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Pulmonary complications of portal hypertension:The overlooked decompensation

World Journal of Clinical Cases 2022年第17期10卷 5531-5540页

作者： Rares Craciun Tudor Mocan Bogdan Procopet Andrada Nemes cristian tefas Mihaela Sparchez Lavinia-Patricia Mocan Zeno Sparchez 3^(rd)Medical Clinic Department of Internal Medicine"Iuliu Hatieganu"University of Medicine and PharmacyCluj-Napoca 400162Romania Gastroenterology Clinic "Prof.Dr.O.Fodor"Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400162Romania Intensiv Care Unit I Cluj County Emergency HosptialCluj-Napoca 400006Romania 2^(nd)Paediatric Clinic "Iuliu Hatieganu"University of Medicine and PharmacyCluj-Napoca 400126Please enter the state or provinceRomania Department of Histology "Iuliu Hatieganu"University of Medicine and PharmacyCluj-Napoca 400349Romania

The systemic nature of cirrhosis and portal hypertension has long been recognized,and the amount of data characterizing the interplay between each system is becoming ever so *** involvement was among the first described associated entities in cirrhosis,with reports dating back to the late nineteenth ***,it appears that throughout the years,interest in the pulmonary complications of portal hypertension has generally faded,especially in contrast to other decompensating events,as expertise in this field has primarily been concentrated in highly experienced tertiary care facilities and liver transplantation *** affecting up to 10%-15%of patients with advanced liver disease and having a proven prognostic impact,hepato-pulmonary syndrome,porto-pulmonary hypertension,and hepatic hydrothorax are frequently misdiagnosed,mistreated,or *** lack of precision might adversely impact patient care,referral to expert centers,and,ultimately,liver disease-related mortality and successful transplantation *** present minireview aims to increase awareness of the pulmonary complications of chronic liver disease by providing a brief overview of each of the three *** paper focuses on the essential theoretical aspects,addressing the most critical knowledge gaps on the one hand and,on the other hand,critically discussing one key issue for each complication.

关键词： Hepato-pulmonary syndrome Porto-pulmonary hypertension Hepatic hydrothorax Cirrhosis Portal hypertension Advanced liver disease

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Endoscopic or percutaneous biliary drainage in hilar cholangiocarcinoma:When and how?

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 2050-2063页

作者： Tudor Mocan Adelina Horhat Emil Mois Florin Graur cristian tefas Rares Craciun Iuliana Nenu Mihaela Spârchez Zeno Sparchez Third Medical Department "Iuliu Hatieganu"University of Medicine and PharmacyCluj-Napoca 400162Romania Institute for Gastroenterology and Hepatology Cluj-Napoca 400162Romania Second Pediatric Department University of Medicine and Pharmacy"Iuliu Hatieganu"Cluj-Napoca 400162Romania

Hilar cholangiocarcinoma (hCCA) is a primary liver tumor associated with a dimprognosis. The role of preoperative and palliative biliary drainage has long beendebated. The most common techniques are endoscopic retrograde cholangiopancreatography(ERCP) and percutaneous transhepatic biliary drainage (PTBD);however, recently developed endoscopic ultrasound-assisted methods are gainingmore atention. Selecting the best available method in any specific scenario iscrucial, yet sometimes challenging. Thus, this review aimed to discuss theavailable techniques, indications, perks, pitfalls, and timing-related issues in themanagement of hCCA. In a preoperative setting, PTBD appears to have someadvantages: low risk of postprocedural complications (namely cholangitis) andbetter priming for surgery. For palliative purposes, we propose ERCP/PTBDdepending on the experience of the operators, but also on other factors: the levelof bilirubin (if very high, rather PTBD), length of the stenosis and the presence ofcholangitis (PTBD), ERCP failure, or altered biliary anatomy.

关键词： Hilar cholangiocarcinoma Endoscopic biliary drainage Percutaneous biliary drainage Endoscopic ultrasound biliary drainage Surgical oncology

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Novel approaches in search for biomarkers of cholangiocarcinoma

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World Journal of Gastroenterology 2022年第15期28卷 1508-1525页

作者： Lavinia-Patricia Mocan Maria Ilieș Carmen Stanca Melincovici Mihaela Spârchez RareșCrăciun Iuliana Nenu Adelina Horhat cristian tefas Zeno Spârchez Cristina Adela Iuga Tudor Mocan Carmen Mihaela Mihu Department of Histology Faculty of Medicine"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400012Romania Department of Proteomics and Metabolomics MedFUTURE Research Center for Advanced Medicine"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400349Romania ^(nd)Pediatrics Department Faculty of Medicine"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400012Romania ^(rd)Medical Department Faculty of Medicine"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400012Romania Department of Gastroenterology "Prof.dr.Octavian Fodor"Institute for Gastroenterology and HepatologyCluj-Napoca 400162Romania Department of Pharmaceutical Analysis Faculty of Pharmacy"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400012Romania

