检索结果-南通市图书馆

Open Journal of Epidemiology 2024年第3期14卷 471-479页

作者： Peter Masikini Irene constantine Stanley Mwita department of Internal Medicine Catholic University of Health and Allied Sciences Mwanza Tanzania department of Pharmaceutics and Pharmacy Practice Catholic University of Health and Allied Sciences Mwanza Tanzania

Introduction: Obesity, excessive alcohol use, cigarette smoking, a lack of physical activity, stress, and an unhealthy diet are modifiable risk factors linked to hypertension. Non-modifiable risk factors for hypertension include older age and a family history of hypertension. The purpose of this study was to assess university students’ knowledge of hypertension risk factors. Methods: This was a cross-sectional study conducted at St. Augustine University of Tanzania. A pre-tested, semi-structured questionnaire was used to collect data. Out of a total score of eight, a score of four or more was considered good knowledge, and a score of less than four was considered poor. All sociodemographic characteristics were included in logistic regression to calculate the adjusted odds ratio. Results: A total of 390 undergraduate students participated in this study. Most of the participants 266 (68.2%) identified stress as a risk factor for hypertension. The median (IQR) knowledge score was 2 (2 - 3). Overall, only 43 (11.0%) of the participants had good knowledge of risk factors for hypertension. However, none of the sociodemographic factors were associated with a good level of knowledge of risk factors for hypertension. Conclusion: Our findings highlight poor knowledge of modifiable and non-modifiable risk factors for hypertension among university students in northwestern Tanzania. Only stress and older age were known by more than half of the students as risk factors for hypertension. To reduce the burden of hypertension, it is crucial for prevention and control programs to target improving university students’ knowledge of risk factors for hypertension.

关键词： Knowledge Risk Factors Hypertension University Students Tanzania

Bendamustine and rituximab as frontline therapy in extranodal marginal zone lymphoma:a single-institution experience

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第6期32卷 1031-1036页

作者： constantine N.LOGOTHETIS NATHAN P.HORVAT TONY KURIAN CELESTE BELLO JULIO CHAVEZ LEIdY ISENALUMHE BIJAL SHAH LUBOMIR SOKOL HAYdER SAEEd JAVIER PINILLA SAMEH GABALLA department of Internal Medicine University of South FloridaTampaFL33602USA College of Medicine University of South Florida MorsaniTampaFL33602USA H.Lee Moffitt Cancer Center and Research Institute TampaFL33612USA

Extranodal marginal zone lymphoma(EMZL)encompasses 70%of cases of marginal zone *** bendamustine and rituximab(BR)were derived from trials involving other indolent non-Hodgkin’s *** one trial has evaluated frontline BR prospectively in *** retrospective study reports outcomes among EMZL patients receiving frontline ***-five patients were included with a median age of 69 years(40–81).Five(20.0%)patients had stage Ⅰ/Ⅱ disease,and 20(80.0%)had stage Ⅲ/Ⅳ *** median number of cycles was 6.0(3.0–6.0).Maintenance rituximab was administered to 10(41.7%)*** response rate(ORR)was 100.0%(60.0%complete response,40.0%partial response).Medians of overall survival and progression-free survival were not *** estimated 2-year progression-free survival was 85.2%and overall survival was 100.0%.Four(16.6%)patients had infections related to treatment;3(12.0%)transformed to diffuse large B-cell lymphoma;5(20.8%)had a relapse or progression of EMZL;and 3(12.0%)died unrelated to *** is an efficacious and well-tolerated front-line regimen for EMZL with response data consistent with existing literature.

关键词： Extranodal marginal zone lymphoma Bendamustine Rituximab Front-line therapy

Protective effects of cyclosporine and its analog NIM-811 in a murine model of hepatic ischemia-reperfusion injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Liver Research 2024年第1期8卷 46-53页

作者： Joshua Hefler Rena Pawlick Braulio A.Marfil-Garza Aducio Thiesen Nerea Cuesta-Gomez Sanaz Hatami darren H.Freed constantine Karvellas david L.Bigam A.M.James Shapiro department of Surgery Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada department of Medicine Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada CHRISTUS-LatAm Hub Excellence&Innovation Center MonterreyMexico Alberta diabetes Institute University of AlbertaEdmontonABCanada Clinical Islet Transplant Program University of AlbertaEdmontonABCanada department of Laboratory Medicine&Pathology Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada

