检索结果-南通市图书馆

Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus

World Journal of Hepatology 2016年第25期8卷 1075-1086页

作者： Juan P Arab Juan C Claro Juan P Arancibia Jorge Contreras Fernando Gomez cristian munoz Leyla Nazal Eric Roessler Rodrigo Wolff Marco Arrese Carlos Benítez Departamento de Gastroenterología Escuela de Medicina Pontificia Universidad Católica de Chile Departamento de Medicina Interna and Programa de Salud Basada en la Evidencia Escuela de Medicina Pontificia Universidad Católica de Chile Sección de Gastroenterología Departamento de Medicina Hospital Clínico Universidad de Chile and Clínica Santa María Unidad de Gastroenterología Universidad del Desarrollo Clínica Alemana Servicio de Gastroentero-logía Unidad de Trasplante Hepático Hospital del Salvador Facultad de Medicina Universidad de Chile and Unidad de Gastroenterología Clínica Alemana de Santiago Clínica Indisa Clínica Las Condes y Servicio de Gastroenterología Hospital Fuerza Aérea de Chile Departamento de Nefrología Facultad de Medicina Pontificia Universidad Católica de Chile

AIM To propose several alternatives treatment of type 1 hepatorenal syndrome(HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal *** A group of eleven gastroenterologists and nephrologists performed a structured analysis of available *** expert was designated to review and answer a *** generated draft statements for evaluation by all the *** input was obtained from medical *** order to reach consensus,a modified three-round Delphi technique method was *** to United States Preventive Services Task Force criteria,the quality of the evidence and level of recommendation supporting each statement was *** Nine questions were *** available evidence was evaluated considering its quality,number of patients included in the studies and the consistency of its *** generated questions were answered by the expert panel with a high level of ***,a therapeutic algorithm was *** role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of *** the other hand the use of the combination of octreotide,midodrine and albumin without vasoconstrictors was *** role of several other options was also evaluated and the available evidence was explored and *** transplantation is considered the definitive treatment for *** present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature,the quality of the evidence and the benefits,adverse effects and availability of the therapeutic tools *** Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1.

关键词： Hepatorenal syndrome Delphi Consensus Evidence-based medicine Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

引用

Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Convergence of the turkey gut microbiota following cohabitation under commercial settings

引用

Journal of Animal Science and Biotechnology 2021年第4期12卷 1635-1644页

作者： Elizabeth A.Miller Brittanie Winfield Bonnie P.Weber cristian Flores-Figueroa Jeannette munoz-Aguayo Jared Huisinga Timothy J.Johnson Department of Veterinary and Biomedical Sciences University of MinnesotaSaint PaulMNUSA University of Minnesota Mid-Central Research and Outreach CenterWillmarMNUSA Science Innovations WillmarMNUSA

Background:Microbiota development is a critical aspect of turkey poult maturation,and the succession of microbes in the turkey gut has been shown to correlate with poult *** purpose of this study was to determine the fate of the microbiota in turkey poults after movement of birds first raised in an isolated hatch brood system into a more traditional commercial brood facility with pre-existing *** poults were first divided into groups raised in conventional brood pens from day-of-hatch and those raised in an experimental hatch brood *** 11 days of growth,hatch brood birds were moved into pens within the conventional brood barn and monitored for an additional 18 *** of both hatch brood and conventional pen birds was performed at multiple timepoints throughout the study,and cecal content was used to analyze the bacterial microbiota using 16S rRNA gene amplicon ***:Alpha diversity tended to be higher in samples from conventional pen birds compared to those from hatch brood birds prior to the day 11 move,but the difference between systems was not observed *** beta diversity metrics,bacterial community succession appeared delayed in the hatch brood system birds pre-move,but post-move community composition quickly converged with that of the conventional pen *** was validated through assessment of significantly different genera between hatch brood system and conventional pen birds,where numbers of significantly different taxa quickly decreased following the *** key taxa previously associated with poult performance were delayed in their appearance and relative abundance in hatch brood ***:Overall,this study demonstrates that the use of isolated hatch brood systems has an impact on the poult gut microbiota,but its impact is resolved quickly once the birds are introduced into a conventional brood ***,the benefits of pathogen reduction with hatch brood systems may out

关键词： Brood Gut Hatch Microbiota Poult Succession Turkey

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Role of PIN Auxin Efflux Carriers in Polar Auxin Transport and Accumulation and Their Effect on Shaping Maize Development

引用

Molecular Plant 2012年第4期5卷 787-798页

作者： cristian Forestan Serena Varotto Department of Environmental Agronomy and Crop Science--University of Padova Viale dell'Universita 16 35020 Legnaro (PD) Italy

