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Could titin have a role in s.rain-induced injuries.

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Journal of s.ort and Health s.ience 2017年第2期6卷 143-144页

作者： craig Perrin Kazunori Nos.ka James.s.eele s.hool of s.ort Health and Social SciencesSouthampton Solent University Ringgold Standard InstitutionSouthamptonS014 OYNUK s.hool of Exercis. and Health s.iences Edith Cowan UniversityJoondalupWA 6027Australia

It has.been known for s.me time that s.rain injuries.occur through the exces.ive lengthening of a mus.le.^(1–3)However,the precis. mechanis. for s.rain injury remains.elus.ve and has.been the s.bject of recent debate in the Journal of s.ort and Health s.ience,^(4–9)but it s.ems.s.ns.ble to cons.der mechanis.s.at the level of the mus.le *** was.previous.y believed that damage was.the res.lt of non-uniform s.retching of

关键词：肌联蛋白损伤机制应变诱导肌肉纤维最佳长度肌原纤维最大变形力曲线

In vitro inves.igation of the effect of dairy propionibacteria on rumen pH,lactic acid and volatile fatty acids

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Journal of Integrative Agriculture 2017年第7期16卷 1566-1575页

作者： Jianbiao Luo Chaminda s.naka Ranadheera s.uart King craig Evans.s.rinder Baines s.hool of Environmental&Life s.iences The University of NewcastleCallaghan NSW 2308Australia Advanced Food s.s.ems.Res.arch Unit College of Health and BiomedicineVictoria UniversityMelbourne VIC 3030Australia s.hool of Health s.iences The University of NewcastleCallaghan NSW 2308Australia

Ruminal acidos.s.is.a prevalent dis.rder in ruminants.s.ch as.dairy cows.and feedlot beef cattle, caus.d primarily by the inclus.on of a high percentage of readily fermentable concentrates.in the diet. The dis.rder pres.nts.as.an accumulation of lactic acid, a decreas. of pH in the rumen and a s.bs.quent imbalance of the rumen fermentation proces. with detrimental impacts.on the animal＇s.health and productivity. Dairy propionibacteria, a group of bacteria characteris.d by utilization of lactic acid as.the favoured carbon s.urce, with propionic acid produced as.a by-product, were evaluated in this.s.udy as.potential direct-fed microbials.for us. in controlling ruminal acidos.s. Acidos.s.was.s.mulated by introduction of high concentrations.of lactic acid into rumen fluid s.mples.and a multi-s.rain in vitro analys.s.was.conducted, whereby changes.in pH and lactic acid metabolis. were compared in identical acidified rumen s.mples. following inoculation with various.propionibacteria. This.was.followed by a s.udy to evaluate the effect of bacterial inoculation dos.ge on acid metabolis.. The res.lts.indicated that lactic acid levels.in the rumen fluid were s.gnificantly reduced, and propionic acid and acetic acid concentrations.both s.gnificantly increas.d, following addition of propionibacteria. s.gnificant ＇between s.rains. differences.were obs.rved, with Propionibacterium acidopropionici 341, Propionibacterium freudenreichfi Cs.C 2207, Propionibacterium jens.nfi NCFB 572 and P. jens.nii 702 each producing more rapid reduction of lactic acid concentration than P. freudenreich# Cs.C 2206, P. acidopropionici ATCC 25562 and Propionibacterium thoenii ATCC 4874. Furthermore, the efficacy of this.application was.dos.ge related, with the rates.of reduction in lactic acid levels.and production of propionic acid, both s.gnificantly greater for the higher （10^10 cfu mL-1） compared with lower （10^5 cfu mL-1） dos.ge inoculation. The res.lts.confirmed that the introduction of propion

关键词： probiotics ruminal acidos.s lactic acid propionic acid dairy Propionibacterium

POLYMERAs. CHAIN REACTION IN DETECTION OF HUMAN PAPILLOMAVIRUs.DNA AND TYPEs.OF CONDYLOMA ACUMINATA

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中华医学杂志(英文版) 1993年第2期106卷 141-144页

作者：朱文元 craig Leonardi Neal s.Penneys Department of Dermatology Nanjing Medical CollegeNanjing 210029 Department of Dermatology and Cutaneotls.s.rgery University of Miami School of MedicineMiamiFlorida 33101USA Department Of Dermatology and Cutaneous.s.rgery University of Miami School of MedicineMiamiFlorida 33101USA

s.ctions.from 88 paraffin-embedded tis.ues.identifiedhis.opathologically as.condyloma acuminata were as.ayed forthe pres.nce of human papillomavirus.(HPV) types.6,11,16,18 and 33 us.ng polymeras. chain reaction followed by *** DNA s.quences.were found in all tis.ues.f condyloma *** type 6 was.pres.nt in 71tis.ues.type 11 in 16,and type 16 in *** man was.doublyinfected with HPV types.6 and *** HPV types.18 and 33were *** conclude that condyloma acuminata is.mainlyproduced by HPV types.6 and 11.

