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Steroidogenic Effects and Phytochemical Profile of Aqueous Extract of Tetracarpidium conophorum (Mull. Arg.) & Hutch Kernels in Male Rats

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Journal of Biosciences and Medicines 2023年第10期11卷 156-167页

作者： Herman Akassa Bonaventure Max Lazare Peneme constantin moukouma Dieu-Merci Bevel Gallo Mongo Rachie Osandze Arnaud Wilfrid Etou Ossibi Ange Antoine Abena Laboratory of Biochemistry and Pharmacology Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo Laboratory of Animal Physiology Faculty of Science and Technology Marien Ngouabi University Brazzaville Republic of the Congo Departement of Pharmacopeia and Traditional Medicine National Institute for Research in Health Sciences (IRSSA) Brazzaville Republic of the Congo Chemistry Unit of the Plant and Life Faculty of the Sciences and Techniques Marien Ngouabi University Brazzaville Republic of the Congo Faculty of Applied Sciences Denis Sassou Nguesso University Kintelé Republic of the Congo

The main aim of this study was to evaluate the steroidogenic effects and phytochemical profile of aqueous extract of Tetracarpidium conophorum in male rats. Assays of biochemical reproductive parameters (total cholesterol, serum testosterone, FSH and LH) were carried out using Cypress and ELISA kits respectively. The chemical screening of the extract was conducted through tube reactions, the principle of which involves adding a reagent to a quantity of the extract, and subsequently observing the resulting reactions such as precipitation and color change. The results obtained showed that oral administration of the aqueous extract of Tetracarpidium conophorum (250 and 500 mg/kg) produced a significant increase (p Tetracarpidium conophorum kernels at the doses studied produced a very significant decrease in total cholesterol levels (p Tetracarpidium conophorum kernels could have hypocholesterolemic and steroidogenic potential. A study of the aqueous extract of Tetracarpidium conophorum on semen quality and oxidative stress parameters deserves to be conducted.

关键词： Tetracarpidium conophorum Steroidogenic Chemical Screaming

Exploring innovative synthetic solutions for advanced polymer-based electrochromic energy storage devices:Phenoxazine as a promising chromophore

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Journal of Energy Chemistry 2024年第4期91卷 433-452页

作者： Catalin-Paul constantin Mihaela Balan-Porcarasu Gabriela Lisa “Petru Poni”Institute of Macromolecular Chemistry Electroactive Polymers&Plasmochemistry Laboratory41A Grigore Ghica Voda AlleyIasi 700487Romania “Gh.Asachi”Technical University Iasi Faculty of Chemical EngineeringBd.Mangeron 71Iasi 700050Romania

The current investigation offers an innovative synthetic solution regarding electrochromic(EC)and energy storage applications by exploring phenoxazine(POZ)***,three POZ-based polymers(polyimide,polyazomethine,and polyamide)were synthesized to ascertain the superior *** polyamide exhibited remarkable attributes,including high redox stability during 500 repetitive CVs,optical contrast of 61.98%,rapid response times of 1.02 and 1.38 s for coloring and bleaching,EC efficiency of 280 cm^(2)C^(-1).and decays of the optical density and EC efficiency of only 12.18%and 6.23%after 1000 ***,the energy storage performance of polyamide PA was tested,for which the following parameters were obtained:74.7 F g^(-1)(CV,scan rate of 10 mV s^(-1))and 118 F g^(-1)(GCD,charging current of 0.1 A g^(-1)).Then,the polyamide was tested in EES devices,which yielded the following EC parameters:an optical contrast of 62.15%,response times of 9.24 and 5.01 s for coloring and bleaching,EC efficiency of 178 cm^(2)C^(-1),and moderate decays of 20.25%and 23.24%for the optical density and EC efficiency after 500 *** energy storage performance included a capacitance of 106 F g^(-1)(CV,scan rate of 0.1 mV s^(-1))and 9.23 F g^(-1)(GCD,charging current of 0.1 A g^(-1)),capacitance decay of 11.9%after500 cycles,and 1.7 V retention after 2 ***,two EES devices connected in series powered a 3 V LED for almost 30 s.

