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World Journal of Transplantation 2024年第1期14卷 1-8页

作者： cristian Lindner raúl riquelme rodrigo San Martín Frank Quezada Jorge Valenzuela Juan P Maureira Martín Einersen Department of radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile Department of radiology Hospital Clínico Regional Guillermo Grant BenaventeConcepción 4030000Chile Department of Statistics Catholic University of MauleTalca 3460000Chile Neurovascular Unit Department of RadiologyHospital Clínico Regional Guillermo Grant BenaventeConcepción 4030000Chile

Hepatic artery thrombosis(HAT)is a devastating vascular complication following liver transplantation,requiring prompt diagnosis and rapid revascularization treatment to prevent graft *** present,imaging modalities such as ultrasound,computed tomography,and magnetic resonance play crucial roles in diagnosing *** imaging techniques have improved sensitivity and specificity for HAT diagnosis,they have limitations that hinder the timely diagnosis of this *** this sense,the emergence of artificial intelligence(AI)presents a transformative opportunity to address these diagnostic *** development of machine learning algorithms and deep neural networks has demonstrated the potential to enhance the precision diagnosis of liver transplant complications,enabling quicker and more accurate detection of *** article examines the current landscape of imaging diagnostic techniques for HAT and explores the emerging role of AI in addressing future challenges in the diagnosis of HAT after liver transplant.

关键词： Liver transplantation Postoperative complications Hepatic artery Thrombosis radiology Artificial intelligence

Engineering hyaluronic acid-based nanoassemblies for monoclonal antibody delivery-design,characterization,and biological insights

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Nano research 2024年第10期17卷 9111-9125页

作者： Ana M.López-Estévez Y.Zhang María Medel Iker Arriaga Lucía Sanjurjo cristian Huck-Iriart Nicola G.A.Abrescia María J.Vicent Defang Ouyang Dolores Torres María José Alonso Center for research in Molecular Medicine and Chronic Diseases(CiMUS) University of Santiago de CompostelaSantiago de Compostela 15782Spain Department of Pharmacology Pharmacy and Pharmaceutical TechnologySchool of PharmacyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain Health research Institute of Santiago de Compostela(IDIS) Santiago de Compostela 15782Spain State Key Laboratory of Quality research in Chinese Medicine Institute of Chinese Medical Sciences(ICMS)University of MacaoMacao 999078China Polymer Therapeutics Laboratory and CIbErONC Prince Felipe research Centre Valencia E-46012Spain Structure and Cell biology of Viruses Lab CIC bioGUNEBasque Research and Technology Alliance(BRTA)Derio 48160Spain ALbA Synchrotron Light Source Experiments DivisionCerdanyola del VallèsBarcelona 08290Spain IKErbASQUE Basque Foundation for ScienceBilbao 48009Spain

The current spotlight of cancer therapeutics is shifting towards personalized medicine with the widespread use of monoclonal antibodies(mAbs).Despite their increasing potential,mAbs have an intrinsic limitation related to their inability to cross cell membranes and reach intracellular *** offers promising solutions to overcome this limitation,however,formulation challenges *** challenges are the limited loading capacity(often insufficient to achieve clinical dosing),the complex formulation methods,and the insufficient characterization of mAb-loaded ***,we present a new nanocarrier consisting of hyaluronic acid-based nanoassemblies(HANAs)specifically designed to entrap mAbs with a high efficiency and an outstanding loading capacity(50%,w/w).HANAs composed by an mAb,modified HA and phosphatidylcholine(PC)resulted in sizes of~100 nm and neutral surface *** modeling identified the principal factors governing the high affinity of mAbs with the amphiphilic HA and *** composition and structural configuration were analyzed using the orthogonal techniques cryogenic transmission electron microscopy(cryo-TEM),asymmetrical flow field-flow fractionation(AF4),and small-angle X-ray scattering(SAXS).These techniques provided evidence of the formation of core-shell nanostructures comprising an aqueous core surrounded by a bilayer consisting of phospholipids and amphiphilic *** vitro experiments in cancer cell lines and macrophages confirmed HANAs’low toxicity and ability to transport mAbs to the intracellular *** reproducibility of this assembling process at industrial-scale batch sizes and the long-term stability was *** conclusion,these results underscore the suitability of HANAs technology to load and deliver biologicals,which holds promise for future clinical translation.

