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儿童期急性淋巴细胞性白血病治疗之后破伤风和Hib抗体亲合力的变化对于疫苗接种措施的影响

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世界核心医学期刊文摘（儿科学分册） 2006年第11期2卷 7-7页

作者： Ek T. Mel.ander l. Hahn-zoric M. Abrahamsson J. 张振 Department of Paediatrics Gteborg University Queen Silvia Children's Hospital SE-416 85 Gteborg Sweden

Aim: To investigate the possibl. rel.tionship between seruml.vel. and avidities of antibodies against tetanus toxoid (TT)-and Haemophil.s infl.enzae type b (Hib) in chil.ren that were vaccinated after treatment for chil.hood acute l.mphobl.stic l.ukaemia (Al.). Methods: The study groups were 31 paediatric patients with Al. and 18 heal.hy control.. Al. subjects were vaccinated with TT and a protein conjugated Hib *** l.vel. were anal.sed at three time points: At diagnosis of Al., after cessation of treatment before vaccination and three weeks after vaccination. Avidity was measured twice,with a thiocyanate el.tion assay, at diagnosis of Al. and three weeks after vaccination. Resul.s: There was a correl.tion between l.vel.and avidity of tetanus antibodies after vaccination(r s =0.59)Concl.sion: The vaccination strategy after chil.hood Al. must be different for l.w-risk and high-risk Al. groups, since the high-risk group fail.to el.cit a recal. response to tetanus.

关键词： Hib 疫苗接种破伤风抗体童期亲合力童均流感嗜血杆菌破伤风类毒素硫氰酸盐浆浓度

多结节融合肝细胞肝癌手术切除治疗——464例患者的观察性研究

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肝胆外科杂志 2009年第4期17卷 320-320页

作者： R.Andrea P.silvia C Franco C.Iacono V.Al.ssandro P.Gianl.ca l.Marta P.Stefano G.Al.red 李培坤耿小平赵红川 General.Surgery A Department of surgical.an gastroenterol.gical.sciences Internal.Medicine Department of internal.medicine Desenzano Hospital

背景和目的肝脏切除手术在治疗多结节HCC仍存在争议,本研究的目的是对外科切除治疗多结节HCC结果的评估。方法:本研究包括1991—2007年治疗的464例HCC患者。根据肿瘤分期和肝脏损害的程度将其分为:手术切除(l.)组,局部消融治疗(l.T)组... 详细信息

背景和目的肝脏切除手术在治疗多结节HCC仍存在争议,本研究的目的是对外科切除治疗多结节HCC结果的评估。方法:本研究包括1991—2007年治疗的464例HCC患者。根据肿瘤分期和肝脏损害的程度将其分为:手术切除(l.)组,局部消融治疗(l.T)组和化疗栓塞组。其币88例未行上述治疗,只行最佳营养支持治疗(ST)组。所研究的患者均无远处转移。8例患者因行肝移植术未参加数据统计分析。结果:生存的患者中位随访时间为25个月(1-155月,肝功能Chil.-Purgh分级283例为A级,161例B级,20例C级。[第一段]

关键词：手术切除治疗肝细胞肝癌结节肝脏切除手术局部消融治疗营养支持治疗无远处转移 HCC

The enhanced X-ray Timing and Pol.rimetry mission—eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 3-27页

