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Clinical Analysis of the Colorectal Cohort within the Wales Cancer Biobank: A Study of Outcomes and Genetic Screening

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Journal of Cancer Therapy 2023年第7期14卷 317-344页

作者： Lisa K. Spary Katie DeLoyde Helen Roberts Fiona martin Chi Pooi Lee Rachel Butler Malcolm D. Mason Geraldine A. Thomas Alison Parry-Jones Richard A. Adams Institute of Cancer and Genetics School of Medicine University Hospital of Wales Main Building Cardiff University Cardiff UK All Wales Medical Genetics Service Institute of Medical Genetics University Hospital of Wales Cardiff UK

Over the last 12 years, the Wales Cancer Biobank (WCB) has consented to more than 2000 patients with colorectal cancer (CRC). From these patients, clinical data has been collected and patients have been followed through their cancer journey. Clinical data from these patients have been analyzed to identify any correlation between disease grade and outcome. In a small cohort, consisting of 407 patients, WCB has performed genetic analysis on patient primary tumor samples, identifying and characterizing mutations in the KRAS, NRAS, BRAF, PIK3CA and TP53 genes. The majority of patients with CRC who were consented to WCB were male with a mean age of 69 years and received surgery as the primary treatment for their disease. Pathology and disease-free survival data confirmed worse prognoses associated with more advanced disease. Heterogeneity within the primary tumor was explored in a subgroup of patients. Analysis of the KRAS and TP53 genes confirmed that more than 40% of CRC patients who were tested, harbored a genetic mutation within these genes in their primary tumor. Due to the limited sample size tested, most mutations did not show significant differences in disease-free survival, however, mutation of the BRAF gene did show a decrease in the disease specific survival, in keeping with the published data. Analysis of the patients diagnosed with CRC within the Biobank has provided us with valuable information on the status of CRC disease and treatment within the Welsh population. Over 12 years of consenting, we have witnessed significant changes in the information that researchers are interested in when sourcing samples for translational research. The development of new drugs that are tailored to the genetics of a cancer is emerging and at WCB we are focusing our collections on samples and data that meet the needs of this ever-evolving field.

关键词： Colorectal Cancer Biobank Outcome Genetics Screening

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Effects of Different Levels of Garlic Powder Incorporated in the Feed Enriched with Stylosanthes guianensis on Reproduction and Pre-Weaning Growth Performances of Cavies (Cavia porcellus)

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Open Journal of Animal Sciences 2023年第4期13卷 574-589页

作者： martin Vidal Tatang Emile Miégoué Margaret Mary Momo Chongsi Wouafo David Fokom Nyah Cédric Kwayep Paulette Ntsafack Tobou France-Gina Djoumessi Mathieu Duclos Fogang Fernand Tendonkeng Department of Animal Science Faculty of Agronomy and Agricultural Sciences University of Dschang Dschang Cameroon Multipurpose Research Station Institute of Agricultural Research for Development Bangangté Cameroon

In order to increase the productivity of the local cavies as a meat animal, a study was carried out between November 2021 and March 2022 at the Research and Experimental Farm, Animal Nutrition and Production Research Unit of the Faculty of Agronomy and Agricultural Sciences (FAAS) and the Microbiology and Anti-Microbial Research Unite of the University of Dschang on 72 cavies aged between 4 and 5 months and weighing an average of 450 ± 50 g produced on the farm, including 60 females and 12 males. The females were distributed according to a completely randomized factorial design in twelve (12) rearing boxes numbered G1 to G12, with 15 females per group distributed in 03 boxes and receiving iso-nitrogenated experimental diet (18% protein) R0 enriched with 20% of Stylosanthes guianensis (0% garlic powder), R0.25 (0.25% garlic powder), R0.50 (0.50% garlic powder) and R0.75 (0.75% garlic powder). Females were identified by numbered ear tags and mated with a sex ratio of 5 females for 1 male. Drinking water enriched with vitamin C (01 tablet of 240 mg in 1.5 liters of water) was served ad libitum and renewed daily. The males were removed after 31 days. A form was established to record the weight of each pregnant female, any abortions during gestation, the date of parturition and the date of birth of each newborn, as well as the number of live-born or stillborn pups. After parturition, the weights of female and newborn cavies were recorded weekly until the 3rd week. The number of cavies that died before weaning and the number of live weaned cavies were also recorded. Reproductive performance significantly increased (p 0.05) fertility rate and net fertility rate, litter size, birth viability rate, and pre-weaning viability rate with rations containing garlic powder, compared to the control ration, especially with the R0.50 ration. In addition, birth mortality and pre-weaning mortality were significantly lower (p 0.05) with rations containing the additive, compare

关键词： Cavy Garlic Powder Pre-Weaning Growth Reproduction Stylosanthes guianensis

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Epidemiological and Clinical Pattern of Open Fractures of Long Bones of the Lower Limbs in the South-West Region of Cameroon: A 5-Year Review