关键词： monoclonal antibody nanoparticles hyaluronic acid characterization particle size computational modeling

beyond the imaging evaluation of fractures of the lateral process of the talus:Let’s not forget concomitant injuries

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World Journal of Clinical Cases 2024年第30期12卷 6410-6412页

作者： cristian Lindner Pedro reyes Eduardo Molina Andrés Olave Department of radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000BiobíoChile Department of radiology Hospital Regional Guillermo Grant BenaventeConcepción 4030000BiobíoChile Department of Musculoskeletal radiology Hospital Regional Guillermo Grant BenaventeConcepción 4030000BiobíoChile

Fractures of the lateral process of the talus(FLPT)are uncommon fractures that represent a clinical *** radiological classification systems rely predominantly on radiographic ***,due to the high rate of FLPT misdiagnosis and the limited accuracy in evaluating concomitant talar injuries through plain radiographs,novel imaging classification systems have been developed that aim to enhance the diagnosis of concomitant talar injuries,thereby optimizing patient management and reducing the incidence of long-term complications.

关键词： Talus bone fracture Subtalar joint Hindfoot injuries Fracture of the talus Intraarticular fracture

Assessment of Contamination Degree of Oil residues on a Former Agricultural Site

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Journal of Agricultural Science and Technology(A) 2024年第2期14卷 67-82页

作者： Marinela Florica bodog Emil Catalin Schiopu Ghita cristian Crainic Andra Nicoleta Lazar Department of Forestry and Forest Engineering University of OradeaBihor 418013Romania Department of Energy Environment and AgritourismFaculty of Engineering“Constantin Brancuși”UniversityTârgu Jiu 210185GorjRomania Department of Agriculture-Horticulture University of OradeaBihor 418013Romania

In this study,our goal is to identify the land surface that has been polluted/degraded by petroleum products or other identified causes through laboratory analysis,to assess the depth of current contamination and to identify the specific causes of *** level of contamination will be assessed by analyzing a total of 90 soil samples,both within the first 30 cm depth and within the 30-60 cm *** potential impact of the petroleum activities and their effects on the environment and agricultural development in the area will be evaluated by studying the distribution of the chemical elements analyzed,particularly total petroleum hydrocarbons(TPH).In addition,a thematic map was created using MapSys 10.0 software based on their distribution,indicating the polluted areas using color codes and *** analysis and mapping revealed that 7,473 square meters of the site were severely contaminated at 30 cm,representing approximately 25% of the site.

关键词： Degradation oil pollution residues soil surface thematic map

Imaging-based prediction of hepatocellular carcinoma recurrence after microwave ablation as bridge therapy: A glimpse into the future

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World Journal of Transplantation 2024年第4期14卷 1-5页

作者： cristian Lindner rodrigo San Martín Andrés Concha David Clemo Jorge Valenzuela Department of radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile Department of radiology Hospital Regional Guillermo Grant BenaventeConcepción 4030000BiobíoChile

Liver transplantation(LT)remains the treatment of choice for early-stage hepato-cellular carcinoma(HCC)and offers the best long-term oncological ***,the increasing waiting list for LT has led to a significant dropout rate as patients experience tumor progression beyond the Milan ***,locoregional therapies,such as microwave ablation(MWA),have emerged as promising bridge treatments for patients awaiting *** therapies have shown promising results in preventing tumor progression,thus reducing the dropout rate of LT *** the efficacy of MWA in treating HCC,tumoral recurrence after ablation remains a major challenge and significantly impacts the prognosis of HCC ***,accurately diagnosing tumoral recurrence post-ablation is *** studies have developed novel imaging features based on magnetic resonance imaging of HCC,which could provide essential information for predicting early tumoral recurrence after *** advancements could address this unresolved challenge,improving the clinical outcomes of patients on the LT waiting *** article explored the current landscape of MWA as a bridge therapy for HCC within the Milan criteria,high-lighting the emerging role of novel imaging-based features aimed at improving the prediction of tumor recurrence after MWA.

