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Medicine in Novel Technology and Devices 2021年第2期10卷 33-40页

作者： Barbara Garita j.nna Maligro Saghi Sadoughi po Hung Wu Ellen Liebenberg Andrew Horvai Thomas M.Link Galateia j.Kazakia Department of Radiology and Biomedical Imaging University of CaliforniaSan Francisco185 Berry St Suite 350San FranciscoCA94107USA Department of Orthopaedic Surgery University of CaliforniaSan Francisco513 Parnassus AvenueSan FranciscoCA94143USA Department of Pathology University of CaliforniaSan Francisco18254th StSan FranciscoCA94143USA

Cortical bone microstructure deficits may increase fracture risk in individuals with cardiovascular disease and *** resolution peripheral quantitative computed tomography(HR-pQCT)enables in vivo microstructure characterization but is limited in its ability to visualize important biological *** conducted histological analyses and HR-pQCT imaging of distal tibia bone samples from 6 donors with cardiovascular disease(CVD)and type 2 diabetes mellitus(T2D).Histology but not HR-pQCT identified previously undocumented morphopathological deficits that may contribute to cortical bone *** observations may provide guidance for improved HR-pQCT microstructural characterization as well as insight into mechanisms of cortical bone degradation.

关键词： Cortical bone porosity Type 2 diabetes HR-pQCT

Templated synthesis of transition metal phosphide electrocatalysts for oxygen and hydrogen evolution reactions

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j.urnal of Energy Chemistry 2024年第2期89卷 646-669,I0014页

作者： Rose Anne Acedera Alicia Theresse Dumlao Dj.Donn Matienzo Maricor Divinagracia j.lie Anne del Rosario Paraggua po-Ya Abel Chuang j.ey Ocon Laboratory of Electrochemical Engineering(LEE) Department of Chemical EngineeringUniversity of the PhilippinesDilimanQuezon City 1101Philippines Mechanical Engineering University of CaliforniaMercedCA 95343USA Energy Engineering Program College of EngineeringUniversity of the PhilippinesDilimanQuezon City 1101Philippines

Transition metal phosphides(TMPs)have been regarded as alternative hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)catalysts owing to their comparable activity to those of noble metal-based *** have been produced in various morphologies,including hollow and porous nanostructures,which are features deemed desirable for electrocatalytic *** synthesis routes are often responsible for such *** paper reviews the latest advances and existing challenges in the synthesis of TMP-based OER and HER catalysts through templated methods.A comprehensive review of the structure-property-performance of TMP-based HER and OER catalysts prepared using different templates is *** discussion proceeds according to application,first by HER and further divided among the types of templates used-from hard templates,sacrificial templates,and soft templates to the emerging dynamic hydrogen bubble *** catalysts are then reviewed and grouped according to their ***,prospective research directions for the synthesis of hollow and porous TMP-based catalysts,such as improvements on both activity and stability of TMPs,design of environmentally benign templates and processes,and analysis of the reaction mechanism through advanced material characterization techniques and theoretical calculations,are suggested.

关键词： OER HER Transition metal phosphide Templated synthesis Electrocatalysts

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A power Interruption Technique for Investigation of Temperature Difference in Stabilized Low Direct-Current Arc Burning in Pure Argon-on Atmospheric Pressure

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Chinese Physics Letters 2008年第4期25卷 1376-1379页

作者： M. M. Kuzmanovie j. j. Savovie D. P. Rankovie M. Stoilj.ovie A. Antie-j.vanovie M.S. Pavlovie M. Marinkovie Faculty for Physical Chemistry University of Belgrade PO Box 137 11001 Belgrade Serbia Laboratory of Physical Chemistry Institute Vinca PO Box 522 11000 Belgrade Serbia

Plasma of argon stabilized arc column, in a current range 3-11 A, is investigated using emission spectrometric diagnostic techniques. Temperatures are evaluated using several methods： argon line to adj.cent recombinational continuum intensity ratio, absolute emissivity of argon line, measurement of electron number density, and power interruption. Electron number density is evaluated from absolute emissivity of recombinational continuum. The difference between electron Te and heavy particle Th temperature ranged from 4500 K for 3 A to 2300 K for 11A arc current. By comparing the present with the previously obtained results, using the same arc device but with the introduction of water aerosol, it is concluded that water aerosol reduces the difference Te - Th and brings plasma closer to the partial thermodynamic equilibrium state.

