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Journal of Geriatric Cardiology 2020年第7期17卷 441-446页

作者： Francisco J Romeo Maximiliano Smietniansky Mariela Cal cristian garmendia Juan M Valle Raleigh Ignacio MSeropian Mariano Falconi Pablo Oberti Vadim Kotowicz Carla RAgatiello Daniel H Berroca Division of Interventional Cardiology Hospital Italiano de Buenos AiresBuenos AiresArgentina Division of Internal Medicine and Geriatrics Hospital Italiano de Buenos AiresBuenos AiresArgentina Division Cardiology Hospital Italiano de Buenos AiresBuenos AiresArgentina Division of Cardiovascular Surgery Hospital Italiano de Buenos AiresBuenos AiresArgentina

Frailty is generally defined as a clinical syndrome of decreased physiologic reserve which drives to increased vulnerability and susceptibility to different stressors together with poor recovery to homeostasis.[1]The relevance of frailty status in a wide range of prospective cohorts is mostly related to an increasing burden in both mortality,hospital readmissions,disability,and falls.

关键词： Aortic stenosis Frailty Transcatheter aortic valve replacement

Context-dependent role of sirtuin 2 in inflammation

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Neural Regeneration Research 2025年第3期20卷 682-694页

作者： NoemíSola-Sevilla Maider garmendia-Berges MCarmen Mera-Delgado Elena Puerta Department of Pharmaceutical Sciences Division of PharmacologySchool of Pharmacy and NutritionUniversity of NavarraPamplonaSpain Navarra Institute for Health Research(IdiSNA) PamplonaSpain

Sirtuin 2 is a member of the sirtuin family nicotinamide adenine dinucleotide(NAD~+)-dependent deacetylases, known for its regulatory role in different processes, including inflammation. In this context, sirtuin 2 has been involved in the modulation of key inflammatory signaling pathways and transcription factors by deacetylating specific targets, such as nuclear factor κB and nucleotide-binding oligomerization domain-leucine-rich-repeat and pyrin domain-containing protein 3(NLRP3). However, whether sirtuin 2-mediated pathways induce a pro-or an anti-inflammatory response remains controversial. Sirtuin 2 has been implicated in promoting inflammation in conditions such as asthma and neurodegenerative diseases, suggesting that its inhibition in these conditions could be a potential therapeutic strategy. Conversely, arthritis and type 2 diabetes mellitus studies suggest that sirtuin 2 is essential at the peripheral level and, thus, its inhibition in these pathologies would not be recommended. Overall, the precise role of sirtuin 2 in inflammation appears to be context-dependent, and further investigation is needed to determine the specific molecular mechanisms and downstream targets through which sirtuin 2 influences inflammatory processes in various tissues and pathological conditions. The present review explores the involvement of sirtuin 2 in the inflammation associated with different pathologies to elucidate whether its pharmacological modulation could serve as an effective strategy for treating this prevalent symptom across various diseases.

关键词： interferon inflammation lipopolysaccharide neuroinflammation NLRP3 nuclear factorκB sirtuin 2

Task Offloading in Edge Computing Using GNNs and DQN

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2649-2671页

作者： Asier garmendia-Orbegozo Jose David Nunez-Gonzalez Miguel Angel Anton Department of Applied Mathematics University of the Basque Country UPV/EHUEibar20600Spain TECNALIA Basque Research and Technology Alliance(BRTA)San Sebastian20009Spain

In a network environment composed of different types of computing centers that can be divided into different layers(clod,edge layer,and others),the interconnection between them offers the possibility of peer-to-peer task *** many resource-constrained devices,the computation of many types of tasks is not feasible because they cannot support such computations as they do not have enough available memory and processing *** this scenario,it is worth considering transferring these tasks to resource-rich platforms,such as Edge Data Centers or remote cloud *** different reasons,it is more exciting and appropriate to download various tasks to specific download destinations depending on the properties and state of the environment and the nature of the *** the same time,establishing an optimal offloading policy,which ensures that all tasks are executed within the required latency and avoids excessive workload on specific computing centers is not *** study presents two alternatives to solve the offloading decision paradigm by introducing two well-known algorithms,Graph Neural Networks(GNN)and Deep Q-Network(DQN).It applies the alternatives on a well-known Edge Computing simulator called PureEdgeSimand compares them with the two defaultmethods,Trade-Off and Round *** showed that variants offer a slight improvement in task success rate and workload *** terms of energy efficiency,they provided similar ***,the success rates of different computing centers are tested,and the lack of capacity of remote cloud servers to respond to applications in real-time is *** novel ways of finding a download strategy in a local networking environment are unique as they emulate the state and structure of the environment innovatively,considering the quality of its connections and constant *** download score defined in this research is a crucial feature for determining the quality of a download path

