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Correction of low corneal astigmatism in cataract surgery

International Journal of Ophthalmology(English edition) 2015年第4期8卷 719-724页

作者： Pia Leon Marco Rocco Pastore Andrea Zanei Ingrid Umari Meriem Messai corrado Negro Daniele Tognetto University Eye Clinic of Trieste Ospedale Maggiore University of Trieste

· AIM: To evaluate and compare aspheric toric intraocular lens(IOL) implantation and aspheric monofocal IOL implantation with limbal relaxing incisions(LRI) to manage low corneal astigmatism(1.0-2.0 D) in cataract surgery.· METHODS: A prospective randomized comparative clinical study was performed. There were randomly recruited 102 eyes(102 patients) with cataracts associated with corneal astigmatism and divided into two groups. The first group received toric IOL implantation and the second one monofocal IOL implantation with peripheral corneal relaxing incisions. Outcomes considered were: visual acuity, postoperative residual astigmatism, endothelial cell count, the need for spectacles, and patient satisfaction. To determine the postoperative toric axis, all patients who underwent the toric IOL implantation were further evaluated using an OPD Scan III(Nidek Co, Japan). Follow-up lasted 6mo.· RESULTS: The mean uncorrected distance visual acuity(UCVA) and the best corrected visual acuity(BCVA) demonstrated statistically significant improvement after surgery in both groups. At the end of the follow-up the UCVA was statistically better in the patients with toric IOL implants compared to those patients who underwent implantation of monofocal IOL plus LRI. The mean residual refractive astigmatism was of 0.4 D for the toric IOL group and 1.1 D for the LRI group(P <0.01). No difference was observed in the postoperative endothelial cell count between the two groups.· CONCLUSION: The two surgical procedures demonstrated a significant decrease in refractive astigmatism. Toric IOL implantation was more effective and predictable compared to the limbal relaxing incision.

关键词： low corneal astigmatism toric intraocular lenses limbal relaxing incisions cataract surgery visual acuity

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Fundamentals of investments Valuation and management

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丛书名： The Irwin/McGraw-Hill series in finance, insurance, and real estate

2000年

作者： Charles J.corrado Bradford D.Jordan

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Intestinal epithelial barrier and neuromuscular compartment in health and disease

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World Journal of Gastroenterology 2020年第14期26卷 1564-1579页

作者： Vanessa D’Antongiovanni Carolina Pellegrini Matteo Fornai Rocchina Colucci corrado Blandizzi Luca Antonioli Nunzia Bernardini Department of Clinical and Experimental Medicine University of PisaPisa 56126Italy Department of Pharmacy University of PisaPisa 56126Italy Department of Pharmaceutical and Pharmacological Sciences University of PadovaPadova 35131Italy

A number of digestive and extra-digestive disorders,including inflammatory bowel diseases,irritable bowel syndrome,intestinal infections,metabolic syndrome and neuropsychiatric disorders,share a set of clinical features at gastrointestinal level,such as infrequent bowel movements,abdominal distension,constipation and secretory *** lines of evidence indicate that morphological and molecular changes in intestinal epithelial barrier and enteric neuromuscular compartment contribute to alterations of both bowel motor and secretory functions in digestive and extra-digestive *** present review has been conceived to provide a comprehensive and critical overview of the available knowledge on the morphological and molecular changes occurring in intestinal epithelial barrier and enteric neuromuscular compartment in both digestive and extra-digestive *** addition,our intent was to highlight whether these morphological and molecular alterations could represent a common path(or share some common features)driving the pathophysiology of bowel motor dysfunctions and related symptoms associated with digestive and extra-digestive *** assessment might help to identify novel targets of potential usefulness to develop original pharmacological approaches for the therapeutic management of such disturbances.

关键词： Digestive disease Enteric nervous system Intestinal epithelial barrier Intestinal motility Metabolic disorders Neuropsychiatric disorders

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Stereovision system for estimating tractors and agricultural machines transit area under orchards canopy

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International Journal of Agricultural and Biological Engineering 2019年第1期12卷 1-5页

作者： corrado Costa Paolo Febbi Federico Pallottino Massimo Cecchini Simone Figorilli Francesca Antonucci Paolo Menesatti Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria(CREA) Centro di ricerca Ingegneria e Trasformazioni AgroalimentariVia della Pascolare 1600015 Monterotondo scaloRomeItaly Department of Agriculture and Forestry Science Tuscia UniversityVia S.Camillo de Lellis snc01100 ViterboItaly

