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可控热膨胀聚合物复合材料的挑战和机遇(英文)

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硅酸盐学报 2009年第5期37卷 689-695页

作者： LIND cora 托利多大学化学系美国托利多OH43606

负热膨胀(negative thermal expansion,NTE)材料可作为填料制备可控热膨胀复合材料。高质量聚合物复合材料的研发面临诸多挑战,包括 NTE填料与基体材料的相容性,NTE相的稳定性,颗料形貌和尺寸的控制及其对混合程度的影响。本文对影响聚... 详细信息

负热膨胀(negative thermal expansion,NTE)材料可作为填料制备可控热膨胀复合材料。高质量聚合物复合材料的研发面临诸多挑战,包括 NTE填料与基体材料的相容性,NTE相的稳定性,颗料形貌和尺寸的控制及其对混合程度的影响。本文对影响聚合物复合材料成型中存在的诸多可能存在的问题进行了述评,讨论了对有望用作填料的 NTE材料的要求,即对NTE填料颗粒尺寸和相容性进行合成控制。通过晶体前驱体到目标NTE相的拓扑转变,可实现对颗粒尺寸的最优控制。

关键词：负热膨胀材料纳米颗粒聚合物复合材料钨酸锆钼酸锆钒酸锆

Forkhead box protein P1, a key player in neuronal development?

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Neural Regeneration Research 2018年第5期13卷 801-802页

作者： Luca Braccioli cora.H.Nijboer Paul J.Coffer Laboratory of Neuroimmunology and Developmental origins of Disease (NIDoD) University Medical Center Utrecht University Regenerative Medicine Center University Medical Center Utrecht Utrecht University Center for Molecular Medicine and Division of Pediatrics University Medical Center Utrecht Utrecht University

Forkhead box protein P1（FoXP1）is a transcription factor belonging to the forkhead box（FoX）proteins,a family of transcriptional regulators sharing a highly conserved forkhead DNA-binding domain（Bacon and Rappold,2012）.Previous reports have proposed a role for FoXP1 in functionally regulating the central nervous system（CNS）,while mutations in FoXP1 have been implicated in cognitive abnormalities（Bacon and Rappold, 2012）.

关键词： a key player in neuronal development Forkhead box protein P1

What makes a cry a cry？ A review of infant distress vocalizations

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Current Zoology 2012年第5期58卷 698-726页

作者： Susan LINGLE Megan T. WYMAN Radim KoTRBA Lisa J. TEICHRoEB cora.A. RoMANoW Department of Biology University of Winnipeg Manitoba R3B 2E9 Canada Department of Population Health and Reproduction School of veterinary Medicine University of California-Davis One Shields Avenue Davis CA 95616 U.S.A. 3 Department of Animal Science and Food Processing in Tropics and Subtropics Czech University of Life Sciences Prague Czech Republic Department of Ethology Institute of Animal Science Prague Czech Republic

In contrast to the cries of human infants, sounds made by non-human infants in different stressful behavioral contexts （hunger or physical discomfort, isolation, capture by humans or predators） are usually treated as distinct types of vocalizations. However, if distress vocalizations produced by different species and in different contexts share a common motivational state and associated neurochemical pathways, we can expect them to share a common acoustic structure and adaptive function, showing only limited variation that corresponds to the infant＇s level of arousal. Based on this premise, we review the acoustic structure and adaptive function of two types of distress calls, those given when infants were isolated from their mothers （isolation caUs） or captured by humans （capture calls）. We conducted a within-context comparison examining the two call types across a diverse se- lection of mammalian species and other vertebrate groups, followed by a comparison of how acoustic structure and function dif- fers between these contexts. In addition, we assessed acoustic traits that are critical to the response of caregivers. Across verte- brate species, distress vocalizations produced in these two behavioral contexts tend to be tonal with a simple chevron, flat or de- scending pattern of frequency modulation. Reports that both isolation and capture calls of vertebrate infants serve to attract care- givers are universal, and the fundamental frequency of infant vocalizations is often critical to this response. The results of our re- view are consistent with the hypothesis that differences in the acoustic structure of isolation and capture distress vocalizations re- flect differences in arousal, and not discrete functions. The similarity in acoustic structure and caregiver response observed across vertebrates adds support to the hypothesis that the production and processing of distress vocalizations are part of a highly-conserved system of social vocal behaviour in vertebrate