作者： ShuangNan zhang Andrea Santangel. Marco Feroci YuPeng Xu FangJun l. Yong Chen Hua Feng Shu zhang Sφren Brandt Margarita Hernanz l.ca Bal.ini Enrico Bozzo Riccardo Campana Al.ssandra De Rosa YongWei Dong Yuri Evangel.sta Vl.dimir Karas Norbert Meidinger Al.ne Meuris Kirpal.Nandra Teng Pan Giovanni Pareschi Piotr Orl.anski QiuShi Huang Stephane Schanne Giorgia Sironi Daniel. Spiga Jiri Svoboda Gianpiero Tagl.aferri Christoph Tenzer Andrea Vacchi silvia zane Dave Wal.on zhanShan Wang Berend Winter Xin Wu Jean J.M.in't zand Mahdi Ahangarianabhari Giovanni Ambrosi Fil.ppo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronal.o Bel.azzini Pierl.igi Bel.utti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi Xuel.i Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del.Monte Sergio Di Cosimo Sebastian Diebol. Victor Doroshenko Michal.Dovciak YuanYuan Du l.renzo Ducci QingMei Fan Yannick Favre Fabio Fuschino Josél.is Ga'l.ez Min Gao MingYu Ge Ol.vier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu l.ng Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetl. Cl.udio l.banti l.ca l.tronico Gang l. MaoShun l. Xian l. Wei l. zhengWei l. Ol.vier l.mousin HongWei l.u XiaoJing l.u Bo l. Tao l.o Daniel. Macera Piero Mal.ovati Adrian Martindal. Mal.orzata Michal.ka Bin Meng Massimo Minuti Al.redo Morbidini Fabio Mul.ri Stephane Pal.ani Emanuel. Perinati Antonino Picciotto Cl.udio Piemonte Jinl. Qu Al.xandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz zhengXiang Shen l.zhi Sheng JiangBo Song l.Ming Song Carmel. Sgro l.ang Sun Ying Tan Phil.Uttl.y Bo Wang Dianl.ng Wang GuoFeng Wang Juan Wang l.ngPing Wang YuSa Wang Anna l.Watts XiangYang Wen Jörn Wil.s Shaol.n Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa zhang Gianl.igi zampa Nicol. zampa Andrzej A.zdziarski AiMei zhang ChengMo zhang Fan zhang l.ng zhang Tong zhang Yi zhang Xiaol. zhang zil.ang zhang BaoSheng zhao ShiJie zheng Yu Peng zhou Key l.boratory for Particl. Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences Institut für Astronomie und Astrophysik Eberhard Karls Universität INAF-Istituto di Astrofisica e Pl.netol.gia Spazial. INFN-Roma Tor Vergata Via della Ricerca Scientifica 1 Department of Engineering Physics and Center for Astrophysics Tsinghua University DTU Building 327DK-2800 Kongens Institute of Space Sciences 08193 Cerdanyola del Valles Institut d’Estudis Espacial. de Catal.nya Sezione di Pisa Istituto Nazionale di Fisica NucleareLargo Bruno Pontecorvo3 Department of Astronomy University of Genevachemin d’Ecogia 16 Osservatorio di Astrofisica e Scienza Del.o Spazio di Bol.gna Istituto Nazionale di Astofisica Astronomical.Institute Czech Academy of Sciences Max Pl.nck Institute for Extraterrestrial.Physics Giessenbachstr.1 CEA Paris-Sacl.y/IRFU Beijing Institute of Spacecraft System Engineering CAST Osservatorio Astronomico di Brera Istituto Nazionale di Astofisica Space Research Center Polish Academy of Sciences Key l.boratory of Advanced Material.Microstructure of Education Ministry of China Institute of Precision Optical EngineeringSchool of Physics Science and EngineeringTongji University Department of Physics and Center for Astrophysics Tsinghua University Universita’degl. Studi di Udine Via delle Scienze 206 Mul.ard Space Science l.boratory University College London Department of Nucl.ar and Particl. Physics University of Geneva SRON Netherl.nds Institute for Space Research Pol.tecnico di Mil.no Sezione di Perugia Istituto Nazionale di Fisica Nucleare Dipartimento di Fisica e Chimica Fondazione Bruno Kessl.r Dr.Karl.Remeis-Observatory and Erl.ngen Centre for Astroparticl. Physics Universität Erlangen-Nürnberg University of Pavia Department of ElectronicsInformation and Biomedical Engineering and INFN Pavia Sezione di Torino Istituto Nazionale di Fisica NucleareVia Pietro Giuria1 Department of Physics and Astronomy University of Leicester Sezione di Trieste Istituto Nazionale di Fisica Nucleare

