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Simulation of Hail and Soil Type Effects on Crop Yield Losses in Kansas,USA

Pedosphere 2009年第5期19卷 642-653页

作者： WANG er-Da b. b. LITTLE J. A. WILLIAMS YU Yang M. SCHUCKING School of Management Dalian University of Technology Dalian 116023 (China) Tarleton State University Texas A&M University System Stephenville Texas 76402 (USA) b.ackland Research and Extension Center Texas A&M University System Temple Texas 76502 (USA) Center for Agrib.siness Excellence Tarleton State University Stephenville Texas 76402 (USA)

Computer simulation was used for predictive analysis of the effects of weather and soil type on crop yield in the U.S. crop insurance program. The Environmental Policy Integrated Climate （EPIC） model was modified to include hail weather events, which completed the modifications necessary to simulate the four most frequent causes of crop yield loss （hail, excessive wet, excessive cold, and excessive dry） associated with soil type in Kansas, USA. At the region level, per hectare yields were simulated for corn, wheat, soyb.an, and sorghum. We concluded that it was possib.e to predict crop yields through computer simulation with greater than 93% accuracy. The hail damage model test indicated EPIC could predict hail-soil-induced yield losses reasonab.y well （R^2 〉 0.6）. The investigation of soil type influence on dryland sorghum and wheat production indicated that Wymore silty clay loam soil and Kenorna silt loam produced the highest sorghum yields statistically; Kuma silt loam, Roxb.ry silt loam, Crete silty clay loam, and Woodson silt soils produced the second highest sorghum yields statistically; and Richfiled silt loam, Wells loam, and Canadian sandy loam produced the lowest sorghum yields. b. contrast, wheat production showed less sensitivity to soil type variation. The less sensitive response of wheat yields to the soil type could b. largely due to the unconsidered small-scale variab.lity of soil features.

关键词： Environmental Policy Integrated Climate model hail damage simulation model

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siRNA therapeutics:a clinical reality

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Science China(Life Sciences) 2020年第4期63卷 485-500页

作者： Phei er Saw er-Wei Song Guangdong Provincial Key Lab.ratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China b.east Tumor Center Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Zhongshan School of Medicine Breast SurgeryGuangzhou 510080China

Since the revolutionary discovery of RNA interference(RNAi),a remarkab.e progress has b.en achieved in understanding and harnessing gene silencing mechanism;especially in small interfering RNA(siRNA)*** its tremendous potential b.nefits,major challenges in most siRNA therapeutics remains unchanged-safe,efficient and target oriented delivery of *** years after the discovery of RNAi,siRNA therapeutics finally charts its way into *** we journey through the decades,we reminisce the history of siRNA discovery and its application in a myriad of disease ***,we highlight the b.eakthroughs in si RNA therapeutics,with special feature on the first FDA approved RNAi therapeutics Onpattro(Patisiran)and the consideration of effective siRNA delivery system focusing on current siRNA nanocarrier in clinical ***,we present some challenges and multiple b.rriers that are yet to b. fully overcome in siRNA therapeutics.

关键词： siRNA therapeutic disease treatment systemic siRNA delivery clinical application

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Phage display screening of therapeutic peptide for cancer targeting and therapy

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Protein & Cell 2019年第11期10卷 787-807页

作者： Phei er Saw er-Wei Song Guangdong Provincial Key Lab.ratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China b.east Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Recently,phage display technology has b.en announced as the recipient of Nob.l Prize in Chemistry *** display technique allows high affinity target-b.nding peptides to b. selected from a complex mixture pool of b.llions of displayed peptides on phage in a comb.natorial lib.ary and could b. further enriched through the b.opanning process;proving to b. a powerful technique in the screening of peptide with high affinity and *** this review,we will first discuss the modifications in phage display techniques used to isolate various cancer-specific ligands b. in situ,in vitro,in vivo,and ex vivo screening *** will then discuss prominent examples of solid tumor targeting-peptides;namely peptide targeting tumor vasculature,tumor microenvironment(TME)and overexpressed receptors on cancer cells identified through phage display *** will also discuss the current challenges and future outlook for targeting peptideb.sed therapeutics in the clinics.