关键词： Polymers Phenoxazine Electrochromic Energy storage Electrochromi cenergy storage devices

Effect of Extending Voluntary Waiting Period on Health of Holstein Friesian Dairy Cows

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Open Journal of Veterinary Medicine 2024年第6期14卷 124-136页

作者： Găvan constantin Șonea Cosmin Research Department Agriculture Research and Development Station imnic Craiova Romania University of Agronomical Sciences and Veterinary Medicine Bucharest Bucureti Romania

The aim of this of this experimental study to investigate the effect of 3 voluntary waiting periods (VWP) on health of dairy cows. A total of 100 lactations of 100 Holstein Friesian cows with high milk production (average 9.442 ± 620 kg) were randomly (based on the ear tags digits of cows) distributed to 1 to 3 experimental groups with VWP of 50 (VWPG50;n = 32), 100 (VWPG100;n = 34) or 150 days (VWPG150;n = 34). Observations relating to diseases of the cows were made by the farm veterinarian and research personnel. Were defined eight disease: puerperal fever, retained fetal membranes, displaced abomasum, metritis, clinical ketosis, clinical mastitis, ovarian cysts, and claw diseases. The experimental days (ED) were from 4 days in milk (DIM) to 100 days after the next calving. The experiment was managed at Dairy Research Farm ?imnic-Craiova January 2018 to December 2022. A clear set of clinical signs were used to define a case at the diseases without the need for laboratory confirmation. Values of Lactational incidence risk (LIR) median postpartum days at diagnosis and pairwise comparison of proportion between VWPs were calculated. LIR for puerperal fiver, retained fetal membranes, displaced abomasum, clinical ketosis, clinical mastitis, ovarian cysts and claw disease were 4;5;2;8;8;and 4% respectively. Numerically, cows with VWP of 100 and150 days had more disease cases compared with VWP of 50 days. The differences between experimental groups of cows regarding proportions of cows with disease cases were not statistically significant. Any of the eight disorders reported in this study was analyzed independently to other health problems. For all enrolled cows (n = 100) VWP was extended until 100 or 150 days postpartum with no effect on the lactational incidence risk for the eight disorders analyzed.

关键词： Voluntary Waiting Period Dairy Cow Health Lactation Disorders Lactation Incidence Risk for Cow Diseases

Demonstrating grating-based phase-contrast imaging of laser-driven shock waves

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Matter and Radiation at Extremes 2024年第4期9卷 90-97页

作者： Leonard Wegert Stephan Schreiner constantin Rauch Bruno Albertazzi Paulina Bleuel Eric Frojdh Michel Koenig Veronika Ludwig Artem SMartynenko Pascal Meyer Aldo Mozzanica Michael Müller Paul Neumayer Markus Schneider Angelos Triantafyllidis Bernhard Zielbauer Gisela Anton Thilo Michel Stefan Funk Plasma Physics Department GSI Helmholtzzentrum fur SchwerionenforschungPlanckstraBe 164291 DarmstadtGermany Erlangen Centre for Astroparticle Physics(ECAP) Friedrich-Alexander-Universität Erlangen-NurnbergNikolaus-Fiebiger-StraBe 291058 ErlangenGermany LULI-CNRS CEASorbonne UniversitésEcole PolytechniqueInstitut Polytechnique de ParisF-91120 Palaiseau CedexFrance Paul Scherrer Institut(Psi) Forschungsstrasse 1115232VilligenSwitzerland Karlsruhe Institute of Technology Institute of Microstructure TechnologyHermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

Single-shot X-ray phase-contrast imaging is used to take high-resolution images of laser-driven strong shock *** a two-grating Talbot interferometer,we successfully acquire standard absorption,differential phase-contrast,and dark-field images of the shocked *** agreement is demonstrated between experimental data and the results of two-dimensional radiation hydrodynamics simulations of the laser-plasma *** main sources of image noise are identified through a thorough assessment of the interferometer’s *** acquired images demonstrate that grating-based phase-contrast imaging is a powerful diagnostic tool for high-energy-density *** addition,we make a novel attempt at using the dark-field image as a signal modality of Talbot interferometry to identify the microstructure of a foam target.

关键词： interaction. shock phase

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自动化技术助力绿氢安全高效生产

流程工业 2024年第5期 32-34页

作者： Veronica constantin 艾默生

自动化技术在推动向清洁燃料经济转型的过程中扮演着至关重要的角色,本文讲述了自动化技术是如何促进更安全且高效的绿氢生产。绿氢生产目前正处于其发展的初级阶段,伴随着行业的逐步探索与成长,短期内确实可能面临更为复杂的安全挑战... 详细信息

自动化技术在推动向清洁燃料经济转型的过程中扮演着至关重要的角色,本文讲述了自动化技术是如何促进更安全且高效的绿氢生产。绿氢生产目前正处于其发展的初级阶段,伴随着行业的逐步探索与成长,短期内确实可能面临更为复杂的安全挑战。氢作为一种能源载体,如同所有可燃物质一样,具有相应的潜在危险。其高度易燃的特性意味着即使氢气与空气的混合比例很低——低至空气中氢气含量达到4%时,就足以构成爆炸风险。

关键词：自动化技术经济转型能源载体潜在危险氢气含量混合比例清洁燃料安全挑战

Hydroxychloroquine-azithromycin,doubase C,and QTc prolongation in congolese patients with COVID-19:Myth or reality?