关键词： Edge computing edge offloading fog computing task offloading

Electro-tribological properties of diamond like carbon coatings

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Friction 2020年第2期8卷 451-461页

作者： Iñigo BRACERAS Iñigo IBÁNEZ Santiago DOMINGUEZ-MEISTER Xabier VELASCO Marta BRIZUELA Iñaki garmendia Tecnalia Research&Innovation Mikeletegi Pasealekua 2Donostia-San Sebastian 20009Spain Mechanical Engineering Department University of the Basque Country UPV/EHUPlaza de Europa1Donostia-San Sebastian 20018Spain

Diamond like carbon(DLC)coatings typically present good self-lubricating tribological properties that could be of interest in sliding dielectric contacts in multiple electrical *** this work electro-tribological studies have been performed on several DLC coatings against aluminum in different humidity conditions,in which the coefficients of friction(CoFs)and electrical contact resistance(ECR)were continuously *** show that CoF and ECR data can be linked to the properties of the coatings(thickness,finishing,microstructure,residual stresses,and wettability)and the degradation modes of their tribological and electrical ***,electro-tribological data can provide valuable information about the performance of dielectric coatings,the reasons behind it,and assist in the development of the *** also shows potential for on-line monitoring of coated parts in operation.

关键词： DLC electro-tribology ECR-electrical contact resistance coefficient of friction

Morphoagronomic characterization and wholegenome resequencing of eight highly diverse wild and weedy *** and *** *** accessions used for the first interspecific tomato MAGIC population

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Horticulture Research 2020年第1期7卷 477-492页

作者： Pietro Gramazio Leandro Pereira-Dias Santiago Vilanova Jaime Prohens Salvador Soler Javier Esteras Alfonso garmendia María JoséDíez Faculty of Life and Environmental Sciences University of Tsukuba1-1-1 Tennodai305-8572 TsukubaJapan Instituto de Conservación y Mejora de la Agrodiversidad Valenciana Universitat Politècnica de ValènciaCamino de Vera 1446022 ValenciaSpain Departamento de Ecosistemas Agroforestales Universitat Politècnica de ValènciaCamino de Vera 1446022 ValenciaSpain Instituto Agroforestal Mediterráneo Universitat Politècnica de ValènciaCamino de Vera 1446022 ValenciaSpain

The wild Solanum pimpinellifolium(SP)and the weedy *** ***(SLC)are largely unexploited genetic reservoirs easily accessible to breeders,as they are fully cross-compatible with cultivated tomato(*** ***).We performed a comprehensive morphological and genomic characterization of four wild SP and four weedy SLC accessions,selected to maximize the range of variation of both *** eight accessions are the founders of the first tomato interspecific multi-parent advanced generation inter-cross(MAGIC)*** morphoagronomic characterization was carried out with 39 descriptors to assess plant,inflorescence,fruit and agronomic traits,revealing the broad range of diversity *** of the morphological variation observed in SP was likely associated to the adaptation of the accessions to different environments,while in the case of SLC to both human activity and adaptation to the ***-genome resequencing of the eight accessions revealed over 12 million variants,ranging from 1.2 to 1.9 million variants in SLC and from 3.1 to 4.8 million in SP,being 46.3%of them(4,897,803)private *** genetic principal component analysis also confirmed the high diversity of SP and the complex evolutionary history of *** was also reflected in the analysis of the potential footprint of common ancestors or old introgressions identified within and between the two *** functional characterization of the variants revealed a significative enrichment of GO terms related to changes in cell walls that would have been negatively selected during domestication and *** comprehensive morphoagronomic and genetic characterization of these accessions will be of great relevance for the genetic analysis of the first interspecific MAGIC population of tomato and provides valuable knowledge and tools to the tomato community for genetic and genomic studies and for breeding purposes.

