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Fully integrated and broadband Si-rich silicon nitride wavelength converter based on Bragg scattering intermodal four-wave mixing

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Photonics Research 2024年第3期12卷 I0001-I0010页

作者： VALERIO VITALI THALÍA DOMÍNGUEZ BUCIO HAO LIU JOSÉMANUEL LUQUE GONZÁLEZ FRANCISCO JURADO-ROMERO ALEJANDRO ORTEGA-MOÑUX GLENN CHURCHILL JAMES C.GATES JAMES HILLIER NIKOLAOS KALFAGIANNIS DANIELE MELATI JENS H.SCHMID ILARIA CRISTIANI PAVEL CHEBEN J.GONZALO WANGÜEMERT-PÉREZ ÑIGO MOLINA-FERNÁNDEZ FREDERIC GARDES cosimo LACAVA PERIKLIS PETROPOULOS Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK 2ElectricalComputer and Biomedical Engineering DepartmentUniversity of PaviaPavia 27100Italy 3Telecommunication Research Institute(TELMA)Universidad de MálagaCEI Andalucı´a TECHE.T.S.I.Telecomunicación29010 MálagaSpain 4School of Science and TechnologyNottingham Trent UniversityNottingham NG118NSUK 5Department of Electrical EngineeringEindhoven University of TechnologyEindhoven 5600 MBThe Netherlands 6Department of Materials Science and EngineeringUniversity of IoanninaIoannina 45110Greece 7Centre de Nanosciences et de NanotechnologiesUniversitéParis-SaclayCNRS91120 PalaiseauFrance 8Advanced Electronics and Photonics Research CenterNational Research Council CanadaOttawaOntario K1A 0R6Canada

Intermodal four-wave mixing(FWM)processes have recently attracted significant interest for all-optical signal processing applications thanks to the possibility to control the propagation properties of waves exciting distinct spatial modes of the same waveguide.This allows,in principle,to place signals in different spectral regions and satisfy the phase matching condition over considerably larger bandwidths compared to intramodal processes.However,the demonstrations reported so far have shown a limited bandwidth and suffered from the lack of on-chip components designed for broadband manipulation of different modes.We demonstrate here a silicon-rich silicon nitride wavelength converter based on Bragg scattering intermodal FWM,which integrates mode conversion,multiplexing and de-multiplexing functionalities on-chip.The system enables wavelength conversion between pump waves and a signal located in different telecommunication bands(separated by 60 nm)with a 3 dB bandwidth exceeding 70 nm,which represents,to our knowledge,the widest bandwidth ever achieved in an intermodal FWM-based system.

关键词： scattering pump modal

Concomitant medications and circulating tumor cells:friends or foes?

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Cancer Drug Resistance 2023年第1期6卷 30-34页

作者： Serena Di cosimo Vera Cappelletti Department of Advanced Diagnostics Fondazione IRCCS Istituto Nazionale dei TumoriMilano 20133Italy

The use of concomitant medications by patients with cancer is observed almost globally;however,little attention has been paid to this topic in the medical literature.Most clinical studies do not describe the type and duration of drugs used at the time of inclusion and during treatment or how these drugs may affect the experimental and/or standard therapy.Even less information has been published on the potential interaction between concomitant medications and tumor biomarkers.However,we do know that concomitant drugs can complicate cancer clinical trials and biomarker development,thus contributing to their interaction,leading to side effects,and resulting in suboptimal adherence to anticancer treatment.On the basis of these premises and moving from the study by Jurisova et al.,which reported the effect of commonly used drugs on the prognosis of women with breast cancer and the detection of circulating tumor cells(CTCs),we comment on the role of CTCs as an emerging diagnostic and prognostic tool for breast cancer.We also report the known and hypothesized mechanisms of CTC interplay with other tumor and blood components,possibly modulated by widespread drugs,including over-the-counter compounds,and discuss the possible implications of commonly used concomitant medications on CTC detection and clearance.After considering all these points,it is conceivable that concomitant drugs are not necessarily a problem,but on the contrary,their virtuous mechanisms can be exploited to reduce tumor spread and enhance the effect of anticancer therapies.

关键词： Breast cancer concomitant medications circulating tumor cells

Practical Implementation and Operational Experience of Dynamic Mode Decomposition in Wide-area Monitoring Systems of Italian Power System

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Journal of Modern Power Systems and Clean Energy 2023年第3期11卷 793-802页

作者： Andrea Vicario Alberto Berizzi Giorgio Maria Giannuzzi cosimo Pisani Department of Energy at Politecnico di Milano MilanItaly Terna S.p.A. RomeItaly

This study presents the assumptions and strategies for the practical implementation of the dynamic mode decomposition approach in the wide-area monitoring system of the Italian transmission system operator,Terna.The procedure setup aims to detect poorly damped interarea oscillations of power systems.Dynamic mode decomposition is a data-driven technique that has gained increasing attention in different fields;the proposed implementation can both characterize the oscillatory modes and identify the most influenced areas.This study presents the results of its practical implementation and operational experience in power system monitoring.It focuses on the main characteristics and solutions identified to reliably monitor the interarea electromechanical modes of the interconnected European power system.Moreover,conditions to issue an appropriate alarm in case of critical operating conditions are described.The effectiveness of the proposed approach is validated by its application in three case studies:a critical oscillatory event and a short-circuit event that occurred in the Italian power system in the previous years,and a 15-min time interval of normal grid operation recorded in March 2021.