Managing orchards requires delicate agricultural operations being typically carried out in narrow zones where the operators usually drive machineries under stress that could result in poor *** such conditions,the use of technology would help manage the machines to reduce the hazardous work and eventual damage to the *** safely drive a tractor,the driver needs to be aware of its surroundings,thus a stereovision system can provide helpful *** imaging has proven to be an effective three-dimensional vision ***,the range(or third coordinate)information is useful to detect the obstacle *** distances,when detected during agricultural operations,could be used to assist the operator in driving the tractor at regular or variable working speeds and eventually to provide manufacturers useful indications to model the form of ROPS(roll over protection structure).This study aimed to verify the closeness of agreement between manual and stereo-image measurements,and thus to provide helpful information regarding safety and working *** system used a custom low-cost dual web-camera in combination with an image analysis algorithm in order to automatically extract the information *** independent measurements were carried out using a metric tape(sensitivity 1 cm).A regular structure was used for the analysis:four rows of ten trees each *** red and blue paper markers were placed on the hazelnut trees(two per tree)of two couples of rows for enhanced *** each couple of trees(one on the right,the other on the left),the four markers formed a trapezoid that was *** results of the analysis demonstrated that the stereo vision provided distance measurements with reasonable accuracy(error<5%)in the range of distances lower than 20 *** resolution assessed for the developed video system is suitable for obtaining distance information in real *** information could be used to assist drivers t

关键词： stereovision precision agriculture digital agriculture hazelnut canopy ROPS orchards

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Impact of age-related comorbidity on results of colorectal cancer surgery

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World Journal of Gastroenterology 2009年第45期15卷 5706-5711页

作者： corrado Pedrazzani Guido Cerullo Giovanni De Marco Daniele Marrelli Alessandro Neri Alfonso De Stefano Enrico Pinto Franco Roviello Department of Human Pathology and Oncology Unit of Surgical OncologyUniversity of Siena 53100 SienaItaly

AIM: To analyze the correlation between preexisting comorbidity and other clinicopathological features, short-term surgical outcome and long-term survival in elderly patients with colorectal cancer (CRC). METHODS: According to age, 403 patients operated on for CRC in our department were divided into group A (< 70 years old) and group B (≥ 70 years old) and analyzed statistically. RESULTS: Rectal localization prevailed in group A (31.6% vs 19.7%, P = 0.027), whereas the percentage of R0 resections was 77% in the two groups. Comorbidity rate was 46.2% and 69.1% for group A and B, respectively (P < 0.001), with a huge difference as regards cardiovascular diseases. Overall, postoperative morbidity was 16.9% and 20.8% in group A and B, respectively (P = 0.367), whereas mortality was limited to group B (4.5%, P = 0.001). In both groups, patients who suffered from postoperative complications had a higher overall comorbidity rate, with preexisting cardiovascular diseases prevailing in group B (P = 0.003). Overall 5-year survival rate was significantly betterfor group A (75.2% vs 55%, P = 0.006), whereas no signif icant difference was observed considering disease-specif ic survival (76.3% vs 76.9%, P = 0.674). CONCLUSION: In spite of an increase in postoperative mortality and a lower overall long-term survival for patients aged ≥ 70 years old, it should be considered that, even in the elderly group, a signif icant number of patients is alive 5 years after CRC resection.

关键词： Colorectal cancer Elderly Post-operative complications Co-morbidity Aged

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Efficient hexane isomers separation in isoreticular bipyrazolate metal-organic frameworks:The role of pore functionalization

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Nano Research 2021年第2期14卷 532-540页

作者： Rebecca Vismara corrado Di Nicola Rodrigo Gil-San Millan Kostiantyn V.Domasevich Claudio Pettinari Jorge A.R.Navarro Simona Galli Dipartimento di Scienza e Alta Tecnologiay University delVInsubria 22100 ComoItaly School of Science and Technology University ofCamerino62032 Camerino(MC)Italy Departamento de Quimica Inorganica Universidad de Granada18071 GranadaSpain Taras Shevchenko National University of Kyiv 01601 KyivUkraine School of Pharmacy University of Camerino62032 Camerino(MC)Italy Istituto di Chimica dei Composti Organometallici(ICCOM-CNR) 50019 Sesto FiorentinoItaly Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali 50121 FirenzeItaly Department of Chemistry University of LiverpoolLiverpool L73NYUK

Hydrocarbons separation in petrochemical industries is a key,energy-consuming stage in the manufacture of high-quality added-value products—hence the need for more efficient materials and environmentally friendly methodologies to improve this *** this context,we have studied the effect of metal-organic frameworks(MOFs)pore functionalization in hexane isomers separation,isolating the robust isoreticular zinc(ll)bipyrazolates Zn(BPZ),showing no pore decoration,Zn(Me_(2)BPZ),the pores of which are decorated with apolar methyl groups,and Zn(BPZ(NH_(2))_(2)),the spacers of which possess polar Lewis-basic functions(H_(2)BPZ=1H,1'H-4,4'-bipyrazole;H_(2)Me_(2)BPZ=3,3'-dimethyl-1H,1'H-4,4'-bipyrazole;H_(2)BPZ(NH_(2))_(2)=3,5-diamino-1H,1'H-4,4'-bipyrazole;DMF=dimethylformamide).After characterizing Zn(BPZ(NH_(2))_(2))as per its crystal structure and thermal behaviour,and all the three MOFs as per their textural properties,we investigated,from the experimental and computational points of view,the impact of the square one-dimensional channels decoration on the separation of the hexane isomers,demonstrating the relevance of pore constrictions in the resolution of the title alkanes mixture.

