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The Functional Redundancy of Neddylation e2s and e3s in Modulating the Fitness of Regulatory T Cells

Research 2024年第2期2023卷 373-387页

作者： di Wu Yi Sun Cancer institute(Key Laboratory of Cancer Prevention and intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RiNG ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation e2-e3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these e2s or e3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation e2s or e3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&Sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double e3-null than with double e2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 e3s,also known to serve as the RiNG component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly

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effect of Modulus Heterogeneity on the equilibrium Shape and Stress Field ofαPrecipitate in Ti-6Al-4V

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Computer Modeling in engineering & Sciences 2024年第7期140卷 1017-1028页

作者： di Qiu Rongpei Shi Materials Genome institute Shanghai UniversityShanghai200444China School of Materials Science and engineering Harbin Institute of TechnologyShenzhen518055China Shanghai Frontier Science Center of Mechanoinformatics Shanghai UniversityShanghai200444China Zhejiang Laboratory Hangzhou311100China

For media with inclusions(e.g.,precipitates,voids,reinforcements,and others),the difference in lattice parameter and the elastic modulus between the matrix and inclusions cause stress concentration at the *** stress fields depend on the inclusions’size,shape,and distribution and will respond instantly to the evolving *** study develops a phase-field model concerningmodulus *** effect of modulus heterogeneity on the growth process and equilibrium state of theαplate in Ti-6Al-4V during precipitation is ***αprecipitate exhibits strong anisotropy in shape upon cooling due to the interplay of the elastic strain and interfacial *** calculated orientation of the habit plane using the homogeneous modulus ofαphase shows the smallest deviation fromthat of the habit plane observed in the experiment,compared to the case where the homogeneous modulus ofβphase is *** addition,the equilibrium volume ofαphase within the systemusing homogeneousβmodulus exhibits the largest dependency on the applied *** stress fields across theα/βinterface are further calculated under the assumption of modulus heterogeneity and compared to those using homogeneous modulus of eitherαorβ*** study provides an essential theoretical basis for developing mechanics models concerning systems with heterogeneous structures.

关键词： elastic heterogeneity habit plane stress field titanium phase-field simulation

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Simplified seismic scenario analysis of existing masonry buildings accounting for local site effects

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Frontiers of Structural and Civil engineering 2024年第2期18卷 309-318页

作者： Ayşe e.ÖZSOYÖZBAY işıl SANRi KARAPiNAR Zehra N.KUTLU ismail e.KiLiÇ Department of Civil engineering Maltepe UniversityIstanbul 34857Turkey School of engineering and Construction Oryx Universal CollegeDoha 12253Qatar

This study discusses the effects of local sites and hazard amplification on the seismic vulnerability assessment of existing masonry *** this context,a rapid seismic evaluation procedure was implemented on an old masonry building stock in the historical center Galata,located inistanbul,to determine the seismic risk priority of the built *** scenarios were generated for all soil classes,different moment magnitudes,and source-to-site distances to obtain more accurate results for the seismic vulnerability assessment of the studied building ***,damage distributions estimated under nine different scenarios with/without site effects were compared and illustrated in maps to discuss changes in vulnerability owing to amplification *** this study,by re-examining the rapid seismic evaluation procedure by including geo-hazard-based assessment,the importance of site effects on the vulnerability and risk assessment of built heritage was *** proposed framework integrating field data and local site effects is believed to advance the current applications for vulnerability assessment of masonry buildings and provide an improvement in the application of rapid seismic assessment procedures with more reliable results.

关键词： masonry buildings seismic vulnerability assessment cultural heritage local site effect

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Landau quantization effects on damping Kawahara solitons in electron–positron–ion plasma in rotating ionized medium

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Communications in Theoretical Physics 2024年第10期76卷 143-152页

作者： e i el-Awady S Hussain N Akhtar Department of Physics Faculty of Science Port Said University Theoretical Physics division (TPD) PINSTECH

For the dynamics of three-dimensional electron–positron–ion plasmas, a fluid quantum hydrodynamic model is proposed by considering Landau quantization effects in dense ***–neutral collisions in the presence of the Coriolis force are also considered. The application of the reductive perturbation technique produces a wave evolution equation represented by a damped Korteweg–de Vries equation. This equation, however, is insufficient for describing waves in our system at very low dispersion coefficients. As a result, we considered the highest-order perturbation, which resulted in the damped Kawahara equation. The effects of the magnetic field, Landau quantization, the ratio of positron density to electron density, the ratio of positron density to ion density, and the direction cosine on linear dispersion laws as well as soliton and conoidal solutions of the damped Kawahara equation are explored. The understanding from this research can contribute to the broader field of astrophysics and aid in the interpretation of observational data from white dwarfs.