关键词： Power system control power system dynamics wide-area monitoring system(WAMS) dynamic mode decomposition

Paraneoplastic myopathy-related rhabdomyolysis and pancreatic cancer:A case report and review of the literature

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世界临床病例杂志 2023年第28期11卷 6823-6830页

作者： Andrea Costantini Lucia Moletta Elisa Sefora Pierobon Simone Serafini Michele Valmasoni cosimo Sperti Department of Surgical Oncological and Gastroenterological SciencesUOC Chirurgia Generale 1University of PaduaPadua 35128Italy Department of Surgical Oncological and Gastroenterological SciencesUOC Chirurgia Generale 2University of PaduaPadua 35128Italy

BACKGROUND Rhabdomyolysis is a life-threatening condition,often leading to progressive renal failure and death.It is caused by destruction of skeletal muscle and the release of myoglobin and other intracellular contents into the circulation.The most frequent cause of this condition is“crush syndrome”,although several others have been described and paraneoplastic inflammatory myopathies associated with various types of cancer are repeatedly reported.CASE SUMMARY We describe a rare case of a patient with pancreatic cancer who developed rhabdomyolysis early on,possibly due to paraneoplastic myositis leading to acute renal failure and eventually to rapid death.A 78-year-old Caucasian woman was referred to our hospital for obstructive jaundice and weight loss due to a lesion in the pancreatic head.She presented increasingly severe renal insufficiency with anuria,a dramatic increase in creatine phosphokinase(36000 U/L,n.v.20-180 U/L)and myoglobin(>120000μg/L,n.v.12-70μg/L).On clinical examination,the patient showed increasing pain in the lower limbs associated with muscle weakness which was severe enough to immobilize her.Paraneoplastic myopathy linked to the malignant lesion of the pancreatic head was suspected.The patient was treated with hemodialysis and intravenous methylprednisolone.Despite all the efforts to prepare the patient for surgery,her general condition rapidly deteriorated and she eventually died 30 d after hospital admission.CONCLUSION The possible causes of rhabdomyolysis in this patient with pancreatic cancer are discussed,the development of paraneoplastic myopathy being the most likely.Clinicians should bear in mind that these syndromes may become clinically manifest at any stage of the cancer course and their early diagnosis and treatment could improve the patient’s prognosis.

关键词： Paraneoplastic myopathy Rhabdomyolysis Pancreatic cancer Acute renal failure Paraneoplastic myositis Prognosis Case report

5-ASA in ulcerative colitis:Improving treatment compliance

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World Journal of Gastroenterology 2009年第35期15卷 4353-4355页

作者： cosimo Prantera Marina Rizzi Department of Gastroenterology Azienda Ospedaliera San Camillo-ForlaniniCirconvallazione Gianicolense 8700152 RomeItaly Department of Gastroenterology University Campus Bio Medicovia Alvaro del Portillo 20000128 Rome Italy

5-aminosalicylic acid(5-ASA)compounds are a highly effective treatment for ulcerative colitis(UC).While UC patient compliance in clinical studies is over 90%, only 40%of patients in every day life take their prescribed therapy.Adherence to medication has been emphasized recently by a Cochrane meta-analysis that has suggested that future trials of 5-ASA in UC should look at patient compliance rather than drug efficacy. Better compliance can be obtained by reducing the number of tablets and times of administration.Given that the 5-ASA formulations have different delivery systems that split the active moiety in various regions of the intestine,it is particularly important that an adequate dose of the drug arrives at the inflamed part of the colon.5-ASA Multi matrix(MMx)is a novel,high strength(1.2 g),oral formulation designed for oncedaily dosing.It releases the active moiety throughout the colon.Different studies with this compound have shown that it is as effective as 5-ASA enema in the treatment of mild-to-moderate,left-sided UC,and is comparable to a pH-dependent,delayed release 5-ASA (Asacol ),even if given once daily.Recently,the effectiveness in the acute phase of UC has been confirmed also in maintenance.In conclusion,at present,5-ASA MMx seems theoretically the best agent for maintaining patient compliance,and consequently,treatment effectiveness.