关键词： Liver transplantation Hepatocellular carcinoma Ablation techniques Multiparametric magnetic resonance imaging Interventional oncology Liver disease Microwaves

Percutaneous decannulation of extracorporeal membrane oxygenation using MANTA device:A real-world single-center experience

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World Journal of Cardiology 2024年第10期16卷 574-579页

作者： Ioannis Milioglou Alice Qian Pedro rafael Vieira de Oliveira Salerno Gabriel Tensol rodrigues Pereira Luis Augusto Palma Dallan Kelsey E Gray Michael Morrison Yasir Abu-Omar Mohammad Eldiasty cristian baeza Department of Cardiology University Hospitals Cleveland Medical CenterClevelandOH 44106United States Department of Surgery University Hospitals Cleveland Medical Center and Case Western Reserve University School of MedicineClevelandOH 44106United States

bACKGrOUND The MANTA vascular closure device(VCD)represents a novel approach to achieving hemostasis after large-bore femoral access *** clinical studies have evaluated the efficacy of the MANTA device across a range of patient populations undergoing different ***,there is still a paucity of data available concerning the use of MANTA devices in aiding the decannulation of venoarterial extracorporeal membrane oxygenation(VAECMO).AIM To present our single-center experience of utilizing the MANTA VCD in patients undergoing this *** This single-center study included all patients undergoing percutaneous decannulation of femoral VA-ECMO using the MANTA plug-based VCD between January 2021 and October 2023 at University Hospitals Cleveland Medical *** criteria were adult patients who required prolonged(>24 hours)hemodynamic support with *** included all-cause mortality,hemostasis,bleeding,limb ischemia,and site *** This is a retrospective cohort study of 19 patients with a mean age of 56.8 *** of them were males with a mean body mass index of *** most common extracorporeal membrane oxygenation indication was acute coronary syndrome complicated by cardiogenic shock at 36.8%.The mean length of intensive care unit stay for these patients was 18.8±8.42 *** out of 19 patients survived to *** MANTA device was successfully deployed in 19 patients,with 10 procedures conducted at the bedside and 9 in an operating room *** hemostasis was achieved within 5 minutes of MANTA deployment in 17 out of 19 *** 2 patients manual compression after Manta deployment was required to achieve adequate ***,acute lower extremity ischemia was noted in two patients,necessitating endovascular *** infections were reported at the site of MANTA *** Overall,based on our experience and that of other centers,the MANTA VCD

关键词： Extracorporeal membrane oxygenation MANTA Decannulation Hemostasis Ischemia

Hidden Markov Models:Inverse Filtering,belief Estimation and Privacy Protection

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Journal of Systems Science & Complexity 2021年第5期34卷 1801-1820页

作者： LOUrENCO Ines MATTILA robert rOJAS cristian r. HU Xiaoming WAHLbErG bo Division of Decision and Control Systems School of Electrical Engineering and Computer ScienceKTH Royal Institute of TechnologyStockholmSweden Division of Optimizations and Systems Theory School of Engineering SciencesKTH Royal Institute of TechnologyStockholmSweden

A hidden Markov model(HMM)comprises a state with Markovian dynamics that can only be observed via noisy *** paper considers three problems connected to HMMs,namely,inverse filtering,belief estimation from actions,and privacy enforcement in such a ***,the authors discuss how HMM parameters and sensor measurements can be reconstructed from posterior distributions of an HMM ***,the authors consider a rational decision-maker that forms a private belief(posterior distribution)on the state of the world by filtering private *** authors show how to estimate such posterior distributions from observed optimal actions taken by the *** the setting of adversarial systems,the authors finally show how the decision-maker can protect its private belief by confusing the adversary using slightly sub-optimal *** range from financial portfolio investments to life science decision systems.