In plants, proper seed development and the continuing post-embryonic organogenesis both require that dif- ferent cell types are correctly differentiated in response to internal and external stimuli. Among internal stimuli, plant hormones and particularly auxin and its polar transport （PAT） have been shown to regulate a multitude of plant phys- iological processes during vegetative and reproductive development. Although our current auxin knowledge is almost based on the results from researches on the eudicot Arabidopsis thaliana, during the last few years, many studies tried to transfer this knowledge from model to crop species, maize in particular. Applications of auxin transport inhibitors, mutant characterization, and molecular and cell biology approaches, facilitated by the sequencing of the maize genome, allowed the identification of genes involved in auxin metabolism, signaling, and particularly in polar auxin transport. PIN auxin efflux carriers have been shown to play an essential role in regulating PAT during both seed and post-embryonic development in maize. In this review, we provide a summary of the recent findings on PIN-mediated polar auxin transport during maize development. Similarities and differences between maize and Arabidopsis are analyzed and discussed, also considering that their different plant architecture depends on the differentiation of structures whose development is con- trolled by auxins.

关键词： auxin PIN-formed auxin efflux carrier PAT Polar Auxin Transport kernel development meristem organ-ogenesis Zea mays.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Subclinical hearing loss associated with aging

引用

Journal of Otology 2023年第3期18卷 111-117页

作者： cristian Aedo-Sanchez Jose Oliveros Constanza Aranguiz Camila munoz Claudia Lazo-Maturana Enzo Aguilar-Vidal Departamento de Tecnología Médica Facultad de MedicinaUniversidad de ChileChile Escuela de Tecnología Médica Facultad de MedicinaUniversidad de ChileChile

Objective:Contribute to clarifying the existence of subclinical hearing deficits associated with ***:In this work,we study and compare the auditory perceptual and electrophysiological performance of normal-hearing young and adult subjects(tonal audiometry,high-frequency tone threshold,a triplet of digits in noise,and click-evoked auditory brainstem response).Study sample:45 normal hearing volunteers were evaluated and divided into two groups according to age.27 subjects were included in the“young group”(mean 22.1 years),and 18 subjects(mean 42.22 years)were included in the“adult group.”Results:In the perceptual tests,the adult group presented significantly worse tonal thresholds in the high frequencies(12 and 16 kHz)and worse performance in the digit triplet tests in *** the electrophysiological test using the auditory brainstem response technique,the adult group presented significantly lower I and V wave amplitudes and higher V wave latencies at the supra-threshold *** the threshold level,we observed a significantly higher latency in wave V in the adult *** addition,in the partial correlation analysis,controlling for the hearing level,we observed a relationship(negative)between age and speech in noise performance and high-frequency *** significant association was observed between age and the auditory brainstem ***:The results are compatible with subclinical hearing loss associated with aging.

关键词： Age-related hearing loss Cochlear synaptopathy Auditory electrophysiology Speech perception Aging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Degenerate Nonlinear Elliptic Equations Lacking in Compactness

引用

Chinese Annals of Mathematics,Series B 2016年第1期37卷 53-72页

作者： Maria MALIN cristian UDREA Department of Mathematics University of Craiova

In this paper, the authors prove the existence of solutions for degenerate elliptic equations of the form-div(a(x)▽_p u(x)) = g(λ, x, |u|^(p-2)u) in R^N, where ▽_pu =|▽u|^(p-2)▽u and a(x) is a degenerate nonnegative weight. The authors also investigate a related nonlinear eigenvalue problem obtaining an existence result which contains information about the location and multiplicity of eigensolutions. The proofs of the main results are obtained by using the critical point theory in Sobolev weighted spaces combined with a Caffarelli-Kohn-Nirenberg-type inequality and by using a specific minimax method, but without making use of the Palais-Smale condition.

关键词： Degenerate equations p-Laplacian Sobolev weighted spaces Mountain-pass theorem

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamic Analysis for the Global Performance of An SPM-Feeder-Cage System Under Waves and Currents

引用

China Ocean Engineering 2015年第3期29卷 415-430页

作者： cristian CIFUENTES M.H.KIM Ocean Engineering Program Department of Civil Engineering Texas A&M University College Station

In the present study, the dynamic response of a coupled SPM-feeder-cage system under irregular waves and shear currents is analyzed. A numerical model is developed by using the commercial software Orca Flex. Hydrodynamics coefficients of the vessel are calculated by using a 3D diffraction/radiation panel program. First- and second-order wave forces are included in the calculations. Morison equation is used to compute the drag force on line elements representing the net. Drag coefficients are determined at every time step in the simulation considering the relative normal velocity between the structural elements and the fluid flow. The dynamic response of the coupled system is analyzed for various environments and net materials. The results of the study show the effects of solidity ratio of the net and vertical positions of the cage on the overall dynamic response of the system, confirming the viability of this type of configuration for future development of offshore aquaculture in deep waters.

