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Envita’s Precision Cancer Care: 35-Fold Improvement in Response Rates

Journal of Cancer Therapy 2024年第4期15卷 99-120页

作者： Sheba Goklany John C. Oertle III Ronald Matthias Jr. Daniel Warren David Medina Rory Sears Robert Zieve Kendra Quart Christopher Aussems Jon Moma Shannon Miller Zach Poteet Conner Coffin courtney middleton Erika Ware Phylicia Zarnosky Julie Nowak Winlove Suasin Daniel Conway Chad Burk Ruth Tan-Lim Dino Prato Envita Medical Centers Scottsdale AZ USA

New clinical approaches are imperative beyond the widely adopted National Comprehensive Cancer Network (NCCN) guidelines, utilized by prominent cancer institutions. Cancer is the leading cause of death among individuals younger than 85 years within the United States. Despite significant technological advances, including the expenditure of hundreds of billions, treatment outcomes and overall survival have not notably improved for most types of advanced cancer over the last several decades. Over the past 24 years, Envita Medical Centers has pioneered a unique form of personalized treatment approach for late-stage and refractory cancer patients, introducing groundbreaking innovations in the field. Our integrated algorithm utilizes advanced genomics, transcriptomics, and highly tailored immunotherapy, resulting in remarkable outcome improvements. This study presents Envita’s innovative personalized treatment algorithms and examines the response outcomes of 199 late-stage cancer patients treated at Envita Medical Centers over a two-year period. Compared to standard of care and palliative chemotherapy, Envita’s treatment demonstrated a remarkable 35-fold improvement in overall response rates (Figure 1). Moreover, 88% of the patients, the majority presenting with Stage 3 or 4 cancer, experienced a 43-fold improvement in quality of life with minimal side effects, as compared to standard of care chemotherapy and palliative care. This revolutionary success is attributed to Envita’s personalized therapeutic algorithms, which incorporate customized immunotherapy. Envita’s precision care approach has also achieved a 100% better response rate compared to over 65 global chemotherapy clinical trials with more than 2700 patients. The results from this study suggest that a wider utilization of Envita’s personalized approach can significantly benefit patients with late-stage and refractory cancer.

关键词： Envita Medical Centers Late-stage Cancer Overall Response Rate Quality of Life Circulating Tumor Cells (CTCs) Mutant Allele Frequency (MAF) Precision Care

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Tomato fruit as a model for tissue-specific gene silencing in crop plants

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Horticulture Research 2020年第1期7卷 839-845页

作者： Ari Feder Sarah Jensen Anquan Wang Lance courtney Lesley middleton Joyce Van Eck Yongsheng Liu James J.Giovannoni Boyce Thompson Institute for Plant Research Cornell UniversityIthacaNYUSA Section of Plant Breeding and Genetics Cornell UniversityIthacaNYUSA School of Biotechnology and Food Engineering Hefei University of Technology230009 HefeiChina Section of Plant Biology Cornell UniversityIthacaNYUSA US Department of Agriculture–Agricultural Research Service Robert W.Holley Center for Agriculture and HealthIthacaNYUSA

Use of CRISPR-Cas9(Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)-CRISPR-associated 9)-mediated genome editing has proliferated for use in numerous plant species to modify gene function and expression,usually in the context of either transient or stably inherited genetic *** extremely useful in many applications,modification of some loci yields outcomes detrimental to further experimental evaluation or viability of the target *** of Cas9 under a promoter conferring gene knockouts in a tissue-specific subset of genomes has been demonstrated in insect and animal models,and recently in *** developed an in planta GFP(green fluorescent protein)assay system to demonstrate fruit-specific gene editing in tomato using a phosphoenolpyruvate carboxylase 2 gene *** then targeted a SET-domain containing polycomb protein,SlEZ2,previously shown to yield pleiotropic phenotypes when targeted via ^(35)S-driven RNA interference and we were able to characterize fruit phenotypes absent additional developmental ***-specific gene editing will have applications in assessing function of essential genes otherwise difficult to study via germline modifications and will provide routes to edited genomes in tissues that could not otherwise be recovered when their germline modification perturbs their normal development.