关键词： belief estimation counter-adversarial systems hidden Markov models inverse decision making inverse filtering

The role of PIN Auxin Efflux Carriers in Polar Auxin Transport and Accumulation and Their Effect on Shaping Maize Development

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Molecular Plant 2012年第4期5卷 787-798页

作者： cristian Forestan Serena Varotto Department of Environmental Agronomy and Crop Science--University of Padova Viale dell'Universita 16 35020 Legnaro (PD) Italy

In plants, proper seed development and the continuing post-embryonic organogenesis both require that dif- ferent cell types are correctly differentiated in response to internal and external stimuli. Among internal stimuli, plant hormones and particularly auxin and its polar transport （PAT） have been shown to regulate a multitude of plant phys- iological processes during vegetative and reproductive development. Although our current auxin knowledge is almost based on the results from researches on the eudicot Arabidopsis thaliana, during the last few years, many studies tried to transfer this knowledge from model to crop species, maize in particular. Applications of auxin transport inhibitors, mutant characterization, and molecular and cell biology approaches, facilitated by the sequencing of the maize genome, allowed the identification of genes involved in auxin metabolism, signaling, and particularly in polar auxin transport. PIN auxin efflux carriers have been shown to play an essential role in regulating PAT during both seed and post-embryonic development in maize. In this review, we provide a summary of the recent findings on PIN-mediated polar auxin transport during maize development. Similarities and differences between maize and Arabidopsis are analyzed and discussed, also considering that their different plant architecture depends on the differentiation of structures whose development is con- trolled by auxins.

关键词： auxin PIN-formed auxin efflux carrier PAT Polar Auxin Transport kernel development meristem organ-ogenesis Zea mays.

Degenerate Nonlinear Elliptic Equations Lacking in Compactness

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Chinese Annals of Mathematics,Series b 2016年第1期37卷 53-72页

作者： Maria MALIN cristian UDrEA Department of Mathematics University of Craiova

In this paper, the authors prove the existence of solutions for degenerate elliptic equations of the form-div(a(x)▽_p u(x)) = g(λ, x, |u|^(p-2)u) in r^N, where ▽_pu =|▽u|^(p-2)▽u and a(x) is a degenerate nonnegative weight. The authors also investigate a related nonlinear eigenvalue problem obtaining an existence result which contains information about the location and multiplicity of eigensolutions. The proofs of the main results are obtained by using the critical point theory in Sobolev weighted spaces combined with a Caffarelli-Kohn-Nirenberg-type inequality and by using a specific minimax method, but without making use of the Palais-Smale condition.

关键词： Degenerate equations p-Laplacian Sobolev weighted spaces Mountain-pass theorem

Dynamic Analysis for the Global Performance of An SPM-Feeder-Cage System Under Waves and Currents

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China Ocean Engineering 2015年第3期29卷 415-430页

作者： cristian CIFUENTES M.H.KIM Ocean Engineering Program Department of Civil Engineering Texas A&M University College Station

In the present study, the dynamic response of a coupled SPM-feeder-cage system under irregular waves and shear currents is analyzed. A numerical model is developed by using the commercial software Orca Flex. Hydrodynamics coefficients of the vessel are calculated by using a 3D diffraction/radiation panel program. First- and second-order wave forces are included in the calculations. Morison equation is used to compute the drag force on line elements representing the net. Drag coefficients are determined at every time step in the simulation considering the relative normal velocity between the structural elements and the fluid flow. The dynamic response of the coupled system is analyzed for various environments and net materials. The results of the study show the effects of solidity ratio of the net and vertical positions of the cage on the overall dynamic response of the system, confirming the viability of this type of configuration for future development of offshore aquaculture in deep waters.

关键词： offshore aquaculture SPM(single point mooring) feeder vessel connecting lines operational/survival environment drag force equivalent net cage grouping net modeling line tensions solidity ratio