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Burden of venous thromboembolism in patients with pancreatic cancer

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World Journal of Gastroenterology 2021年第19期27卷 2325-2340页

作者： corinne Frere Department of Haematology Pitie-Salpetriere HospitalAssistance Publique Hopitaux de ParisParis F-75013France INSERM UMRS_1166 Institute of Cardiometabolism And NutritionGRC 27 GRECOSorbonne UniversitéParis F-75013France Groupe Francophone Thrombose et Cancer Saint-Louis HospitalParis F-75010France

Pancreatic cancer(PC)is a devastating malignancy with fewer than 10%of patients being alive at 5 years after *** thromboembolism(VTE)occurs in approximatively 20%of patients with PC,resulting in increased morbidity,mortality and significant health care *** management of VTE is particularly challenging in these frail *** selection of the most appropriate anticoagulant for each individual patient according to the current international guidelines is warranted for overcoming treatment *** International Initiative on Thrombosis and Cancer multi-language web-based mobile application(downloadable for free at ***)has been developed to help clinicians in decision making in the most complex *** this narrative review,we will discuss the contemporary epidemiology and burden of VTE in PC patients,the performances and limitations of current risk assessment models to predict the risk of VTE,as well as evidence from recent clinical trials for the primary prophylaxis and treatment of cancer-associated VTE that support updated clinical practice guidelines.

关键词： Pancreatic cancer Venous thromboembolism Low-molecular weight heparin Direct oral anticoagulant Multi-language mobile application Risk-assessment models Thromboprophylaxis

Induced pluripotent stem cell-derived neural stem cell therapies for spinal cord injury

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Neural Regeneration Research 2015年第1期10卷 10-16页

作者： corinne A.Lee-Kubli Paul Lu Department of Neurosciences University of California Veterans Administration Medical Center

The greatest challenge to successful treatment of spinal cord injury is the limited regenerative capacity of the central nervous system and its inability to replace lost neurons and severed axons following injury. Neural stem cell grafts derived from fetal central nervous system tissue or embryonic stem cells have shown therapeutic promise by differentiation into neurons and glia that have the potential to form functional neuronal relays across injured spinal cord segments. However, implementation of fetal-derived or embryonic stem cell-derived neural stem cell ther- apies for patients with spinal cord injury raises ethical concerns. Induced pluripotent stem cells can be generated from adult somatic cells and differentiated into neural stem cells suitable for therapeutic use, thereby providing an ethical source of implantable cells that can be made in an autologous fashion to avoid problems of immune rejection. This review discusses the therapeutic potential of human induced pluripotent stem cell-derived neural stem cell transplantation for treatment of spinal cord injury, as well as addressing potential mechanisms, future perspectives and challenges.

关键词： transplantation axonal growth axonal regeneration neuroprotection remyelination differentiation neuronal relay human astrocytes neurons oligodendrocytes secondary degeneration

The Ultrastructure of a Chlamydomonas reinhardtii Mutant Strain Lacking Phytoene Synthase Resembles that of a Colorless Alga

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Molecular Plant 2008年第6期1卷 925-937页

作者： William Inwood corinne Yoshihara Reena Zalpuri Kwang-Seo Kim Sydney Kustu Department of Plant and Microbial Biology 111 Koshland Hall University of California Berkeley CA 94720-3102 USA Electron Microscope Laboratory 26 Giannini Hall University of California Berkeley CA 94720-3330 USA

Chlamydomonas reinhardtii strains lacking phytoene synthase, the first enzyme of carotenoid biosynthesis, are white. They lack carotenoid pigments, have very low levels of chlorophyll, and can grow only heterotrophically in the dark. Our electron and fluorescence microscopic studies showed that such a mutant strain （Itsl-204） had a proliferated plastid envelope membrane but no stacks of thylakoid membranes within the plastid. It accumulated cytoplasmic compartments that appeared to be autophagous vacuoles filled with membranous material. The Its1 mutants apparently lacked pyrenoid bodies, which normally house ribulose bisphosphate carboxylase-oxygenase （Rubisco）, and accumulated many starch granules. Although these mutant strains cannot synthesize the carotenoid and carotenoid-derived pigments present in the phototactic organelle （eyespot）, the mutant we examined made a vestigial eyespot that was disorganized and often mislocalized to the posterior end of the cell. The absence of a pyrenoid body, the accumulation of starch, and the disorganization of the eyespot may all result from the absence of thylakoids. The ultrastructure of Its1 mutant strains is similar to but distinct from that of previously described white and yellow mutant strains of C. reinhardtii and is similar to that of naturally colorless algae of the Polytoma group.