关键词： Crying Mother-infant communication Isolation calls Distress calls Motivational-structural rules Parental care Phylogeny

Structural sensitivity in HIV modeling: A case study of vaccination

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Infectious Disease Modelling 2017年第4期2卷 399-411页

作者： cora.L.Bernard Margaret L.Brandeau Department of Management Science and Engineering Stanford UniversityStanfordCAUSA

Structural assumptions in infectious disease models,such as the choice of network or compartmental model type or the inclusion of different types of heterogeneity across individuals,might affect model predictions as much as or more than the choice of input *** explore the potential implications of structural assumptions on HIV model predictions and policy *** illustrate the value of inference robustness assessment through a case study of the effects of a hypothetical HIV vaccine in multiple population subgroups over eight related transmission models,which we sequentially modify to vary over two dimensions:parameter complexity(e.g.,the inclusion of age and HCV comorbidity)and contact/simulation complexity(e.g.,aggregated compartmental ***/disaggregated compartmental *** models).We find that estimates of HIV incidence reductions from network models and individual compartmental models vary,but those differences are overwhelmed by the differences in HIV incidence between such models and the aggregated compartmental models(which aggregate groups of individuals into compartments).Complexities such as age structure appear to buffer the effects of aggregation and increase the threshold of net vaccine effectiveness at which aggregated models begin to overestimate *** differences introduced by parameter complexity in estimated incidence reduction also translate into substantial differences in cost-effectiveness *** complexity does not appear to play a consistent role in differentiating the projections of network models.

关键词： HIV transmission HIV vaccine Structural sensitivity analysis Inference robustness assessment Network model Dynamic compartmental model

Invasive European frogbit(Hydrocharis morsus-ranae L.)in North America:an updated review 2003-16

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Journal of Plant Ecology 2018年第1期11卷 17-25页

作者： Bin Zhu cora.C.ottaviani Rahmat Naddafi Zhicong Dai Daolin Du Department of Biology University of Hartford200 Bloomfield AvenueWest HartfordCT 06117USA Department of Aquatic Resources Institute of Coastal ResearchSwedish University of Agricultural Sciences74242ÖregrundUppsala CountySweden Institute of Environment and Ecology Jiangsu University301 Xuefu RoadZhenjiangJiangsu 212013China

Aims European frogbit(Hydrocharis morsus-ranae L.)is an aquatic plant originating from Europe that has emerged as an invasive species,spreading in the USA and Canada since it was first brought to North America in *** can now be found in many water bodies,from small ponds and long rivers to large lakes such as Lake ontario and Lake *** continuous spread of this spe-cies indicates its success as an invasive species despite legisla-tive attempts to limit its *** et al.(Catling PM,Miltrow G,Haber E,et al.(2003)The biology of Canadian *** morsus-ranae *** J Plant Sci 83:1001-16)wrote a thorough review about this invasive species in North *** review aims for a compilation of the most recent available data and recent studies on ***-ranae *** focuses primarily on its environmental uses,ecological impacts and *** purpose of this review is to offer an organ-ized and updated report on European frogbit that can be used towards future studies with the goal of eradicating this invasive species and providing insights on management of other invasive *** Findings our findings reveal that European forgbit’s ecological effects on other species and the invaded environment were shown to be less harmful than previously *** frogbit had negative impacts on native plants and reduced dissolved oxygen ***,water chemistry,phytoplankton and zooplankton communities were actually not affected by European *** fungi,bacteria and macroinvertebrates,studies have showed complex and sometimes conflicting *** also specifically discussed the new method to control this species using shading and the more recent studies on biological *** with a shade cloth has been shown to effectively remove European frogbit and had minor environmental ***,using biological control to combat the spread of the invasive frogbit seems not as successful as we wished.

关键词： European frogbit invasive plants ecological impacts biological control shading

The American Heart Association’s Get With the Guidelines(GWTG)-Stroke development and impact on stroke care

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Stroke & Vascular Neurology 2017年第2期2卷 94-105页

作者： cora.H ormseth Kevin N Sheth Jeffrey L Saver Gregg C Fonarow Lee H Schwamm Neurology Yale University School of MedicineNew HavenConnecticutUSA Department of Neurology UCLA Medical CenterLos AngelesCaliforniaUSA Department of Cardiology UCLA Medical CenterLos AngelesCaliforniaUSA Department of Neurology Massachusetts General HospitalBostonMassachusettsUSA

The American Heart Association’s Get With the Guidelines(GWTG)-Stroke programme has changed stroke care delivery in the USA since its establishment in *** is a voluntary registry and continuous quality improvement initiative that collects data on patient characteristics,hospital adherence to guidelines and inpatient *** of the programme saw increased provision of evidence-based care and improved patient *** review will describe the development of the programme and discuss the impact on stroke outcomes and transformation of stroke care delivery that followed its implementation.

