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对慢性丙型肝炎无应答患者每日用组合干扰素加利巴韦林治疗:一项随机、开放标记的先导研究

世界核心医学期刊文摘（胃肠病学分册） 2006年第5期2卷 52-52页

作者： cornberg m. Hadem.J. Herrm.nn E. m.P. m.nns 刘丽娜 Departm.nt of Gastroenterology Hepatology and Endocrinology Medizinische Hochschule Hannover Carl- Neuberg-Str. 1 D-30625 Hannover Germany

Background/Aim.: Therapeutic options for hepatitis C nonresponder patients are lim.ted. m.thods: We initiated an open-label pilot study to investigate the efficacy of CIFN plus ribavirin on viral kinetics, sustained virological response (SVR), and histological response in hepatitis C non-responder patients. Seventy-seven patients were enrolled to receive CIFN given daily in com.ination with 1000/1200 m. ribavirin. An 8 week induction-dosing regim.n of 18 μ g CIFN, followed by 9 μ g for 40 weeks was com.ared to 9 μ g CIFN for 48 weeks. 90% of patients were infected with HCV-genotype 1. Results: Overall, 82% of the patients dem.nstrated an early virological response, 65% had an end-of-treatm.nt response, and the SVR was 30% . Interferon/ribavirin non-responders dem.nstrated a SVR of 22% . Induction-dosing resulted in a greater first-phase HCV-RNA decay that, however, did not translate to better SVRs, presum.bly due to m.re dose m.difications. High ALT, younger age, and second-phase viral kinetics were associated with SVR. Only sustained responders and relapse patients showed an im.roved liver histology. Conclusions: Daily dosing of CIFN plus ribavirin m.y be a prom.sing concept for selected non-responder patients before considering therapies which are anti-viral but not curative. However,m.tivation and com.liance are requisites and a CIFN induction is not required.

关键词：慢性丙型肝炎组合干扰素利巴韦林无应答患者治疗持续病毒学应答病毒动力学随机丙型肝炎病毒

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Endothelial dysfunction contributes to severe COVID-19 in com.ination with dysregulated lym.hocyte responses and cytokine networks

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Signal Transduction and Targeted Therapy 2022年第1期7卷 243-257页

作者： Louisa Ruhl Isabell Pink Jenny F.Kiihne Kerstin Beushausen Jana Keil Stella Christoph Andrea Sauer Lennart Boblitz Julius Schm.dt Sascha David Hans-m.rtin Jack Edith Roth m.rkus cornberg Thom.s F.Schulz Tobias Welte m.rius m.Hoper Christine S.Falk Institute of Transplant Im.unology MHHDHanoverGermany Departm.nt of Pneum.logy MHHDHanoverGermany Departm.nt of Intensive Care m.dicine University of ZurichCHZurichSwitzerland Division of m.lecular Im.unology Internal Medicine IIINikolaus-Fiebiger-Center of Molecular MedicineFriedrich-Alexander University Erlangen-NurnbergDErlangenGermany Departm.nt of Gastroenterology Hepatology and Endocrinology MHHDHanoverGermany Center for Individualized Infection m.dicine Ciim HanoverGermany lnstitute of Virology MHHDHanoverGermany Germ.n Center for Infection Research DZIFTTU-IICHMarburgGermany Excellence Cluster 2155 RESIST MHHHanoverGermany Germ.n Center for Lung Diseases DZL/BREATH MarburgGermany

The system.c processes involved in the m.nifestation of life・threatening COVID-19 and in disease recovery are still incom.letely understood,despite investigations focusing on the dysregulation of im.une responses after SARS-CoV-2 *** define hallm.rks of severe COVID-19 in acute disease(n=58)and in disease recovery in con valesce nt patie nts(n=28)from.Han nover m.dical School,we used flow cytom.try and proteom.cs data with unsupervised clustering *** our observational study,we com.ined analyses of im.une cells and cytokine/chem.kine networks with endothelial activation and *** patients displayed an altered im.une signature with prolonged lym.hopenia but the expansion of granulocytes and plasm.blasts along with activated and term.nally differentiated T and NK cells and high levels of SARS-CoV-2-specific *** core signature of seven plasm. proteins revealed a highly inflam.atory m.croenvironm.nt in addition to endothelial injury in severe *** within this sign ature were associated with either disease progression or *** sum.ary,our data suggest that besides a strong inflam.atory response,severe COVID-19 is driven by endothelial activation and barrier disruption,whereby recovery depends on the regeneration of the endothelial integrity.

关键词： cytokine networks signature

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