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全身性脑膜炎球菌菌血症儿童纤溶酶原激活物抑制剂1基因中的4G/5G启动因子多态现象

世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 18-18页

作者： Geishofer G. Binder A. mller m. W. Zenz 贺莉 Department of General Paedi atrics Medical University of Graz Auenbruggerplatz 30 8036 Graz Austria

meningococcal disease may present as sepsis, meningitis or a combination of bo th. Impaired fibrinolysis and massive elevation of the plasminogen activator inh ibitor-1 (PAI-1) is a characteristic feature of meningococcal sepsis. Previous ly, an association between mortality and the functional 4G/5G promoter polymorph ism of the PAI-1gene in a cohort of UK and Dutch children with meningococcal se psis was reported. We carried out a prospective, multicentre study to investigat e the association of the 4G/5G PAI-1 polymorphism, diagnosis, and outcome in me ningococcal disease in a Central European and UK population. Blood samples and c linical information of 347 previously healthy children with meningococcal infect ion were collected from 95 paediatric hospitals in Germany, Switzerland, Italy, the United Kingdom, and Austria from 2000 until 2002. mortality was significantl y associated with the 4G/4G genotype (12 of 90 (13%) vs. 15 of 240 (6%), P =0. 037), resulting in an odds ratio of 2.31. The diagnosis of sepsis (independent o f symptoms of meningitis) was significantly more frequent in carriers of the 4G/ 4G genotype (P =0.01), resulting in an odds ratio of 2.21 to develop sepsis. men ingitis was not associated with the PAI-1 4G/5G polymorphism, and allele freque ncies were similar in patient and control groups. Conclusion:Our data show a cor relation between the 4G/4G genotype in the plasminogen activator inhibitor-1 ge ne and poor outcome in children with meningococcal infection. In addition, 4G ho mozygous patients were prone to develop sepsis. We found no influence of the pla sminogen activator inhibitor-1 polymorphism on the susceptibility to invasive m eningococcal infection.

关键词：脑膜炎球菌菌血症多态现象启动因子感染性疾病脓毒症临床信息机能减退血液样本儿童医院

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8%氯倍他索甲涂液治疗银屑病甲:10例患者的治疗经验

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世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 14-14页

作者： Regaa m.S. Ezquerra G.m. millet P.U. mateos F.L. 崔荣 Psoriasis Center Department of Dermatology Hospital Sagrat Cor C/Pars 83- 87 08029 Barcelona Spain

Background: Treatment of nail psoriasis is difficult. Several topical therapies have been employed with poor results because drug penetration is limited in this localization. Recently, a new formulation containing 8% clobetasol- 17-propionate in a colourless nail lacquer vehicle has shown good results in the control of nail psoriasis. Objective: To determine the efficacy and safety of 8% clobetasol- 17-propionate in a lacquer vehicle in nail psoriasis. methods: Ten patients with both nail bed and matrix psoriasis were included in the study. They were treated with a colourless nail lacquer containing 8% clobetasol- 17-propionate that was applied once daily for 21 days and then twice weekly for 9 months. Results: Within 4 weeks of therapy there was a reduction of all the nail alterations, including nail pain. Therapeutic response was directly related to the length of therapy. The nail parameters that responded best to therapy were onycholysis, pitting and salmon patches. Subungual hyperkeratosis and splinter haemorrhages on the other hand had moderate and poor improvement, respectively. The treatment was well tolerated in all of the patients and there were no local (i.e. atrophy and sobreinfection) or systemic secondary effects. Conclusions: The formulation containing 8% clobetasol- 17-propionate is a safe, effective and cosmetically highly acceptable treatment for nail bed and matrix psoriasis.