Background and aim:The liver is susceptible to ischemia-reperfusion injury(IRI)during hepatic surgery,when the vessels are compressed to control bleeding,or liver transplantation,when there is an obligate period of *** hallmark of IRI comprises mitochondrial dysfunction,which generates reactive oxygen species,and cell death through necrosis or ***(CsA),which is a well-known immunosuppressive agent that inhibits calcineurin,has the additional effect of inhibiting the mito-chondrial permeability transition pore(mPTP),thereby,preventing mitochondrial swelling and ***-811,which is the nonimmunosuppressive analog of CsA,has a similar effect on the *** this study,we tested the effect of both agents on mitigating warm hepatic IRI in a murine *** and methods:Before ischemic insult,the mice were administered with intraperitoneal normal saline(control);CsA at 2.5,10,or 25 mg/kg;or NIM-811 at 10 mg/***,the mice were subjected to partial warm hepatic ischemia by selective pedicle clamping for 60 min,followed by 6 h of recovery after *** alanine transaminase(ALT)was measured,and the liver tissue was examined histologically for the presence of apoptosis and the levels of inflammatory ***:Compared with the control mice,the mice treated with 10 and 25 mg/kg of CsA and NIM-811 had significantly lower ALT levels(Pd 0.031,respectively).Moreover,the liver tissue showed reduced histological injury scores after treatment with CsA at 2.5,10,and 25 mg/kg and NIM-811(P=0.041,d 0.043,respectively)and significant decrease in apoptosis after treatment with CsA at all doses(P=0.012,0.007,andd keratinocyte chemoattractant/human growth-regulated oncogene significantly decreased in the mice treated with the highest dose of CsA(25 mg/kg)than those in the control ***

关键词： Cyclosporine(CsA) Cyclosporine analogue Liver surgery Ischemia-reperfusion injury(IRI) Animal model NIM-811

Potential driving Systems Associated with Extreme Rainfall across East Africa during October to december (ONd) Season 2019

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geoscience and Environment Protection 2024年第7期12卷 25-49页

作者： constantine Ingeri Wang Wen Joseph Ndakize Sebaziga Vedaste Iyakaremye Samuel Ekwacu Prosper Ayabagabo Anthony Twahirwa Jonah Kazora School of Atmospheric Sciences Nanjing University of Information Science and Technology Nanjing China Rwanda Meteorology Agency (Meteo Rwanda) Kigali Rwanda School of Science and Technology University of Rwanda (UR-CST) Kigali Rwanda Climate and Clean Air Coalition Secretariat Paris France Rwanda Environment Management Authority (REMA) Kigali Rwanda Uganda National Meteorological Authority (UNMA) Kampala Uganda department of Earth and Climate Science University of Nairobi Nairobi Kenya

The East African (EA) region highly experiences intra-seasonal and inter-annual variation in rainfall amounts. This study investigates the driving factors for anomalous rainfall events observed during the season of October-November-december (ONd) 2019 over the region. The study utilized daily rainfall data from Climate Hazards Group InfraRed Precipitation with Station data Version 2 (CHIRPSv2) and the driving systems data. Statistical spatiotemporal analysis, correlation, and composite techniques were performed to investigate the teleconnection between ONd 2019 seasonal rainfall and global synoptic climate systems. The findings showed that the ONd 2019 experienced seasonal rainfall that was twice or greater than its seasonal climatology and varied with location. Further, the ONd 2019 rainfall showed a positive correlation with the Indian Ocean dipole (IOd) (0.81), Nino 3 (0.51), Nino 3.4 (0.47), Nino 4 (0.40), Pacific decadal Oscillation (PdO) (0.22), and North Tropical Atlantic (NTA) (0.02), while El Nino-Southern Oscillation (ENSO) showed a negative correlation (−0.30). The region was dominated by southeasterly warming and humid winds that originated from the Indian Ocean, while the geopotential height, vertical velocity, and vorticity anomalies were closely related to the anomalous rainfall characteristics. The study deduced that the IOd was the major synoptic system that influenced maximum rainfall during the peak season of ONd 2019. This study therefore provided insights on the diagnosis study of ONd 2019 anomalous rainfall and its attribution over the EA. The findings of the study will contribute to improvements in forecasting seasonal rainfall by regional climate centers and national meteorological centers within the region.

关键词： East Africa driving Climate Systems October-November-december (ONd) 2019 Rainfall

Influence of an External dC Electric Current on Plasma Cleaning Rate: an Application on the Enlarged Plasma-Surface Theor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plasma Science and Technology 2013年第5期15卷 448-454页

作者： constantine L. XAPLANTERIS Eleni d. FILIPPAKI Plasma Physics Lab IMS NCSR "Demokritos" Hellenic Military Academy

during the last decades many researchers have been occupied with other plasma applications apart from the big challenge which the thermonuclear fusion poses. Many experiments have been carried out on the plasma behavior in contact with a solid surface; when the surface material consists of chemical compounds （e.g. oxides of metals）, then the plasma chemistry takes place. The present paper contains the final experimental and theoretical work of Plasma Laboratory at ＂demokritos＂, which consists of an elaboration of plasma sheath parameters adapted to experimental conditions, a suitable choice of plasma gases （either H 2 or N 2 ）, and an electric po-tential current enforcement on objects. Additionally, a brief theory is given to explain the results, with a short reference to both boundary phenomena in thermonuclear reactors and low pressure plasma of glow discharges, so as to reveal the similarities and differences of these two cases. An extensive examination of the treated objects by X-ray diffraction method （XRd） gives results in agreement with the theoretical predictions. Using this improvement on plasma restoration system, （a combination of electric current on metallic object into suitable plasma）, it is shown that better results can be achieved on the cleaning and conservation of archaeological objects.

