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Journal of Thermal Science 2013年第6期22卷 555-564页

作者： A.Marsan I.Trébinjac S.coste G.Leroy Laboratoire de Mécanique des Fluides et d'Acoustique UMR CNRS 5509 cole Centrale de Lyon Turbomeca Safran group

The temporal behaviour of a flow separation in the hub-suction side comer of a transonic diffuser is studied thanks to unsteady numerical simulations based on the phase-lagged approach. The validity of the numerical re- sults is confn＇med by comparison with experimental unsteady pressure measurements. An analysis of the instan- taneous skin-friction pattern and particles trajectories is presented. It highlights the topology of the separation and its temporal behaviour. The major result is that, despite of a highly time-dependent core flow, the separation is found to be a ＂fixed unsteady separation＂ characterized by a fixed location of the main saddle of the separation but an extent of the stall region modulated by the pressure waves induced by the impeller-diffuser interaction.

关键词： Corner Separation Radial Vaned Diffuser Centrifugal Compressor Surge

Ombitasvir/paritaprevir/ritonavir + dasabuvir +/-ribavirin in real world hepatitis C patients

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World Journal of Gastroenterology 2019年第18期25卷 2229-2239页

作者： Nicole Loo Eric Lawitz Naim Alkhouri Jennifer Wells Carmen Landaverde Angie coste Rossalynn Salcido Michael Scott Fred Poordad Academic and Clinical Affairs Texas Liver Institute

BACKGROUND The hepatitis C virus(HCV) NS5A inhibitor ABT-267(ombitasvir, OBV), the HCV NS4/4A protease inhibitor ABT-450(paritaprevir, PTV), the CYP3A inhibitor ritonavir(r) and the non-nucleoside NS5B polymerase inhibitor ABT-333(dasabuvir, DSV)(OBV/PTV/r + DSV) with or without ribavirin(RBV) is a direct-acting antiviral regimen approved in the United States and other major countries for the treatment of HCV in genotype 1(GT1) infected patients. Patients with HCV who are considered "hard-to-cure" have generally been excluded from registration trials due to rigorous study inclusion criteria, presence of comorbidities and previous treatment *** To investigate the efficacy of this regimen in HCV G1-infected patients historically excluded from clinical *** Patients were ≥ 18 years old and chronically infected with HCV GT1(GT1a, GT1b or GT1a/1b). Patients were treatment-na?ve or previously failed a regimen including pegylated interferon/RBV +/-telaprevir, boceprevir, or *** hundred patients were treated with the study drug regimen, which was administered for 12 or 24 wk +/-RBV according to GT1 subtype and presence/absence of cirrhosis. Patients were evaluated every 4 wk from treatment day 1 and at 4 and 12 wk after *** Many of the patients studied had comorbidities(44.2% hypertensive, 33.7%obese, 20.2% cirrhotic) and 16% previously failed HCV treatment. Ninety-six patients completed study follow-up and 99% achieved 12-wk sustained virologic response. The majority(88.4%) of patients had undetectable HCV RNA by week 4. The most common adverse events were fatigue(12%), headache(10%),insomnia(9%) and diarrhea(8%); none led to treatment discontinuation. Physical and mental patient reported outcomes scores significantly improved after treatment. Almost all(98%) patients were treatment *** In an all-comers HCV GT1 population, 12 or 24-wk of OBV/PTV/r + DSV +/-RBV is highly effective and tolerable and results

关键词： Hepatitis C Ombitasvir Paritaprevir Ritonavir Dasabuvir Genotype 1

Gait spectral index (GSI): a new quantification method for assessing human gait

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Health 2010年第1期2卷 38-44页

作者： Rodolphe Héliot Christine Azevedo-coste Laszlo Schwirtlich Bernard Espiau 不详

This paper introduces a simple, quantitative as-sessment tool to follow up the recovery of gait. Today, micro-electro-mechanical systems (MEMS) technology provides with small, simple, low-pow- er consuming and easy to don and doff sensors. In our approach we have selected an accelerome- ter and introduced a new quantity that charac-terizes the gait pattern in the frequency domain, we term it Gait Spectral Index (GSI). GSI allows assessing gait quality and closely relates to the speed and cadence of gait (dynamics). We have tested the GSI approach to quantify the quality of the gait of healthy young and elderly, and post- stroke hemiplegic individuals. We investigated the repeatability and coherence of GSI in healthy individuals (young and elderly) and contrasted this to the post-stroke hemiplegic individuals. We found that high correlation of the GSI with conventional gait parameters. This suggests that GSI, which needs only data from one acceler-ometer, could be an objective quantitative mea- sure of the quality of the walking thereby a sim- ple yet reliable measure of the recovery of func-tion during neuronrehabilitation.

关键词： Gait Evaluation Walk Training Accelerometer Spectral Analysis

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冰与火一次在巅峰的相遇

汽车生活 2011年第2期 78-95页

作者： DIMITRI coste

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关键词：卡特琳娜

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群上的概率化：随机游动和不变扩散

数学译林 2002年第3期21卷 212-226页

作者： LaurentSaloff-coste 贾淑梅

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剪切下交联研究

石油勘探与开发 2002年第4期29卷 101-102页

作者：胡菁华刘玉章白宝君李良雄 coste Jean Paul 中国石油勘探开发研究院

研究剪切下交联情况 ,将交联过程描述为 4个连续阶段 ,最后一阶段得到均匀分散的微凝胶颗粒。低毒交联体系(聚丙烯酰胺共聚物 /Al3 + )的实验结果证明 ,交联剂浓度、pH值、流变仪狭缝大小和剪切速率等因素对交联时间和凝胶的最终剪切黏... 详细信息

