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Copper as an alternative antimicrobial coating for implants-An in vitro study

World Journal of Transplantation 2017年第3期7卷 193-202页

作者： Claudia Bergemann Sarah Zaatreh katharina Wegner kathleen Arndt Andreas Podbielski Rainer Bader cornelia Prinz Ulrich Lembke J Barbara Nebe Department of Cell Biology University Medical Center Rostock Biomechanics and Implant Technology Research Laboratory University Medical Center Rostock Institute of Medical Microbiology Virology and HygieneUniversity Medical Center Rostock DOT GmbH

AIM To investigate osteoconductive and antimicrobial properties of a titanium-copper-nitride(TiC uN) film and an additional BONIT~? coating on titanium *** For micro-structuring, the surface of titanium test samples was modified by titanium plasma spray(TPS). On the TPS-coated samples, the Ti Cu N layer was deposited by physical vapor deposition. The BONIT~? layer was coated electrochemically. The concentration of copper ions released from TiC uN films was measured by atomic absorption spectrometry. MG-63 osteoblasts on Ti Cu N and BONIT~? were analyzed for cell adhesion, viability and spreading. In parallel, Staphylococcus epidermidis(S. epidermidis) were cultivated on the samples and planktonic and biofilm-bound bacteria were quantified bycounting of the colony-forming units. RESULTS Field emission scanning electron microscopy(FESEM) revealed rough surfaces for TPS and TiC uN and a special crystalline surface structure on TiC uN + BONIT~?. TiC uN released high amounts of copper quickly within 24 h. These release dynamics were accompanied by complete growth inhibition of bacteria and after 2 d, no planktonic or adherent S. epidermidis were found on these samples. On the other hand viability of MG-63 cells was impaired during direct cultivation on the samples within 24 h. However, high cell colonization could be found after a 24 h pre-incubation step in cell culture medium simulating the in vivo dynamics closer. On pre-incubated TiC uN, the osteoblasts span the ridges and demonstrate a flattened, well-spread phenotype. The additional BONIT~?-coating reduced the copper release of the TiC uN layer significantly and showed a positive effect on the initial cell *** The Ti Cu N-coating inhibits the formation of bacterial biofilms on orthopedic implants by influencing the "race for the surface" to the advantage of osteoblasts.

关键词： Implant-coating Antimicrobial effect Titanium plasma spray Titanium-copper-nitride BONIT^(®) Osteoconductivity

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Effect of a 12-Week Dietary Intervention with Folic Acid or Folate-Enhanced Foods on Folate Status in Healthy Egyptian Women

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Food and Nutrition Sciences 2016年第14期7卷 1339-1351页

作者： Mohammed E. Hefni Mohamed T. Shalaby Rasha A. Mohamed Ahmad M. Elwa cornelia M. Witthöft Food Industries Department Faculty of Agriculture Mansoura University Mansoura Egypt Department of Chemistry and Biomedical Sciences Linnaeus University Kalmar Sweden Faculty of Nursing Mansoura University Mansoura University Mansoura Egypt Clinical Pathology Department Faculty of Medicine Mansoura University Mansoura Egypt

The Egyptian government introduced wheat-flour fortification with iron and folic acid to reduce the incidence of neural tube defects, but suspended it for technical reasons. We previously developed novel legume foods with enhanced folate content. In this study, we investigated the efficacy of 12-week intervention with folate-enhanced foods versus folic acid supplement in improving folate status in Egyptian women. A randomized, parallel intervention trial with two active groups (n = 19, n = 18) and one blinded control group (n = 20) was executed over 12 weeks. Volunteers received either germinated legume foods and orange juice (≈250 μg/d folate) or folic acid supplement (500 μg/d) or apple juice (0 μg/d folate). Folate status was assessed by erythrocyte and plasma folate and total homocysteine (tHcy) at day 0, and after 8 and 12 weeks of intervention. After 12 weeks, mean plasma folate increased by 14 (P ks, 90% of subjects in the folic acid group and 70% in the food group had erythrocyte folate concentrations exceeding 906 nmol/L. tHcy concentration was decreased by 20% (P = 0.007) and 18% (P = 0.006) in the folic acid and food group, respectively, but remained unchanged in the control group during intervention. Folate-enhanced foods effectively improve folate status in women of reproductive age. These foods could be used as a complement to folic acid fortification.