关键词： supernova explosion proto-neutron star shock wave

New insights in the pathogenesis of alcohol-related liver disease:The metabolic,immunologic,and neurologic pathways

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Liver Research 2023年第1期7卷 1-8页

作者： Tom Ryu Kyurae Kim Sung Eun Choi Katherine po Sin Chung Won-Il j.ong Laboratory of Liver Research Graduate School of Medical Science and EngineeringKAISTDaejeonRepublic of Korea

Alcohol-related liver disease(ALD)became an important health issue *** chronic alcohol consumption,the development of ALD might be caused by metabolic and immunologic factors,such as reactive oxygen species(ROS)and pro-inflammatory *** example,hepatic cytochrome P4502E1 enzyme increases ROS production and stimulates de novo lipogenesis after alcohol *** addition,damage-and pathogen-associated molecular patterns stimulate their specific receptors in nonparenchymal cells,including Kupffer cells,hepatic stellate cells(HSCs),and lymphocytes,which result in hepatocyte death and infiltration of pro-inflammatory cells(e.g.,neutrophils and macrophages)in the ***,our studies have suggested the novel involvement of neurologic signaling pathways(e.g.,endocannabinoid and glutamate)through the metabolic synapse between hepatocytes and HSCs in the development of alcohol-related hepatic ***,agouti-related protein and beta2-adrenergic receptors aggravate hepatic ***,organ-crosstalk has emerged as a critical issue in *** alcohol consumption induces dysbiosis and barrier disruption in the gut,leading to endotoxin leakage into the portal circulation,or lipolysis-mediated transport of triglycerides from the adipose tissue to the *** summary,this review addresses multiple pathogeneses of ALD,provides novel neurologic signaling pathways,and emphasizes the importance of organ-crosstalk in the development of ALD.

关键词： Alcohol-related liver disease(ALD) Cannabinoid receptor Steatohepatitis Lipopolysaccharide(LPS) Metabotropic glutamate receptor(mGluR) Toll-like receptor 4(TLR4)

Using classification assignment rules to assess land-use change impacts on forest biodiversity at local-to-national scales

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Forest Ecosystems 2018年第2期5卷 162-176页

作者： Kathrin Affeld Susan K. Wiser Ian j. Payton Miquel DeCaceres Manaaki Whenua - Landcare Research PO Box 69040 Lincoln 7640 New Zealand Lincoln University PO Box 85084 Lincoln 7647 New Zealand Forest Science Centre of Catalonia Ctra. Sant Llorenc km.2 E-25280 Solsona Spain

Background： Ecosystem representation is one key component in assessing the biodiversity impacts of land-use changes that will irrevocably alter natural ecosystems. We show how detailed vegetation plot data can be used to assess the potential impact of inundation by a proposed hydroelectricity dam in the Mokihinui gorge, New Zealand, on representation of natural forests. Specifically we ask： 1） How well are the types of forest represented Locally, regionally, and nationally; and 2） How does the number of distinct communities （i.e. beta diversity） in the target catchment compare with other catchments nationally？ Methods： For local and regional comparisons plant species composition was recorded on 45 obj.ctively located 400 m2 vegetation plots established in each of three gorges, with one being the proposed inundation area of the Mokihinui lower gorge. The fuzzy classification framework of noise clustering was used to assign these plots to a specific alliance and association of a pre-existing national-scale classification. NationaLly, we examined the relationship between the number of alliances and associations in a catchment and either catchment size or the number of plots per catchment by fitting Generalised Additive Models. Results： The four alliances and five associations that were observed in the Mokihinui lower gorge arepresent in the region but limited locally. One association was narrowly distributed nationally, but is the mostfrequent association in the Mokihinui lower gorge; inundation may have consequences of national importance to its long-term persistence. That the Mokihinui lower gorge area had nearly twice as many plots that could not be assigned to pre- existing alliances and associations than either the Mokihinui upper or the Karamea lower gorges and proportionally more than the national dataset emphasises the compositional distinctiveness of this gorge. These outlier plots in the Mokihinui lower gorge may be unsorted assemblages of species or reflect