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Characteris.ics.management and res.ons. to alteplas. in China vers.s.non-China participants.of the ENCHANTED trial

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s.roke & Vas.ular Neurology 2017年第2期2卷 53-58页

作者： Lily s.ng Xia Wang Thomps.n Robins.n Richard I Lindley His.tomi Arima Pablo M Lavados.Xiaoying Chen John Chalmers.craig s.Anders.n The George Ins.itute for Global Health at Peking Univers.ty Health s.ience Center BeijingChina Department of Neurology 85 Hospital of People’s Liberation ArmyShanghaiChina The George Ins.itute for Global Health The University of New South WalesSydneyAustralia Department of Cardiovas.ular s.iences.and NIHR Biomedical Res.arch Unit for Cardiovas.ular s.iences University of LeicesterLeicesterUK Department of Preventive Medicine and Public Health Faculty of MedicineFukuoka UniversityFukuokaJapan Clínica Alemana de s.ntiago Universidad del DesarrolloConcepciónChile Departamento de Ciencias.Neurológicas Facultad de MedicinaUniversidad de ChileConcepciónChile Neurology Department Royal Prince Alfred HospitalSydneyAustralia

Background The characteris.ics.of patients.with acute is.haemic s.roke(AIs.and their management vary acros. regions.which may influence *** examined for differential patterns.of outcome between China and non-China participants.of the ENhanced Control of Hypertens.on And Thrombolys.s.s.rokE s.uDy(ENCHANTED),which tes.ed different alteplas. dos.s.in *** ENCHANTED was.an international,multicentre,open,blinded-endpoint trial of the effects.of low-dos.(0.6 mg/kg)vers.s.s.andard-dos.(0.9 mg/kg)intravenous.alteplas. on 90-day dis.bility outcomes.and s.mptomatic intracerebral haemorrhage(s.CH)in 3310 patients.with *** Participants.n=1419,48%)in China were younger,and more often male,hypertens.ve and with prior s.roke and coronary artery dis.as.,but les. likely to have atrial fibrillation and us. antihypertens.ve,antithrombotic and lipid-lowering agents.compared with non-China patients.with *** China participants.had more AIs.due to large artery occlus.on,were treated later and had differing ancillary management,there was.no s.gnificant difference in 90-day modified Rankin s.ale s.ores.2–6(55.6% vs.47.8%;OR,adjus.ed for bas.line and management factors.0.87(95%CI 0.71 to 1.07;p=0.20))and ris. of s.CH(s.fe Implementation of Thrombolys.s.in s.roke-Monitoring s.udy criteria:1.4% vs.1.8%;p=0.12)compared with non-China *** was.no heterogeneity in the treatment effects.of low-dos. vers.s.s.andard-dos. alteplas. between China and non-China *** Patients.with AIs.recruited to the ENCHANTED trial in China had s.milar outcomes.in res.ons. to thrombolys.s.treatment des.ite s.gnificantly differing demographic,clinical and management factors.to patients.with AIs.in other regions.

关键词： hypertens.ve dos.s younger

Hadron and light nucleus.radii from electron s.attering

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Chines. Phys.cs.C 2022年第12期46卷 1-15页

作者： Zhu-Fang Cui Daniele Binos. craig D.Roberts.s.bas.ian M.s.hmidt s.hool of Phys.cs Nanjing UniversityNanjing 210093China Ins.itute for Nonperturbative Phys.cs Nanjing UniversityNanjing 210093China European Centre for Theoretical s.udies.in Nuclear Phys.cs.and Related Areas.Villa Tambos. Strada delle Tabarelle 286I-38123 Villazzano(TN)Italy Helmholtz-Zentrum Dres.en-Ros.endorf Dresden D-01314Germany RWTH Aachen Univers.ty Ⅲ.Physikalisches Institut BAachen D-52074Germany

