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Syringaldehyde exerts neuroprotective effect on cerebral ischemia injury in rats through anti-oxidative and anti-apoptotic properties

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Neural Regeneration Research 2014年第21期9卷 1884-1890页

作者： Aras Adem Bozkurt Guven Mustafa Akman Tar?k Ozkan Adile Sen Halil murat K?l?coglu Mesut Kalkan Y?ld?ray Silan Coskun cosar murat Department of Neurosurgery ?anakkale Onsekiz Mart UniversityCanakkaleTurkey Department of Neurology ?anakkale Onsekiz Mart UniversityCanakkaleTurkey Department of Medical Biochemistry Ondokuz May?s UniversitySamsunTurkey Deparment of Histology and Embryology Faculty of MedicineRecep Tayyip Erdo?an UniversityRizeTurkey Department of Pharmacology ?anakkale Onsekiz Mart UniversityCanakkaleTurkey

There are few studies on the neuroprotective effects of syringaldehyde in a rat model of cerebral ischemia. The study aimed to elucidate the mechanisms underlying the neuroprotective effects of syringaldehyde on ischemic brain cells. Rat models of cerebral ischemia were intraperitoneally administered syringaldehyde. At 6 and 24 hours after syringaldehyde administration, cell damage in the brain of cerebral ischemia rats was obviously reduced, superoxide dismutase activity and nuclear respiratory factor 1 expression in the brain tissue were markedly increased, malondi-adehyde level was obviously decreased, apoptosis-related cysteine peptidase caspase-3 and -9 immunoreactivity was obviously decreased, and neurological function was markedly improved. These ifndings suggest that syringaldehyde exerts neuroprotective effects on cerebral ischemia injury through anti-oxidation and anti-apoptosis.

关键词： nerve regeneration syringaldehyde brain ischemia neuroprotective effects inflammatory oxidative stress apoptosis neural regeneration

Comparison of visual acuity, refractive results and complications of femtosecond laser with mechanical microkeratome in LASIK

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International Journal of Ophthalmology(English edition) 2013年第3期6卷 350-355页

作者： Cemile Banu cosar Tansu Gonen murat Moray Asim Bozkurt Sener Department of Ophthalmology Acibadem University Department of Ophthalmology Namlk Kemal University Eye Clinic Acibadem Bursa Hospital Eye Clinic Acibadem Maslak Hospital

AIM: To compare the outcomes of laser in situ keratomileusis (LASIK) performed with a femtosecond laser (Femtec, Technolas Perfect Vision GmbH, Germany) versus a mechanical microkeratome (Hansatome, Bausch and Lomb, USA) for the correction of myopia and astigmatism. ·METHODS: In this retrospective study, patients who had undergone LASIK using the 80 -kHz Femtec femtosecond laser were compared to age- and refraction- matched patients in whom the Hansatome microkeratome was used. Refractive and visual results 1 month and 3 months postoperatively, and complication rates were compared between the two groups. ·RESULTS: A total of 280 eyes were analyzed (140 in each group). At 3 months postoperatively in the Femtec vs Hansatome group, spherical equivalent refraction was within ±1.00D of emmetropia in 140 vs 138 eyes (P = 0.498), the cylinder was within ±0.50D in 137 vs 139 eyes (P =0.622), and the UDVA was 20/20 or better in 136 vs 137 eyes (P =0.724), respectively. There was no statistically significant difference in the complication rates between the two groups (P =0.099). ·CONCLUSION: LASIK performed both with Femtec femtosecond laser and Hansatome microkeratome achieved satisfactory refractive and visual results at 3 months postoperatively, without significant differences in efficacy, safety, and complication rates between the two procedures.

关键词： laser in situ keratomileusis femtosecond laser Femtec microkeratome Hansatome

The impact of macular surgery in different grades of epiretinal membrane

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International Journal of Ophthalmology(English edition) 2017年第12期10卷 1877-1882页

作者： cosar Batman Mehmet Citirik Yuksek Ihtisas University Koru HospitalAnkara 06520Turkey University of Health Science Ankara Ulucanlar Eye Education and Research HospitalAnkara 06230Turkey

AIM：To assess the impact of macular surgery on the functional and anatomic outcomes of the patients in different grades of epiretinal membrane（ERM）.METHODS：Seventy-one eyes of 71 patients who underwent 23-gauge transconjunctival sutureless pars plana vitrectomy for primary isolated ERM were evaluated in this ***：There were 38 females（53.5%） and 33 males（46.5%）.The average age of the patients was 68.1 y（range 42-89 y）.Mean follow up period was 14 mo（range 6-26 mo）.The cases were divided into two subgroups of cellophane maculopathy（CM） and macular pucker（MP）.An improvement was observed in the postoperative best-corrected visual acuity（BCVA）,as well as a decrement in central foveal thickness（CFT） in both groups（both of these being statistically significant;P=0.001）.In comparison between two groups,it was found that there was a significant improvement on BCVA and CFT in CM group than MP group（P=0.01）.Furthermore,the postoperative fundus findings regarding RPE alterations and macular edema were significantly higher in MP group when compared to the CM group（P=0.01）.CONCLUSION：ERM and internal limiting membrane peeling surgery can lead to a significant reduction of CFT and visual improvements in idiopathic ERM.A long-term ERM persistence will cause unrecoverable retinal damage and visual loss.

