aiding in personalized treatment and better predicting *** letter underscores the importance of integrating novel imaging techniques into prognostic tools to better manage and treat HCC.

关键词： Hepatocellular carcinoma Radiofrequency ablation Transcatheter arterial chemoembolization Prognosis Magnetic resonance imaging Radiomics Artificial intelligence

Global Trends of Usage of Chlorophyll Fluorescence and Projections for the Next Decade

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Plant Phenomics 2020年第1期2卷 409-418页

作者： Alonso Zavafer Leen Labeeuw cristian Mancilla Research School of Biology The Australian National UniversityCanberraACTAustralia University of Technology Sydney Climate Change ClusterFaculty of ScienceSydneyNSW 2007Australia Independent Researcher La FloridaChile

Chlorophyll fluorescence is the most widely used set of techniques to probe photosynthesis and plant *** great versatility has given rise to different routine methods to study plants and *** three main technical platforms are pulse amplitude modulation(PAM),fast rise of chlorophyll fluorescence,and fast repetition ***-induced fluorescence(SIF)has also gained interest in the last few *** have compared their advantages and their underlying theory,with many arguments advanced as to which method is the most accurate and *** date,no data has assessed the exact magnitude of popularity and influence for each *** this work,we have taken the bibliometrics of the past decade for each of the four platforms,have evaluated the public scientific opinion toward each method,and possibly identified a geographical *** used various metrics to assess influence and popularity for the four routine platforms compared in this study and found that,overall,PAM currently has the highest values,although the more recent SIF has increased in popularity rapidly during the last *** indicates that PAM is currently one of the fundamental tools in chlorophyll fluorescence.

关键词： algae routine Fluorescence

Imaging features of malignant vs stone-induced biliary obstruction:Aspects to consider

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World Journal of Clinical Cases 2024年第15期12卷 2678-2681页

作者： cristian Lindner Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile

Radiological studies play a crucial role in the evaluation of patients with biliary duct obstruction,allowing for the guidance of clinical diagnosis towards a malignant or stone-induced etiology through the recognition of relevant imaging features,which must be continuously revisited given their prognostic *** article aims to emphasize the importance of recognizing crucial imaging aspects of malignant and stone-induced biliary obstruction.

关键词： Malignant biliary obstruction Choledocholithiasis Dilated bile ducts Magnetic resonance Multidetector computed tomography

Tales of the Tail and Sperm Head Aches --Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail

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Asian Journal of Andrology 2012年第1期14卷 14-23,174页

作者： Hector E Chemes cristian Alvarez Sedo Laboratory of Testicular Physiology and Pathology Center for Research in Endocrinology National Research Council （CONICET） Endocrinology Division Buenos Aires Children＇s Hospital Gallo 1330 C1425SEFD Buenos Aires Argentina Centro de Estudios en Ginecologia y Reproduccion （CEGyR） C1425SEFD Buenos Aires Argentina

This article presents an update on the variable prognostic significance of different sperm pathologies in patients with severe male factor infertility due to morphology and motility disorders. Severe asthenozoospermia is one of the leading causes of male infertility as spermatozoa cannot reach the oocyte and/or penetrate normally. Identifying structural causes of sperm immotility was of great concern before the advent of intracytoplasmic sperm injection （ICSI）, because immotility was the limiting factor in the treatment of these patients. In these cases, in vitro methods are used to identify live spermatozoa or stimulate sperm motility to avoid selection of non-viable cells. With these advances, fertilization and pregnancy results have improved dramatically. The identification of genetic phenotypes in asthenozoospermia is important to adequately inform patients of treatment outcomes and risks. The one sperm characteristic that seriously affects fertility prognosis is teratozoospermia, primarily sperm head and neck anomalies. Defects of chromatin condensation and acrosomal hypoplasia are the two most common abnormalities in severe teratozoospermia. The introduction of microscopic methods to select spermatozoa and the development of new ones to evaluate sperm quality before ICSI will assure that ultrastructural identification ofsperm pathologies will not only be of academic interest, but will also be an essential tool to inform treatment choice. Herein, we review the differential roles played by sperm components in normal fertilization and early embryo development and explore how assisted reproductive technologies have modified our concepts on the prognostic significance of sperm pathologies affecting the head, neck, mid-piece and tail.

关键词： acrosomal hypoplasia chromatin anomalies fertility prognosis intracytoplasmic sperm injection intracytoplasmic injection of morphologically selected spermatozoa sperm neck defects sperm pathologies tail abnormalities teratozoospermia

Sperm quality in mice acutely treated with parathion

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Asian Journal of Andrology 2000年第2期2卷 147-150页

作者： cristian Sobarzo Eduardo Bustos-Obregon Faculty of Basic Sciences Catholic University of Temuco and Biology of Reproduction Unit Program of Morphology ICBM Faculty of Medicine University of Chile. Santiage 7 Chile.Faculty of Basic Sciences Catholic University of Temuco and Biology of Reproduction Unit Program of Morphology ICBM Faculty of Medicine University of Chile. Santiage 7 Chile.