关键词： Coriolis force Kawahara equation Landau quantization magnetoplasmas quantum plasma solitary and cnoidal waves

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Transition from oceanic subduction to continental collision:insights from volcanogenic-sedimentary rocks of the Tannuola terrane(northern Central Asian Orogenic Belt)

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Geoscience Frontiers 2024年第4期15卷 41-60页

作者： e.V.Vetrov N.i.Vetrova V.S.Sobolev institute of Geology and Mineralogy SB RAS Koptyuga ave.3NovosibirskRussia

Magmatism associated with oceanic subduction plays a dominant role in crustal growth during the earth's *** Tannuola terrane,situated in the northern Central Asian Orogenic Belt(CAOB),is a key area to understanding oceanic subduction and initial collision processes in the northern *** order to investigate the switch from subduction to collision settings,detailed field mapping,zircon SHRiMP U-Pb geochronological and whole-rock geochemical studies of volcanogenic-sedimentary rocks from the Tannuola terrane were carried *** U-Pb ages indicate multi-stage volcanism lasted at least 30 Ma from~540 to~510 Ma,that can be divided into three events:the late ediacaran(before~540 Ma),the early Cambrian(~520 Ma)and the middle Cambrian(~510 Ma).These ages are inter-preted to the initial,main and final stages of oceanic subduction during the late Proterozoic-early *** the late ediacaran,tholeiitic basalts with highεNd(t)values(from+7.4 to+8.5)were *** forming by the 10%-30%partial melting of spinel-garnet mantle source during slab *** the early Cambrian,transitional from tholeiitic to calc-alkaline basaltic rocks withεNd(t)value(+5.6)and coeval intermediate-felsic volcanic rocks with similarεNd(t)values(+5.9 and+6.5)*** early Cambrian basaltic rocks are interpreted to be derived by 10%-30%partial melt-ing of a depleted mantle source metasomatized by slab-derived fluids released from the subducting ocea-nic *** middle Cambrian calcalkaline basaltic rocks withεNd(t)value of+6.2 might be emplaced as a result of low(5%-10%)degree partial melting of a metasomatized mantle followed by fractional crys-tallization of clinopyroxene and *** intermediate-felsic volcanic rocks withεNd(t)values from+6.0 to+6.8 were formed through fractionation of the juvenile Neoproterozoic *** middle Cambrian volcanism is interpreted to be triggered by the slab break-off during the transition to a collisional se

关键词： island-arc magmatism ediacaran Cambrian zircon U-Pb dating Nd isotopes Central asian orogenic belt

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Prescribed Performance Tracking Control of Time-Delay Nonlinear Systems With Output Constraints

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ieee/CAA Journal of Automatica Sinica 2024年第7期11卷 1557-1565页

作者： Jin-Xi Zhang Kai-di Xu Qing-Guo Wang ieee the State Key Laboratory of Synthetical Automation for Process industries Northeastern UniversityShenyang 110819China institute of Artificial intelligence and Future Networks Beijing Normal UniversityZhuhai 519087 Guangdong Key Laboratory of Artificial intelligence and Multi-Modal Data Processing Beijing Normal University-Hong Kong Baptist University United International CollegeZhuhai 519087

The problem of prescribed performance tracking control for unknown time-delay nonlinear systems subject to output constraints is dealt with in this paper. in contrast with related works, only the most fundamental requirements, i.e., boundedness and the local Lipschitz condition, are assumed for the allowable time delays. Moreover, we focus on the case where the reference is unknown beforehand, which renders the standard prescribed performance control designs under output constraints infeasible. To conquer these challenges, a novel robust prescribed performance control approach is put forward in this ***, a reverse tuning function is skillfully constructed and automatically generates a performance envelop for the tracking error. in addition, a unified performance analysis framework based on proof by contradiction and the barrier function is established to reveal the inherent robustness of the control system against the time delays. it turns out that the system output tracks the reference with a preassigned settling time and good accuracy,without constraint violations. A comparative simulation on a two-stage chemical reactor is carried out to illustrate the above theoretical findings.