关键词： offshore aquaculture SPM(single point mooring) feeder vessel connecting lines operational/survival environment drag force equivalent net cage grouping net modeling line tensions solidity ratio

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A high Q terahertz metamaterial absorber using concentric elliptical ring resonators for harmful gas sensing applications

引用

Defence Technology（防务技术） 2023年第4期22卷 69-73页

作者： Bhargav Appasani Avireni Srinivasulu cristian Ravariu Department of Electronics Engineering Kalinga Institute of Industrial TechnologyBhubaneswarIndia Department of Electronics Engineering K R Mangalam UniversityGurgaonIndia Department of Electronic Devices Circuits and ArchitecturesPolytechnic University of BucharestBucharestRomania

A nearly perfect metamaterial absorber is proposed that can find utility in terahertz sensing *** design consists of two concentric elliptical ring resonators(ERRs)whose parameters are appropriately set to achieve dual band absorption with near perfect *** first absorption band at 3.62 THz having a Q-factor of 51.7 was caused due to the currents in the outer and inner *** second absorption peak at 3.814 THz having a Q factor of 1411.11 was a consequence of currents flowing across the gap between the two concentric ***,it is observed that the absorption bands are sensitive to the variation in refractive index of the surrounding *** sensitivity's in the absorption bands are 3 THz/RIU and 3.59 THz/RIU respectively.A sensor is proposed based on this design to detect harmful gases,which is demonstrated for detection of Methane and *** Q-factor and high sensitivity of the narrow band makes the design an excellent sensor for detecting variations in the refractive index.

关键词： Refractive index Plasma frequency Metamaterials Terahertz absorption Q-factor Gas sensing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Redox regulation of mammalian sperm capacitation

引用

Asian Journal of Andrology 2015年第4期17卷 583-590页

作者： cristian O'Flaherty Urology Research Laboratory Surgery Department (Urology Division) Faculty of Medicine McGill University Montreal Quebec Canada The Research Institute McGillUniversity Health Centre Montreal Quebec Canada.

Capacitation is a series of morphological and metabolic changes necessary for the spermatozoon to achieve fertilizing ability. One of the earlier happenings during mammalian sperm capacitation is the production of reactive oxygen species （ROS） that will trigger and regulate a series of events including protein phosphorylation, in a time-dependent fashion. The identity of the sperm oxidase responsible for the production of ROS involved in capacitation is still elusive, and several candidates are discussed in this review. Interestingly, ROS-induced ROS formation has been described during human sperm capacitation. Redox signaling during capacitation is associated with changes in thiol groups of proteins located on the plasma membrane and subcellular compartments of the spermatozoon. Both, oxidation of thiols forming disulfide bridges and the increase on thiol content are necessary to regulate different sperm proteins associated with capacitation. Reducing equivalents such as NADH and NADPH are necessary to support capacitation in many species including humans. Lactate dehydrogenase, glucose-6-phospohate dehydrogenase, and isocitrate dehydrogenase are responsible in supplying NAD （P） H for sperm capacitation. Peroxiredoxins （PRDXs） are newly described enzymes with antioxidant properties that can protect mammalian spermatozoa; however, they are also candidates for assuring the regulation of redox signaling required for sperm capacitation. The dysregulation of PRDXs and of enzymes needed for their reactivation such as thioredoxin/thioredoxin reductase system and glutathione-S-transferases impairs sperm motility, capacitation, and promotes DNA damage in spermatozoa leading to male infertility.

关键词： dehydrogenases oxidases peroxiredoxins reactive oxygen species spermatozoa thiols thioredoxins

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dispersed multiphase flows:advances in measuring,simulation and modeling

引用

Acta Mechanica Sinica 2022年第8期38卷 1-3页

作者： cristian Marchioli Lihao Zhao Department of Engineering and Architecture University of UdineUdine33100Italy Key Laboratory of Applied Mechanics Department of Engineering MechanicsTsinghua UniversityBeijing100084China

Dispersed multiphase flows are commonly encountered in a wide variety of natural and industrial applications,from sedimentation in rivers and plankton surfacing in oceanic flows to fluidized bed in chemical reactors and pneumatic conveying *** these flows,a dispersed phase(con-sisting of particles,droplets and/or bubbles)is transported by a carrier *** interaction between the phases re-sults in complex dynamics(e.g.,transport,spatial clustering,and deformation or break-up)that is rich in physics and poses a wide spectrum of theoretical,computational,and experimental *** challenges are at the very core of the research efforts made by the multiphase flow community over the past decades.

关键词： multiphase flows dispersed

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：