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World Journal of Virology 2024年第2期13卷 107-114页

作者： Brady Madioko Makanzu Jean-Robert Makulo Madone Ndona Mandina Dimosi Roger Wumba Murielle Mashi Longokolo Hippolyte Situakibanza Ossam Odio Donat Sonzi Mangala constantin Mihigo Bashengezi Benjamin Kabwe Mwilambwe Gilbert Kabanda Kurhenga Benjamin Longo-Mbenza Roger Mwimba Mbungu Department of Cardiology Kinshasa University HospitalKinshasaDR CongoKinshasa University HospitalKinshasa 11Congo Nephrology Unit Kinshasa University HospitalKinshasaDemocratic Republic of the CongoKinshasa 11KinshasaCongo Department of Infectious Diseases Kinshasa University HospitalKinshasaDR CongoKinshasa 11Congo Department of Tropical Medicine University of KinshasaKinshasa 11Congo Department of Infectious Diseases University of Kinshasa HospitalKinshasa 11Congo Department of Tropical Medicine and Infectious Disease School of MedicineUniversity of KinshasaKinshasa 11Congo COVID-19 Treatment Center Kinshasa University HospitalKinshasaKinshasa 11Congo Centre de Recherche en Phytothérapie Pharmacopée Africaine et Technologie pharmaceutiqueKinshasa 11Congo Intensive Care Unit Kinshasa University HospitalKinshasa 11Congo Department of Gynecology and Obstetrics Kinshasa University HospitalKinshasa 11Congo

BACKGROUND QTc interval prolongation with an increased risk of torsade de pointes(Tsd)has been described in coronavirus disease 2019(COVID-19)patients treated with hydroxychloroquine(HCQ)and azithromycin(AZI)in Western *** the DR Congo,few studies have evaluated the safety of this association or proposed new *** To determine the incidence of QTc prolongation and Tsd in COVID-19 patients treated with HCQ-AZIs vs doubase C(new molecule).METHODS In present randomized clinical trial,we have included patients with mild or moderate COVID-19 treated with either HCQ-AZI or doubase ***(ECG)changes on day 14 of randomization were determined based on pretreatment *** QTc was defined as≥500 ms on day 14 or an increase of≥80 ms compared to pretreatment *** with cardiac disease,those undergoing other treatments likely to prolong QTc,and those with disturbed ECG tracings were excluded from the *** The study included 258 patients(mean age 41±15 years;52%men;3.4%diabetics,11.1%hypertensive).Mild and moderate COVID-19 were found in 93.5%and 6.5%of patients,*** baseline,all patients had normal sinus rhythm,a mean heart rate 78±13/min,mean PR space 170±28 ms,mean QRS 76±13 ms,and mean QTc 405±30 *** complaints suggesting cardiac involvement were reported during or after *** four patients(1.5%)experienced QTc interval prolongation beyond 500 ***,only five patients(1.9%)had an increase in the QTc interval of more than 80 *** prolongation was more significant in younger patients,those with high viral load at baseline,and those receiving HCQ-AZI(P<0.05).None of the patients developed *** QTc prolongation without Tsd was observed at a lower frequency in patients treated with HCQ-AZI vs doubase *** absence of comorbidities and concurrent use of other products that are likely to cause arrhythmia may explain our results.

关键词： QTc prolongation COVID-19 Doubase C HCQ-AZT Sub-Saharan Africa

Surgical outcomes for cutaneous squamous cell carcinoma of the auricle

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第4期9卷 295-301页

作者： constantin Manole Liam J.Skinner Martin J.Donnelly Department of Otolaryngology/Head and Neck Surgery University Hospital WaterfordWaterfordRepublic of Ireland Consultant in Otolaryngology/Head and Neck Surgery University Hospital WaterfordWaterfordRepublic of Ireland