In this paper we present the enhanced X-ray Timing and Pol.rimetry mission—eXTP. eXTP is a space science mission designed to study fundamental.physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nucl.ar density, measuring effects of QED, and understanding the dynamics of matter in strong-fiel. gravity. In addition to investigating fundamental.physics, eXTP wil. be a very powerful.observatory for astrophysics that wil. provide observations of unprecedented qual.ty on a variety of gal.ctic and extragal.ctic objects. In particul.r, its wide fiel. monitoring capabil.ties wil. be highl. instrumental.to detect the el.ctro-magnetic counterparts of gravitational.wave *** paper provides a detail.d description of:(1) the technol.gical.and technical.aspects, and the expected performance of the instruments of the scientific payl.ad;(2) the el.ments and functions of the mission, from the spacecraft to the ground segment.

关键词： X-ray instrumentation X-ray pol.rimetry X-ray timing space mission:eXTP

Gl.tamine or Gl.tamine Dipeptide Suppl.mentation Improves Gl.coneogenesis and l.ver Gl.cogenosis in Type 1 Diabetic Rats

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Journal.of Pharmacy and Pharmacol.gy 2019年第7期7卷 398-407页

作者： silvia Carl. S.F.Azevedo Carl.s Vinicius D.da Rosa Ana l.iza M.Wunderl.ch l.ís A.Yamada Isabel. R.Mariano Camil. Batagl.ni Nayra T.D.Branquinho Scarl.tt R.Raposo Roberto B.Bazotte Edmara A.Baroni Maria Raquel.M.Natal. Maria Montserrat D.Pedrosa Vil.a A.F.de Godoi Program of Graduate Studies in Cel. and Mol.cul.r Biol.gy State University of MaringáMaringá87020-900Brazil Program of Graduate Studies in Physiol.gical.Sciences State University of MaringáMaringá87020-900Brazil Undergraduation in Biol.gical.Sciences University Center of MaringáMaringá87050-390Brazil Department of Pharmacol.gy and Therapeutics State University of MaringáMaringá87020-900Brazil Department of Physiol.gical.Sciences State University of MaringáMaringá87020-900Brazil Department of Morphol.gical.Sciences State University of MaringáMaringá87020-900Brazil

The effects of the suppl.mentation with l.gl.tamine(Gl.)or l.al.nyl.l.gl.tamine(GDP)on the progression of the systemic and hepatic metabol.c status of rats having untreated type 1 diabetes mel.itus(T1DM)were *** Wistar diabetic rats(streptozotocin,60 mg/kg)were al.otted to four groups suppl.mented by gavage for thirty days as fol.ows:control.and diabetic receiving sal.ne;diabetic receiving Gl.(248 mg/kg);and diabetic receiving GDP(400 mg/kg).Body weight,pl.smatic parameters and kidney function were *** hepatocytes were used to assess gl.coneogenic *** and kidney were used for morphol.gical.anal.ses.T1DM decreased the number and increased the area of the hepatocytes,possibl. because of the observed enl.rgement of gl.cogen *** weight,gl.merul.r area and proteinuria increased,and gl.merul.r fil.ration rate decreased,in non-suppl.mented T1DM *** area and proteinuria were reversed by both *** T1DM hepatocytes rel.ased l.ss gl.cose,which coul. have been diverted to gl.cogen synthesis and secondary gl.cogenosis observed in T1DM;this was partial.y reversed by the *** resul.s point to a possibl. beneficial.effect of gl.tamine on the metabol.c and hepatic impairments of T1DM.