关键词：丙酸氯倍他索银屑病甲治疗经验患者治疗反应新型制剂治疗时间穿透性安全性

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流行性出血热内生肌酐清除率的检测与临床意义

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中华内科杂志 1987年第8期26卷 458-460+509页

作者：袁光辉管美英巫振欧周文华张天衡王德芳刘新梅 Huggins John W. Cosgriff Thomas m. Smith Joseph I. 湖北医学院附属第一医院传染病教研室湖北医学院出血热实验室湖北省武昌县人民医院传染科湖北省成宁市人民医院传染科美国陆军军事医学传染病研究所

本文对46例各型流行性出血热(EHF)患者各期进行了内生肌酐清除率(Ccr)的动态检测。结果表明, Ccr的检测, 能在早期发现肾功能受损并能监测肾功能恢复, 对中、重型患者尤为明显。根据Ccr在发热期即开始下降, 至低血压期、少尿期达最低值,... 详细信息

本文对46例各型流行性出血热(EHF)患者各期进行了内生肌酐清除率(Ccr)的动态检测。结果表明, Ccr的检测, 能在早期发现肾功能受损并能监测肾功能恢复, 对中、重型患者尤为明显。根据Ccr在发热期即开始下降, 至低血压期、少尿期达最低值, 以后逐渐回升的动态变化, 表明Ccr降低与病情轻重呈正相关。在恢复期患者出院时Ccr均值未恢复正常者达27.5%。

关键词：肌酸酐/血液肾综合征出血热/血液

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微粒填充夹层复合材料的处理及其在低速冲击荷载下的响应

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钢结构 2008年第7期23卷 84-84页

作者： Hosur m.V. mohammed A.A. Zainuddin S. Jeelani S.

制作普通的和带有微粒泡沫核的3层碳纤维环氧复合夹芯板，普通的和带有Nanocor I-28E微粒泡沫核的重量比为0．5％和1％。通过注射树脂成型制造夹芯板，将含量为1％～2％质量微粒的SC-15环氧注入到3层碳编织布中的方法制作面层。从复合... 详细信息

制作普通的和带有微粒泡沫核的3层碳纤维环氧复合夹芯板，普通的和带有Nanocor I-28E微粒泡沫核的重量比为0．5％和1％。通过注射树脂成型制造夹芯板，将含量为1％～2％质量微粒的SC-15环氧注入到3层碳编织布中的方法制作面层。从复合板上切割出100mm×l00mm尺寸的样本，采用冲击试验设备，进行低速冲击荷载试验，记录样本的冲击响应并进行比较。然后，将试验样本分成两半，采用扫描仪、光学电子显微镜进行扫描以确定破坏模式。与普通的对应部分相比，带有微泡沫的样本可以承受较高荷载及具有较少的破坏区域。微泡沫核显示出脆性特性。

关键词：微复合材料夹芯板结构低速冲击破坏模式

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39例不典型腔隙综合征患者的临床研究

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世界核心医学期刊文摘（神经病学分册） 2006年第6期2卷 42-42页

作者： Arboix A. López-Grau m. Casasnovas C. 张慧 Cerebrovascular Division Department of Neurology Hospital Universitari del Sagrat Cor Viladomat 288 E-08029 Barcelona Spain Dr.

The aim of this study was to describe the clinical characteristics of atypical lacunar syndrome (ALS) based on data collected from a prospective acute stroke registry. In total, 2500 acute stroke patients were included in a hospital based prospective stroke registry over a 12 year period, of whom 39 were identified as having ALS and radiologicallly proven (by computed tomography or magnetic resonance imaging) lacunes. ALS accounted for 1.8%of all acute stroke patients, 2.1%of acute ischaemic stroke, and 0.8%of lacunar syndromes. ALS included dysarthria facial paresis (n = 12) or isolate dysarthria (n = 9), isolated hemiataxia (n = 4), pure motor hemiparesis with transient internuclear ophthalmoplegia (n = 4), pure motor hemiparesis with transient subcortical aphasia (n = 3), unilateral (n = 2) or bilateral (n = 3) paramedian thalamic infarct syndrome, and hemichorea hemiballismus (n = 2). Atypical lacunar syndromes were due to small vessel disease in 96%of patients. Atherothrombotic infarction occurred in one patient and cardioembolic infarct in another, both presenting pure dysarthria. Outcome was good (in hospital mortality 0%, symptom free at discharge 28.2%). After multivariate analysis, the variables of speech disturbances, nausea/vomiting, ischae mic heart disease, and sensory symptoms were found to be significantly associated with ALS. In conclusion, atypical lacunar syndrome is an infrequent stroke subtype (one of each 14 lacunar strokes). ALS occurred in 6.8%of lacunar strokes. Isolated dysarthria or dysarthria facial paresis were the most frequent presenting forms. The prognosis of this infrequent non-classic lacunar syndrome is good .

