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HLA-DRB1 allele in 35 patients with alveolar echinococcosis in Gansu Province of China

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Chinese Medical Journal 2003年第10期116卷 1557-1560页

作者：李富荣石佑恩史大中 Dominique Angele Vuitton Philip simon craig Clinic Medical Research Center Shenzhen People's Hospitalthe Second Affiliated HospitalJi'nan University Department of Parasitology Tongji Medical CollegeHuazhong University of Science and Technology Department of Parasitology Lanzhou Medical College Centre Hospitalier Universitaire Division of Biological Sciences University of Salford

Objective To investigate the association between histocompatibility leukocyte antigen (HLA)-DRB1 alleles and alveolar echinococcosis (AE).Methods Thirty-five patients with AE in high prevalence areas in Gansu Province of China were tested for the HLA-DRB1 gene using the polymerase chain reaction with sequence-specific primer (PCR-SSP) technique. The results were compared with those of 104 healthy *** The frequency of the HLA-DRB1*040x gene was 26% in the patient group,which was significantly higher than that in the control group (9.62%) with a relative risk (RR) of 4.45 (χ 2 =13.67, P <0.01),and an etiological fraction (EF) of 0.20. The frequency of the HLA-DRB1 *0701 allele was significantly lower in the patient group (2.86%) as compared to the control group (13.94%; χ 2=6.67,P <0.05) with a preventable fraction (PF) of 0.30. The frequencies of other DRB1 alleles were not significantly *** Susceptibility to AE is significantly associated with the HLA-DRB1*040x. HLA-DRB1 *0701 gene might confer protection against AE in humans.

关键词： HLA-DR antigens· echincoccosis polymerase chain reaction

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中国物流与采购 2013年第14期 28-29页

作者： craig simon 联邦快递

在过去的大多数岁月里，我们很难想象到现在这样一个联通全球的供应链。如今通往市场之路已成为了一条超级高速公路。这是一条永不停歇的市场之路，一周七天，一天二十四小时时刻不停地运转。全球贸易不分昼夜。事实上，全球贸易连个盹... 详细信息

在过去的大多数岁月里，我们很难想象到现在这样一个联通全球的供应链。如今通往市场之路已成为了一条超级高速公路。这是一条永不停歇的市场之路，一周七天，一天二十四小时时刻不停地运转。全球贸易不分昼夜。事实上，全球贸易连个盹都不会打。路上飞奔的车轮，空中划过的机翼，以及水中穿梭的船身，这些交通工具为我们连接起了一个几乎没有国界之分的世界经济。

关键词：供应链全球贸易高速公路世界经济交通工具市场联通

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空运商务 2013年第8期 60-61页

作者： craig simon 联邦快递

在过去的大多数岁月里,我们很难想象到现在这样一个联通全球的供应链。如今通往市场之路已成为一条超级高速公路。这是一条永不停歇的市场之路,一周七天,一天二十四小时时刻不停地运转。全球贸易不分昼夜。事实上,全球贸易连个盹都不会... 详细信息

在过去的大多数岁月里,我们很难想象到现在这样一个联通全球的供应链。如今通往市场之路已成为一条超级高速公路。这是一条永不停歇的市场之路,一周七天,一天二十四小时时刻不停地运转。全球贸易不分昼夜。事实上,全球贸易连个盹都不会打。路上飞奔的车轮,空中划过的机翼,以及水中穿梭的船身,

关键词：供应链全球贸易高速公路市场联通

南瓜子-槟榔法治疗藏区疑似带绦虫病效果观察

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寄生虫病与感染性疾病 2010年第4期8卷 177-180页

作者：龙昌平李调英陈兴旺肖宁 Akira Ito 谭勇阿斗塔 Philip simon craig 四川省甘孜藏族自治州雅江县疾病预防控制中心四川雅江627450 四川省疾病预防控制中心寄生虫病所日本旭川医学院四川省甘孜藏族自治州疾病预防控制中心英国索尔福特大学

目的通过采用南瓜子-槟榔法治疗四川省甘孜藏族自治州雅江县绦虫病患者,了解南瓜子-槟榔法的驱绦效果,为控制绦虫病/囊尾蚴病提供安全、有效的药物治疗。方法于2007-05/2009-11,在四川省雅江县7个乡镇18个村寨,对部分村民进行问卷调查,... 详细信息

