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Randomized Trial Comparing Cyclophosphamide, Methotrexate, and 5-Fluorouracil (CMF) Regimen with Rotational CMFEV Regimen (E=Epirubicin, V=Vincristine) as Adjuvant Chemotherapy in Moderate Risk Operable Breast Carcinoma

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Journal of Cancer Therapy 2011年第3期2卷 342-353页

作者： Giorgio Cocconi corrado boni Maurizio Tonato Rodolfo Passalacqua Mariantonietta Colozza Anna M. Mosconi Giancarlo Bisagni Ermanno Rondini Lina Rodinò Amalia Carpi Francesco Di Costanzo Mauro Brugia Giuseppe Attardo Luigi Acito Riccardo Rossetti Maria Bella Roberta Camisa Francesco Cardinale Beatrice Dozin 不详

Objectives: The CMFEV (cyclophosphamide, methotrexate, 5-fluorouracil, epirubicin, vincristine) regimen is an innovative schedule, designed by our Group, aimed at administering five partially or totally no cross-resistant cytotoxic agents in breast carcinoma. It was randomly compared to CMF (cyclophosphamide, methotrexate, 5-fluorouracil) as primary treatment in operable disease and demonstrated a short-term significant increase in clinical complete response rate and a long-term significant locoregional relapse-free survival in premenopausal patients. So, it seemed worth comparing this regimen with CMF as adjuvant chemotherapy in moderate risk operable breast carcinoma. Methods: Four hundred and eighty-nine patients with stage I or II moderate risk breast carcinoma were randomized to receive CMF or CMFEV regimen for 6 cycles after surgery. Main end points were overall survival (OS), invasive disease-free survival (IDFS) and recurrence-free interval (RFI), as estimated by Kaplan-Meier analyses and log-rank tests. Results: At a median observation time of 7.3 years (range 5.4 months-10.3 years), no significant differences in OS and IDFS were observed between the two arms. Deaths from breast carcinoma were more frequent with CMF (58.5%) than with CMFEV regimen (41.7%) as well as recurrences from breast carcinoma (58.8% with CMF and 41.2% with CMFEV). These differences were not statistically significant. Conclusion: CMFEV appears more effective than CMF in preventing recurrences from primary disease in patients with moderate risk stage I-II breast carcinoma. The lack of statistical significance of the observed differences was probably due to the limited number of patients enrolled which rendered the study underpowdered.

关键词： Breast Carcinoma Adjuvant Chemotherapy CMF Regimen Epirubicin Vincristine Second Malignancy

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In advanced gastric cancer:Prognosis and treatment of patients with positive peritoneal cytology

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World Journal of Gastrointestinal Surgery 2013年第5期5卷 135-137页

作者： Francesco Frattini Stefano Rausei corrado Chiappa Francesca Rovera Luigi boni Gianlorenzo Dionigi Department of Surgical Sciences University of Insubria School of Medicine

Positive peritoneal cytology in gastric cancer is classified as M1 disease by the 7thEdition of American Joint Committee on Cancer staging system.With the introduction of laparoscopy and peritoneal washing cytology in the staging of gastric cancer a new category of patients has been identified.These are patients with no macroscopic peritoneal metastases but with peritoneal cytology positive(P0C1).Prognosis and treatment of such patientsrepresent a controversial issue.We evaluate the state of the art of staging system in gastric cancer and discusss tandardisation in staging and treatment procedures.There is still a lack of uniformity in the use of laparoscopy with peritoneal cytology in clinical decision making and in the surgical treatment for gastric cancer.Survival of this patient subset remains poor.Multimodal therapies and new therapeutic strategies are required to improve the survival of these patients.

关键词： Advanced gastric cancer Peritoneal washing cytology Staging laparoscopy Reverse transcription-polymerase chain reaction

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