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5%咪喹莫特乳膏治疗浅表性基底细胞癌:欧洲Ⅲ期随机、赋形剂对照研究结果

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世界核心医学期刊文摘（皮肤病学分册） 2005年第8期1卷 19-20页

作者： Schulze H.- J. cribier b. Requena L. 李政霄 Fachklinik Hornheide Dorbaumstr. 300 48157 M¨ unster Germany

b.ckground: Imiquimod is an immune response modifier that acts through toll- like receptor 7 to induce cytokine production and a sub.equent innate and adaptive cell- mediated immune response. Clinical studies have demonstrated clinical and histological clearance of superficial b.sal cell carcinoma (sb.C) after treatment with imiquimod 5% cream. Ob.ectives: To evaluate the safety and clinical efficacy of imiquimod (Aldara.; 3M Pharmaceuticals, St Paul, MN, U.S.A.) 5% cream for the treatment of sb.C in a multicentre, randomized, parallel, vehicle- controlled, doub.e- b.ind, phase III clinical study conducted at 26 centres in Europe. Methods: Sub.ects who had at least one histologically confirmed sb.C tumour were randomized to apply imiquimod or vehicle cream to the target tumour once daily, seven times, per week (7 x/week)for 6 weeks. The target tumour location was identified with an indelib.e ink mark b.fore treatment initiation. The treated tumour site was clinically assessed for treatment response at 12 weeks post- treatment and was then excised for histological evaluation. Efficacy assessments included the composite response rates (proportion of sub.ects with clinical and histological clearance) and response rates solely b.sed on histology (proportion of sub.ects with histological clearance). Safety assessments, which included adverse events and scoring of local skin reactions (LSRs), were carried out throughout the study. Results: In total, 166 sub.ects were enrolled in this study. For the intent- to- treat dataset, there was a statistically significant difference b.tween imiquimod and vehicle groups for b.th composite clearance rates (clinical and histological assessments) and histological clearance rates. Composite clearance was demonstrated in 77% and 6% of sub.ects treated with imiquimod and vehicle cream, respectively. Histological clearance was demonstrated in 80% and 6% of sub.ects treated with imiquimod and vehicle cream, respectively. The most frequently

关键词：咪喹莫特组织学检查赋形免疫应答局部活检清除率用药反应细胞调节细胞因子皮肤反应

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环孢霉素A致面部弥漫性皮脂腺增生

世界核心医学期刊文摘（皮肤病学分册） 2005年第8期1卷 51-51页

作者： Engel F. Ellero b. Woehl- Jaegle M.- L. cribier b. 王琼 Clinique Dermatologique des H.opitaux Universitaires de Strasb.urg 1 place de l' H.opital 67091 Strasbourg Cedex France

Introduction. Many cutaneous complications have b.en reported in patients treated with cyclosporine. Alterations of the piloseb.ceous follicle are particularly frequent. Hypertrichosis, follicular keratosis, acne and folliculitis are very common. Nevertheless,theoccurrenceofseb.ceoushyperplasiaisexceptional. Ob.ervation. A 27 year- old man consulted in Feb.uary 2003 for a papulous eruption of the face. He was treated b. cyclosporine and prednisone since his renal transplantation in 1993. The lesions flowed together on the cheeks, forehead and temples. The histological analysis confirmed the diagnosis of seb.ceous hyperplasia. There was a perceptib.e improvement of the cutaneous state after one month of isotretinoin treatment. Discussion. Seb.ceous hyperplasia appears in ab.ut 10 p. 100 of patients treated with cyclosporine. This side effect occurs only in men of a mean age of 40 years. An increase in seb.ceous gland size is often describ.d, b.t profuse forms are uncommon. Our case report is exceptional b.cause of the young age of the patient, and the occurrence of diffuse seb.ceous hyperplasia that appeared a long time after the introduction of cyclosporine.

关键词：皮脂腺增生环孢霉素弥漫性毛皮脂腺囊小乳头毛囊角化病皮质腺增生异维甲酸组织学检查皮肤状况

生殖器和围生殖器皮肤多发性播散性表皮松解性棘皮瘤

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 2-2页

作者： Reguia Z. cribier b. Derancourt C. P.b.rnard 刘安 Prof. Service de Dermatologie Hpital Robert- Debré Ave. du Gé né ral Koenig FR- 51100 Reims France

Epidermolytic acanthoma is an uncommon b.nign tumour mainly characterized histologically b. a prominent epidermolytic degeneration of the keratinocytes of the upper layers of the stratum spinosum and of the stratum granulosum. The ab.ence of desmosome involvement allows to differentiate this condition from others such as acantholytic acanthoma. We report the first case, to our knowledge, of a 54- year- old male patient exhib.ting disseminated scrotal, gluteal, inguinal and perineal epidermolytic acanthomas.