关键词： Folic Acid Folate-Enhanced Legume Foods Human Intervention Folate Status

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Antibacterial Zinc Oxide Nanoparticle Coating of Polyester Fabrics

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Journal of Textile Science and Technology 2015年第2期1卷 65-74页

作者： Claudia Rode Michael Zieger Ralf Wyrwa Susanne Thein cornelia Wiegand Monika Weiser Andreas Ludwig Dirk Wehner Uta-Christina Hipler Department of Dermatology Jena University Hospital Jena Germany INNOVENT e.V. Biomaterials Department Jena Germany Textile Research Institute Thuringia-Vogtland Greiz Germany Thorey Gera Textilveredelung GmbH Gera Germany

Polyester knitted fabrics have been equipped with antibacterial properties by coating with aqueous suspensions of zinc oxide (ZnO) with different particle diameters. It can be shown that the antibacterial efficacy against Staphylococcus aureus and klebsiella pneumonia and the permanence of the coating after defined washing cycles depends on the composition of the ZnO dispersion. To improve the wettability of the textile, the combustion chemical vapor deposition (CCVD) is used to generate a hydrophilic nano layer of a hydroxyl terminated silicon network on the surface of the textiles. The comparison of CCVD-treated and untreated polyester samples does not show differences in the antibacterial activity. The influence of the coating in terms of amount and particle size of ZnO on the viability and proliferation of 3T3 mouse fibroblast cells is examined. A particle content of a maximum of 20 μg ZnO/cm2 is found to be cytocompatible for coating of textiles.

关键词： Antibacterial Textile ZnO Nanoparticles Cytocompatibility

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中国企业赴德国最大并购案分析

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中国对外贸易 2015年第5期 44-45页

作者： Jan Bauer cornelia Topf Michael Burian 德国Gleiss Lutz律师事务所

近年来，中国企业的对外投资显著增加。很长一段时间里中国投资者热衷于收购欧洲企业，特别是德国企业。但真正重大的交易最近几年才发生，最重要和最引人注目的一起交易便是山东重工集团旗下潍柴动力并购德国凯做集团（kION）。其规模... 详细信息

近年来，中国企业的对外投资显著增加。很长一段时间里中国投资者热衷于收购欧洲企业，特别是德国企业。但真正重大的交易最近几年才发生，最重要和最引人注目的一起交易便是山东重工集团旗下潍柴动力并购德国凯做集团（kION）。其规模巨大，可谓一个里程碑式的交易。潍柴动力投资约86亿元人民币，使得该交易成为迄今为止中国在德国最大规模的直接投资。

关键词：德国企业中国企业并购案对外投资最大规模中国投资者欧洲企业直接投资

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The Digital Agricultural knowledge and Information System(DAkIS):Employing digitalisation to encourage diversified and multifunctional agricultural systems

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Environmental Science and Ecotechnology 2023年第4期16卷 177-189页

作者： Ioanna Mouratiadou Nahleen Lemke Cheng Chen Ariani Wartenberg Ralf Bloch Marco Donat Thomas Gaiser Deepak Hanike Basavegowda katharina Helming Seyed Ali Hosseini Yekani Marcos krull kai Lingemann Joseph Macpherson Marvin Melzer Claas Nendel Annette Piorr Mostafa Shaaban Peter Zander cornelia Weltzien Sonoko Dorothea Bellingrath-kimura Leibniz Centre for Agricultural Landscape Research(ZALF) Eberswalder Straße 8415374MünchebergGermany ISARA Laboratory of Rural Studies Research UnitLyon23 Rue Jean Baldassini69364Lyon Cedex 07France Faculty of Landscape Management and Nature Conservation University for Sustainable Development(HNEE)Schickler Straße 516225EberswaldeGermany Institute of Crop Science and Resource Conservation University of Bonn53115BonnGermany Leibniz Institute for Agricultural Engineering and Bioeconomy(ATB) Max-Eyth-Allee 10014469PotsdamGermany German Research Center for Artificial Intelligence(DFkI) Trippstadter Strasse 12267663KaiserslauternGermany Institute of Biochemistry and Biology University of PotsdamAm Mühlenberg 314476Potsdam(Golm)Germany Global Change Research Institute The Czech Academy of ScienceBělidla 986/4a60300BrnoCzech Republic

