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Impact of ribavirin dose on retreatment of chronic hepatitis C patients

World Journal of Gastroenterology 2012年第23期18卷 2966-2972页

作者： Christiane Stern Michelle Martinot-Peignoux Marie Pierre Ripault Nathalie Boyer corinne castelnau Dominique Valla Patrick Marcellin Service d'Hépatologie and INSERM U773-CRB3 H pital Beaujon University Paris-Diderot

AIM: To study the efficacy and factors associated with a sustained virological response (SVR) in chronic hepatitis C (CHC) relapsing patients. METHODS: Out of 1228 CHC patients treated with pegylated interferon (PEG-IFN) and ribavirin (RBV), 165 (13%) had a relapse. Among these, 62 patients were retreated with PEG-IFN-2a or-2b and RBV. Clinical, biological, virological and histological data were collected. Initial doses and treatment modifications were recorded. The efficacy of retreatment and predictive factors for SVR were analyzed. RESULTS: An SVR was achieved in 42% of patients. SVR was higher in young ( 15.2 mg/kg per day (70% vs 35%, P = 0.04). In logistic regression, predictors of a response were age (P = 0.018), genotype (P = 0.048) and initial RBV dose/body weight (P = 0.022). None of the patients without a complete early virological response achieved an SVR (negative predictive value = 100%). CONCLUSION: Retreatment with PEG-IFN/RBV is effective in genotype 2 or 3 relapsers, especially in young patients. A high dose of RBV seems to be important for the retreatment response.

关键词： Chronic hepatitis C Relapse Retreatment Ribavirin Pegylated interferon

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小儿Ⅰ型神经纤维瘤的并发症:100例随访研究

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世界核心医学期刊文摘（儿科学分册） 2006年第12期2卷 14-14页

作者： Bonnemaison E. Roze-Abert B. Lorette G. P. castelnau 陈莉萍 Service de neurologie et neurochirurgie pédiatrique centre de pédiatrie Gatien-de-ClochevilleCHRU de Tours49boulevard Béranger37044 Tours cedex 01France

Neurofibromatosis 1 (NF1) is a frequent genetic disease. Diagnostic criterias were established in 1988. The patients can exhibit various and unpredictable complications. Objectives:To check the efficiency of a coordinated follow-up in specialized multidisciplinary centers providing a higher quality of management and to have a better knowledge of the complications including their true frequencies. Population and methods:We report a serie of 100 NF1 children who were followed-up during 4 years in a specialized center at the Tours University Hospital. Three hospital check-up at 2-5,6-7,14-15 years of age were performed as well as an annual physical ***:In our serie,the mean age was 7.8 years old with a sex ratio of 1. The mean age at diagnosis was 3.8 years old and the main diagnosis criteria were the café-au-lait spots and the family history for 80%of the patients. The optic nerve glioma has a low frequency of 5%. Learning disabilities clearly represent the most frequent complication (46%of the patients).Conclusion:An early detection of these difficulties is a priority for the appropriate management of these children.

关键词：神经纤维瘤随访研究实际发生率专科中心视神经胶质瘤男女性别比遗传性疾病大学医院受试人群

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苍白球刺激可改善泛酸激酶相关神经变性

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世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 11-11页

作者： castelnau P. Cif L. Valente E.M. P. Coubes 袁海峰 Research Unit on Movement Disorders Department of Pediatric Neurosurgery Centre Hospitalo-Universitaire Montpellier FranceDr.

Pantothenate kinase-associated neurodegeneration (PKAN)-causes a progressive generalized dystonia which remains pharmacologically intractable. We performed bilateral internal globus pallidus stimulation in six patients with genetically confirmed PKAN who obtained a major and long-lasting improvement of their painf ul spasms, dystonia, and functional autonomy. This study shows the benefits of p allidal DBS for the dystonia of PKAN patients.

关键词：神经变性苍白球肌张力障碍痛性痉挛药物难治性

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