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Hepatitis E virus in patients with acute severe liver injury

World journal of Hepatology 2014年第6期6卷 426-434页

作者： Claire Louise Crossan Kenneth j Simpson Darren G craig Christopher Bellamy janice Davidson Harry R Dalton Linda Scobie Department of Life Sciences Glasgow Caledonian UniversityGlasgowG4 0BAUnited Kingdom Scottish Liver Transplant Unit Royal Infirmary of EdinburghEdinburghEH16 4SAUnited Kingdom Department of Pathology University of EdinburghEdinburghEH16 4SBUnited Kingdom Gastrointestinal Unit Royal Cornwall Hospitaland European Centre for the Environment and Human HealthUniversity of Exeter Medical SchoolTruroTR1 3HDUnited Kingdom Department of Life Sciences School of Health and Life SciencesGlasgow Caledonian UniversityGlasgowG40BAUnited Kingdom

AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant ***: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the Scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain ***: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient

关键词： Virology Infection Acute liver injury Hepatitis E virus

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Laser additive manufacturing for infrastructure repair:A case study of a deteriorated steel bridge beam

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journal of Materials Science & Technology 2023年第23期154卷 149-158页

作者： Shengbiao Zhang Peijun Hou jiyun Kang Tianyi Li Shahryar Mooraj Yang Ren Catherine H.Chen A.john hart Simos Gerasimidis Wen Chen Department of Mechanical and Industrial Engineering University of Massachusetts Amherst MA 01003 USA Department of Civil and Environmental Engineering University of Massachusetts Amherst MA 01003 SA Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA X-ray Science Division Argonne National Laboratory Lemont IL 60439 USA Massachusetts Department of Transportation Boston MA 02116 USA Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA Department of Physics City University of Hong Kong Kowloon Hong Kong China

As our transportation infrastructure ages,its deterioration is becoming a growing *** and effective methods for repair can reduce the need for time-and cost-intensive replacement of structures such as roadway *** this work,laser-based additive manufacturing(AM)was developed for the repair of damaged beams in steel bridges.A corroded structural beam of low-carbon A36 steel was selected for this case study and 316L stainless steel was used for repair due to its excellent mechanical properties and corrosion *** repair experiments were performed on specimens extracted from the beam,and prepared with various groove shapes(Rectangular,Trapezoidal,and U-shaped).More in-depth parametric and microstructural studies were carried out with a series of U-shaped specimens repaired with the linear laser input energy varied from 19.5 to 30.0 j mm–*** tensile properties of the repaired specimens and interface structures were also investigated in *** was found that the repaired specimens had a slightly higher tensile strength despite a reduction in tensile elongation compared to the A36 steel base *** influence of interfacial microstructure and heterogeneity on the mechanical properties of the repaired specimens was *** work suggests the promising potential to employ AM for structural repair and provides fundamental insights into processing-structure-property relationships in laser AM-repaired materials.

关键词： Additive manufacturing Structural repair Mechanical properties Transportation infrastructure Dissimilar joint

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频率波数域分级偏移

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国外油气勘探 1989年第6期 1-14页

作者： craig j Beasley 陈丽英

Stolt的频率-波数(f-k)法是一种有效的计算方法。对于常速介质,该算法倾角精度是很高的。虽然垂向速度变化不太大时f-k法也可以应付,但当这种速度变化大而倾角又陡的情况下,所产生的误差就无法接受了。本文论述了一种f-k法的扩展,这种... 详细信息

Stolt的频率-波数(f-k)法是一种有效的计算方法。对于常速介质,该算法倾角精度是很高的。虽然垂向速度变化不太大时f-k法也可以应付,但当这种速度变化大而倾角又陡的情况下,所产生的误差就无法接受了。本文论述了一种f-k法的扩展,这种方法不受垂向速度变化的限制,而精度又与相移偏移法相当,其计算时间却只有相移法的几分之一。和分级有限差分偏移一样,这种扩展的f-k法的基础是分离速度场,并进行多级f-k偏移。在每级偏移中,偏移速度场要比做常规偏移(即只有一级)时更接近于一个常数,这就是f-k偏移的理想情况。实验结果和误差分析表明,对于实际的任何垂向非均匀的速度场来说,最多用4级f-k算法就足以使陡同相轴的偏移结果与相移法结果一样地准确。由于该方法比较准确有效,所以它可以成为二维时间偏移、二次三维偏移和一次三维时间偏移中可供选择的方法。

关键词： f-k 域三维偏移偏移误差速度场横向速度陡倾同相轴

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Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury

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World journal of Gastroenterology 2016年第27期22卷 6192-6200页