Cholangiocarcinoma(CCA)arises from the ductular epithelium of the biliary tree,either within the liver(intrahepatic CCA)or more commonly from the extrahepatic bile ducts(extrahepatic CCA).This disease has a poor prognosis and a growing worldwide *** poor outcomes of CCA are partially explained by the fact that a final diagnosis is challenging,especially the differential diagnosis between hepatocellular carcinoma and intrahepatic CCA,or distal CCA and pancreatic head *** patients present with an advanced disease,unresectable disease,and there is a lack in non-surgical therapeutic *** least,there is an acute lack of prognostic biomarkers which further complicates disease ***,there is a dire need to find alternative diagnostic and follow-up pathways that can lead to an accurate result,either singlehandedly or combined with other *** the"-omics"era,this goal can be attained by various means,as it has been successfully demonstrated in other primary *** variants can reach a biomarker status ranging from circulating nucleic acids to proteins,metabolites,extracellular vesicles,and ultimately circulating tumor ***,given the relatively heterogeneous data,extracting clinical meaning from the inconsequential noise might become a tall *** current review aims to navigate the nascent waters of the non-invasive approach to CCA and provide an evidence-based input to aid clinical decisions and provide grounds for future research.

关键词： Cholangiocarcinoma Biomarker Proteomics Metabolomics Extracellular vesicles Circulating nucleic acids

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Statins in risk-reduction and treatment of cancer

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World Journal of Clinical Oncology 2020年第8期11卷 573-588页

作者： Cristina I Barbalata Lucia R tefas Marcela Achim Ioan Tomuta Alina S Porfire Department of Pharmaceutical Technology and Biopharmaceutics Faculty of Pharmacy“Iuliu-Hatieganu”University of Medicine and PharmacyCluj-Napoca 400012Romania

Statins,which are competitive inhibitors of 3-hydroxy-3-methyl-glutarylcoenzyme A reductase,reduce cholesterol blood levels and the risk of developing cardiovascular diseases and their related *** addition to this main activity,statins show pleiotropic effects such as antioxidant,anti-inflammatory and antiproliferative properties,with applications in many *** on their antiproliferative properties,in vitro and in vivo studies have investigated their effects on various types of cancer(i.e.,breast cancer,prostate cancer,colorectal cancer,ovarian cancer,lung cancer)with different genetic and molecular *** positive results were obtained,but they were highly dependent on the physiochemical properties of the statins,their dose and treatment *** therapies of statins and cytotoxic drugs have also been tested,and synergistic or additive effects were ***,observational studies performed on patients who used statins for different pathologies,revealed that statins reduced the risk of developing various cancers,and improved the outcomes for cancer ***,there are many ongoing clinical trials aimed at exploring the potential of statins to lower the mortality and the disease-recurrence *** these results are the foundation of new treatment directions in cancer therapy.

关键词： Statins Cancer Pleiotropic effects Risk reduction Clinical trials 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase Mevalonate pathway

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Neuromorphic silicon photonics with 50 GHz tiled matrix multiplication for deep-learning applications

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Advanced Photonics 2023年第1期5卷 50-57页

作者： George Giamougiannis Apostolos Tsakyridis Miltiadis Moralis-Pegios George Mourgias-Alexandris Angelina RTotovic George Dabos Manos Kirtas Nikolaos Passalis Anastasios tefas Dimitrios Kalavrouziotis Dimitris Syrivelis Paraskevas Bakopoulos Elad Mentovich David Lazovsky Nikos Pleros Aristotle University of Thessaloniki Department of InformaticsThessalonikiGreece NVIDIA AthensGreece NVIDIA YokneamIsrael Celestial AI Santa ClaraCaliforniaUnited States

The explosive volume growth of deep-learning(DL)applications has triggered an era in computing,with neuromorphic photonic platforms promising to merge ultra-high speed and energy efficiency credentials with the brain-inspired computing *** transfer of deep neural networks(DNNs)onto silicon photonic(SiPho)architectures requires,however,an analog computing engine that can perform tiled matrix multiplication(TMM)at line rate to support DL applications with a large number of trainable parameters,similar to the approach followed by state-of-the-art electronic graphics processing ***,we demonstrate an analog SiPho computing engine that relies on a coherent architecture and can perform optical TMM at the record-high speed of 50 *** potential to support DL applications,where the number of trainable parameters exceeds the available hardware dimensions,is highlighted through a photonic DNN that can reliably detect distributed denial-of-service attacks within a data center with a Cohen’s kappa score-based accuracy of 0.636.

关键词： neuromorphic photonics optical computing deep learning silicon photonics

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