关键词： Nonlinear systems output constraints prescribed performance reference tracking time delays

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Lead-free perovskites-based photonic synaptic devices with zero electric energy consumption

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Science China(information Sciences) 2024年第6期67卷 433-441页

作者： Dandan HAO di YANG Haixia LiANG Jia HUANG Fukai SHAN College of electronics and information Qingdao University Key Laboratory of Biofuels Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of Sciences School of Materials Science and engineering Tongji University National Key Laboratory of Autonomous intelligent Unmanned Systems Tongji University

The von Neumann bottleneck is a critical limitation in synaptic devices. Therefore, artificial synaptic devices resembling biological neuromorphic synapses have been developed to overcome the von Neumann bottleneck. However, synaptic devices require voltages, which results in considerable energy consumption. Here, photonic synaptic devices with the vertical structure of indium tin oxide（iTO）/SnO2/Al2O3/CsBi3i10/Au are fabricated, which can work in the self-powered mode owing to the photovoltaic effect endowed by a vertical multilayer structure. Several fundamental synaptic functions, such as excitatory postsynaptic current, paired-pulse facilitation, short-term plasticity（STP）, long-term plasticity（LTP）, pulse-frequency-dependent plasticity, transition of STP to LTP, and the learning experience are emulated. Moreover, Morse-coded external light information is decoded by self-powered photonic synaptic devices. The results indicate that self-powered photonic synaptic devices based on lead-free perovskites exhibit great potential for efficient neuromorphic computing and optical wireless communication.

关键词： photonic synaptic devices lead-free perovskites zero energy consumption synaptic plasticity Morse code

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Flame Morphology and Characteristic of Co-Firing Ammonia with Pulverized Coal on a Flat Flame Burner

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Journal of Thermal Science 2024年第5期33卷 1935-1945页

作者： WANG Shengye CUi Mingshuang LiU Pengzhong di Yi NiU Fang China Coal Research institute Beijing 100013China Beijing Tiandi Rongchuang Technology Co.Ltd. Beijing 100013China National energy Technology&equipment Laboratory of Coal Utilization and emission Control Beijing 100013China

Ammonia as a new green carbon free fuel co-combustion with coal can effectively reduce CO_(2)emission,but the research of flame morphology and characteristics of ammonia-coal co-combustion are not *** this work,we studied the co-combustion flame of NH_(3)and pulverized coal on flat flame burner under different oxygen mole fraction(X_(i,O_(2)))and NH_(3)co-firing energy ratios(e_(NH_(3))).We initially observed that the introduction of ammonia resulted in stratification within the ammonia-coal co-combustion flame,featuring a transparent flame at the root identified as the ammonia combustion *** to challenges in visually observing the ignition of coal particles in the ammonia-coal co-combustion flame,we utilized Matlab software to analyze flame images across varying e_(NH_(3))and X_(i,O_(2)).The analysis indicates that,compared to pure coal combustion,the addition of ammonia advances the ignition delay time by 4.21 ms to 5.94 *** e_(NH_(3))increases,the ignition delay time initially decreases and then ***,an increase in X_(i,O_(2))results in an earlier ignition delay *** burn-off time and the flame divergence angle of pulverized coal demonstrated linear decreases and increases,respectively,with the growing ammonia *** addition of ammonia facilitates the release of volatile matter from coal ***,in high-ammonia environments,oxygen consumption also impedes the surface reaction of coal ***,measurements of gas composition in the ammonia-coal flame flow field unveiled that the generated water-rich atmosphere intensified coal particle gasification,resulting in an elevated concentration of ***,nitrogen-containing substances and coke produced during coal particle gasification underwent reduction reactions with NO_(x),leading to reduced NO_(x)emissions.