作者： Natalia A Osna Wayne G Carter Murali Ganesan Irina A Kirpich craig j Mc Clain Dennis R Petersen Colin T Shearn Maria L Tomasi Kusum K Kharbanda Research Service Veterans Affairs Nebraska-Western Iowa Health Care System Omaha NE 68105 United States Department of Internal Medicine 982000 Nebraska Medical Center Omaha NE 68198 United States School of Medicine University of Nottingham Royal Derby Hospital Centre Derby DE22 3DT United Kingdom Division of Gastroenterology Hepatology and Nutrition Department of Medicine Department of Medicine and Pharmacology and Toxicology University of Louisville Louisville KY 40202 United States University of Colorado Denver School of Pharmacy Department of Pharmaceutical Sciences Aurora CO 80045 United States Division of Gastroenterology Department of Medicine Davis research building suite 2096/2035 Cedars-Sinai Medical Center Los Angeles CA 90048 United States Department of Biochemistry and Molecular Biology 985870 Nebraska Medical Center Omaha NE 68198 United States

It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining cellular hemostasis. Alcohol exposure significantly alters several of these post-translational modifications leading to impairments of many essential physiological processes. Here, we present new insights into novel modifications following ethanol exposure and their role in the initiation and progression of liver injury. This critical review condenses the proceedings of a symposium at the European Society for the Biomedical Research on Alcoholism Meeting held September 12-15, 2015, in Valencia, Spain.

关键词： Alcohol Acetylation Liver Carbonylation methylation Dysfunction Methylation Glycosylation Phosphorylation Ubiquitination Sumoylation Betaine Post-translational protein modification

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Additive manufacturing(3D printing)of electrically conductive polymers and polymer nanocomposites and their applications

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eScience 2022年第4期2卷 365-381页

作者： Kirstie R.Ryan Michael P.Down Nicholas j.Hurst Edmund M.Keefe craig E.Banks Faculty of Science and Engineering Manchester Metropolitan UniversityChester StreetManchesterM15GDUK

Additive manufacturing,or three-dimensional(3D)printing,offers a unique solution for fabricating complex geometries with high ***,many commercial additive manufacturing machines focus on the printing of polymers with limited ***,conductive polymers(CPs)can be processed to enable the additive manufacturing of conductive,low-density,and low-cost parts for a myriad of *** review summarizes the relevant achievements in the additive manufacturing of conductive polymers(CPs)and conductive polymer nanocomposites,with a discussion of the advantages and limitations of processing and printing these materials compared with alternative traditional manufacturing methods and their ***,the prospective applications of these additive manufacturing printed conductive materials are explored.

关键词： Conducting polymers Additive manufacturing Electrochemcial applications Supercapacitors Batteries

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Serum measurements of testosterone, insulin-like growth factor 1, and insulin-like growth factor binding protein-3 in the diagnosis of prostate cancer among Korean men

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Asian journal of Andrology 2008年第2期10卷 207-213页

作者： Sung Kyu Hong Byung Kyu hart jae Seung jeong Seong jin jeong Ki Hyuk Moon Seok Soo Byun Sang Eun Lee Department of Urology Seoul National University Bundang Hospital Seongnam 463-707 Korea

Aim： To investigate the relationships of serum testosterone, insulin-like growth factor （IGF）- 1 and IGF-binding protein （IGFBP）-3 levels with prostate cancer risk and also with known prognostic parameters of prostate cancer in Korean men who received radical retropubic prostatectomy （RRP） for clinically-localized prostate cancer. Methods： Serum levels of total testosterone, free testosterone, IGF-1 and IGFBP-3 were determined in 592 patients who subsequently received prostate biopsy. Results were compared between patients who eventually received RRP for prostate cancer （n = 159） and those who were not diagnosed with prostate cancer from biopsy （control group, n = 433）. Among the prostate cancer only patients, serum hormonal levels obtained were analyzed in relation to serum prostate specific antigen （PSA）, pathological T stage and pathological Gleason score. Results： Prostate cancer patients and the control group demon- strated no significant differences regarding serum levels of total testosterone, free testosterone, IGF-I and IGFBP-3 across the different age groups. Among the cancer only patients, no significant associations were observed for serum levels of total testosterone, free testosterone, IGF-1 and IGFBP-3 levels with pathological T stage, pathological Oleason score and preoperative PSA. Conclusion： Our data indicate that simple quantifications of serum testosterone and IGF-1 along with IGFBP-3 levels might not provide useful clinical information in the diagnosis of clinically localized prostate cancer in Korean men. Also, our results suggest that serum levels of testosterone, IGF-1 and IGFBP-3 might not be significantly associated with known prognostic factors of clinically localized prostate cancer in Korean men. （Asian j Androl 2008 Mar; 10： 207-213）

关键词： prostate prostate cancer testosterone insulin-like growth factor insulin-like growth factor-binding protein-3

