检索结果-南通市图书馆

Antimicrobial Activities of Plant Extracts against Streptococcus pneumoniae Isolated from Pediatric Patients at Federal Teaching Hospital Abakaliki, Ebonyi State

引用

American Journal of Plant Sciences 2024年第10期15卷 847-857页

作者： Euslar Nnenna Onu Donatus Chukwuma Ilang cornelius ituma azi Theophilus Onwe Eze Chinedu Obasi Akpa Oluwatoyin Oluwatosin Kelechi-Mathew Okechukwu Emmanuel Ogbonna Samuel Eleojo Agada Department of Microbiology Faculty of Biological Sciences Alex-Ekwueme Federal University Ndufu-Alike Ikwo Ebonyi State Nigeria Northern Care Alliance NHS Foundation Trust Manchester United Kingdom Park Hospital Burntstump Country Park Nottingham United Kingdom Department of Haematology Faculty of Basic Clinical Sciences Alex-Ekwueme Federal University Ndufu-Alike Ikwo Abakaliki Nigeria Department of Stems and Regenerative Medicine University of Chester Chester United Kingdom Department of Biotechnology University of Chester Chester United Kingdom

Antibiotic-resistant genes have become a threat to synthetic or conventional medications and because of this much work has been done on using plants and plants part to treat disease caused by bacteria, Herbal medicine has served as effective treatment against various diseases caused by pathogenic bacteria and multi drug-resistant strains of bacteria which made it advantageous over synthetic medications. This study aimed to reveal the sensitivity of Streptococcus pneumoniae from clinical isolate and perform antibacterial assay on the organism using plants leaf extracts of Ocimum gratissimum, Sida acuta, Newbouldia laevia and Mimosa pudica. Gram staining and various biochemical test were used for the identification of Streptococcus pneumoniae. The plants leaves were aseptically washed, dried and ground into fine powder and diluted in varying concentration and agar well diffusion method was used to test for the antimicrobial properties of this plants on Streptococcus pneumoniae at various concentrations as follows 0.1 g/ml, 0.4 g/ml, 0.6 g/ml and 1 g/ml. The plants extract of Ocimum gratissimum showed a greater antibacterial effects on Streptococcus pneumoniae in high concentration more than other plant extracts while Sida acuta and Newbouldia laevia plant extract showed weak antibacterial properties to the organism. This proves that Ocimum gratissimum and Mimosa pudica leaves have good and strong antibacterial properties against Streptococcus pneumoniae than Sida acuta and Newbouldia laevia and can be used as antibacterial agent at adequate concentrations.

关键词： Conventional Herbal Antibacterial Extracts Concentrations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antibiogram of Bacteria Isolated from Tuberculosis Patients Attending Hospital within Izzi-Abakaliki in Ebonyi State

引用

Journal of Biosciences and Medicines 2024年第10期12卷 285-296页

作者： Euslar Nnenna Onu Donatus Chukwuma Ilang cornelius ituma azi Theophilus Onwe Eze Chinedu Obasi Akpa Okechukwu Emmanuel Ogbonna Samuel Eleojo Agada Oluwatoyin Oluwatosin Kelechi-Mathew Michael Chinedu Onwe Department of Microbiology Faculty of Biological Sciences Alex-Ekwueme Federal University Ndufu-Alike Ikwo Abakaliki Nigeria Northern Care Alliance NHS Foundation Trust Manchester UK The Park Hospital Nottingham UK Department of Haematology Faculty of Basic Clinical Sciences Alex-Ekwueme Federal University Ndufu-Alike Ikwo Abakaliki Nigeria Department of Stem Cell and Regenerative Medicine University of Chester Chester UK Department of Biotechnology University of Chester Chester UK Independent Researcher Birmingham UK