关键词： Ultrastructure Phytoene carotenoid biosynthesis

Hemostasis testing in patients with liver dysfunction: Advantages and caveats

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World Journal of Gastroenterology 2021年第42期27卷 7285-7298页

作者： Guillaume Nguyen Manon Lejeune Benjamin Crichi corinne Frere Department of Hematology Trousseau HospitalAssistance Publique Hôpitaux de ParisParis 75012France Department of Hematology Pitié-Salpêtrière HospitalAssistance Publique Hôpitaux de ParisParis 75013France Department of Internal Medicine Saint-Louis HospitalAssistance Publique Hôpitaux de ParisParis 75010France Inserm UMRS_1166 Institute of Cardiometabolism and NutritionSorbonne UniversitéParis 75013France

Due to concomitant changes in pro-and anti-coagulant mechanisms,patients with liver dysfunction have a“rebalanced hemostasis”,which can easily be tipped toward either a hypo-or a hypercoagulable *** are often faced with the question whether patients with chronic liver disease undergoing invasive procedures or surgery and those having active bleeding require correction of the hemostasis *** coagulation screening tests,such as the prothrombin time/international normalized ratio and the activated partial thromboplastin time have been demonstrated to have numerous limitations in these patients and do not predict the risk of bleeding prior to high-risk *** introduction of global coagulation assays,such as viscoelastic testing(VET),has been an important step forward in the assessment of the overall hemostasis profile.A growing body of evidence now suggests that the use of VET might be of significant clinical utility to prevent unnecessary infusion of blood products and to improve outcomes in numerous *** present review discusses the advantages and caveats of both conventional and global coagulation assays to assess the risk of bleeding in patients with chronic liver disease as well as the current role of transfusion and hemostatic agents to prevent or manage bleeding.

关键词： Hemostasis Bleeding risk Conventional tests Thrombin generation Viscoelastic tests Hemostatic agents

An Rh1-GFP Fusion Protein Is in the Cytoplasmic Membrane of a White Mutant Strain of Chlamydomonas reinhardtii

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Molecular Plant 2008年第6期1卷 1007-1020页

作者： corinne Yoshihara Kentaro Inoue Denise Schichnes Steven Ruzin William Inwood Sydney Kustu Department of Plant and Microbial Biology 111 Koshland Hall University of California Berkeley CA 94720-3102 USA Department of Plant Sciences 131 Asmundson Hall University of California One Shields Avenue Davis CA 95616 USA CNR Biological Imaging Facility 381 Koshland Hall University of California Berkeley CA 94720-3102 USA

The major Rhesus （Rh） protein of the green alga Chlamydomonas reinhardtii, Rhl, is homologous to Rh proteins of humans. It is an integral membrane protein involved in transport of carbon dioxide. To localize a fusion of intact Rhl to the green fluorescent protein （GFP）, we used as host a white （Its1） mutant strain of C. reinhardtii, which is blocked at the first step of carotenoid biosynthesis. The Its1 mutant strain accumulated normal amounts of Rhl heterotrophically in the dark and Rhl-GFP was at the periphery of the cell co-localized with the cytoplasmic membrane dye FM4-64. Although Rhl carries a potential chloroplast targeting sequence at its N-terminus, Rhl-GFP was clearly not associated with the chloroplast envelope membrane. Moreover, the N-terminal half of the protein was not imported into chloroplasts in vitro and N-terminal regions of Rhl did not direct import of the small subunit of ribulose bisphosphate carboxylase （SSU）. Despite caveats to this interpretation, which we discuss, current evidence indicates that Rhl is a cytoplasmic membrane protein and that Rhl-GFP is among the first cytoplasmic membrane protein fusions to be obtained in C. reinhardtii. Although Its1 （white） mutant strains cannot be used to localize proteins within sub-compartments of the chloroplast because they lack thylakoid membranes, they should nonetheless be valuable for localizing many GFP fusions in Chlamydomonas.

关键词： CO2 acquisition fluorescence imaging membrane biology protein targeting.

Molecular evidence for novel Cantharellus (Cantharellales, Basidiomycota) from tropical African miombo woodland and a key to all tropical African chanterelles

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Fungal Diversity 2013年第1期58卷 281-298页

作者： Bart Buyck Frank Kauff corinne Cruaud Valérie Hofstetter Département Systématique etévolution UMR7205Muséum National d’Histoire NaturelleCP39Rue Buffon 1275005 ParisFrance Fachbereich Biologie Abt.Molekulare PhylogenetikTechnische Universität KaiserslauternPostfach 304967653 KaiserslauternGermany Centre national de séquençage Genoscope2 rue Gaston-CrémieuxCP 570691057 Evry cedexFrance Department of plant protection Agroscope Changins-Wädenswil Research Station ACWRte De Duiller1260 NyonSwitzerland

The authors present a combined morphological and molecular approach of the genus Cantharellus in *** descriptions and detailed illustrations are provided for five new species from the Zambezian savannah woodlands in tropical Africa:***,***,***,*** and ***.A maximum likelihood analysis of tef-1 sequences obtained for 83 collections of Cantharellus that are representative of all major groups in world wide Cantharellus,places a total of 13 African chanterelles,including the five newly described *** recognition of a separate genus Afrocantharellus is *** identification key based on the re-examination of all existing type material is provided for all presently known African Cantharellus.