关键词： otherwise specific editing

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Histone Deacetylase Genes in Arabidopsis Development

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Journal of Integrative Plant Biology 2008年第7期50卷 875-885页

作者： courtney Hollende Department of Cell Biology and Molecular Genetics University of Maryland College ParkMaryland 20742USA

Histone acetylation and deacetylation are directly connected with transcriptional activation and silencing in eukaryotes. Gene families for enzymes that accomplish these histone modifications show surprising complexity in domain organization, tissue-specific expression, and function. This review is focused on the family of histone deacetylases （HDACs） that remove the acetyl group from core histone tails, resulting in a ＂closed＂ chromatin and transcriptional repression. In Arabidopsis, 18 HDAC genes are divided into three different types - RPD3-1ike, HD-tuin and sirtuin - with two or more members in each type. The structural feature of each HDAC class, the expression profile of each HDAC gene during development and functional insights of important family members are summarized here. It is clear that HDACs are an important class of global transcriptional regulators that play crucial roles in plant development, defense, and adaptation.

关键词： chromatin epigenetic regulation gene silencing histone deacetylase plant development

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HOW TO SUCCESSFULLY IMPLEMENT LEED:DOCUMENTATION CHALLENGES AND SOLUTIONS

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Journal of Green Building 2007年第4期2卷 3-13页

作者： courtney France France Sustainable Solutions France

INTRODUCTION Market Transformation The market’s attention to environmentally-related issues has drastically increased over the past *** over rising fuel costs,urban air quality,national security,and local development impacts have influenced a growing trend for improved environmental *** and commercial building expansion will continue,but balancing needs with resources,and infrastructure demand with capacity,proves to be a challenge for any scope of development.

关键词： LEED Transformation continue

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Shock tube design for high intensity blast waves for laboratory testing of armor and combat materiel

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Defence Technology（防务技术） 2014年第2期10卷 245-250页

作者： Elijah courtney Amy courtney Michael courtney BTG Research P.O.Box 62541Colorado Springs Exponent Inc.3440 Market StreetPhiladelphia

Shock tubes create simulated blast waves which can be directed and measured lo study blast wave effects under laboratory *** is desirable to increase available peak pressure from ~1 MPa to ~5 MPa to simulate closer blast sources and facilitate development and testing of personal and vehicle *** methods are experimentally investigated to increase peak simulated blast pressure produced by an oxyacetylene driven shock tube while maintaining suitability for laboratory *** first method is the addition of a Shchelkin spiral priming section which supports a deflagration to detonation *** approach increases the average peak pressure from 1.17 MPa to 5.33 MPa while maintaining a relevant pressure-time curve(near Friedlander waveform).The second method is a bottleneck between the driving and driven *** a 79 mm diameter driving section to a 53 mm driven section increases the peak pressure from 1.17 MPa to 2.25 MPa.A 103 mm driving section is used to increase peak pressure to 2.64 *** third method,adding solid fuel to the driving section with the oxyacetylene,results in a peak pressure increasing to 1.70 MPa.

关键词：实验室测试激波管冲击波装甲高强度峰值压力设计物资

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Mainstreaming Early Warning Systems in Development and Planning Processes: Multilevel Implementation of Sendai Framework in Indus and Sahel

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International Journal of Disaster Risk Science 2015年第2期6卷 189-199页

作者： Asim Zia courtney Hammond Wagner Department of Community Development and Applied Economics University of Vermont Department of Computer Science University of Vermont Rubenstein School of the Environment and Natural Resources University of Vermont

The third UN World Congress on Disaster Risk Reduction, held in Sendai, Japan in March 2015, agreed on a new framework to guide disaster risk reduction policy and practice for the next 15 years. The Sendai Framework for Disaster Risk Reduction 2015–2030(SFDRR) leaves important implementation issues unspecified and potentially creates both problems and opportunities for complex,multilevel governance systems in coping with hazards and disastrous events. Early warning systems(EWS), if built into the mainstream of planning for development and disaster relief and recovery, could present a significant opportunity to realize many SFDRR goals. We explore the complexities of using hydrometeorological EWS to prepare for drought and flood disasters in the densely populated communities of Pakistan’s Indus River Basin in contrast to the African Sahel’s less densely settled grasslands. Multilevel governance systems are often dominated by a topdown, technocentric, centralized management bias and have great difficulty responding to the needs of peripheral and vulnerable populations. People-centered, bottom-up approaches that incorporate disaggregated communities with local knowledge into a balanced, multilevel disaster risk management and governance structure have adramatically better chance of realizing the SFDRR goals for disaster risk reduction.