Multifunctional and diversified agriculture can address diverging pressures and demands by simultaneously enhancing productivity,biodiversity,and the provision of ecosystem *** use of digital technologies can support this by designing and managing resource-efficient and context-specific agricultural *** present the Digital Agricultural knowledge and Information System(DAkIS)to demonstrate an approach that employs digital technologies to enable decision-making towards diversified and sustainable *** develop the DAkIS,we specified,together with stakeholders,requirements for a knowledge-based decision-support tool and reviewed the literature to identify limitations in the current generation of *** results of the review point towards recurring challenges regarding the consideration of ecosystem services and biodiversity,the capacity to foster communication and cooperation between farmers and other actors,and the ability to link multiple spatiotemporal scales and sustainability *** overcome these challenges,the DAkIS provides a digital platform to support farmers'decision-making on land use and management via an integrative spatiotemporally explicit approach that analyses a wide range of data from various *** approach integrates remote and in situ sensors,artificial intelligence,modelling,stakeholder-stated demand for biodiversity and ecosystem services,and participatory sustainability impact assessment to address the diverse drivers affecting agricultural land use and management design,including natural and agronomic factors,economic and policy considerations,and socio-cultural preferences and ***,the DAkIS embeds the consideration of ecosystem services,biodiversity,and sustainability into farmers'decision-making and enables learning and progress towards site-adapted small-scale multifunctional and diversified agriculture while simultaneously supporting farmers'objectives and societal demands.

关键词： Digital agriculture Ecosystem services Decision support system Farming practices Biodiversity Modelling Small-scale management

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桂林唐家湾剖面中—上泥盆统碳酸盐岩沉积相和成岩作用

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沉积与特提斯地质 1993年第3期14卷 9-17页

作者： cornelia klindworth Werner Sehneider 刘效曾德国布伦瑞克工大地质古生物研究所成都地质学院

本文的工作区域是按中国地矿部和德国下萨克森州科学和艺术部之间科学台作协议而提供的。在唐家湾地区的中上泥盆统碳酸盐岩中可以见到以下8种微相类型:泥岩、具纹层球粒-颗粒岩/泥粒岩、无纹层球粒-颗粒岩/泥粒岩、介形虫-颗粒岩/泥粒... 详细信息

本文的工作区域是按中国地矿部和德国下萨克森州科学和艺术部之间科学台作协议而提供的。在唐家湾地区的中上泥盆统碳酸盐岩中可以见到以下8种微相类型:泥岩、具纹层球粒-颗粒岩/泥粒岩、无纹层球粒-颗粒岩/泥粒岩、介形虫-颗粒岩/泥粒岩、枝状层孔虫-粒泥岩、枝状层孔虫-棘皮类-粒泥岩、生物碎屑-粒泥岩和骨架岩。这些微相类型可指示不同的能量指数及水深。同欧文(Irwin,1965)浅水碳酸盐沉积模式对比,唐家湾泥盆纪(吉维特期和弗拉斯期)属于Y带和Z带沉积,并可分出发育生物丘-生物层的正常海环境、局限浅水沉积环境和潮坪沉积环境。最大水深估计为10m—20m。唐家湾剖面碳酸盐岩经历了三种早成岩环境:海水成岩环境、大气水成岩环境和混合水成岩环境。其后又经历了晚成岩阶段的压溶、重结晶和交代作用。白云石化部分为混合水成因,部分为晚成岩期交代成因。

关键词：碳酸盐岩沉积相微相类型成岩作用

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Sirolimus-induced drug fever and ciclosporin-induced leukencephalopathia with seizures in one liver transplant recipient

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World Journal of Gastroenterology 2007年第45期13卷 6090-6093页

作者： Doris Schacherer Martina Zeitoun Roland Büttner cornelia Gelbmann Aiman Obed Hans-Jürgen Schlitt Jürgen Schlmerich Gabi I kirchner Department of Internal MedicineⅠ University of Regensburg Regensburg 93042 Germany Department of Surgery University of Regensburg Regensburg 93042 Germany

We describe the first case of sirolimus-induced drug fever in a female liver transplant recipient, with a history of hepatitis C-induced end-stage liver cirrhosis in 1999. In 2005, six years after transplantation, she developed calcineurin inhibitor-induced renal function impairment. Immunosuppression was switched from tacrolimus to sirolimus. Two days after the intake of sirolimus, she developed daily fever spikes, but no infectious focus was found. Antibiotic therapy had no influence on the fever. After fourteen days, sirolimus was switched back to tacrolimus and the fever disappeared. In history, the patient developed ciclosporin-induced generalized seizures eleven days after liver transplantation, followed by the development of a motoric speech disorder. Magnetic resonance imaging (MRI) findings were consistent with leucoencephalopathy, therefore immunosuppressive therapy was changed from ciclosporin to tacrolimus and the neurologic symptoms improved significantly. Our case is the first reported case of sirolimus-induced drug fever. In addition, the patient showed the rare occurrence of ciclosporin-induced leukencephalopathy with seizures.