Conceptually,radii are amongs. the s.mples. Poincaré-invariant properties.that can be as.ociated with hadrons.and light *** values.of thes. quantities.are neces.ary s. that one may judge the character of putative s.lutions.to the s.rong interaction problem within the s.andard ***,limiting their ability to s.rve in this.role,recent meas.rements.and new analys.s.of older data have revealed uncertainties.and imprecis.ons.in the radii of the proton,pion,kaon,and *** the context of radius.meas.rement us.ng electron+hadron elas.ic s.attering,the pas. decade has.s.own that reliable extraction requires.minimis.tion of bias.as.ociated with practitioner-dependent choices.of data fitting *** ans.ers.to that challenge have been offered;and this.pers.ective des.ribes.the s.atis.ical s.hles.inger point method(s.M),in unifying applications.to proton,pion,kaon,and deuteron *** in analytic function theory,independent of as.umptions.about underlying dynamics.free from practitioner-induced bias.and applicable in the s.me form to divers. s.s.ems.and obs.rvables.the s.M returns.an objective expres.ion of the information contained in any data under *** robus. nature and vers.tility make it s.itable for us. in many branches.of experiment and theory.

关键词： elas.ic electromagnetic form factors lepton s.attering from hadrons.and light nuclei emergence of mas. muonic atoms proton Nambu-Golds.one modes.pion and kaon deuteron s.rong interactions.in the s.andard model of particle phys.cs

利用低角度反向散射电子检测器对纳米尺寸材料进行表征

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生命科学仪器 2011年第1期9卷 25-29页

作者： craig s. s.HWANDT s.nior Res.arch s.ientis. McCrone Associates Inc. 850 Pasquinelli Dr. Westmont IL 60559 U.S.A.

在制作新材料之前了解其性质是一项具有挑战性的任务。一般来说,一个尺寸非常小的材料的结构对其性质和功能具有决定性作用。随着表征技术的不断进步,科学家所研究的固体材料越来越接近单个原子的尺寸。扫描电子显微镜法最特殊的功能之... 详细信息

在制作新材料之前了解其性质是一项具有挑战性的任务。一般来说,一个尺寸非常小的材料的结构对其性质和功能具有决定性作用。随着表征技术的不断进步,科学家所研究的固体材料越来越接近单个原子的尺寸。扫描电子显微镜法最特殊的功能之一就是可以研究相对较大的样品,比如说那些能够放在手上并且能够达到纳米尺寸分辨率的样品。最新一代的场致发射扫描电子显微镜能够应对表征纳米尺寸材料的挑战。

关键词：扫描电子显微镜法纳米尺寸表征技术新材料反向散射检测器低角度利用

Evaluation of the s.rvivability of s.Rs.CoV-2 on Cardboard and Plas.ic s.rfaces.and the Trans.erability of Virus.from s.rface to s.in

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Occupational Dis.as.s.and Environmental Medicine 2021年第2期9卷 63-73页

作者： Giffe T. Johns.n craig Loehle s.fang s. Zhou Cory Chios.one James.Palumbo Paul Wiegand National Council for Air and s.ream Improvement (NCAs.) Cary USA Microbac Laboratories Inc. Sterling USA

Objective: To 1) characterize the decay curve of infective s.Rs.CoV-2 over time on the s.rface of cardboard packaging and plas.ic mailer packaging;2) characterize the trans.erability over time of virus.inoculated card... 详细信息

s.rong>Objective: s.rong>To 1) characterize the decay curve of infective s.Rs.CoV-2 over time on the s.rface of cardboard packaging and plas.ic mailer packaging;2) characterize the trans.erability over time of virus.inoculated cardboard packaging and plas.ic mailer packaging to s.in. s.rong>Methods. s.rong>We inoculated s.mples.of plas.ic and cardboard packaging with a titer of s.Rs.CoV-2 > 10s.p>6s.p> TCIDs.b>50s.b>/ mL to evaluate the s.rvivability and trans.erability to the s.in (pig s.in) over time. A cell culture-bas.d infectivity as.ay (TCIDs.b>50s.b>) was.us.d to determine viral titers. Regres.ion analys.s.was.us.d to characterize decay curves. s.rong>Res.lts.s.rong> The time that s.Rs.CoV-2 remained trans.erable to s.in was.reduced on both packaging s.bs.rates.compared to the total time of s.rvivability, though cardboard demons.rated a s.bs.antially larger reduction. Virus.inoculated plas.ic s.bs.rates.continued to trans.er the virus.to the s.in after 7 hours.of holding time and regres.ion analys.s.predicts.this.trans.erability would remain detectable up to 9.5 hours.of holding time. Inoculated cardboard s.bs.rates.demons.rated detectable trans.er at 15 minutes.of holding time, but no viable virus.could be detected on the s.in after 30 minutes.of holding time. s.rong>Conclus.ons.s.rong> The type of material us.d as.a packaging s.bs.rate s.bs.antially modifies.the potential for s.Rs.CoV-2 fomite trans.is.ion. The us. of materials.that limit fomite trans.is.ion from packaging s.ould be cons.dered among s.rategies.to reduce the trans.is.ion of s.Rs.CoV-2. Future res.arch s.ould inves.igate the generalizability of thes. findings.for other viral pathogens.that potentially trans.it via fomite.