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Open Journal of Orthopedics 2021年第9期11卷 278-287页

作者： Chunteng T. Nana Fokam Pius Mokake N. martin Morane Mbongnu Sam D. Movuh Freddy Mertens Bombah Ndasi Henry Palle J. Ngunde A. Chichom-Mefire Department of Surgery Faculty of Health Sciences University of Buea Buea Cameroon Departement of surgery Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon

Background: An open fracture is an injury in which the fracture site and/or hematoma communicates with the external environment. It is associated with significant morbidity and disability and is a challenge to the surgical team. The lower extremities are the most often exposed to traumatic injuries compared to other anatomical parts of the body. Patterns of open fractures differ with different mechanisms of injury and the segment of the long bone affected. The correct and timely management of open fractures is beneficial to the patients and leads to a more favorable outcome. This study aimed at describing the pattern of open fractures of long bones of the lower limb treated in 3 major hospitals of the south west region, Cameroon. Methodology: This was a hospital-based retrospective review of files of patients with open fractures of long bones of the lower limb managed at the surgical units of three secondary health facilities in the South-West region of Cameroon from the 1st of January 2015 to the 31st of December 2019. The socio-demographic characteristics, clinical presentation, treatment modalities, and outcomes were recorded. The data was stored and analyzed using Epi info version 7.0 and SPSS version 23.0 respectively. Results: A total of 195 files of patients aged 8 to 80 years were studied. The main age group affected was between 20

关键词： Open Fractures Long Bones Lower Limb

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战争的文化

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作者： (以)马丁·范克勒韦尔德(martin Van Creveld)

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乡村空间转型研究的中西比较

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城市发展研究 2021年第11期28卷 53-61页

作者：张园林刘玉亭马丁·菲利普斯华南理工大学建筑学院/亚热带建筑科学国家重点实验室莱斯特大学地理地质与环境学院

西方乡村转型基本遵循生产主义到后生产主义的演化路径,相应地,其乡村空间认知经历了从物质到表征、从客体到主体、从生产性到后生产性、从静态单维到动态多维的转变,并开始关注微观主体"人"的日常生活实践,重视乡村空间的整体性。乡村... 详细信息

西方乡村转型基本遵循生产主义到后生产主义的演化路径,相应地,其乡村空间认知经历了从物质到表征、从客体到主体、从生产性到后生产性、从静态单维到动态多维的转变,并开始关注微观主体"人"的日常生活实践,重视乡村空间的整体性。乡村空间三重模型是乡村空间研究较为系统的理论框架,同时关注乡村空间的整体性特征以及动态转型趋势。在全球乡村背景下,对西方乡村空间理论及实践应用的分析能为解析中国乡村空间内涵及转型规律提供部分启示。现阶段中国的乡村空间研究仍多聚焦物质空间等单一维度,"整体性"视角仍显不足。乡村振兴背景下,本研究尝试从"内涵认知、整体维度、时空特征、转型机制"逻辑构建中国乡村空间转型研究框架,以期为中国乡村空间转型的理论及实证研究提供探讨,也为乡村空间规划提供进一步的思考。

关键词：乡村空间转型生产主义后生产主义乡村空间三重模型结构化关联

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2008年布瑞福（Brive）国家赛冠军——杰柯明·尚马克（Jacquemain Jean-Marc）

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科学养鸽 2008年第5期 38-41页

作者：马丁·马腾斯（martin Martens）

通常，布瑞福国家赛被定为比利时长距离国家赛的序幕。2008年布瑞福国家赛原本预定在五月三十一日（星期六）展开，但是由于天气不稳定（尤其是在法国东部），为了公平起见，大会决定将比赛延后一天（星期日）举行。只是没有人知道星期... 详细信息

通常，布瑞福国家赛被定为比利时长距离国家赛的序幕。2008年布瑞福国家赛原本预定在五月三十一日（星期六）展开，但是由于天气不稳定（尤其是在法国东部），为了公平起见，大会决定将比赛延后一天（星期日）举行。只是没有人知道星期日的天气状况是否会比星期六更稳定，因此有人质疑大会主席菲利浦·诺曼（Fillip Norman）的决定是否明智。天气不稳与其他一些人为因素．导致今年的交鸽数比2007年少了将近1500羽。

关键词：天气状况人为因素长距离比利时菲利浦鸽

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Outcomes of Patients with Heart Failure followed in a Cardiological Setting to Parakou from 2016 to 2020

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World Journal of Cardiovascular Diseases 2022年第11期12卷 490-506页

作者： Codjo Houétondji Léopold Dohou Serge Hugues Mahougnon Biaou Chabi Olaniran Alphonse S.T.G. Mawuton Bokossa Covalic Melic Amegan Hamondji Nicolas Houenassi martin Dèdonougbo Cardiology Teaching and Research Unit Health Sciences Faculty University of Abomey-Calavi Cotonou Benin Cardiology Teaching and Research Unit Faculty of Medicine University of Parakou Parakou Benin Regional Institute of Public Health University of Abomey-Calavi Ouidah Benin Doctoral School of Health Sciences Health Sciences Faculty University of Abomey-Calavi Cotonou Benin