关键词：肝移植免疫移植环孢霉素肝疾病

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Correction to:Proposed nomenclature for Pseudallescheria,Scedosporium and related genera

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Fungal Diversity 2022年第2期113卷 193-194页

作者： Michaela Lackner G.Sybren de Hoog Liyue Yang Leandro Ferreira Moreno Sarah A.Ahmed Fritz Andreas Josef kaltseis Markus Nagl cornelia Lass-Florl Brigitte Risslegger Gunter Rambach cornelia Speth Vincent Robert Walter Buzina Sharon Chen Jean-Philippe Bouchara Jose F.Cano-Lira Josep Guarro Josepa Gene Fabiola Fernandez Silva Rosa Haido Gerhard Haase Vladimir Havlicek Dea Garcia-Hermoso Jacques F.Meis Ferry Hagen Martin kirchmair Johannes Rainer katharina Schwabenbauer Mirjam Zoderer Wieland Meyer Felix Gilgado Vania A.Vicente Elena Pieckova Monika Regenermel Peter-Michael Rath Joerg Steinmann Xisto Wellington de Alencar Françoise Symoens kathrin Tintelnot krzysztof Ulfig Aristea Velegraki Anna Maria Tortorano Sandrine Giraud Sara Mina kinga Rigler-Hohenwarter Fernando L.Hernando Andoni Ramirez-Garcia Aize Pellon Jashanpreet kaur Eliana Barreto Bergter Jardel Vieira de Meirelles Ingrid Dutra da Silva Laurence Delhaes Ana Alastruey-Izquierdo Ruo-yu Li Qiaoyun Lu Tarek Moussa Omar Almaghrabi Hassan Al-Zahrani Gen Okada Shuwen Deng Wangqing Liao Jingsi Zeng Jouni Issakainen Livia Cristina Liporagi Lopes Division of Hygiene and Medical Microbiology Innsbruck Medical UniversityInnsbruckAustria CBS Fungal Biodiversity Centre UtrechtThe Netherlands Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Sun Yat-Sen Memorial Hospital Sun Yat-Sen UniversityGuangzhouChina Medical University of Graz GrazAustria Centre for Infectious Diseases and Microbiology Westmead HospitalWestmeadAustralia Laboratoire de Parasitologie-Mycologie Centre Hospitalier UniversitaireAngersFrance Unitats de Microbiologia i d’Anatomia Patologica Facultat de Medicina i Ciencies de la Salut IISPVUniversitat Rovira i VirgiliReusSpain Universidade Federal do Estado do Rio de Janeiro Rio de JaneiroBrazil Institute of Medical Microbiology University Hospital RWTHAachenGermany Institute of Microbiology Academy of SciencesPragueCzech Republic Institut Pasteur Unite de Mycologie MoleculaireCentre National de Reference Mycoses Invasives et AntifongiquesParisFrance Department of Medical Microbiology and Infectious Diseases Canisius-Wilhelmina HospitalNijmegenThe Netherlands Department of Medical Microbiology RadboudumcNijmegenThe Netherlands Institute of Microbiology eopold-Franzens-University InnsbruckInnsbruckAustria Molecular Mycology Research Laboratory Centre for Infectious Diseases and MicrobiologySydneyMedical School—Westmead HospitalMarie Bashir Institute for Infectious Diseases and BiosecurityThe University of SydneyWestmead Millennium InstituteWestmeadNSWAustralia Basic Pathology Department Federal University of Parana StateCuritibaParanaBrazil Fellowship from Conselho Nacional de Desenvolvimento Cientifico e Tecnologico(CNPq) BrasiliaBrazil Institute of Preventive and Clinical Medicine BratislavaSlovakia Institut für Hygiene und Mikrobiologie Landesklinikum St.Pölten St.PoltenAustria Institute of Medical Microbiology University Hospital EssenEssenGermany Nursing School of Unigranrio Rio de JaneiroBrazil Scientific Institute of Public Health Culture Collect

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