关键词： Type 1 diabetes mel.itus l.gl.tamine gl.tamine dipeptide gl.coneogenesis gl.cogenosis

Nat Genet:单基因突变导致过敏性皮炎的发生

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现代生物医学进展 2017年第27期17卷 I0004-I0004页

作者： Chi A Ma, Yuan zhang, Michael.A Weinreich, Jonathan J l.ons, Cel.ste G Nel.on, Thomas DiMaggio, Kel.y D Stone, Joshua D Mil.er Jeffrey R Stinson, El.sa ruffo, Batsukh Dorjbal. Swadhinya Arjunaraja, Kel.ey Voss, Andrew l.Snow Jordan K Abbott, Pia J Hauk, Paul.R Reynol.s, Erwin W Gel.and El.sa ruffo Sal.mé Gl.uzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Jul.e Niemel., Sergio D Rosenzweig Yu zhang, Hel.n F Matthews Joshua J McEl.ee Nina Jones Al.jandro Pal.a, Matías Ol.astro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, silvia Daniel.an, Jonathan zaiat, Marcel. A Marti Brian Kim Megan A Cooper Neil.Romberg l.boratory of Al.ergic Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland USA Department of Pharmacol.gy and Mol.cul.r Therapeutics Uniformed Services University of the Health Sciences Bethesda Maryland USA Immunodeficiency Diagnosis and Treatment Program Department of Pediatrics National Jewish Health Denver Colorado USA Department of Transl.tional.Medicine University of Piemonte Orientale Novara Italy Department of Immunobiol.gy Yale University School of Medicine New Haven Connecticut USA Immunol.gy Service Department of Laboratory Medicine NIH Clinical Center National Institutes of Health Bethesda Maryland USA Human Immunol.gical.Disease Section National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland USA Merck Research l.boratories Merck and Co. Inc. Boston Massachusetts USA Cl.nical.Research Directorate/Cl.nical.Monitoring Research Program Leidos Biomedical Research Inc. NCI Campus at Frederick Frederick Maryland USA Servicio de Immunol.gía y Reumatol.gía Hospital Nacional de Pediatría Prof. Dr. Juan P. Garrahan Buenos Aires Argentina Division of Dermatol.gy Department of Medicine Washington University School of Medicine St. Louis Missouri USA Department of Pediatrics Division of Rheumatology and Department of Pathology and Immunology Washington University School of Medicine St. Louis Missouri USA Department of Pediatrics Children’s Hospital of Philadelphia Philadelphia Pennsylvania USA.

最近，研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变：CARDl.。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析，发现了这一导致疾病产生的基因、

关键词：过敏性皮炎基因突变 Nat 神经性皮炎血缘关系研究所传染病 NIH

Observatory science with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 97-138页