关键词： adsorption molecular sieving nitrogen-donor ligands gas separation pow der diffraction variable-tem perature pulse gas chromatography

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Endoscopic ablation of Barrett's esophagus using high power setting argon plasma coagulation: A prospective study

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World Journal of Gastroenterology 2005年第12期11卷 1872-1875页

作者： corrado Pedrazzani Filippo Catalano Mara Festini Germana Zerman Anna Tomezzoli Andrea Ruzzenente Alfredo Guglielmi Giovanni de Manzoni First Department of General Surgery

AIM: This prospective study evaluated the effectiveness of 90 W argon plasma coagulation (APC) for the ablation of Barrett's esophagus (BE) that is considered to be the main risk factor for the development of esophageal ***: The results from 25 patients, observed at the First Department of General Surgery, University of Verona, Italy, from October 2000 to October 2003, who underwent APC for histologically proven BE were prospectively ***: The ablation treatment was completed in all the patients but one (96%). The mean number of APC sessions needed to complete ablation was 1.6 (total number: 40). The eradication was obtained in the majority of cases by one session only (60%), two sessions were required in 24% of the cases and three or more in 16%.About 43% of the sessions were complicated. Retrosternal pain (22.5%) and fever (17.5%) were the most frequent symptoms. Only one major complication occurred, it was an hemorrhage due to ulcer formation on the treated esophagus that required urgent endoscopic sclerosis and admission. The follow-up was accomplished in all the patients with a mean period of 26.3 mo and 20 patients (84%) with a follow-up period longer than 24 mo. Only one patient showed a relapse of metaplastic mucosa 12 mo after the completion of ablation. The patient was hence re-treated and now is free from recurrence 33 mo ***: High power setting (90 W) APC showed to be safe and effective. The effects persist at a mean follow-up period of two years with a comparable cost in term of complications with respect to standard power settings. Further studies with greater number of patients are required to confirm these results and to assess if ablation reduces the incidence of malignant progression.

关键词： Barrett's esophagus Argon plasma coagulation Endoscopic treatment

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Lansoprazole prevents experimental gastric injury induced by non-steroidal anti-inflammatory drugs through a reduction of mucosal oxidative damage

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World Journal of Gastroenterology 2005年第26期11卷 4052-4060页

作者： corrado Blandizzi Matteo Fornai Rocchina Colucci Gianfranco Natale Valter Lubrano Cristina Vassalle Luca Antonioli Gloria Lazzeri Mario Del Tacca Division of Pharmacology and Chemotherapy Department of Oncology Transplants and Advanced Technologies in Medicine University of PisaPisaItaly Department of Human Morphology and Applied Biology University of Pisa Pisa Italy Institute of Clinical Physiology National Research Council Pisa Italy Division of Pharmacology and Chemotherapy Department of Oncology Transplants and Advanced Technologies in Medicine University of Pisa Pisa Italy

AIM:This study investigated the mechanisms of protection afforded by the proton pump inhibitor lansoprazole against gastric injury induced by different non-steroidal anti-inflammatory drugs (NSAIDs) in rats. METHODS: Male Sprague-Dawley rats were orally treated with indomethacin (100 μmol/kg), diclofenac (60 μmol/kg), piroxicam (150 μmol/kg) or ketoprofen (150 μmol/kg). Thirty minutes before NSAIDs, animals were orally treated with lansoprazole 18 or 90 umol/kg. Four hours after the end of treatments, the following parameters were assessed: gastric mucosal PGE2, malondialdehyde (MDA), myeloperoxidase (MPO) or non-proteic sulfhydryl compounds (GSH) levels; reverse transcription-polymerase chain reaction (RT-PCR) of mucosal COX-2 mRNA; gastric acid secretion in pylorus-ligated animals; in vitro effects of lansoprazole (1-300 μmol/L) on the oxidation of low density lipoproteins (LDLs) induced by copper sulphate. RESULTS: All NSAIDs elicited mucosal necrotic lesions which were associated with neutrophil infiltration and reduction of PGE2 levels. Increments of MPO and MDA contents, as well as a decrease in GSH levels were detected in the gastric mucosa of indomethacin- or piroxicam-treated animals. Indomethacin enhanced mucosal cyclooxygenase-2 expression, while not affecting cyclooxygenase-1. At the oral dose of 18 μmol/kg lansoprazole partly counteracted diclofenac-induced mucosal damage, whereas at 90 μmol/kg it markedly prevented injuries evoked by all test NSAIDs. Lansoprazole at 90 μmol/kg reversed also the effects of NSAIDs on MPO, MDA and GSH mucosal contents, without interfering with the decrease in PGE2 levels or indomethacin-induced cyclooxygenase-2 expression. However, both lansoprazole doses markedly inhibited acid secretion in pylorus-ligated rats. Lansoprazole concentration-dependently reduced the oxidation of LDLs in vitro. CONCLUSION: These results suggest that, besides the inhibition of acid secretion, lansoprazole protection against NSAID-induced gastr