The Antibiogram of the bacterial isolates from Tuberculosis (TB) patients attending hospitals within Izzi-Abakaliki was evaluated. The bacterial isolates were isolated and identified from the sputum samples according to microbiological principles while the antibiotics susceptibility test was done by disc diffusion method using Ofloxacin, Pefloxacin, Ciprofloxacin, amoxicillin/clavulanate, Gentamycin, Streptomycin, Cephalosporin, Cotrimoxazole, Nalidixic acid and Ampicillin. Bacteria isolated include 5 E. coli (25%), 3 Streptococcus pyogenes (15%), 2 Streptococcus pneumoniae (10%), 1 Klebsiella spp. (5%), 3 Haemophilus influenza (15%), 2 Pseudomonas (10%), 3 Proteus spp. (15%), 1 Staphylococcus aureus (10%). The result of Antibiogram shows that E. coli was 100% resistant to Amoxicillin/clavulanate and cotrimoxazole, followed by Streptomycin (80%) and 100% susceptible to Pefloxacin with inhibition zone diameter of 18 mm and 18 mm for Ofloxacin (60%). S. pneumoniae and Klebsiella spp. were highly resistant to Amoxicillin/clavulanate (100%), Gentamycin (100%) and Ampicillin (100%) and 100% susceptible to Pefloxacin with inhibition zone 18 mm, Ciprofloxacin (17 mm). S. pyogenes was resistant to streptomycin and Ceporex, with 100% sensitivity to Ofloxacin, Ciprofloxacin and Pefloxacin. Pseudomonas spp. and S. aureus were both 100% resistant to all antibiotics except Ofloxacin, Ciprofloxacin, and Pefloxacin respectively. Proteus spp. was susceptible to Pefloxacin (100%), Ofloxacin (66.7%) and Ciprofloxacin (66.7%) but highly resistant to Streptomycin (100%) and Ampicillin (100%). Haemophilus influenzae were susceptible to Ofloxacin (100%) and Pefloxacin (100%), with high resistance to Amoxicillin/clavulanate (100%) and Ceporex (100%). From the study, Ofloxacin and Pefloxacin are susceptible to all bacteria isolated and are recommended for treatment of the bacterial infection with TB patient.

关键词： Tuberculosis pneumoniae Infection Sputum Antibiotics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prevalence and Viral Load Determination of Hepatitis B Virus among Hiv Seropositive Patients Attending Kogi State Specialist Hospital Lokoja, Kogi State

引用

Open Journal of Applied Sciences 2023年第3期13卷 288-301页

作者： Euslar Nnenna Onu Okolo Martin-Luther Oseni Ochada Zainab Peninnah cornelius ituma azi Oghenevwogaga Obukohwo Edenya Chinedu Obasi Akpa Mbah Emmanuel Onu Nwali Thomas Sunday Ezeokoli Ozioma Emmanuel Department of Medical Microbiology Faculty of Basic Clinical Sciences Alex-Ekwueme Federal University Ndufu-Alike Ikwo Abakaliki Nigeria Department of Microbiology Faculty of Natural Sciences Kogi State University Anyigba Nigeria Laboratory Department General Hospital Koton-Karfe Nigeria Al Shamli General Hospital Hail Saudi Arabia Department Chemical Pathology Faculty of Basic Clinical Sciences Alex-Ekwueme Federal University Ndufu-Alike Ikwo Abakaliki Nigeria Department of Haematology Faculty of Basic Clinical Sciences Alex-Ekwueme Federal University Ndufu-Alike Ikwo Abakaliki Nigeria

Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV) share common risk factors and HBV occurs in people with HIV resulting in an increased risk for HIV/HBV co-infection. Globally, hepatitis B virus infection is of serious public health causing morbidity and mortality. The increasing incidence of liver diseases caused by HBV is emerging as a significant cause of morbidity and mortality among HIV-infected individuals. A clearer knowledge of HBV prevalence in Kogi State is important in order to educate, inform the population and control epidemics through extensive vaccination and treatment programme. The aim of this study was to determine the seroprevalence of Hepatitis B infection and to evaluate molecularly HBV infection among HIV seropositive individuals. Sera samples were obtained from 218 consented HIV participants and screened for HBsAg using the commercial membrane based rapid qualitative test kit and real-time PCR was performed using Tianlong to assay the virus quantitatively. A structured questionnaire was used to collect information on patient’s demographic variables and risk factors for HBV transmission. Overall, 17 of the participants were seropositive to HBsAg. There was a significant difference between the age distribution with (P-value = 0.006) and marital status with (P-value = 0.044). Type of marriage, occupation, place of residence and risk factors associated with HIV and HBV co-infection do not show significant differences. A total of 17 HBsAg positive samples were subjected to viral load analysis, out of which 7 were highly unsuppressed, 5 were suppressed while the remaining 5 were undetectable. This study confirmed a moderately high HIV/HBV co-infection rate (7.8%). The highly unsuppressed viral load obtained from the study is a potential risk for Hepatocellular carcinoma among the study population. Enlightenment programme on routes of virus acquisition with a view to reducing the morbidity and mortality of HIV/HBV co-infection should be

关键词： Real-Time PCR Co-Infection Morbidity Mortality CD4 Receptor Monocytes Macrophages Dendritic Viral Hepatitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：