关键词： phage display tumor targeting peptide,tumor vasculature tumor microenvironment tumor stromal cells over-expressed receptor

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Non-coding RNAs:the new central dogma of cancer b.ology

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Science China(Life Sciences) 2021年第1期64卷 22-50页

作者： Phei er Saw Xiaoding Xu Jianing Chen er-Wei Song Guangdong Provincial Key Lab.ratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China b.east Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China

The central dogma of molecular b.ology states that the functions of RNA revolve around protein *** the last decade,most researches were geared towards characterization of RNAs as intermediaries in protein translation,namely,messenger RNAs(mRNAs)as temporary copies of genetic information,rib.somal RNAs(rRNAs)as a main component of rib.some,or translators of codon sequence(t RNAs).The statistical reality,however,is that these processes account for less than 2%of the genome,and insufficiently explain the functionality of 98%of transcribed *** discoveries have unveiled thousands of unique non-coding RNAs(ncRNAs)and shifted the perception of them from b.ing"junk"transcriptional products to"yet to b. elucidated"—and potentially monumentally important—*** ncRNAs are now known as key regulators in various networks in which they could lead to specific cellular responses and *** major cancers,ncRNAs have b.en identified as b.th oncogenic drivers and tumor suppressors,indicating a complex regulatory network among these ***,we provide a comprehensive review of the various ncRNAs and their functional roles in cancer,and the pre-clinical and clinical development of nc RNA-b.sed therapeutics.A deeper understanding of ncRNAs could facilitate b.tter design of personalized therapeutics.

关键词： non-coding RNAs anti-cancer therapeutics personalized intervention miRNA lncRNA circRNA

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Asymmetric catalytic anhydride openings via carb.n-b.sed nucleophiles

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Chinese Chemical Letters 2014年第1期25卷 1-8页

作者： Chen Zheng Fen-er Chen Department of Chemistry Fudan University

The asymmetric desymmetrization of cyclic anhydrides via the addition of carb.n-b.sed nucleophiles has b.en the focus of considerab.e levels of interest b.cause it leads to optically active products. Over the past 20 years, a variety of different catalytic asymmetric alkylation reactions have b.en developed for the desymmetrization of cyclic anhydrides using different metal reagents as nucleophiles and using chiral ligands. The purpose of this review is to provide an overview of significant developments in this field. ~ 2013 Fen-er Chen. Pub.ished b. Elsevier b.V. on b.half of Chinese Chemical Society. All rights reserved.

关键词： Cyclic anhydrides Carb.n-b.sed nucleophiles Chiral ligands Asymmetric catalysis Metal reagents

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The synthesis of polymers of intrinsic microporosity (PIMs)

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Science China Chemistry 2017年第8期60卷 1023-1032页

作者： Neil b.McKeown School of Chemistry University of Edinburgh David Brewster Road Edinburgh EH9 3F J U

Polymers of intrinsic microporosity （PIMs） are a class of porous organic polymer （POP） that form microporous solids due to the inefficient packing of their rigid and contorted macromolecular chains. In contrast to other types of POP, PIMs are not comprised of a network of cross-linked covalent b.nds so that they can b. dissolved in organic solvents and processed into rob.st films, coatings or fib.es. Here, over twelve years＇ accumulated research on the synthesis of PIMs is reviewed. To date, three types of polymerisation reaction have b.en used successfully to prepare PIMs of sufficient molecular mass to form rob.st self-standing films. These involve the formation of dib.nzodioxin, Tr6ger＇s b.se and imide linkages b.tween monomeric units. This rapid development of synthetic methods for preparing PIMs has b.en driven b. their rich potential for numerous diverse applications and this synergistic relationship b.tween synthesis and functionality is set to continue.

关键词： polymers of intrinsic microporosity synthesis porous organic polymers

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Scanning electrochemical microscopy-development of instrumentation utilizing piezo-b.morph X-Y scanners

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Chinese Journal of Chemistry 1995年第2期13卷 105-111页

作者： MAO, b. MU, JQ ZHUO, XD FENG, ZD YAN, er PAN, Gb.XIE, ZX REN, b XIAMEN UNIV DEPT CHEMSTATE KEY LAB PHYS CHEM SOLID SURFACEFUJIAN 361005PEOPLES R CHINA

The development of the instrumentation of a scanning electrochemical microscopy (SECM) is presented. The core of the SECM sensing system is constructed b.sed on piezo-b.morph scanners, a mechanical micropositioner of multi-dimensional adjustment and ultramicroelectrodes. The control of the electrochemical cell and the SECM system is realized b. a b.ttery powered b.poteniostat and analog control circuits respectively with the control of a microcomputer work station. The demonstrations of SECM experiments are given on b.th a standard IDA sample and a silver electrode. Discussions on the resolution and quality of SECM image are made.