关键词： Early warning systems Infrastructure development Land-use planning Policy implementation Risk governance Sendai Framework Science-policy interface

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AI Sentience and Socioculture

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Journal of Social Computing 2023年第3期4卷 205-220页

作者： AJ Alvero courtney Peña the Department of Sociology University of FloridaGainesvilleFL 32601USA the Stanford School of Medicine Stanford UniversityStanfordCA 94305USA

Artificial intelligence(AI)sentience has become an important topic of discourse and inquiry in light of the remarkable progress and capabilities of large language models(LLMs).While others have considered this issue from more philosophical and metaphysical perspectives,we present an alternative set of considerations grounded in sociocultural theory and ***,we focus on sociocultural perspectives on interpersonal relationships,sociolinguistics,and culture to consider whether LLMs are *** examples grounded in quotidian aspects of what it means to be sentient along with examples of AI in science fiction,we describe why LLMs are not sentient and are unlikely to ever be *** present this as a framework to reimagine future AI not as impending forms of sentience but rather a potentially useful tool depending on how it is used and built.

关键词： sentience sociology sociolinguistics culture interpersonal relationships quotidian

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APOBEC deaminases-mutases with defensive roles for immunity

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Science China(Life Sciences) 2009年第10期52卷 893-902页

作者： courtney PROCHNOW Ronda BRANSTEITTER Molecular and Computational Biology University of Southern CaliforniaLos Angeles CA 90089 USA

In recent years, tremendous progress has been made in the elucidation of the biological roles and molecular mechanisms of the apolioprotein B mRNA-editing enzyme catalytic polypeptide (APOBEC) family of enzymes. The APOBEC family of cytidine deaminases has important functional roles within the adaptive and innate immune system. Activation induced cytidine deaminase (AID) plays a central role in the biochemical steps of somatic hypermutation and class switch recombination during antibody maturation, and the APOBEC 3 enzymes are able to inhibit the mobility of retroelements and the replication of retroviruses and DNA viruses, such as the human immunodeficiency virus type-1 and hepatitis B virus. Recent advances in structural and functional studies of the APOBEC enzymes provide new biochemical insights for how these enzymes carry out their biological roles. In this review, we provide an overview of these recent advances in the APOBEC field with a special emphasis on AID and APOBEC3G.

关键词： APOBEC cytidine deaminase activation induced cytidine deamination somatic hypermutation class switch recombination HyperIgM 2 syndrome human immunodeficiency virus (HIV) DNA deamination

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Harnessing the stem cell properties of pericytes to repair the brain

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Neural Regeneration Research 2020年第6期15卷 1021-1022页

作者： Jo-Maree courtney Brad A.Sutherland School of Medicine College of Health and Medicine University of Tasmania

Over the last ten years or so,it has become apparent that pericytes have the potential to differentiate into other cell types which may help in the repair and regeneration of tissue after *** fact,pericytes have been described as a precursor to mesenchymal stem *** location at the interface between the microvasculature and the brain parenchyma means they are ideally positioned to initiate repair and regeneration in response to various *** this perspective,we will highlight how pericytes have stem cell potential alongside their role in regulating processes,such as angiogenesis and inflammation,and discuss how pericytes could be harnessed to promote tissue repair in the brain(Figure 1).

关键词： pericyte inflammation Figure

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Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids

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Acta Pharmaceutica Sinica B 2015年第2期5卷 129-134页

作者： courtney B.Ferrebee Paul A.Dawson Department of Pediatrics Division of Gastroenterology Hepatology and Nutrition Emory University Molecular Medicine Graduate Program Wake Forest School of Medicine

The classical functions of bile acids include acting as detergents to facilitate the digestion and absorption of nutrients in the gut. In addition, bile acids also act as signaling molecules to regulate glucose homeostasis, lipid metabolism and energy expenditure. The signaling potential of bile acids in compartments such as the systemic circulation is regulated in part by an efficient enterohepatic circulation that functions to conserve and channel the pool of bile acids within the intestinal and hepatobiliary compartments. Changes in hepatobiliary and intestinal bile acid transport can alter the composition, size,and distribution of the bile acid pool. These alterations in turn can have significant effects on bile acid signaling and their downstream metabolic targets. This review discusses recent advances in our understanding of the inter-relationship between the enterohepatic cycling of bile acids and the metabolic consequences of signaling via bile acid-activated receptors, such as farnesoid X nuclear receptor(FXR)and the G-protein-coupled bile acid receptor(TGR5).

关键词： Bile acids Liver Intestine Transporters Lipid metabolism Energy homeostasis

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