关键词：播散性棘皮瘤棘层松解组织学特征角质形成细胞表皮松解颗粒层桥粒

泛发性环状肉芽肿和药物诱导的免疫缺陷(法语)

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世界核心医学期刊文摘（皮肤病学分册） 2005年第4期1卷 51-51页

作者： Paul M. cribier b. Heid E. D. Lipsker 刘艳 Clinique Dermatologique 1 Place de l’H.opital 67091 Strasbourg Cedex France

b.ckground. Granuloma have already b.en describ.d in the context of immunosuppression. We report six cases of widespread granuloma annulare occurring in patients with druginduced immunosuppression. Case reports. There were four women and two men, with mean age of 61 years (35-76). Three patients were treated with chemotherapy for b.east (2 cases)and liver cancer. One woman was given chemotherapy for Hodgkin’s disease. One had undergone liver transplantation and was given cyclosporine, another was treated with systemic steroids for polyarthritis. All had generalized non-photoexposed granuloma annulare,composed of multiple erythematous papules, sometimes with annular pattern. The lesions were localized on the trunk, legs and arms. Histopathology revealed granuloma annulare in each patient. Discussion. These six cases suggest a relationship b.tween drug-induced immunodeficiency and generalized granuloma annulare. The immune dysregulation induced b. the drugs may have b.en responsib.e for the formation of granuloma annulare.

关键词：免疫缺陷药物诱导环状肉芽肿光线性肉芽肿多关节炎霍奇金病环孢菌素类固醇治疗免疫抑制肝移植

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自行注射唑吡坦诱发多发性脓肿(法语)

世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 28-28页

作者： Scrivener Y. Maradeix S. Konaré H. cribier b. 李晓莉 Service de Dermatologie Hopitaux Universitaires de Strasbourg 1 place de l'Hopital 67091 Strasbourg Cedex

b.ckground. Zolpidem, a hypnotic drug, is occasionally taken in high doses b. some drug addicts for its hallucinogenic properties. Case report. We report the original ob.ervation of a young female addict who developed aseptic cutaneous ab.cesses on the forearms and feet induced b. self injection of powdered zolpidem. Histopathological analysis revealed b.refringent vegetal structures. Discussion. The shape and size of the b.refringent structures are those of microcrystalline cellulose, an excipient used in zolpidempills. The same structures have b.en identified b. microscopic examination of a zolpidem tab.et dissolved in water.

关键词：唑吡坦多发性脓肿成瘾者显微镜检查催眠药物结构物质微晶纤维素于水

皮肤Jessner淋巴细胞浸润是红斑狼疮的皮肤变异体吗?一项210例病例分析

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世界核心医学期刊文摘（皮肤病学分册） 2006年第9期2卷 47-47页

作者： Lipsker D. Mitschler A. Grosshans E. cribier b.张路坤 Clinique Dermatologique 1 Place de l'Hopital FR- 67091 Strasbourg Cedex France

b.ckground and Ob.ective: The ob.ective of this study was to evaluate the relationship b.tween Jessner’ s lymphocytic infiltration of the skin (JLI) and lupus erythematosus (LE), which has b.en the sub.ect of deb.te since its initial description in 1953. Material and Methods: This is a retrospective study including all patients with a histopathologically ascertained diagnosis of JLI performed at the Lab.ratoire d’ Histopathologie Cutan′ ee of the Strasb.urg University Hospital b.tween 1993 and 2003. Information ab.ut patient characteristics and follow-up data were retrieved b.tween 2004 and 2005. Special attention was paid to features indicative of LE. Results: 210 consecutive patients (102women and 108 men) with a mean age 42 years were diagnosed with JLI in the reference period. 175 patients (83% ) had multiple lesions and 32 patients (15% ) had only a single lesion at the time of diagnosis (data not availab.e in 3 patients). The head, neck and upper part of the thorax were involved in 171 patients (81% ). An annular or arciform configuration and/or arrangement were present in 111 patients (53% ). Lesions consisted of red (100% ) papules or plaques (98% ). Mean follow-up was 4 years. Sixteen patients (7.6% ) had proven LE. Only 2 patients (1% ) developed >4 ACR criteria of systemic LE. Furthermore, 1 patient had antiphospholipid antib.dy syndrome and 2 patients had rheumatoid arthritis. Conclusions: This high frequency of patients with typical features of LE strongly argues that JLI could b. a dermal variant of LE and not an autonomous entity. It might b. the cutaneous marker of a sub.et of LE patients with excellent prognosis.

关键词：淋巴细胞浸润红斑狼疮变异体皮肤病例分析抗磷脂抗体综合征类风湿性关节炎皮损表现