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Interdisciplinary management of central nervous system metastasis and neoplastic meningitis:recent developments and future perspectives

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 163-175页

作者： Ghazaleh Tabatabai Marilin Koch Cristiana Roggia Juliane Ebert Claus Garbe Friedegund Meier Sara Brucker Eva Maria Grischke Diethelm Wallwiener Robert Möhle Lothar Kanz Walter Erich Aulitzky Ulrike Ernemann Christian laFougere Konstantin Nikolaou Bernd Pichler Jens Schittenhelm Manuela Neumann Falko Fend Stefan Czemmel Sven Nahnsen Frank Paulsen Daniel Zips Maike van Lessen Hans-Otto Karnath Ulf Ziemann constantin roder Marco Skardelly Jürgen Bernd Honegger Marcos Tatagiba Interdisciplinary Division of Neuro-Oncology Departments of Vascular Neurology and NeurosurgeryUniversity Hospital TübingenHertie Institute for Clinical Brain ResearchEberhard Karls University72076 TübingenGermany Division of Dermato-Oncology Department of DermatologyUniversity Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Gynecology and Ostetrics University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Internal Medicine(II) University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Hematology and Oncology Robert Bosch Hospital StuttgartStuttgartGermanyComprehensive Cancer CenterTübingen StuttgartGermany Department of Diagnostic and Interventional Neuroradiology University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Nuclear Medicine University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Diagnostic and Interventional Radiology University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Preclinical Imaging and Radiopharmacy University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Pathology and Neuropathology University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Radiation Oncology University Hospital TübingenEberhard Karls University72076 TübingenGermany Division of Neuropsychology University Hospital TübingenHertie Institute for Clinical Brain ResearchEberhard Karls University72076 TübingenGermany Center for CNS tumors Comprehensive Cancer Center Tübingen StuttgartGermany Center for Personalized Medicine University Hospital TübingenEberhard Karls UniversityTübingenGermany Center for Dermato-Oncology University Hospital DresdenGermany Quantitative Biology Center(QBiC) Eberhard Karls UniversityTübingenGermany DKTK DKFZ partner site Tübingen.18Department of ImmunologyEberhard Karls University TübingenGermany

The incidence of metastatic disease in the central nervous system(CNS)is *** to current estimates,up to a third of adult cancer patients will suffer from CNS *** evidence-based data from prospective randomized trials are rare,however,because CNS metastasis patients were often excluded from clinical trial *** management of CNS metastasis patients is therefore rather ill-defined and an interdisciplinary *** basic and translational science data have begun contributing to a more profound understanding of the molecular mechanisms leading to invasion of tumor cells into the *** report reviews advances,challenges,and perspectives in this field.

关键词： Brain tumor central nervous system metastases interdisciplinary management

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