关键词： agronomic breeding MAGIC

抗独特型抗体在鼠体内诱导产生口蹄疫病毒中和抗体

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中国兽药杂志 1990年第4期24卷 56-58页

作者： A.E.garmendia 郭伟干

应用口蹄疫病毒中和性单克隆抗体(AB_1)在兔体内诱生抗独特型抗体(a-IdAb)。以蛋白 A-Sepharose 分离兔 a-IdAb(AB_2),并通过亲和层析法反复提纯。经固相放射免疫试验和竞争性放射免疫试验测定 AB_2具有 AB_1表位特异性。以不同的方法... 详细信息

应用口蹄疫病毒中和性单克隆抗体(AB_1)在兔体内诱生抗独特型抗体(a-IdAb)。以蛋白 A-Sepharose 分离兔 a-IdAb(AB_2),并通过亲和层析法反复提纯。经固相放射免疫试验和竞争性放射免疫试验测定 AB_2具有 AB_1表位特异性。以不同的方法和剂量给小鼠接种 AB_2(a-2 PD_(11))后,借放射免疫试验最先在第五周从接种50μgAB_2的小鼠检测到抗病毒抗体 AB_3),第六周 AB_3在接种50μg和5μg的免疫小鼠均达到最高水平,而接种50μg者 AB_3水平又比接种5μg的高三倍。此外,AB_3在组织培养和乳鼠保护试验中对口蹄疫病毒感染呈现中和作用。总之,经 AB_2免疫接种的小鼠产生不同程度的免疫反应。试验还以结合钥孔血蓝蛋白(KLH)的 a-2 PD_(11)给小鼠进行免疫接种,结果经皮下多点注射和脚掌注射的比经皮下单点注射的更早检出 AB_3。这些结果为口蹄疫疫苗制备中有可能以 a-IdAb 代替病毒的主要决定簇提供了证据。

关键词：抗独特型抗体鼠诱导口蹄疫病毒

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西班牙巴拉卡尔多体育馆

中国建筑装饰装修 2012年第4期 186-191页

作者： Carlos garmendia Fernández

客户必须为校园环境中的一处游戏空间提供遮挡,以阶梯状太阳能板为主要特色。鉴于场地的环境,建筑师决定创造一个标志性的体量,以吸引不同角度的眼光,同时还使其成为学校附近的一个参照点。混凝土柱子和梁巧妙地应用于设计当中,

关键词：体育馆西班牙卡尔校园环境游戏空间太阳能板阶梯状标志性

Botulinum Toxin A, Effect on Tensile Strength of Skin Wounds;Animal Study

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Journal of Biosciences and Medicines 2020年第2期8卷 17-24页

作者： Carlos A. Gonzalez-Alvarado Juan Garzon-Muvdi Roxanna Perez-garmendia Victoria Ramirez Luz Graciela Cervantes Adriana Rodriguez-Gomez Rodrigo Davila-Diaz Cuahutemoc Marquez-Espriella Plastic and Reconstructive Surgery Division Hospital Central Sur de alta Especialidad de Petroleos Mexicanos Mexico City Mexico Experimental Surgery Department Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubiran Mexico City Mexico Pharmacology Department Instituto Nacional de Cardiologia Ignacio Chavez Mexico City Mexico Pathology Department Hospital Angeles del Pedregal Mexico City Mexico

Wound healing and cicatrization is a process that involves several phases. The main goal of a surgeon and specially the plastic surgeon is to achieve the best cosmetic results and avoid complications. Several tools are available to achieve the best result. One of the tools recently studied is the use of Botulinum toxin. The use of Botulinum toxin has showed to be a useful aid by improving macroscopic cosmetic changes, as histopathologic ones. The increase of the tensile strength is also one of the positive changes that come with the use of botulinum toxin.

关键词： Botulinum Toxin Wound Tensile Strength