目的通过采用南瓜子-槟榔法治疗四川省甘孜藏族自治州雅江县绦虫病患者,了解南瓜子-槟榔法的驱绦效果,为控制绦虫病/囊尾蚴病提供安全、有效的药物治疗。方法于2007-05/2009-11,在四川省雅江县7个乡镇18个村寨,对部分村民进行问卷调查,对近年内有排绦虫节片史且自愿接受治疗的患者采用南瓜子-槟榔法进行驱绦。对驱绦后获得的绦虫标本用mu ltip lex PCR作进一步虫种鉴定。结果共治疗175例,完成治疗后5h内共计112例排出绦虫,获虫率为64.0%。在排出虫体的112例中,83.0%(93例)排出全虫(可见头节),其余19例仅排出绦虫节片。药物常见不良反应是头昏和胃肠不适,排虫后均自行消失。结论南瓜子-槟榔法是安全、有效的治疗带绦虫病方法。

关键词：南瓜子-槟榔法带绦虫问卷调查获虫率

Urban and river flooding:Comparison of flood risk management approaches in the UK and China and an assessment of future knowledge needs

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Water Science and Engineering 2019年第4期12卷 274-283页

作者： Matteo Rubinato Andrew Nichols Yong Peng Jian-min Zhang craig Lashford Yan-peng Cai Peng-zhi Lin simon Tait Faculty of Engineering Environment and ComputingSchool of EnergyConstruction and EnvironmentCoventry UniversityCoventry CV15FBUK Centre for Agroecology Water and ResilienceCoventry UniversityCoventry CV15FBUK Civil and Structural Engineering Department University of SheffieldSheffield S13JDUK State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu 610065China School of Environment Beijing Normal UniversityBeijing 100875China

Increased urbanisation,economic growth,and long-term climate variability have made both the UK and China more susceptible to urban and river flooding,putting people and property at increased *** paper presents a review of the current flooding challenges that are affecting the UK and China and the actions that each country is undertaking to tackle these *** emphases in this paper are laid on(1)learning from previous flooding events in the UK and China,and(2)which management methodologies are commonly used to reduce flood *** paper concludes with a strategic research plan suggested by the authors,together with proposed ways to overcome identified knowledge gaps in flood *** briefly comprise the engagement of all stakeholders to ensure a proactive approach to land use planning,early warning systems,and water-sensitive urban design or redesign through more effective policy,multi-level flood models,and data driven models of water quantity and quality.

关键词： Urban flooding River flooding Water management Review Strategic research plans Sponge cities

Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford

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World Journal of Gastroenterology 2020年第30期26卷 4428-4441页

作者： Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers simon Travis Ian craig Lawrance Centre for Inflammatory Bowel Diseases St John of God HospitalSubiaco 6008Western AustraliaAustralia Translational Gastroenterology Unit NIHR Oxford Biomedical Research CentreOxford University Hospitals NHS Foundation TrustJohn Radcliffe HospitalOxford OX39DUUnited Kingdom Inflammatory Bowel Disease Research Group Queensland institute of Medical ResearchHerston 4006QueenslandAustralia Department of Gastroenterology Mater HospitalBrisbane 4101QueenslandAustralia Department of Gastroenterology Mater HospitalSouth Brisbane 4101QueenslandAustralia of Gastroenterology Eastern HealthBox Hill 3128VictoriaAustralia Department of Gastroenterology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Department of Gastroenterology Austin HealthHeidelberg 3084VictoriaAustralia Department of Gastroenterology St Vincent’s HospitalFitzroy 3065VictoriaAustralia Department of Gastroenterology Northern HealthEpping 3076VictoriaAustralia Department of Gastroenterology The Alfred HospitalMelbourne 3004VictoriaAustralia Department of Gastroenterology St Vincent’s HospitalDarlinghurst 2010New South WalesAustralia Department of Gastroenterology Flinders Medical CentreBedford Park 5042South AustraliaAustralia Department of Gastroenterology Liverpool HospitalSydney 2170New South WalesAustralia Department of Gastroenterology Royal Adelaide Hospital&University of AdelaideAdelaide 5000South AustraliaAustralia Department of Gastroenterology Townsville HospitalDouglas 4814QueenslandAustralia Institute for Health Research University of Notre DameFremantle 6160Western AustraliaAustralia School of Medicine and Pharmacology University of Western AustraliaCrawley 6009Western AustraliaAustralia

BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)*** To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving *** A retrospective review of Australian and Oxford,United Kingdom data for UC *** response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were *** regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing *** outcomes were *** Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were *** clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo ***-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 *** VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome.