关键词： Afrocantharellus Biodiversity Guineocongolian rain forest Identification key Phylogeny Tanzania Zambezian woodlands

Hepatic portal venous gas: Physiopathology, etiology, prognosis and treatment

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World Journal of Gastroenterology 2009年第29期15卷 3585-3590页

作者： Bassam Abboud Jad El Hachem Thierry Yazbeck corinne Doumit Department of General Surgery Hotel-Dieu de France Hospital Boulevard Alfred Naccache Beirut 16-6830 Lebanon

Hepatic portal venous gas (HPVG), an ominous radiologic sign, is associated in some cases with a severe underlying abdominal disease requiring urgent operative intervention. HPVG has been reported with increasing frequency in medical literature and usually accompanies severe or lethal conditions. The diagnosis of HPVG is usually made by plain abdominal radiography, sonography, color Doppler flow imaging or computed tomography (CT) scan. Currently, the increased use of CT scan and ultrasound in the inpatient setting allows early and highly sensitive detection of such severe illnesses and also the recognition of an increasing number of benign and non-life threatening causes of HPVG. HPVG is not by itself a surgical indication and the treatment depends mainly on the underlying disease. The prognosis is related to the pathology itself and is not influenced by the presence of HPVG. Based on a review of the literature, we discuss in this paper the pathophysiology, risk factors, radiographic findings, management, and prognosis of pathologies associated with HPVG.

关键词： Hepatic portal venous gas Bowel ischemia/necrosis Diverticulitis Gastric pathologies Ulcerativecolitis Abdominal computed tomography scan Crohn'sdisease Liver transplantation Chemotherapy

Effect of Replacing Vanadium by Niobium and Iron on the Tribological Behavior of HIPed Titanium Alloys

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Acta Metallurgica Sinica(English Letters) 2017年第11期30卷 1089-1099页

作者： Mamoun Fellah Linda Aissani Mohammed Abdul Samad Alain Iosts Touhami Mohamed Zine Alex Montagnes corinne Nouveau Mechanical Engineering Department ABBES Laghrour University P.O. 1252 40004 Khenchela Algeria Tribology Materials Surface and Interfaces GroupLaboratory of Foundry BADJI Mokhtar University BO 12CP 23000 Annaba Algeria Physics Department ABBES Laghrour University P.O.1252 40004 Khenchela Algeria Mechanical Engineering Department KFUPM Box 1180Dhahran 31261 Kingdom of Saudi Arabia Laboratory of Mechanics Surfaces and Processing Materials ARTS ET METIERS ParisTech Boulevard Louis XIV 859046 Lille Cedex France La.Bo.Ma.P ENSAM Rue Porte de Paris 71250 ClunyFrance

This study aims to examine the effect of replacing vanadium by niobium and iron on the tribological behavior of hot-isostatic-pressed titanium alloy （Ti-6Al-4V） biomaterial, using a ball-on-disk-type oscillating tribometer, under wet conditions using physiological solution in accordance with the ISO7148 standards. The tests were carried out under a normal load of 6 N, with an AISI 52100 grade steel ball as a counter face. The morphological changes and structural evolution of the nanoparticle powders using different milling times （2, 6, 12 and 18 h） were studied. The morphological characterization indicated that the particle and crystallite size continuously decrease with increasing milling time to reach the lowest value of 4 nm at 18-h milling. The friction coefficient and wear rate were lower in the samples milled at 18 h （0.226, 0.297 and 0.423; and 0.66 × 10-2, 0.87 × 10-2 and 1.51 × 10-2 μm3 N-1 i, tm-1） for Ti-6Al-4Fe, Ti-6A1-7Nb and Ti-6Al-4V, respectively. This improvement in friction and wear resistance is attributed to the grain refinement at 18-h milling. The Ti-6Al-4Fe samples showed good tribological performance for all milling times.

关键词： Tribological behavior Titanium alloys Wear testing Nanotribology Milling time Hot isostatic pressing(HIPing)

The Applications of Genome Editing in Xenotransplantation

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Journal of Genetics and Genomics 2016年第5期43卷 233-237页

作者： Andrea Perota Irina Lagutina corinne Quadalti Giovanna Lazzari Emanuele Cozzi Cesare Galli Avantea Laboratory of Reproductive Technologies Cremona Italy Department of Veterinary Medical Sciences University of Bologna Italy Avantea Foundation Cremona Italy Transplant Immunology Unit Padua General Hospital Padua Italy

Higher living standards and better medical care are increasing the lifespan of people around the *** populations,however,have an increased incidence of loss of function or failure of cell,tissue or *** has led to the ... 详细信息

关键词： disciplines Genome populations enormous editing programmable incidence rejection targeting pancreas