Introduction: Heart failure (HF) is a serious pathology whose evolution is made of episodes of acute decompensation, rhythmic and thromboembolic complications, causes of iterative hospitalizations and death. The objective of this study was to describe the outcomes of patients followed for heart failure in a cardiological setting in Parakou from 2016 to 2020. Methods: This was a longitudinal, descriptive and analytical retrospective study of heart failure patients followed in consultation and/or hospitalization over a period of 5 years (October 2016 to July 2020) in cardiology units of Parakou. The outcome of HF was assessed by the NYHA symptomatic stage, rehospitalization, complications and death. Epidata 3.1 fr and SPSS 21 software were used for data processing and analysis. Results: Of the 4902 cardiovascular admissions, 453 cases of HF (9.24%) were observed. At the onset of care, 51.50% of patients were at NYHA stage IV and 69.46% had left ventricular systolic dysfunction. During the follow-up period, there was a symptomatic improvement in the first 06 months but at one year of follow-up, 45.28% of the subjects were seen with a deteriorated stage. At one year of follow-up, the rehospitalization rate was 23.58%. The complications noted were arrhythmias in 8.32% of cases. The mortality rate was 30.37%. Advanced age > 60 years, Charlson score ≥ 3, hypokalemia and poor adherence to treatment were the factors associated with unfavorable outcomes. Conclusion: HF is associated with significant morbidity and mortality. This highlights the importance of its prevention, its better etiological research and patient’s therapeutic education.

关键词： Heart Failure Outcomes Mortality Associated Factors Parakou

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软件设计

软件设计

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作者： (加拿大)马丁·P.罗毕拉德(martin P.Robillard)

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阿瑟·米勒论剧散文 1

阿瑟·米勒论剧散文

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丛书名：文化生活译丛

1987年

作者：（美）马丁（martin R.A.）陈瑞兰杨淮生选译

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Relevance of plasma lipoproteins and small metabolites in assessment of nutritional status among patients with severe injuries

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Journal of Intensive Medicine 2024年第4期4卷 496-507页

作者： Esmee A.H.Verheul Suzan Dijkink Pieta Krijnen Aswin Verhoeven martin Giera Roula Tsonaka Jochem M.Hoogendoorn Sesmu M.Arbous Ron Peters Inger B.Schipper Department of Trauma Surgery Leiden University Medical CenterLeidenThe Netherlands Acute Care Network West Netherlands LeidenThe Netherlands Center for Proteomics and Metabolomics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Data Sciences Leiden University Medical CenterLeidenThe Netherlands Department of General Surgery Haaglanden Medical CenterThe HagueThe Netherlands Department of Intensive Care Leiden University Medical CenterLeidenThe Netherlands Department of Intensive Care Haaglanden Medical CenterThe HagueThe Netherlands

Background:This study aimed to identify plasma lipoproteins and small metabolites associated with high risk of malnutrition during intensive care unit(ICU)stay in patients with severe ***:This observational prospective exploratory study was conducted at two level-1 trauma centers in the *** patients(aged≥18 years)who were admitted to the ICU for more than 48 h between July 2018 and April 2022 owing to severe injuries(polytrauma,as defined by Injury Severity Scores of≥16)caused by blunt trauma were eligible for *** least squares discriminant analysis was used to analyze the relationship of 112 lipoprotein-related components and 23 small metabolites with the risk of malnutrition(mod-ified Nutrition Risk in Critically Ill score).Malnutrition was diagnosed based on Subjective Global Assessment *** relationship of lipoprotein properties and small metabolite concentrations with malnutrition(during ICU admission)was evaluated using mixed effects logistic ***:Overall,51 patients were ***(very)low-density lipoprotein([V]LDL)(free)cholesterol and phospholipid levels,low particle number,and higher levels of LDL triglycerides were associated with a higher risk of malnutrition(variable importance in projection[VIP]value>1.5).Low levels of most(V)LDL and intermediate-density lipoprotein subfractions and high levels of high-density lipoprotein Apo-A1 were associated with the diagnosis of malnutrition(VIP value>1.5).Increased levels of dimethyl sulfone,trimethylamine N-oxide,creatinine,N,N-dimethylglycine,and pyruvic acid and decreased levels of creatine,methionine,and acetoacetic acid were also indicative of malnutrition(VIP value>1.5).Overall,14 lipoproteins and 1 small metabolite were significantly associated with a high risk of malnutrition during ICU admission(P<0.05);however,the association did not persist after correcting the false discovery rate(P=0.35 for all).Conclusion:Increased triglyceride in sev

关键词： Trauma Severely injured Metabolites Lipoproteins Malnutrition Nutritional status

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