关键词：腔隙综合征卒中患者动脉粥样硬化性血栓性脑梗死临床研究偏侧舞蹈症核间性眼肌麻痹构音障碍心源性梗死腔隙性卒中

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观察冠状动脉疾病病人心肌灌注:320-mDCT与82Rb PET的比较

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国际医学放射学杂志 2018年第4期 500-500页

作者： R.N.Jr Dantas A.N.Jr Assuncao I.A.marques m.G.Fahel C.H.Nomura L.F.R.Avila 吴迪 Computed Tomography Department Heart InstituteIn-CorUniversity of Sao Paulo Medical School

目的尽管CT多期相mPI在无创性心肌灌注成像（mPI）评估方面取得了进展,但其方案尚未与高度精确的82Rb PET mPI进行比较。故本研究旨在评估82Rb PET和320层CT（320-CT）mPI在疑似CAD病人中使用多期相方案的一致性。方法前瞻性纳入44例参... 详细信息

目的尽管CT多期相mPI在无创性心肌灌注成像（mPI）评估方面取得了进展,但其方案尚未与高度精确的82Rb PET mPI进行比较。故本研究旨在评估82Rb PET和320层CT（320-CT）mPI在疑似CAD病人中使用多期相方案的一致性。方法前瞻性纳入44例参加mPI评估并接受双嘧达莫应激82Rb PET和多期相320-CT mPI（压力期间连续5次容积采集）的病人。统计分析使用R软件进行。结果总和压力评分≥4（κ=0.77,95%CI:0.55～0.98,PmPI和82Rb PET mPI对于评估中度危险性的可疑CAD病人,两者间存在一致性,多期相320-CT mPI方案是可行的,可诊断并且具有相对较低的辐射照射量。

关键词： PET mPI CAD Rb PET

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HEmIVEIN PULSATION CHANGES cor- RELATE WITH SITE OF VISUAL FIELD LOSS IN GLAUCOmA

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国际眼科杂志 2003年第1期3卷 123-123页

作者： W.H.morgan m.L.Hazelton C.Balaratnasingem P.H.House D-Y.Yu S.J.Cringle R.Townsend University of Western Australia AustraliaUniversity of Western Australia AustraliaUniversity of Western Australia AustraliaUniversity of Western Australia AustraliaUniversity of Western Australia AustraliaUniversity of Western Australia AustraliaUniversity of Western Australia Australia

Aim: The occurrence of optic disk rim haemorrhages and association with venous occlusions suggest that vascular problems, perhaps involving the veins occur in glaucoma Downstream narrowing of the retinal veins is known to cause an increase in IOP required to induce venous pulsation. methods: Humphrey 24-2 SITA standard visual field records were examined calcu-

关键词：青光眼视野损害半静脉搏动相关性静脉阻滞视神经盘

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与进行性核上性麻痹患者区域性脑萎缩相关的临床异常

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 2-2页

作者： cordato N.J. Duggins A.J. Halliday G.m. 邢咏新 Department of Geriatric medicine Westmead Hospital Westmead NSW 2145 Australia Dr.