关键词： Beta-diversity Biodiversity conservation Environmental impacts Ecosystem representation Hydroelectricity dams Land-use change National vegetation classification Noise clustering New Zealand NVS databank Plant community composition

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Spiking neural P systems with neuron division and budding

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Science China(Information Sciences) 2011年第8期54卷 1596-1607页

作者： P■UN Gheorghe PREZ-j.MNEZ Mario j. Department of Computer Science and Artificial Intelligence University of Sevilla Avda Reina Mercedes s/n 41012 Sevilla Spain Institute of Mathematics of the Romanian Academy po Box 1-764 014700 Bucuresti Romania

Spiking neural P systems are a class of distributed and parallel computing models inspired by spiking *** this work,the features of neuron division and neuron budding are introduced into the framework of spiking neural P systems,which are processes inspired by neural stem cell division. With neuron division and neuron budding,a spiking neural P system can generate exponential work space in polynomial time as the case for P systems with active *** this way,spiking neural P systems can efficiently solve computationally hard problems by means of a space-time tradeoff,which is illustrated with an efficient solution to SAT problem.

关键词： natural computing membrane computing spiking neural P system neuron division

Bioactive glass coatings on metallic implants for biomedical applications

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Bioactive Materials 2019年第1期4卷 261-270页

作者： j.y-anne N.Oliver Yingchao Su Xiaonan Lu po-Hsuen Kuo j.ncheng Du Donghui Zhu Department of Materials Science and Engineering University of North TexasDentonTX76203USA Department of Biomedical Engineering University of North TexasDentonTX76203USA Department of Biomedical Engineering Stony Brook UniversityStony BrookNYUSA

Metallic implant materials possess adequate mechanical properties such as strength,elastic modulus,and ductility for long term support and stability in *** metallic biomaterials,including stainless steels,cobalt-chromium alloys,and titanium and its alloys,have been the gold standards for load-bearing implant materials in hard tissue applications in the past *** metals including iron,magnesium,and zinc have also emerged as novel biodegradable implant materials with different in vivo degradation ***,they do not possess good bioactivity and other biological *** glasses have been widely used as coating materials on the metallic implants to improve their integration with the host tissue and overall biological *** present review provides a detailed overview of the benefits and issues of metal alloys when used as biomedical implants and how they are improved by bioactive glass-based coatings for biomedical applications.

关键词： Bioactive glass coating Metallic biomaterials Biodegradation Biocompatibility Bioactivity.contents

3D Chromatin Architecture of Large Plant Genomes Determined by Local A/B Compartments

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Molecular Plant 2017年第12期10卷 1497-1509页

作者： Pengfei Dong Xiaoyu Tu po-Yu Chu Peitao Lu Ning Zhu Donald Grierson Baij.an Du Pinghua Li Silin Zhong State Key Laboratory of Crop Biology College of Agronomy Shandong Agricultural University Tai'an Shandong China State Key Laboratory of Agrobiotechnology School of Life Sciences The Chinese University of Hong Kong Hong Kong China Zhej.ang Provincial Key Laboratory of Horticultural Plant Integrative Biology Zhejiang University Hangzhou Zhejiang China These authors contributed equally to this article.

The spatial organization of the genome plays an important role in the regulation of gene expression. How- ever, the core structural features of animal genomes, such as topologically associated domains （TADs） and chromatin loops, are not prominent in the extremely compact Arabidopsis genome. In this study, we examine the chromatin architecture, as well as their DNA methylation, histone modifications, accessible chromatin, and gene expression, of maize, tomato, sorghum, foxtail millet, and rice with genome sizes ranging from 0.4 to 2.4 Gb. We found that these plant genomes can be divided into mammalian-like A/B compartments. At higher resolution, the chromosomes of these plants can be further partitioned to local Aj. compartments that reflect their euchromatin, heterochromatin, and polycomb status. Chromatins in all these plants are organized into domains that are not conserved across species. They show similarity to the Drosophila compartment domains, and are clustered into active, polycomb, repressive, and interme- diate types based on their transcriptional activities and epigenetic signatures, with domain border overlaps with the local A/B compartment j.nctions. In the large maize and tomato genomes, we observed extensive chromatin loops. However, unlike the mammalian chromatin loops that are enriched at the TAD border, plant chromatin loops are often formed between gene islands outside the repressive domains and are closely associated with active compartments. Our study indicates that plants have complex and unique 3D chromatin architectures, which require further study to elucidate their biological functions.