关键词： Lansoprazole Gastric injury Non-steroidal anti-inflammatory drugs

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Increasing of Resistance and Resilience of an Urban System against Calamities in the Light of the Maximum Ordinality Principle

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Journal of Applied Mathematics and Physics 2021年第8期9卷 1926-1945页

作者： corrado Giannantoni Laura Cennini Rome Italy Colli del Tronto Ascoli Piceno Italy

The present paper aims at showing how it is possible to requalify the structures of an urban system, in order to increase its resistance and its correlative resilience, against natural calamities (earthquakes, hurricanes, etc.), by adopting as reference criterion the Maximum Ordinality Principle (MOP). In this sense, the paper opens a radically new perspective in this field. In fact, the village assumed as a case study was modelled as a Self-Organizing System. This is because, although the village is usually considered as being solely made of buildings, streets, places and so on, in reality it has been conceived, planned and realized by human beings during several centuries. In addition, the people who actually leave in such an urban center, systematically deal with its maintenance, in order to possibly increase its functionality. This justifies the assumption of the village as being a Self-Organizing System and, consequently, it has been analyzed in the light of the MOP, which represents a valid reference principle for analyzing both “non-living”, “living” and “conscious” self-organizing systems.

关键词： Resistance and Resilience of Urban Systems Maximum Ordinality Principle Incipient Derivative

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Elevated fibrinogen plasma level is not an independent predictor of poor prognosis in a large cohort of Western patients undergoing surgery for colorectal cancer

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World Journal of Gastroenterology 2016年第45期22卷 9994-10001页

作者： corrado Pedrazzani Guido Mantovani Gian Luca Salvagno Elisabeth Baldiotti Andrea Ruzzenente Calogero Iacono Giuseppe Lippi Alfredo Guglielmi Division of General and Hepatobiliary Surgery Department of Surgical Sciences Dentistry Gynecology and Pediatrics University of Verona Section of Clinical Biochemistry Department of Neurological Biomedical and Movement Sciences University of Verona

AIM To evaluate the clinical significance of the preoperative fibrinogen plasma level as a prognostic marker after surgery for colorectal *** This retrospective study analysed 652 patients undergoing surgery for stage Ⅰ-Ⅳ colorectal cancer between January 2005 and December 2012, at the Division of General Surgery A, University of Verona Hospital Trust, in whom preoperative fibrinogen plasma values were assessed at baseline. Fibrinogen is involved in tumourigenesis as well as tumour progression in several malignancies. Correlations between preoperative plasma fibrinogen values and clinicopathological characteristics were investigated. Univariate and multivariate survival analyses were performed to identify factors associated with overall and tumour-related *** Among the 652 patients, the fibrinogen value was higher than the threshold of 400 mg/dL in 345 patients(53%). The preoperative mean ± SD of fibrinogen was 426.2 ± 23.2 mg/dL(median: 409 mg/dL; range: 143-1045 mg/d L). Preoperative fibrinogen values correlated with age(P = 0.003), completeness of tumour resection, potentially curative vs palliative(P < 0.001), presence of systemic metastasis(P < 0.001), depth of tumour invasion p T(P < 0.001), nodes involvement p N(P = 0.001) and CEA serum level(P < 0.001). The mean fibrinogen value(± SD) was 395.6 ± 120.4 mg/d L in G1 tumours, 424.1 ± 121.4 mg/dL in G2 tumours and 453.4 ± 131.6 mg/dL in G3 tumours(P = 0.045). The overall survival and tumourrelated survival were significantly higher in patients with fibrinogen values ≤ 400 mg/d L(P < 0.001). However, hyperfibrinogenemia did not retain statistical significance regarding either overall(P = 0.313) or tumour-related survival(P = 0.355) after controlling for other risk factors in a multivariate *** Preoperative fibrinogen levels correlate with cancer severity but do not help in predicting patient prognosis after colorectal cancer surgery.

关键词： Colorectal cancer Fibrinogen Tumour markers Prognosis Colorectal surgery

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