关键词： impact programme

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Kodak＇s Magic Marker

空中英语教室（高级版．彭蒙惠英语） 2009年第4期 20-21页

作者： cora.Daniels

GRK5 is an essential co-repressor of the cardiac mineralocorticoid receptor and is selectively induced by finerenone

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World Journal of Cardiology 2022年第4期14卷 220-230页

作者： Celina M Pollard Malka S Suster Natalie cora.Alexandra M Carbone Anastasios Lymperopoulos Laboratory for the Study of Neurohormonal Control of the Circulation Department of Pharmaceutical Sciences(Pharmacology)College of PharmacyNova Southeastern UniversityFort LauderdaleFL 33328-2018United States

BACKGRoUND In the heart,aldosterone(Aldo)binds the mineralocorticoid receptor(MR)to exert damaging,adverse remodeling-promoting *** recently showed that G protein-coupled receptor-kinase(GRK)-5 blocks the cardiac MR by directly phosphorylating it,thereby repressing its transcriptional *** antagonist(MRA)drugs block the cardiac MR reducing morbidity and mortality of advanced human heart ***-steroidal MRAs,such as finerenone,may provide better cardio-protection against Aldo than classic,steroidal MRAs,like spironolactone and *** To investigate potential differences between finerenone and eplerenone at engaging GRK5-dependent cardiac MR phosphorylation and subsequent *** We used H9c2 cardiomyocytes,which endogenously express the MR and *** GRK5 phosphorylates the MR in H9c2 cardiomyocytes in response to finerenone but not to *** eplerenone,finerenone alone potently and efficiently suppresses cardiac MR transcriptional activity,thus displaying inverse ***5 is necessary for finerenone’s inverse agonism,since GRK5 genetic deletion renders finerenone incapable of blocking cardiac MR transcriptional *** alone does not fully suppress cardiac MR basal activity regardless of GRK5 expression ***,GRK5 is necessary for the antiapoptotic,anti-oxidative,and anti-fibrotic effects of both finerenone and eplerenone against Aldo,as well as for the higher efficacy and potency of finerenone at blocking Aldo-induced apoptosis,oxidative stress,and *** Finerenone,but not eplerenone,induces GRK5-dependent cardiac MR inhibition,which underlies,at least in part,its higher potency and efficacy,compared to eplerenone,as an MRA in the ***5 acts as a co-repressor of the cardiac MR and is essential for efficient MR antagonism in the myocardium.

关键词： Aldosterone Cardiac myocyte Finerenone G protein-coupled receptor kinase-5 Mineralocorticoid receptor antagonist Signal transduction

Ready to migrate?Reading cellular signs of migration in an epithelial to mesenchymal transition model

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BIoCELL 2022年第11期46卷 2353-2356页

作者： TAMARA FERNÁNDEZ-CALERo IGNACIo LÓPEZ MARCoS DAVYT cora.CHALAR RICARDo EHRLICH MÓNICA MARÍN Biochemistry-Molecular Biology Faculty of ScienceUniversidad de la RepúblicaMontevideo11400Uruguay Bioinformatics Unit Institut Pasteur de MontevideoMontevideo11400Uruguay Departamento de Ciencias Exactas y Naturales Universidad Católica del UruguayMontevideo11600Uruguay Institut Pasteur de Montevideo Montevideo11400Uruguay

The epithelial to mesenchymal transition(EMT)is a cellular program that drives de-differentiation of cells in both physiological and pathological *** of the characteristics of cells describing an EMT is the(re)acquisition of a motility capacity that allows them to migrate through the original tissue as well as to other sites in the *** molecular mechanisms that control the EMT are rapidly emerging and here we add to the idea that the adaptation required for cells to commit to the EMT includes adjustments of the translation machinery and metabolic pathways to cope with a high demand of extracellular components.

关键词： EMT Migration Translation machinery Metabolism