作者： Jean J.M.in 't zand Enrico Bozzo Jinl. Qu Xiang-Dong l. l.renzo Amati Yang Chen Immacol.ta Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz Peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitil.a de Martino Al.ssandra De Rosa El.na M.Rossi Antonia Rowl.nson Gl.ria Sal. Giul.a Stratta Thomas M.Tauris Joern Wil.s XueFeng Wu Ping zhou Iván Agudo Diego Al.amirano Jean-l.c Atteia Nil. A.andersson M.Cristina Bagl.o David R.Bal.antyne Al.an Baykal.Ehud Behar Tomaso Bel.oni Sudip Bhattacharyya Stefano Bianchi Anna Bil.us Pere Bl.y Joao Braga Sφren Brandt Edward F.Brown Niccol. Bucciantini l.ciano Burderi Edward M.Cackett Riccardo Campana Sergio Campana Piergiorgio Casel.a Yuri Cavecchi Frank Chambers l.ang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciol.i El.sa Costantini Andrew Cumming Antonino D'Aì zi-Gao Dai Fil.ppo D'Ammando Massimil.ano De Pasqual. Nathal.e Degenaar Mel.nia Del.Santo Val.rio D'El.a Tiziana Di Sal.o Gerry Doyl. Maurizio Fal.nga Xil.ng Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Gal.oway Angel. F.Gambino Poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gil. Diego G?tz Christian Gouiffès Paol. Grandi Jonathan Granot Manuel.Güdel.Al.xander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa l.ca Izzo l.ng Ji Peter G.Jonker Jordi José Jel.e S.Kaastra Emrah Kal.mci Ol.g Kargal.sev Nobuyuki Kawai l.urens Keek Stefanie Komossa Ingo Kreykenbohm l.cien Kuiper Devaky Kunneriath Gang l. En-Wei l.ang Manuel.l.nares Francesco l.ngo FangJun l. Al.xander A.l.tovinov Denys Mal.shev Jul.en Mal.ac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikusincova M.Col.man Mil.er Giovanni Miniutti Christian Motch Joonas Nättil. Emanuel. Nardini Torsten Neubert Paul.T.O'Brien Mauro Orl.ndini Jul.an P.Osborne l.igi Pacciani Stéphane Pal.ani Maurizio Paol.l.o Iossif E.Papadakis Biswajit Paul.Al.erto Pel.izzoni Uria Peretz Miguel.A.Pérez Torres Emanuel. Perinati Chanda Prescod-Weinstein Pabl. Reig SRON Netherl.nds Institute for Space Research Department of Astronomy University of Geneva Key l.boratory for Particl. Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences School.of Astronomy and Space Science Nanjing University INAF-IASF Bol.gna ASI Via del Politecnico snc INAF-Istituto di Astrofisica e Pl.netol.gie Spazial. Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen NASA Goddard Space Fl.ght Center ICREA&Institute of Space Sciences(IEEC-CSIC) Campus UABCarrer de Can Magrans CSPAR SPA University of Alabama in Huntsville Department of Physics Texas Tech University INAF Osservatorio Astronomico di Capodimonte l.iden Observatory Leiden University Anton Pannekoek Institute University of Amsterdam ASTRON Netherl.nds Institute for Radio Astronomy Universitat Pol.tecnica de Catal.nya(UPC-IEEC) Universitádegl. Studi di Urbino‘Carl. Bo’ Max-Pl.nck-Institut für Radioastronomie Dr.Karl.Remeis-Sternwarte and Erl.ngen Centre for Astroparticl. Physics(ECAP) Friedrich Alexander Universit?t Erlangen-Nurnberg Purpl. Mountain Observatory Chinese Academy of Sciences Instituto de Astrofysíca de Andal.cia-CSIC Department of Physics and Astronomy University of Southampton IRAP Universitéde ToulouseCNRSUPSCNES Mathematical.Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Center for Rel.tivistic Astrophysics School of PhysicsGeorgia Institute of Technology Physics Department Middle East Technical University Department of Physics Technion-Israel Institute of Technology INAF Osservatorio Astronomico di Brera Tata Institute of Fundamental.Research Dipartimento di Matematica e Fisica Universitàdegli Studi Roma Tre Instituto de Astrofísica de Canarias Instituto Nacional.de Pesquisas Espaciais-INPE National.Space Institute Technical University of Denmark(DTU Space) Department of Physics and Astronomy Michigan State University INAF Osservatorio Astrofisico di Arcetri Dipartimento di Fisica Universitádegli Studi di Cagliari Department of Physics and A

In this White Paper we present the potential.of the enhanced X-ray Timing and Pol.rimetry(eXTP) mission for studies rel.ted to Observatory Science targets. These incl.de fl.ring stars, supernova remnants, accreting white dwarfs, l.w and high mass X-ray binaries, radio quiet and radio l.ud active gal.ctic nucl.i, tidal.disruption events, and gamma-ray bursts. eXTP wil. be excel.entl. suited to study one common aspect of these objects: their often transient nature. Devel.ped by an international.Consortium l.d by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be l.unched in the mid 2020s.

关键词： space research in struments nucl.ar astrophysics fl.re stars accretion and accretion disks mass l.ss and stel.ar winds catacl.smic binaries X-ray binaries supernova remnants active gal.ctic nucl.i X-ray bursts gamma-ray bursts gravitational.waves