关键词： impurities plasma sheath parameters reduction of surfaces external poten-tial treatment rate

Pathophysiology of increased intestinal permeability in obstructive jaundice

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第48期13卷 6458-6464页

作者： Stelios F Assimakopoulos Chrisoula d Scopa constantine E Vagianos department of Internal Medicine School of Medicine University of Patras department of Pathology School of Medicine University of Patras 1~(st) Surgical department "Saint Panteleimon" General Hospital of Nikaia

despite advances in preoperative evaluation and postoperative care, intervention, especially surgery, for relief of obstructive jaundice still carries high morbidity and mortality rates, mainly due to sepsis and renal dysfunction. The key event in the pathophysiology of obstructive jaundice-associated complications is endotoxemia of gut origin because of intestinal barrier failure. This breakage of the gut barrier in obstructive jaundice is multi-factorial, involving disruption of the immunologic, biological and mechanical barrier. Experimental and clinical studies have shown that obstructive jaundice results in increased intestinal permeability. The mechanisms implicated in this phenomenon remain unresolved, but growing research interest during the last decade has shed light in our knowledge in the field. This review summarizes the current concepts in the pathophysiology of obstructive jaundice-induced gut barrier dysfunction, analyzing pivotal factors, such as altered intestinal tight junctions expression, oxidative stress and imbalance of enterocyte proliferation and apoptosis. Clinicians handling patients with obstructive jaundice should not neglect protecting the intestinal barrier function before, during and after intervention for the relief of this condition, which may improve their patients’ outcome.

关键词： Obstructive jaundice Intestinal barrier Intestinal permeability Endotoxemia Bacterial translocation Tight junctions Occludin Claudin-4 Apoptosis Oxidative stress

Application and Validation of a Multi-block Constitutive Model at Landslides of the Wenchuan Earthquake

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

工程科学与技术 2018年第3期50卷 33-45页

作者： STAMATOPOULOS constantine XIONG Ke dI Baofeng Stamatopoulos and Associates Limited Liability Company 5 Isavron Street Athens 114-71 Greece &Hellenic Open University Parodos Aristotelous 18 Patra 26335 Greece Institute for disaster Management and Reconstruction Sichuan University Chengd

A multi-block model and a corresponding computer program have been developed which predict the kinematics of ***,a unique event for studying different models simulating the triggering and movement of landslides is the 2008Wenchuan earthquake in the mountainous region in Sichuan Province of China,which caused a large number of rapid *** purpose of the paper is two-fold:(a)to propose and incorporate into the multi-block model constitutive relations predicting soil response along slip surfaces,and(b)to apply the multi-block model with the constitutive relations at landslides triggered by the Wenchuan *** proposed constitutive equations predict the shape of the shear stress-displacement response measured in ring shear *** the application,four landslides caused by the Wenchuan earthquake were *** in one of these landslides the shear resistance-displacement response along the slip surface has been measured in laboratory *** this landslide,the triggering and movement of the landslide was *** the other landslides,back analyses were performed and it was observed that the multi-block model predicted reasonably well the final configuration of all *** addition,as the measured and back-estimated total friction angle of all landslides was less than 180,and the materials along the slip surface were sandy,it is inferred that some,or all of the slip surface during these slides was sheared in an undrained manner and excess pore pressures generated during sliding played a key role in the triggering and movement of these ***,the paper(A)proposed and validated a multi-block constitutive model which can be applied to predict the triggering and movement of earthquake-induced slides and(B)by analyzing four landslides of the 2008 Wenchuan earthquake,it concludes that some,or all of the slip surface during these slides,was sheared in an undrained manner and excess pore pressures generated during s

关键词： Wenchuan earthquake multi-block model seismic displacement landslides back analysis strain softening

Wave Fans are Special

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2008年第3期24卷 369-374页

作者： constantine M.dafermos division of Applied Mathematics Brown UniversityProvidenceRI 02912USA

It is shown that self-similar BV solutions of genuinely nonlinear strictly hyperbolic systems of conservation laws are special functions of bounded variation, with vanishing Cantor part.

关键词： Hyperbolic conservation laws self-similar solutions special functions of bounded variation

STRONG SHOCKS IN NONISENTROPIC GAS dYNAMICS

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Scientia 2009年第4期29卷 973-979页

作者： constantine M. dafermos division of Applied Mathematics Brown University

In nonisentropic gas dynamics, with general equations of state, strong cornpressive shocks satisfying the Liu E-condition may violate the Second Law of thermodynamics.

关键词： gas dynamics entropy Lax E-condition Liu E-condition