关键词：溃疡性结肠炎氨基水杨酸灌肠治疗依从性加州大学活性成分抗坏血酸计量设计

A Note on Black Hole Information Paradox in de Sitter Spacetimes

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Communications in Theoretical Physics 2009年第7期52卷 78-80页

作者： cosimo Bambi Department of Physics and Astronomy Wayne State University Michigan Center for Theoretical Physics University of Michigan

马厩或黑洞信息悖论的答案通常被相信现象学地不能接受的伪马厩普朗克常数团黑人洞残余的可能性。因为我们为每个可能的起始的状态需要黑洞残余，残余的数字被期望无限，那将与粗略地超过普朗克常数团的一个全部的可得到的精力在任何物... 详细信息

马厩或黑洞信息悖论的答案通常被相信现象学地不能接受的伪马厩普朗克常数团黑人洞残余的可能性。因为我们为每个可能的起始的状态需要黑洞残余，残余的数字被期望无限，那将与粗略地超过普朗克常数团的一个全部的可得到的精力在任何物理过程导致残余对生产。在这笔记，我指出宇宙的一个积极宇宙论的常数将自然地在可能的残余的数字上导致上面的界限。

关键词：黑洞悖论信息普朗克质量西特宇宙常数初始状态物理过程

Staging chronic pancreatitis with exocrine function tests: Are we better?

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World Journal of Gastroenterology 2017年第38期23卷 6927-6930页

作者： cosimo Sperti Lucia Moletta Department of Surgery Oncology and Gastroenterology 3rd Surgical Clinic University of Padua

Chronic pancreatitis(CP) is an inflammatory disease of the pancreas evolving in progressive fibrotic disruption of the gland with exocrine and endocrine pancreatic insufficiency. Although imaging features of CP are well known, their correlation with exocrine pancreatic function tests are not obvious, particularly in the early stage of the disease. There are many clinical classification of CP, all suggested for better distinguish and manage different forms based on etiological and clinical factors, and severity of the disease. Recently, a new classification of CP has been suggested: the M-ANNHEIM multiple risk factor classification that includes etiology, stage classification and degree of clinical severity. However, more accurate determination of clinical severity of CP requires a correct determination of exocrine function of the pancreas and fecal fat excretion. Recently, Kamath et al demonstrated that the evaluation of exocrine pancreatic function by acid steatocrit and fecal elastase-1(EF-1) was helpful, but EF-1 was able to detect exocrine pancreatic insufficiency in more patients, upgrading some patients in higher stage of disease according to M-ANNHEIM classification. So, EF-1 is a more accurate test to determine exocrine pancreatic insufficiency and to stage chronic pancreatitis in the M-ANNHEIM classification. On the contrary, EF-1 determination shows low sensitivity in detecting exocrine pancreatic insufficiency in early stage of the disease.

关键词：长期的胰腺炎外分泌胰腺的不足烘便的 elastase-1 胰腺的功能测试 Steathorrea

Analysis of smart contracts balances

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Blockchain(Research and Applications) 2021年第3期2卷 46-67页

作者： cosimo Laneve Claudio Sacerdoti Coen Department of Computer Science and Engineering University of BolognaINRIA FocusBologna40126Italy

We define a technique for analyzing updates of smart contracts balances due to transfers of digital assets.The analysis addresses a lightweight smart contract language and consists of a two-step translation.First,we define the input-output behaviors of smart contract functions by means of a simple functional language with static dispatch.Then we associate the terms of this intermediate language with cost equations that compute the loss or gain of digital assets.The resulting equations can be fed to an off-the-shelf cost analyzer to provide upper bounds to the loss or gain.Our analysis has been prototyped and we report its assessments and discuss extensions with additional features.

关键词： Smart contracts Blockchain Static analysis Cost analysis Cryptocurrency Movements

Pancreatic resection in very elderly patients:A critical analysis of existing evidence

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World Journal of Gastrointestinal Oncology 2017年第1期9卷 30-36页

作者： cosimo Sperti Lucia Moletta Gioia Pozza Department of Surgery Oncology and Gastroenterology3~(rd)Surgical ClinicUniversity of Padua35128 PaduaItaly

The aging of the population results in a rise of number of elderly patients(aged 80 years and older) with pancreatic or periampullary cancer, and more pancreatectomies could eventually be performed in such complex patients. However, early and long-term results after pancreatic resection in octogenarians are still controversial, and may trouble the surgeon when approaching this type of population. Evaluation of reported experiences shows that for almost all Authors, pancreatectomy can be performed safely in elderly population, although overall morbidity and mortality rates were 34.9% and 13.2% respectively, with a mean length of hospital stay of 18 d. These features appear higher in older patients compared to the younger counterpart. Less than 50% of patients underwent adjuvant therapy after operation. Long-term survival is reported not significantly different in aged 80 years and older patients, with a median overall survival time of 17.6 mo. The quality of life after pancreatic resection is only sporadically evaluated but, when considered, it highlights the need of health facility service after operation for these "frail" patients. Prospective studies on the quality of life of pancreatectomized octogenarians are welcome. Proper selection of patients, geriatric assessment with multidisciplinary approach, centralization of pancreatic surgery in high-volume centres and rehabilitation programs after surgery appear to be crucial points in order to improve surgical treatments of pancreatic tumors in very elderly patients.

关键词：老八十至八十九岁 Pancreatectomy 胰腺的瘤幸存