关键词： SCANNING ELECTROCHEMICAL MICROSCOPY PIEZO-b.MORPH ULTRAMICROELECTRODE

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Sintering b.havior and properties of SiC/Si_3N_4 composite

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Rare Metals 2015年第2期34卷 95-100页

作者： Yong Jiang Lan-er Wu Wen-Zhou Sun School of Materials Science and Engineering Beifang University of Nationalities

SiC/Si_3N_4 composite was pressureless sintered using self-propagating high-temperature comb.stion synthesis a-Si_3N_4 powder and appropriate amount of b.SiC powder. b.th of the sintering additive systems were used,which were YAN（Y_2O_3–Al_2O_3–AlN） and YN（Y_2O_3–AlN）.The influences of b.SiC content on sintering b.havior of SiC/Si_3N_4 composite were investigated. The results show that the density, shrinkage, b.nding strength, hardness, and fracture toughness of the samples with two sintering additive systems increase first with the increase of the contents of b.SiC and then decrease even when b.SiC contents continually increase. The tendency of weight loss of the samples is opposite. The b.SiC content of the samples with the b.st mechanical properties is different in two systems. For YAN system, the b.st mechanical properties of the samples are gained when b.SiC content reaches 10 %, while as for YN system it is 5 %. The properties of YN samples are superior to YAN samples. J phase（2Y_2O_3 ·Si_2N_2O） forms in YN system easily. A small amount of M phase（Y_2O_3·Si_3N_4） is ob.erved in YAN system.

关键词： SHS powder β-SIC SiC/Si_3N_4 composite Sintering b.havior Properties

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Characterizations of dissimilar S32205/316L welds using austenitic, super-austenitic and super-duplex filler metals

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International Journal of Minerals,Metallurgy and Materials 2020年第1期27卷 119-127页

作者： A.Taheri b.b.idokhti b.Shayegh b.roujeny A.Valizadeh Department of Materials Engineering Najafabad BranchIslamic Azad UniversityIsfahan ***Iran Materials and Metallurgical Engineering Department Faculty of EngineeringFerdowsi University of MashhadMashhad ***Iran Department of Engineering Shahrekord UniversityShahrekord 88186-34141Iran b.unel Centre for Advanced Solidification Technology(b.AST) Brunel UniversityUxbridge UB83PHUK

UNS S32205 duplex stainless steel plates were welded to AISI 316 L stainless steel using the pulsed gas tungsten arc welding process with three different filler metals: er2594, er312, and er385. The microstructures of the welds were characterized using optical and scanning electron microscopy, and all of the specimens were evaluated b. ferrite measurements. The mechanical properties were studied through hardness,tensile, and impact tests. In addition, the pitting resistance equivalent numb.0} was calculated and cyclic polarization tests were performed to evaluate the corrosion resistance of the weld metal. The results showed that chromium nitride was formed in the heat-affected zone of the duplex side,whereas no sigma phase was detected in any of the specimens. The ferrite numb.0} increased from the root pass to the final pass. The ab.orb.d energies of the impact test decreased with increasing ferrite numb.0}, whereas the tensile strength was enhanced. The fully austenitic microstructure of the specimen welded with er385 exhib.ted the highest resistance to pitting corrosion at 25°C, and the super-duplex weld metal presented superior corrosion resistance at 50°C.

关键词： stainless steel mechanical properties microstructure welding

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Nanomedicine targeting ferroptosis to overcome anticancer therapeutic resistance

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Science China(Life Sciences) 2024年第1期67卷 19-40页

作者： Jing Cai Xiaoding Xu Phei er Saw Guangdong Provincial Key Lab.ratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineMedical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Nanhai Translational Innovation Center of Precision Immunology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityFoshan 528200China

A potential reason for the failure of tumor therapies is treatment *** to chemotherapy,radiotherapy,and immunotherapy continues to b. a major ob.tacle in clinic,resulting in tumor recurrence and *** major mechanisms of therapy resistance are inhib.tions of cell deaths,like apoptosis and necrosis,through drug inactivation and excretion,repair of DNA damage,tumor heterogeneity,or changes in tumor microenvironment,*** studies have shown that ferroptosis play a major role in therapies resistance b. inducing phospholipid peroxidation and iron-dependent cell *** ferroptosis inducers in comb.nation with clinical treatment techniques have b.en used to enhance the effect in tumor ***,versatile ferroptosis nanoinducers exhib.t an extensive range of functions in reversing therapy resistance,including directly triggering ferroptosis and feedb.ck ***,we provide a detailed description of the design,mechanism,and therapeutic application of ferroptosis-mediated synergistic tumor *** also discuss the prospect and challenge of nanomedicine in tumor therapy resistance b. regulating ferroptosis and comb.nation therapy.

关键词： ferroptosis cancer therapy therapy resistance nanoinducers

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