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Prenatal administration of heparin-binding epidermal growth factor-like growth factor in an experimental model of necrotizing enterocolitis decreased both incidence and severity of the disease

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world Journal of Pediatric Surgery 2022年第1期5卷 18-24页

作者： Marla Ashley Sacks Yomara Stephanie Mendez Faraz A Khan Robert Propst craig w zuppan Christopher G wilson Andrei Radulescu Division of Pediatric Surgery Department of SurgeryLoma Linda University Children's HospitalLoma LindaCaliforniaUSA Department of Pathology Loma Linda University Children's HospitalLoma LindaCaliforniaUSA Department of Neonatology Loma Linda University Children's HospitalLoma LindaCaliforniaUSA

background Necrotizing enterocolitis(NEC)is the leading gastrointestinal cause of death in premature infants and causes long-term disabilities.Previously,enteral heparin-binding epidermal growth factor-like growth factor(HB-EGF)administered after birth demonstrated decreased incidence and severity of NEC in a neonatal animal model of NEC.we investigated the potential prophylactic strategy of preventing NEC using prenatally administered HB-EGF.Methods An HB-EGF(800μg/kg/dose)dose was injected into pregnant rats via tail vein or intraperitoneal route 2 hours prior to delivery.After cesarean section(C-section)at 21 days’gestation,the rat pups were subjected to the NEC protocol by inducing stressors:hypoxia,hypothermia,hypertonic feeds,and orogastric gavage of lipopolysaccharide(2 mg/kg).Postnatally,pups were monitored for 96 hours and assessed for the development of clinical and postmortem histological NEC.results The experimental NEC incidence in untreated,stressed rat pups was 66%.Compared with untreated pups,the maternal administration of HB-EGF correlated with a significant NEC incidence and severity decrease in rat pups.The strongest decrease was seen when HB-EGF was administered via the intraperitoneal route 2 hours prior to C-section(66%vs 31%,*pwith the greatest benefit observed in the group that received HB-EGF intraperitoneally 2 hours before delivery.Conclusions Prenatal administration of HB-EGF decreases the incidence and severity of NEC,preserves gut barrier function and increases survival.This may represent a novel prophylactic clinical strategy for NEC offered to mothers at risk of delivering a premature infant.

关键词： severity heparin incidence

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Aggressive primary hepatic histiocytic sarcoma: case report and literature review

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Hepatoma Research 2016年第1期2卷 300-304页

作者： Guang Yang Jeremy Deisch Haixia Qin craig zuppan Anwar S.Raza Department of Pathology Loma Linda University Medical CenterLoma LindaCA 92354USA Department of Medicine Loma Linda University Medical CenterLoma LindaCA 92354USA

Histiocytic sarcoma is an uncommon non-Langerhans histiocyte disorder of mature tissue histiocytes.The authors presented an example of this rare tumor in a 14-year-old girl who presented with left upper quadrant pain,loss of appetite,and weight loss.A large 18 cm×10 cm heterogeneous solid and cystic enhancing mass was found in the left lobe of the liver.Based on the histomorphology and positivity for histiocyte-specific markers in a needle biopsy,a diagnosis of histiocytic sarcoma was made.Chemotherapy was initiated,but the tumor did not respond well,and she died about 7 weeks following initial diagnosis with multi-organ failure.At autopsy,the tumor showed extensive necrosis,with no evidence of metastatic spread.In conclusion,the diagnosis of histiocytic sarcoma is challenging,and requires a high index of suspicion,with an appropriate panel of confirmatory immunohistochemical stains.Recognition of this rare tumor is important because of its poor response to chemotherapy and high mortality.

关键词： Histiocytic sarcoma hepatic neoplasms liver

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