Background:Cutaneous squamous cell carcinoma (CSCC) on the auricle is believed to carry a higher risk of metastatic *** rates of lymphatic metastasis reported in the literature have varied *** are no established prognostic criteria to determine which of these tumors are higher risk and warrant prophylactic treatment of the associated lymphatic ***:To retrospectively evaluate outcomes after surgical treatment of auricular CSCC in our department,examining excision completeness,tumor recurrence,and lymphatic ***,to identify factors associated with lymphatic ***:One hundred and thirty‐eight consecutive cases of auricular SCC were excised from 126 patients in our department over a 7‐year period (January 2012–December 2018).Data were retrospectively collected on patient characteristics,tumor histology,surgical procedures,and follow‐***:Incomplete initial excision occurred in 17 cases (12.32%).Six patients (4.76%) had a local *** metastasis occurred in eight patients (6.35%),on average within 10.25 months after primary *** patients with metastasis died during follow‐up,with a mean survival of 10.2 *** age was associated with lymphatic metastasis (P = 0.0267).Other factors,including tumor recurrence,size,grade,cartilage invasion,and positive margins,were evaluated and not significantly associated with ***:In this study,the metastatic rate of auricular SCC was 6.35%,which is within the previously reported *** histological prognostic factors were identified in this study,which may be due to our limited sample *** the absence of established prognostic criteria,decisions regarding prophylactic treatment should be made on an individual basis with multidisciplinary support.

关键词： cutaneous malignancy external ear metastasis squamous cell carcinoma

The Electromagnetic Nature of Gravitation and Matter-Antimatter Antigravity. Surmise on Quantum Vacuum Gravitation and Cosmology

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Journal of Modern Physics 2022年第6期13卷 949-968页

作者： constantin Meis National Institute for Nuclear Science and Technology CEA-Saclay Gif-sur-Yvette France

We show that the electromagnetic quantum vacuum derives directly from Maxwell’s theory and plays a primary role in quantum electrodynamics, particle physics, gravitation and cosmology. It corresponds to the electromagnetic field ground state at zero frequency, a zero-energy cosmic field permeating all of space and it is composed of real states, called kenons (κενο = vacuum). Photons are local oscillations of kenons guided by a non-local vector potential wave function with quantized amplitude. They propagate at the speed imposed by the vacuum electric permittivity ε0 and magnetic permeability μ0, which are intrinsic properties of the electromagnetic quantum vacuum. The electron-positron elementary charge derives naturally from the electromagnetic quantum vacuum and is related to the photon vector potential. We establish the masse-charge equivalence relation showing that the masses of all particles (leptons, mesons, baryons) and antiparticles are states of the elementary charges and their magnetic moments. The equivalence between Newton’s gravitational law and Coulomb’s electrostatic law results naturally. In addition, we show that the gravitational constant G is expressed explicitly through the electromagnetic quantum vacuum constants putting in evidence the electromagnetic nature of gravity. We draw that G is the same for matter and antimatter but gravitational forces should be repulsive between particles and antiparticles because their masses bear naturally opposite signs. The electromagnetic quantum vacuum appears to be the natural link between quantum electrodynamics, particle physics, gravitation and cosmology and constitutes a basic step towards a unified field theory. Dark Energy and Dark Matter might originate from the electromagnetic quantum vacuum fluctuations. The calculated electromagnetic vacuum energy density, related to the cosmological constant considered responsible for the cosmic acceleration, is in good agreement with the astr

关键词： Photons Electromagnetic Waves Electromagnetic Quantum Vacuum Dark Light Kenons Gravitation Matter-Antimatter Antigravity Electromagnetic Push Gravity Dark Energy Cosmological Constant Dark Matter Elementary Charges Mass-Charge Relation Cosmology Unified Field Theory

Photon Structure and Wave Function from the Vector Potential Quantization

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Journal of Modern Physics 2023年第3期14卷 311-329页

作者： constantin Meis National Institute for Nuclear Science and Technology CEA-Saclay Gif-sur-Yvette France

A photon structure is advanced based on the experimental evidence and the vector potential quantization at a single photon level. It is shown that the photon is neither a point particle nor an infinite wave but behaves rather like a local “wave-corpuscle” extended over a wavelength, occupying a minimum quantization volume and guided by a non-local vector potential real wave function. The quantized vector potential oscillates over a wavelength with circular left or right polarization giving birth to orthogonal magnetic and electric fields whose amplitudes are proportional to the square of the frequency. The energy and momentum are carried by the local wave-corpuscle guided by the non-local vector potential wave function suitably normalized.

关键词： Photons Photon Wave Function Vector Potential Quantization Photon Electric and Magnetic Fields Photon Structure Wave-Corpuscle Representation Photon “Energy-Vector Potential” Equation