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大运河复灌的效益与环境影响分析

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环境保护 2015年第3期43卷 62-64页

作者：刘怀宇 craig hart 马中马昃昀中国传媒大学文化发展研究院中国人民大学环境学院

2014年,中国大运河(京杭大运河,简称"大运河")申遗成功,其再开发和环境保护问题被广泛讨论。对此,文章分析指出对大运河进行复灌可以解决其长期以来的水体污染及断流问题;同时,通过地表水补注地下水,能在一定程度上缓解华北地区的地下... 详细信息

2014年,中国大运河(京杭大运河,简称"大运河")申遗成功,其再开发和环境保护问题被广泛讨论。对此,文章分析指出对大运河进行复灌可以解决其长期以来的水体污染及断流问题;同时,通过地表水补注地下水,能在一定程度上缓解华北地区的地下水超采困境;疏通复灌后的大运河除了供水和生态环境效益以外,还可以带来沿线城市文化和经济的可持续发展。

关键词：大运河复灌水环境生态环境效益

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Finite element modeling of the viscoelastic responses of the eye during microvolumetric changes

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journal of Biomedical Science and Engineering 2013年第12期6卷 29-37页

作者： Benjamin Cruz Perez Hugh j. Morris Richard T. hart jun Liu Department of Biomedical Engineering The Ohio State University Columbus USA Department of Biomedical Engineering The Ohio State University Columbus USA Department of Ophthalmology The Ohio State University Columbus USA

A linear viscoelastic finite element model was built to investigate factors that influenced the intraocular pressure (IOP) elevations due to micro-volumetric changes in the eye at three different rates. The viscoelastic properties of the cornea and the sclera, including the instantaneous modulus, equilibrium modulus, and relaxation time constants, parametrically varied to examine their effects on IOP elevations at different rates of volumetric changes. The simulated responses were in good agreement with the previously reported experimental results obtained from porcine globes, showing the general trend of higher IOP elevations at faster rates. The simulations showed that all viscoelastic properties influenced the profile of the dynamic IOP due to volumetric changes, and the relative significance of a specific parameter was highly dependent on the rate of change.

关键词： Viscoelasticity Finite Element Modeling Intraocular Pressure Cornea Sclera

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Massively Deployable, Low-Cost Airborne Sensor Motes for Atmospheric Characterization

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Wireless Sensor Network 2020年第1期12卷 1-11页

作者： Michael Bolt j. craig Prather Tyler Horton Mark Adams Department of Electrical and Computer Engineering Auburn University Auburn AL USA

A low-cost airborne sensor mote has been designed for deployment en masse to characterize atmospheric conditions. The designed environmental sensing mote, or eMote, was inspired by the natural shape of auto-rotating maple seeds to fall slowly and gather data along its descent. The eMotes measure and transmit temperature, air pressure, relative humidity, and wind speed estimates alongside GPS coordinates and timestamps. Up to 2080 eMotes can be deployed simultaneously with a 1 Hz sampling rate, but the system capacity increases by 2600 eMotes for every second added between samples. All measured and reported data falls within accuracy requirements for reporting with both the World Meteorological Organization (WMO) and the National Oceanic and Atmospheric Administration (NOAA). This paper presents the design and validation of the eMote system alongside discussions on the implementation of a large-scale, low-cost sensor network. The eMote represents unprecedented in-situ atmospheric measurement capabilities with the ability to deploy more than 260 times the number of sensing units as the most comparable commercially available dropsonde.

关键词： Atmospheric Sensing Airborne Biomimetic MF-TDMA

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Management of metal-on-metal hip implant patients: Who,when and how to revise?

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World journal of Orthopedics 2016年第5期7卷 272-279页

作者： Reshid Berber john A Skinner Alister j hart joint Reconstruction Unit Institute of Orthopaedics and Musculoskeletal Sciences Royal National Orthopaedic Hospital

The debate on how best to manage patients with metal-on-metal(MOM) hip implants continues. With over 1 million patients affected worldwide, the impact is far reaching. The majority of the aggressive failures of MOM hip implants have been dealt with by revision hip surgery, leaving patients with a much more indolent pattern of failure of devices that have been in situ for more than 10 years. The longer-term outcome for such patients remains unknown, and much debate exists on how best to manage these patients. Regulatory guidance is available but remains open to interpretation due to the lack of current evidence and long-term studies. Metal ion thresholds for concern have been suggested at 7 ppb for hip resurfacing arthroplasty and below this level for large diameter total hip arthroplasties. Soft tissue changes including pseudotumours and muscle atrophy have been shown to progress, but this is not consistent. New advanced imaging techniques are helping to diagnose complications with metal hips and the reasons for failure, however these are not widely available. This has led to some centres to tackle difficult cases through multidisciplinary collaboration, for both surgical management decisions and also follow-up decisions. We summarise current evidence and consider who is at risk, when revision should be undertaken and how patients should be managed.

关键词： Metal on metal hip Management Multidisciplinary Revision Decision

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