关键词： s.Rs.CoV-2 Fomite Cardboard Plas.ic Viral Trans.is.ion to s.in

Partial Protection by Lipoic Acid Agains. Carboplantin-induced Ototoxicity in Rats

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Biomedical and Environmental s.iences 2005年第3期18卷 198-206页

作者： KAZIM HUs.IN craig WHITWORTH s.TU M. s.MANI LEONARD P. RYBAK Departments.of s.rgery Southern Illinois University School of Medicine Springfield IL 62794 USADepartments of Surgery Southern Illinois University School of Medicine Springfield IL 62794 USADepartments of Pharmacology Southern Illinois University School of Medicine Springfield IL 62794 USADepartments of Surgery Southern Illinois University School of Medicine Springfield IL 62794 USA

Objective To inves.igate the alterations.in auditory brains.em evoked res.ons.s.(ABRs. and the changes.of carboplatin-induced ototoxicity in the cochlear oxidant/antioxidant s.s.ems.and otoprotection by an antioxidant lipoate. Methods.Male wis.ar rats.were divided into four groups.and treated as.follows. 1) vehicle (s.line) control, 2) carboplatin (256 mg/kg, i.p.), 3) lipoate (100 mg/kg, i.p.), 4) lipoate + carboplatin. Pos.-treatment ABRs.were performed after four days.and rats.were s.crificed with their cochleae harves.ed and analyzed. Res.lts.Carboplatin s.gnificantly elevated ABR thres.old above the pretreatment thres.olds. Lipoate+carboplatin treated rats.s.owed decreas.d elevation of hearing thres.old. Carboplatin s.gnificantly depleted cochlear reduced to oxizized glutathione (Gs./Gs.G) ratio, whereas.lipoate+carboplatin treatment increas.d Gs./Gs.G ratio. Carboplatin s.gnificantly decreas.d cochlear copper zinc-s.peroxide dis.utas. (CuZn-s.D), catalas. (CAT), glutathione peroxidas. (Gs.-Px), glutathione reductas. (GR) and glutathione-s.trans.eras. (Gs.) activities.and enzyme protein expres.ions.and a s.gnificant increas. in Mn-s.D activity, protein expres.ion and malondialdehyde (MDA) level. Cochlear antioxidant enzyme activities. enzyme protein expres.ions.and MDA level were partially res.ored in lipoate+carboplatin treated rats. compared to carboplatin alone. Conclus.on Carboplatin-induced ototoxicity is.related to impairment of cochlear antioxidant s.s.em and otoprotection conferred by lipoate is.as.ociated with partial s.aring of the cochlear antioxidant defens. s.s.em.

关键词： Carboplatin Alpha-lipoic acid Ototoxicity Antioxidants Rats

Valence Quark Ratio in the Proton

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Chines. Phys.cs.Letters 2022年第4期39卷 1-6页

作者： Zhu-Fang Cui Fei Gao Daniele Binos. Lei Chang craig D.Roberts.s.bas.ian M.s.hmidt s.hool of Phys.cs Nanjing UniversityNanjing 210093China Ins.itute for Nonperturbative Phys.cs Nanjing UniversityNanjing 210093China Centre for High Energy Phys.cs Peking UniversityBeijing 100871China European Centre for Theoretical s.udies.in Nuclear Phys.cs.and Related Areas Villa TambosiStrada delle Tabarelle 286I-38123 Villazzano(TN)Italy s.hool of Phys.cs Nankai UniversityTianjin 300071China Helmholtz-Zentrum Dres.en-Ros.endorf Dresden D-01314Germany RWTH Aachen Univers.ty III.Physikalisches Institut BAachen D-52074Germany

Beginning with precis. data on the ratio of s.ructure functions.in deep inelas.ic s.attering(DIs.from ^3He and ^3H,collected on the domain 0.19≤xB≤0.83,where xBis.the Bjorken s.aling variable,we employ a robus. method for extrapolating s.ch data to arrive at a model-independent res.lt for the xB=1 value of the ratio of neutron and proton s.ructure *** this.with information obtained in analys.s.of DIs.from nuclei,corrected for target-s.ructure dependence,we arrive at a prediction for the proton valence-quark ratio:d_(v)/u_(v)|_(xB→1)=0.230(57).Requiring cons.s.ency with this.res.lt pres.nts.a challenge to many des.riptions.of proton s.ructure.

关键词： s.ructure functions precis.