most cerebral imaging studies of patients with progressive supranuclear palsy (PSP) have noted subtle atrophy, although the full extent of atrophy and any cor relates to clinical features have not been determined. We used voxel-based morp hometry analysis of grey matter, white matter and CSF on mRI brain scans to map the statistical probability of regional tissue atrophy in 21 patients with PSP, 17 patients with Parkinson’s disease and 23 controls. PSP and Parkinson’s dise ase cohorts were selected to approximate the mid-stages of their respective dis ease courses. Where regions of significant tissue atrophy were identified in a d isease group relative to controls, the probability of tissue loss within those r egions was correlated with global indices of motor disability, and behavioural a nd cognitive disturbance for that disease group. minimal regional atrophy was ob served in Parkinson’s disease. PSP could be distinguished from both controls an d Parkinson’s disease by symmetrical tissue loss in the frontal cortex (maximal in the orbitofrontal and medial frontal cortices), subcortical nuclei (midbrain , caudate and thalamic) as well as periventricular white matter. For PSP, motor deficits correlated with atrophy of the caudate and motor cingulate, while behav ioural changes related to atrophy in the orbitofrontal cortex and midbrain. Thes e data suggest that intrinsic neurodegeneration of specific subcortical nuclei a nd frontal cortical subrogions together contribute to motor and behavioural dist urbances in PSP and differentiate this disorder from Parkinson’s disease within 2-4 years of symptom onset.

关键词：脑萎缩核上性麻痹运动障碍神经核影像学检查尾状核神经元变性额叶皮质皮质下额叶皮层

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乌克兰地盾西南部麻粒岩杂岩体的构造与变质演化

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世界地质 1991年第1期 41-41页

作者： V.V.Fed'kin I.V.Lavrent'eva V.m.Venidiktov 吴福元

本文展示了乌克兰地盾西南部麻粒岩杂岩体中高铝镁铁质岩的复杂构造—岩石学研究成果。运用构造-岩石学方法进行详细的地质研究,可将本区划分成三个构造变质旋回。第一旋回的变质建造主要以小型的被强烈改造的形式（残留体、“捕虏体”... 详细信息

本文展示了乌克兰地盾西南部麻粒岩杂岩体中高铝镁铁质岩的复杂构造—岩石学研究成果。运用构造-岩石学方法进行详细的地质研究,可将本区划分成三个构造变质旋回。第一旋回的变质建造主要以小型的被强烈改造的形式（残留体、“捕虏体”）存在于其后的变质建造之中,由泥质、变泥质和变基性片麻岩组成。其Fe—mg矿物的mg/（mg+Fe）比值最高。变泥质岩的共生矿物有:Gr、Hyp、cor、Bi、Pl,Fsp、Sp,Q和mt;变基性岩为Cpx、Hyp、Hb、Bi、Pl、Q和mt。黑云母含钛量变化较大,尖晶石含7％ZnO,Cr2O3含量小于2％。麻粒岩杂岩体基底由第二系第三旋回的岩石组成,分别代表进变质和退变质岩系。Fe—mg矿物中镁的含量逐渐降低,在旋回Ⅱ中中

关键词：麻粒岩杂岩变泥质岩地盾地台西南部共生矿物变质旋回岩石学变基性岩电子光学仪器电子探针乌克兰

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帕金森病“关”期间的步态僵硬和颞叶分辨阈值的关系研究

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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 48-48页

作者： Lee m.-S. Kim H.-S. Lyoo C.-H. 邓剑平 Department of Neurology Youngdong Severance Hospital 146-92Dogok-dong Kangnam-gu Seoul South Korea Dr.

Objective: To investigate the relationship between temporal discrimination thr eshold (TDT) and “off" period gait freezing(OGF) in patients with fluctuating P arkinson disease (PD).methods: TDT values were measured at the dorsum of the toe s in 11 control subjects and 22 patients with PD with a wearing off phenomenon ( 16 patients with OGF and 6 patients without OGF). Results: During the L-dopa “ off" period, TDT values increased abnormally in both patient groups but were sig nificantly higher in patients with OGF than in those without OGF. A positive cor relation was found between the severity of OGF and TDT values measured by differ ent point stimulation. In patients with OGF, a single dose of L-dopa treatment normalized TDTvalues and ameliorated OGF. Conclusions: Dopa-responsive abnormal discriminative sensory processing may be a possible cause of “off" period gait freezing observed in patients with fluctuating Parkinson disease.

关键词：帕金森病步态僵硬分辨阈左旋多巴 stimulation abnormal 背侧不稳定性 fluctuating 感觉异常

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