关键词： Hi-C chromatin loop compartment domain local compartment

Correlation between plasmid DNA damage induced by PM_(10) and trace metals in inhalable particulate matters in Beij.ng air

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Science China Earth Sciences 2006年第12期49卷 1323-1331页

作者： T. P. j.nes L. Merolla R. j. Richard Department of Earth Ocean and Planetary Sciences Cardiff UniversityCardiff CF10 3YE UK School of Biosciences Cardiff University PO Box 911 Cardiff CF10 3US UK

Based on the study of Beij.ng PM10 bioreactivity with the newly developed plasmid DNA assay method, and analysis for trace elements of PM10, the cause of plasmid DNA damage by PM10 was investigated. The study showed that plasmid DNA oxidative damages by PM10 are of difference in different seasons at various areas. The concentrations of TM50 of PM10 in whole samples respectively collected at urban and comparison sites during winter were 900 μg mL?1 and 74 μg mL?1, while those in their corresponding soluble fractions were 540 μg mL?1 and 86 μg mL?1. In contrast, TM50 contents of PM10 from summer whole samples at urban areas and comparison sites were 116 μg mL?1 and 210 μg mL?1, whereas those in their soluble fractions were 180 μg mL?1 and 306 μg mL?1. The difference of bioreactivity of Beij.ng PM10 resulted from the variation of trace elements. The oxidative damage of plasmid DNA caused by Pb, Zn, As in PM10 (whole sample) was relatively strong. TM50 and Mn, V, Zn display stronger correlation in the soluble fraction. It implies that Zn could be the maj.r trace element in Beij.ng PM10 which contributes to oxidative damage to plasmid DNA.

关键词： Beij.ng PM10 trace metals correlation health effect.

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IgG and fibrinogen driven nanoparticle aggregation

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Nano Research 2015年第8期8卷 2733-2743页

作者： Risto Cukalevski Silvia A. Ferreira Christopher j. Dunning Tord Berggard Tommy Cedervall Department of Biochemistry and Structural Biology Centre for Molecular Protein Science Chemical Centre Lund University PO Box 124 SE-22100 Lund Sweden Centre for Biological Engineering University of Minho Campus Gualtar 4710-057 Braga Portugal Neuronal Survival Unit Department of Experimental Medical Science Wallenberg Neuroscience Center Lund University BMC B 11 22184 Lund Sweden Alligator Bioscience AB Lund Sweden

A thorough understanding of how proteins induce nanoparticle （NP） aggregation is crucial when designing in vitro and in vivo assays and interpreting experimental results. This knowledge is also crucial when developing nano-applications and formulation for drug delivery systems. In this study, we found that extraction of immunoglobulin G （IgG） from cow serum results in lower polystyrene NPs aggregation. Moreover, addition of isolated IgG or fibrinogen to fetal cow serum enhanced this aggregation, thus demonstrating that these factors are maj.r drivers of NP aggregation in serum. Counter-intuitively, NP aggregation was inversely dependent on protein concentration; i.e., low protein concentrations induced large aggregates, whereas high protein concentrations induced small aggregates. Protein-induced NP aggregation and aggregate size were monitored by absorbance at 400 nm and dynamic light scattering, respectively. Here, we propose a mechanism behind the protein concentration dependent aggregation; this mechanism involves the effects of multiple protein interactions on the NP surface, surface area limitations, aggregation kinetics, and the influence of other serum proteins.

关键词： nanoparticles(NPs) protein coron aggregation immunoglobulin