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Regulation of D-galacturonate metabolism in <i>Caulobacter crescentus</i>by HumR, a LacI-family transcriptional repressor

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Advances in Bioscience and Biotechnology 2013年第10期4卷 63-74页

作者： Aaesha I. Sheikh Deborah Caswell Cynthia Dick Spencer Gang Justin Jarrell Ankita Kohli Amanda Lieu Jared Lumpe Meghan Garrett Jennifer Parker craig stephens Biology Department Santa Clara University 500 El Camino Real Santa Clara USA

The oligotrophic freshwater bacterium Caulobacter crescentus encodes a cluster of genes (CC_1487 to CC_1495) shown here to be necessary for metabolism of D-galacturonate, the primary constituent of pectin, a major plant polymer. Sequence analysis suggests that these genes encode a version of the bacterial hexuronate isomerase pathway. A conserved 14 bp sequence motif is associated with promoter regions of three operons within this cluster, and is conserved in homologous gene clusters in related alpha-Proteobacteria. Embedded in the hexuronate gene cluster is a gene (CC_1489) encoding a member of the LacI family of bacterial transcription factors. This gene product, designated here as HumR (hexuronate metabolism regulator), represses expression of the uxaA and uxaC operon promoters by binding to the conserved operator sequence. Repression is relieved in the presence of galacturonate or, to a lesser extent, by glucuronate. Other genes potentially involved in pectin degradation and hexuronate transport are also under the control of HumR. Adoption of a LacI-type repressor to control hexuronate metabolism parallels the regulation of xylose, glucose, and maltose utilization in C. crescentus, but is distinct from the use of GntR-type repressors to control pectin and hexuronate utilization in gamma-Proteobacteria such as Escherichia coli.

关键词： Caulobacter Galacturonate LacI

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Do medical students studying in the United Kingdom have an adequate factual knowledge of basic life support?

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World Journal of Emergency Medicine 2019年第2期10卷 75-80页

作者： Robert D.Willmore Damjan Veljanoski Feray Ozdes Bethan stephens James Mooney Seamus G.Crumley Arpan Doshi Philippa Davies Shreya Badhrinarayanan Emily Day Kristian Tattam April Wilson Nathan Crang Lorna Green craig A.Mounsey Howell Fu Joseph Williams Michelle S.D'souza Dhanya Sebastian Liam A.Mcgiveron Matthew G.Percy James Cohen Imogen J.John Alice Lethbridge Imogen Watkins Omar Amin Mubasher A.Qamar John Gerrard Hanrahan Emily Cramond-Wong Barts Health NHS Trust Barts & the London Medical School Queen Mary University of London Norwich Medical School University of East Anglia Lancaster Medical School Lancaster University School of Medicine Dentistry and Biomedical Sciences Queen's University Belfast Faculty of Medicine University of St Andrews Faculty of Medicine Dentistry and Health University of Sheffi eld Brighton and Sussex University Hospitals NHS Trust St George's University of London University of Liverpool School of Medicine University of Exeter medical school Faculty of Medicine University of Southampton Medical Sciences Division University of Oxford University of Edinburgh Medical School Faculty of Medicine University of Warwick University College London Medical School Cardiff University School of Medicine College of Medical and Dental Sciences University of Birmingham College of Medical Veterinary and Life Sciences University of Glasgow Guys Kings and St Thomas School of Medicine King’s College London Faculty of Life Sciences & Medicine King's College London Faculty of Health Sciences at the University of Nottingham

BACKGROUND: Healthcare professionals have a duty to maintain basic life support(BLS) skills. This study aims to evaluate medical students' factual knowledge of BLS and the training they ***: A cross-sectional, closed-response questionnaire was distributed to the fi rst-and fourth-year students studying at institutions in the United Kingdom. The paper questionnaire sought to quantify respondent's previous BLS training, factual knowledge of the BLS algorithm using five multiple choice questions(MCQs), and valuate their desire for further BLS training. Students received 1 point for each correctly identifi ed answer to the 5 MCQ'***: A total of 3,732 complete responses were received from 21 medical schools. Eighty percent(n=2,999) of students completed a BLS course as part of their undergraduate medical studies. There was a signifi cant difference(P<0.001) in the percentage of the fourth-year students selecting the correct answer in all the MCQ's compared to the fi rst-year students except in identifyingthe correct depth of compressions required during CPR(P=0.095). Overall 10.3%(95% CI 9.9% to 10.7%) of respondents correctly identified the answer to 5 MCQ's on BLS: 9% of the first-year students(n=194) and 12% of the fourth-year students(n=190). On an institutional level the proportion of students answering all MCQ's correctly ranged from 2% to 54% at different universities. Eighty-one percent of students(n=3,031) wished for more BLS training in their ***: Factual knowledge of BLS is poor among medical students in the UK. There is a disparity in standards of knowledge across institutions and respondents indicating that they would like more training.

关键词： Emergency Medicine Basic life support Medical education Resuscitation

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Achieving fish passage outcomes at irrigation infrastructure;a case study from the Lower Mekong Basin

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Aquaculture and Fisheries 2021年第2期6卷 113-124页

作者： Lee J.Baumgartner Chris Barlow Martin Mallen-Cooper craig Boys Tim Marsden Garry Thorncraft Oudom Phonekhampheng Douangkham Singhanouvong William Rice Michael Roy Lin Crase Bethany Cooper Institute for Land Water and SocietyCharles Sturt UniversityElizabeth Mitchell DriveAlburyNew South WalesAustralia Department of Primary Industries Port Stephens Fisheries CentrePrivate Bag 1Nelson BayNew South Wales2315Australia Australasian Fish Passage Services 27 Beachside PlaceShoal PointQLD4750Australia National University of Laos PO Box 10864Dongdok CampusVientianeLao Democratic People’s Republic Living Aquatic Resources Research Centre Phonsavang VillageSikhotabong DistrictVientianeLao Democratic People’s Republic United States Department of the Interior International Technical Assistance Program1849 C StreetNWWashington DC20240United States University of South Australia School of CommerceCity West CampusAdelaideSouth AustraliaAustralia

Irrigation infrastructure expansion threatens the diversity of freshwater fish *** infrastructure creates migration barriers which can block access to important nursery,feeding and spawning *** PDR is a landlocked country situated within the Lower Mekong River Basin where there is a substantial dependency on rice and fish for food,income and *** country is experiencing an unprecedented boom in irrigation infrastructure investment,with modernisation programs being implemented in every *** significant investment in infrastructure upgrades,and the potential impact on freshwater fish,little consideration has been given to fish passage *** 2008,we commenced a fish passage program in Lao *** intent of this case study is to outline the pivotal elements of the program of knowledge development and transfer,in the context of river connectivity and fisheries management in Lao *** also highlight challenges in international research in development and lessons learned.

关键词： Fish passage Tropical rivers Lower mekong basin Migration Fishway Lao PDR

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