Aim: To investigate the toxic effect of a single injection of the organophosphorous agropesticide, parathion, on sper-matogenesis in immature male mice. Methods: Seven-day old mice received a single injection of parathion intraperi-toneally at a dose of 1/3 LD_50. The epididymal sperm count, sperm morphology and chromatin thermal stability wereanalyzed 28 and 50 days after injection. Results: Sperm counts were decreased and teratozoospermia and thermal de-naturation of DNA increased after parathion injection. Sperm parameters were changed to a greater extent in younger an-imals, denoting a higher lability of spermatogenic process at its beginning. The damages could recover a long time afterparathion administration. Conclusion: Organophosphorous agropesticides are testicular toxicants, eliciting reversiblecytotoxic and cytogenetic alterations in germ cells.

关键词： epididymis spermatozoa organophosphorous compounds agropesticides spermatogenesis

Machine learning assisted derivation of minimal low-energy models for metallic magnets

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npj Computational Materials 2023年第1期9卷 353-364页

作者： Vikram Sharma Zhentao Wang cristian D.Batista Department of Physics and Astronomy The University of TennesseeKnoxvilleTN 37996USA School of Physics and Astronomy University of MinnesotaMinneapolisMN 55455USA Quantum Condensed Matter Division and Shull-Wollan Center Oak Ridge National LaboratoryOak RidgeTN 37831USA Present address:Center for Correlated Matter and School of Physics Zhejiang UniversityHangzhou 310058China

We consider the problem of extracting a low-energy spin Hamiltonian from a triangular Kondo Lattice Model(KLM).The non-analytic dependence of the effective spin-spin interactions on the Kondo exchange excludes the use of perturbation theory beyond the second *** then introduce a Machine Learning(ML)assisted protocol to extract effective two-and four-spin *** resulting spin model reproduces the phase diagram of the original KLM as a function of magnetic field and single-ion anisotropy and reveals the effective four-spin interactions that stabilize the field-induced skyrmion crystal ***,this model enables the computation of static and dynamical properties with a much lower numerical cost relative to the original KLM.A comparison of the dynamical spin structure factor in the fully polarized phase computed with both models reveals a good agreement for the magnon dispersion even though this information was not included in the training data set.

关键词： Kondo dynamical derivation

Bi-normalized response spectra and seismic intensity in Bucharest for 1986 and 1990 Vrancea seismic events

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Earthquake Engineering and Engineering Vibration 2014年第1期13卷 125-135页

作者： Florin Pavel Radu Vacareanu cristian Neagu Andrei Pricopie Department of Reinforced Concrete Structures Technical University of Civil Engineering BucharestRomania Department of Strength of Materials Bridges and TunnelsTechnical University of Civil Engineering BucharestRomania

The Vrancea subcrustal earthquakes of August 30,1986 and May 30,1990 are the two most recent seismic events that have occurred in Romania with moment magnitudes M W ≥ *** spectral analysis of the strong ground motions recorded in Bucharest reveals that despite small differences in magnitude between the 1986 and 1990 earthquakes,their frequency contents are very different,sometimes even *** main focus of this study is to conduct a comparative analysis of the response spectra in terms of the bi-normalized response spectra(BNRS) proposed by Xu and Xie(2004 and 2007) for strong ground motions recorded in Bucharest during these two seismic *** mean absolute acceleration and relative velocity response spectra for the two earthquakes are discussed and ***,the mean bi-normalized absolute acceleration and normalized relative velocity response spectra with respect to the control period T C are computed for the ground motions recorded in Bucharest in 1986 and *** predominant period T P is also used in this study for the normalization of the spectral period ***,the methodology proposed by Martinez-Perreira and Bommer(1998) is applied in order to estimate the seismic intensity of the two *** results are discussed and several conclusions regarding the possibility of using the bi-normalized response spectra(BNRS) are given.

关键词： response spectra bi-normalized response spectra dynamic amplifi cation factor control period damage potential parameters

Jet CAT P80 Thermal Analyses and Performance Assessment Using Different Fuels Types

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Journal of Thermal Science 2018年第4期27卷 389-393页

作者： Grigore CICAN Adina TOMA cristian PUSCASU Razvan CATANA Politehnica University of Bucharest Faculty of Aerospace Engineering 1-7 Polizu Street 011061 Bucharest 1 Romania National Research and Development Institute for Gas Turbines - COMOTI 220D Iuliu Maniu Ave Bucharest 6 Romania

The micro gas turbine propulsion systems represent a good choice for the unmanned aerial vehicles(UAVs). The present work monitors the engine parameters, correlating them with other important engine instrumentation data. The aim of this research was to study the operation of the Jet CAT using various types of fuels under various operating conditions: normal acceleration and sudden acceleration. The measured parameters were monitored under different conditions:(A) Engine operation at two different ambient temperatures – outdoor at 0oC and inside at 19oC; and(B) Using 4 fuel types: kerosene, diesel fuel, kerosene with 5% gasoline and kerosene with 10% gasoline. The relevance of this work is given by the fact that a detailed analysis is performed for the idle regime. The paper will present the detailed test plan used and the most relevant charts with the obtained results for: start time, force, temperature before turbine, fuel flow, depending on micro turbo engine speed.

关键词： Jet CAT P80 fuel performance testing thermal analysis