研究剪切下交联情况 ,将交联过程描述为 4个连续阶段 ,最后一阶段得到均匀分散的微凝胶颗粒。低毒交联体系(聚丙烯酰胺共聚物 /Al3 + )的实验结果证明 ,交联剂浓度、pH值、流变仪狭缝大小和剪切速率等因素对交联时间和凝胶的最终剪切黏度等理化性能都有影响 ,通过控制合适的剪切条件 ,可以制备新型分散凝胶体系。图 4参 2 (胡菁华摘 )

关键词：剪切交联凝胶剪切黏度分散凝胶体系油井堵水

Implementation and Validation of a Stride Length Estimation Algorithm,Using a Single Basic Inertial Sensor on Healthy Subjects and Patients Suffering from Parkinson’s Disease

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Health 2015年第6期7卷 704-714页

作者： Benoit Sijobert Mourad Benoussaad Jennifer Denys Roger Pissard-Gibollet Christian Geny Christine Azevedo coste DEMAR INRIA-LIRMMMontpellierFrance INRIA MontbonnotFrance Neurological Department CHU Gui de ChauliacMontpellierFrance

As low cost and highly portable sensors, inertial measurements units (IMU) have become increas-ingly used in gait analysis, embodying an efficient alternative to motion capture systems. Mean-while, being able to compute reliably accurate spatial gait parameters using few sensors remains a relatively complex problematic. Providing a clinical oriented solution, our study presents a gy-rometer and accelerometer based algorithm for stride length estimation. Compared to most of the numerous existing works where only an averaged stride length is computed from several IMU, or where the use of the magnetometer is incompatible with everyday use, our challenge here has been to extract each individual stride length in an easy-to-use algorithm requiring only one inertial sensor attached to the subject shank. Our results were validated on healthy subjects and patients suffering from Parkinson’s disease (PD). Estimated stride lengths were compared to GAITRite? walkway system data: the mean error over all the strides was less than 6% for healthy group and 10.3% for PD group. This method provides a reliable portable solution for monitoring the in-stantaneous stride length and opens the way to promising applications.

关键词： Inertial Measurement Unit(IMU) Stride Length Gait Analysis Parkinson’s Disease Biologging

Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors

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Journal of Molecular Cell Biology 2020年第3期12卷 202-215页

作者： Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès coste Bettina Couderc Institut Claudius Regaud-IUCT Oncopole Universite de ToulouseToulouseFrance INSERM UMR 1037 Cancer Research Center of Toulouse(CRCT)ToulouseFrance UMR 152 Pharma Dev Universite de ToulouseIRDUPSToulouseFrance UMR CNRS 5089 Institut de Pharmacologie et de Biologie Structurale(IPBS)ToulouseFrance

Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and *** this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs *** tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor ***,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor *** CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral *** ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of *** high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance.

关键词： chemoresistance macrophages mesenchymal stromal cells ovarian adenocarcinoma chemokines

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冰与火

汽车生活 2011年第3期 36-37页

作者： Sinatra（编译） Dimitri coste（摄影）

法国车厂喜欢把钱花在一些比较另类的方面：比如打造一辆适合家庭使用且制作工艺精湛的主流B级车,抑或是精雕细琢的A级车。而各大车展便成了他们的秀场,看看这些年他们推出的那些惊为天人的概念车就知道,业内大腕们可能都在颤抖了,可能... 详细信息

法国车厂喜欢把钱花在一些比较另类的方面：比如打造一辆适合家庭使用且制作工艺精湛的主流B级车,抑或是精雕细琢的A级车。而各大车展便成了他们的秀场,看看这些年他们推出的那些惊为天人的概念车就知道,业内大腕们可能都在颤抖了,可能是法拉利,可能是保时捷。

关键词：制作工艺冰 A级车概念车法拉利保时捷车展

High Sensitivity of Porous Cu-Doped SnO₂ Thin Films to Methanol

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Advances in Nanoparticles 2016年第2期5卷 140-148页

作者： Sara Benzitouni Mourad Zaabat Aicha Khial Djamil Rechem Ahlem Benaboud Dhikra Bouras Abdelhakim Mahdjoub Mahdia Toubane Raphael coste Laboratoire des Composants Actifs et Matériaux (LCAM) Université Larbi Ben M’hidi Oum El Bouaghi Algérie Laboratoire des Matériaux et Structure des Systèmes Electromécaniques et leur Fiabilité (LMSSEF) Université Larbi Ben M’hidi Oum El Bouaghi Algérie Unité de Recherche Matériaux Procédés et Environnement (URMPE) Université M’hamed Bougara Boumerdes Algérie Laboratoire de Recherche en Nanoscience (LRN) UFR Sciences Université de Reims Reims France

Porous Cu-doped SnO2 thin films were synthesized by the sol-gel dip-coating method for enhancing methanol sensing performance. The effect of Cu doping concentration on the SnO2 sensibility was investigated. XRD data confirm that the fabricated SnO2 films are polycrystalline with tetragonal rutile crystal structure. AFM and SEM micrographs confirmed the roughness and the porosity of SnO2 surface, respectively. UV-Vis spectrum shows that SnO2 thin films exhibit high transmittance in the visible region ~95%. The band gap (3.80 - 3.92 eV) and the optical thickness (893 - 131 nm) of prepared films were calculated from transmittance data. The sensing results demonstrate that SnO2 films have a high sensitivity and a fast response to methanol. In particular, 3% Cu-SnO2 films have a higher sensitivity (98%), faster response (10-2 s) and shorter recovery time (18 s) than other films.

关键词： SnO2 Cu-Doped Sensitivity Porosity Response Time Band Gap Thin Films