关键词： Vedolizumab Ulcerative colitis Outcomes

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除了实行负利率还能做什么?

商业周刊（中文版） 2019年第15期 30-31页

作者： simon Kennedy craig Stirling 许诺(译) 不详

欧洲央行人士认为,政府在提供财政刺激措施方面应该扮演更主要的角色中央银行实行负利率政策是要付出代价的。人们谴责负利率造成的各种负面效应,包括压榨商业银行、损害储户,让原本濒死的企业得以苟延残喘,并助长了可能难以持续的资产... 详细信息

欧洲央行人士认为,政府在提供财政刺激措施方面应该扮演更主要的角色中央银行实行负利率政策是要付出代价的。人们谴责负利率造成的各种负面效应,包括压榨商业银行、损害储户,让原本濒死的企业得以苟延残喘,并助长了可能难以持续的资产价格飙升。

关键词：负利率利率政策中央银行负面效应商业银行资产价格财政储户

Automated monitoring of early neurobehavioral changes in mice following traumatic brain injury

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Neural Regeneration Research 2016年第2期11卷 248-256页

作者： Wenrui Qu Nai-kui Liu Xin-min (simon) Xie Rui Li Xiao-ming Xu Hand & Foot Surgery and Reparative & Reconstructive Surgery Center Orthopaedic Hospital of the Second Hospital of Jilin UniversityChangchun Jilin Province China Spinal Cord and Brain Injury Research Group Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN USA Department of Neurological Surgery Indiana University School of Medicine Indianapolis IN USA Department of Anatomy and Cell Biology Indiana University School of Medicine Inclianapolis IN USA Goodman Campbell Brain and Spine Inctianapolis IN USA AfaSci Research Laboratories Redwood City CA USA

Traumatic brain injury often causes a variety of behavioral and emotional impairments that can develop into chronic disorders. Therefore, there is a need to shift towards identifying early symptoms that can aid in the prediction of traumatic brain injury outcomes and behavioral endpoints in patients with traumatic brain injury after early interventions. In this study, we used the Smart Cage system, an automated quantitative approach to assess behavior alterations in mice during an early phase of traumatic brain injury in their home cages. Female C57BL/6 adult mice were subjected to moderate controlled cortical impact（CCI） injury. The mice then received a battery of behavioral assessments including neurological score, locomotor activity, sleep/wake states, and anxiety-like behaviors on days 1, 2, and 7 after CCI. Histological analysis was performed on day 7 after the last assessment. Spontaneous activities on days 1 and 2 after injury were significantly decreased in the CCI group. The average percentage of sleep time spent in both dark and light cycles were significantly higher in the CCI group than in the sham group. For anxiety-like behaviors, the time spent in a light compartment and the number of transitions between the dark/light compartments were all significantly reduced in the CCI group than in the sham group. In addition, the mice suffering from CCI exhibited a preference of staying in the dark compartment of a dark/light cage. The CCI mice showed reduced neurological score and histological abnormalities, which are well correlated to the automated behavioral assessments. Our findings demonstrate that the automated Smart Cage system provides sensitive and objective measures for early behavior changes in mice following traumatic brain injury.

关键词： nerve regeneration traumatic brain injury controlled cortical impact automated behavior motor activity anxiety exploratoryactivity sleep neural regeneration

Lateral Magma Flow in Mafic Sill-complexes

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Acta Geologica Sinica(English Edition) 2016年第S1期90卷 4-5页

作者： craig Magee James D Muirhead Alex Karvelas simon P Holford Christopher A-L Jackson Ian D.Bastow Nick Schofield Carl TE Stevenson Charlotte Mc Lean William Mc Carthy Olga Shtukert Basins Research Group Department of Earth Science and Engineering Imperial CollegeLondon Department of Geological Sciences University of Idaho Schlumberger Multiclient Schlumberger House Buckingham Gate Australian School of Petroleum University of Adelaide Geology & Petroleum Geology School of Geosciences University of Aberdeen School of Geography Earth & Environmental Sciences University of Birmingham School of Geographical and Earth Sciences University of Glasgow Department of Earth Sciences University of St Andrews

The structure of upper crustal magma plumbing systems controls the distribution of volcanism and influences tectonic *** the structure and volume of plumbing systems is,however,difficult because:(1)active

关键词： Lateral Magma Flow in Mafic Sill-complexes