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Audit of the Physico-Chemical Quality of Amoxicillin Based Drugs Marketed in Senegal

American Journal of Analytical Chemistry 2023年第9期14卷 351-361页

作者： coulibaly dalané bernadette Sow Fatoumata Tata Naco Mohamed El Béchir N’Diaye Mahamar Toure Hamadoun Abba Mariko Madani Dackouo Blaise Diouf Diéry Koumare Benoit Yaranga Sarr Serigne Omar Faculty of Medicine Pharmacy and Odonto-Stomatology University Cheik Anta DIOP Dakar Dakar Sénégal Faculty of Pharmacy of Bamako University of Technical and Technological Sciences of Bamako (FAPH/USTTB) Bamako Mali National Health Laboratory of Mali Bamako Mali National Drug Control Laboratory of Senegal (LNCM) Dakar Sénégal

Non-compliant antibiotics pose problems of therapeutic efficacy at the level of the individual, but also a serious public health problem. The objective of our study was to evaluate the quality of generic amoxicillin (42 samples) by analytical methods in Dakar/Senegal. At 100% visual inspection of compliance;100% compliance uniformity test;at the dissolution test all > 80% (86.8% to 108.8%). The presence of amoxicillin with the following contents: Tablets (95.2% to 104.1%);Capsules (91.5% to 113.9%) and Suspensions drinkable (96.9% - 118.7%). All the samples in our study are 100% compliant according to the European and American pharmacopoeias (90% - 120%). Other studies should therefore be oriented in the direction of stability as well as the dosage of degradation products.

关键词： Quality Control Amoxicillin Analytical Methods

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Preliminary Research Study for Antibiotics in Eggs Produced and Sold in Bamako, Mali

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Food and Nutrition Sciences 2022年第3期13卷 252-258页

作者： dalané bernadette coulibaly Mohamed El Béchir Naco Dougoutigui Tangara Fatoumata Tata Sow Fanta Kaba Camara Hamadoun Abba Toure Madani Mariko Blaise Dackouo Seydou Moussa coulibaly Benoit Yaranga Koumare Faculty of Pharmacy of Bamako/University of Technical and Technological Sciences of Bamako Bamako Mali National Health Laboratory Bamako Mali National Food Safety Agency Bamako Mali

The quality of agri-food products, in particular those of poultry origin, has now become an imperative. Because of the antibiotics used in poultry production, we are seeing the presence of antibiotic residues in products from poultry farming, especially eggs. Residues in eggs do not always comply with regulatory requirements, which can have harmful consequences for consumers such as: risk of allergies or risk of antibiotic resistance. This study was carried out with the aim of evaluating the presence of residues of veterinary antibiotics in eggs produced and marketed in the district of Bamako and surroundings. All samples were analyzed using the Premi ®Test which is a rapid detection kit for antibiotic residues in different materials. We collected 900 eggs from 10 farms and 10 markets in Bamako. Out of 900 eggs, 228 were tested. One hundred and eighty-nine (189) eggs tested negative for the presence of antibiotic residues, i.e. 82.9%;on the other hand, 39 were positive, i.e. 17.1%. This study clearly shows the presence of antibiotic residues in eggs from farms and various markets in Bamako and the surrounding area. This will allow us to continue our study at a later date to identify the types of antibiotic and to dose them.

关键词： Antibiotic Residues Eggs Mali

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Hypertensive Retinopathy in Normotensive Blacks: About 3 Cases

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World Journal of Cardiovascular Diseases 2018年第7期8卷 381-389页

作者： Benedicte Carine Boka Iklo coulibaly Hermann Yao Ghyslain Ouffouet Marie-Paule bernadette Ncho-Mottoh Arnaud Kouadio Ekou Institute of Cardiology Abidjan Cote d’Ivoire

In case of hypertension, hypertensive retinopathy is normally an indicator of target organ damage. This sign can be frequently detected even in normotensive subjects. Among 94 normotensive volunteers chosen with regard of the hypertensive status of their parents, we could report the case of 3 black women who had hypertensive retinopathy. As changes in retinal microvasculature precede other signs of damage, we suggest fundus photography routine to be performed more frequently in assessing cardiovascular risks in hypertensive individual and their offspring, especially in black African population, where hypertension is severe.

关键词： Hypertensive Retinopathy-Normotensive-Blacks

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