关键词： cellophane maculopathy epiretinal membrane intemal limiting membrane peeling macular pucker membranepeeling vitrectomy

Low eradication rate of Helicobacterpyloriwith triple 7-14 days and quadriple therapy in Turkey

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World Journal of Gastroenterology 2004年第5期10卷 668-671页

作者： Yuksel Gumurdulu Ender Serin Birol zer Fazilet Kayaselcuk Kursat Ozsahin Arif Mansur cosar murat Gursoy Gurden Gur Ugur Yilmaz Sedat Boyacioglu Faculty of Medicine Baskent UniversityDepartment of GastroenterologyAdana Teaching and Medical Research CenterAdanaTurkey Department of Pathology Adana Teaching and Medical Research CenterAdanaTurkey Department of Family Physician Adana Teaching and Medical Research CenterAdanaTurkey Faculty of Medicine Baskent UniversityDepartment of GastroenterologyAnkara HospitalAnkaraTurkey

AIM:The eradication rate of Helicobacter pylori (H pylori) shows variation among countries and regimens of treatment. We aimed to study the eradication rates of different regimens in our region and some factors affecting the rate of eradication. METHODS:One hundred and sixty-four H pylori positive patients (68 males,96 females;mean age:48±12 years) with duodenal or gastric ulcer without a smoking history were included in the *** patients were divided into three groups according to the treatment *** 20mg,clarithromycin 500mg,amoxicillin 1g were given twice daily for 1 week (Group Ⅰ) and 2 weeks (Group Ⅱ). Patients in Group Ⅲ received bismuth subsitrate 300mg, tetracyline 500mg and metronidazole 500mg four times daily in addition to Omeprazole 20mg twice *** biopsies each before and after treatment were obtained from antrum and corpus,and histopathologically evaluated. Eradication was assumed to be successful if no H pylorus was detected from four biopsy specimens taken after *** effects of factors like age,sex,H pylori density on antrum and corpus before treatment,the total H pylori density,and the inflammation scores on the rate of H pylori eradication were evaluated. RESULTS:The overall eradication rate was 42%.The rates in groups Ⅱ and Ⅲ were statistically higher than that in group Ⅰ (P<0.05).The rates of eradication were 24.5%, 40.7% and 61.5% in groups Ⅰ,Ⅱ and Ⅲ,*** eradication rate was negatively related to either corpus H pylori density or total H pylori density (P<0.05).The median age was older in the group in which the eradication failed in comparison to that with successful eradication (55 yr vs 39 yr,P<0.001).No correlation between sex and H pylori eradication was found. CONCLUSION:Our rates of eradication were significantly lower when compared to those reported in *** believe that advanced age and high H pylori density are negative predictive factors for the rate of H pylori eradication.

关键词： Helicobacter pylori Adolescent Adult Aged Amoxicillin dosage Anti-Bacterial Agents Anti-Infective Agents Anti-Ulcer Agents Clarithromycin Comparative Study Drug Therapy, Combination Duodenal Ulcer Female Helicobacter Infections Humans Male Metronidazole Middle Aged Omeprazole Organometallic Compounds Stomach Ulcer Tetracycline Treatment Outcome Turkey

Hepatopulmonary Syndrome and Liver Transplantation:A Recent Review of the Literature

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Journal of Clinical and Translational Hepatology 2016年第1期4卷 47-53页

作者： Caglar cosarderelioglu Arif M.cosar Merve Gurakar Nabil N.Dagher Ahmet Gurakar Johns Hopkins University School of Medicine Department of Gastroenterology/Hepatology Baltimore MD USA Virginia Commonwealth University School of Medicine Richmond VA USA Johns Hopkins University School of Medicine Department of Surgery/Liver Transplant Baltimore MD USA

A severe and common pulmonary vascular complication of liver disease is hepatopulmonary syndrome (HPS).It is a triad of liver dysfunction and/or portal hypertension,intrapulmonary vascular dilatations,and increased alveolar-arterial oxygen *** varies according to various study groups from 4%-47%.While the most common presenting symptom of HPS is dyspnea,it is usually asymptomatic,and thus all liver transplant candidates should be screened for its *** oximetry is a useful screening method,but arterial blood gas examination is the gold *** there is an abnormal P (A-a)O2 gradient,microbubble transthoracic echocardiography should be done for *** is unpredictable,and there is currently no effective medical *** only effective therapy is considered to be liver *** resolution of HPS after liver transplantation is seen within a year in most HPS patients.

关键词： Hepatopulmonary syndrome Pulmonary complications of cirrhosis Liver transplantation

遍多酸对鏈霉素及双氫鏈霉素毒性反应的保护作用

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郑州大学学报(医学版) 1958年第1期 108-108页

作者： R.Ducrot O.Leau C.cosar 翁世艾

鏈霉素及双氫鏈霉素長期应用所產生的前庭及听覺障碍,限制了它們的臨床应用。不少作者企圖設法來減少它們对机体的毒性作用。动物实驗進行的研究,指出了遍多酸能減少鏈霉素及双氫鍵霉素对白鼠的毒性作用。最近Keller等更進一步指出遍多... 详细信息

鏈霉素及双氫鏈霉素長期应用所產生的前庭及听覺障碍,限制了它們的臨床应用。不少作者企圖設法來減少它們对机体的毒性作用。动物实驗進行的研究,指出了遍多酸能減少鏈霉素及双氫鍵霉素对白鼠的毒性作用。最近Keller等更進一步指出遍多酸能預防白鼠長期应

关键词：遍多酸泛酸毒性作用白鼠