关键词： co-firing ammonia with coal flame characteristic gas component ignition delay time burn-off time flame divergence angle flat flame burner flame morphology

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Toughening additive manufactured Zr-based bulk metallic glass composites by martensite phase transformation

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Journal of Materials Science & Technology 2024年第3期170卷 95-102页

作者： Pengcheng Zhang Cheng Zhang Jie Pan di Ouyang Lin Liu State Key Laboratory of Materials Processing and die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Additive manufacturing technology based on laser powder bed fusion(LPBF)offers a novel approach for fabricating bulk metallic glass(BMG)products without restriction in size and ***,the BMGs prepared by LPBF usually suffered from less plasticity and poorer fracture toughness as compared to their cast counterparts due to partial crystallization in heat-affected zones(HAZs).Since crystallization in HAZs is hard to avoid completely in LPBF BMGs,it is desirable to design a suitable alloy system,in which only ductile crystalline phase,instead of brittle intermetallics,is formed in *** unique structure could effectively increase the toughness/plasticity of the LPBF *** achieve this goal,a quaternary BMG system with a composition of Zr_(47.5)Cu_(45.5)Al_(5)Co_(2)is adopted and subjected to *** is found that nearly a single phase of B_(2)-ZrCu is precipitated in HAZs,while a fully amorphous phase is formed in molten pools(MPs).This B_(2)phase reinforced BMG composite exhibits excellent mechanical properties with enhanced plasticity and ***,it is easy to modulate the mechanical properties by altering the amount of the B_(2)phase via adjusting the laser energy ***,the best combination of strength,plasticity,and notch toughness is obtained in the BMG composite containing 27.4%B_(2)phase and 72.6%amorphous phase,which exhibits yield strength(σ_(s))of 1423 MPa,plastic strain(ε_(p))of 4.65%,and notch toughness(K_(q))of 53.9 MPa m 1/***,a notable strain-hardening is also *** improvement of plasticity/toughness and appearance of strain-hardening behavior are mainly due to the martensite phase transformation from the B_(2)phase to the Cm phase during plastic deformation(i.e.,the phase transformation-induced plasticity effect).The current work provides a guide for making advanced BMGs and BMG composites by additive manufacturing.

关键词： Laser powder bed fusion Bulk metallic glass composites Phase transformation-induced plasticity Deformation mechanism

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A hybrid attention model based on first-order statistical features for smoke recognition

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Science China(Technological Sciences) 2024年第3期67卷 809-822页

作者： GUO Nan LiU JiaHui di KeXin GU Ke QiAO JunFei Beijing Laboratory of Smart environmental Protection Beijing Key Laboratory of Computational Intelligence and Intelligent SystemBeijing Artificial Intelligence InstituteBeijing 100124China Faculty of information Technology Beijing University of TechnologyBeijing 100124China

Smoke and fire recognition are of great importance on foreseeing fire disasters and preventing environmental pollution by monitoring the burning process of objects(e.g., straw, fuels). However, since fire images suffer from problems like the variability of the features, complexity of scenarios, interference from background, changeable weather conditions as well as image quality problems, identifying smoke and fire accurately and promptly from a given image still remains a substantial challenge. Automatically learning the features of smoke images by CNNs has improved the target recognition ability compared to traditional approaches,nonetheless, convolutions and pooling operations in CNNs may cause severe information loss which may lead to *** tackle the above problems, this paper proposed a hybrid attention model based on the characteristics of smoke images. This model adopted multiple optimized attention mechanism in several stages to quickly and precisely capture the important features,achieving state-of-the-art performance on smoke and fire recognition in terms of accuracy and speed. Our proposed module mainly consists of two stages: pooling and attention. in the first stage, we conducted several newly proposed first-order pooling methods. Through traversing the data space in a larger scope, features are better reserved, thus constructing a more intact feature space of smoke and fire in an image. in the second stage, feature maps are aggregated together to perform channel and spatial attention. The channel and spatial dependencies allow us to quickly catch the important features presented in an image. By fully exploring the feature space and prominent salient features, characteristics of smoke and fire are better presented so as to obtain better smoke and fire detection results. experiments have been conducted on public smoke detection dataset and new proposed fine-grained smoke and fire detection database. experimental results revealed that the propose

关键词： hybrid attention first-order pooling smoke and fire detection deep convolutional neural networks

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