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Study of Factors Associated with the Practice of Vaccination against COVID-19 among Medical Science Students in Dakar (Senegal)

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Open Journal of Epidemiology 2024年第2期14卷 199-220页

作者： Chafika Ibrahim Zanguina Theresa Stella Esperance Fouckou Moko Jean Augustin Diegane tine Department of Medicine El Hadji Ibrahima Niasse University of Dakar Dakar Senegal Department of Preventive Medicine and Public Health Faculty of Medicine Pharmacy and Odontology Cheikh Anta Diop University Dakar Senegal

Introduction: Almost a year after the start of the COVID-19 pandemic, Senegal embarked on a vaccination campaign to protect its population. The objective of this study was to identify the factors influencing the COVID-19 vaccination practices within a health training university in Dakar. Methodology: This was a cross-sectional, descriptive and analytical study carried out from October 21 2021 to February 21 2022 among students at the Elhadj Ibrahima Niass private University in Dakar, Senegal. A 28-question online questionnaire was sent to all students enrolled at the university during this period. Results: Of the 576 students who responded, the average age was 22.60 years, with females predominating (57.81%). Medical students accounted for 66.14% of participants, pharmacy 22.40% and dental surgery 11.46%. Of these, 42.01% were bachelor’s students, 29.51% master’s students and 28.47% doctoral students. Vaccination coverage was 50.35%. Students who considered COVID-19 to be very dangerous were more likely to be vaccinated (OR = 5.05 [2.24-11.9]). Those with poor knowledge of vaccines were less likely to be vaccinated (OR = 0.07 [0.03-0.18]), as were those with poor knowledge of contraindications to vaccination (OR = 0.49 [0.28-0.86]). No association was found between vaccination status and socio-demographic or educational characteristics. Conclusion: In view of the importance of knowledge about COVID-19 vaccination, our results suggest that it is important to involve health students in the Ministry of Health’s awareness-raising strategies, because their support is necessary for better public awareness.

关键词： COVID-19 Vaccination Health Students Senegal

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The Role of Music Therapy in Supporting Intellectually Disabled Youth in Senegal

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Health 2024年第5期16卷 521-534页

作者： Raymond Birane Youm kadidiatou Diarra Mathias Pouye Jean Augustin Diégane tine National School of Arts (ENA) Dakar Senegal EDSEV in Cheikh Anta Diop University (UCAD) Dakar Senegal ISED in Cheikh Anta Diop University (UCAD) Dakar Senegal

Introduction: Music therapy is a practice for helping and supporting people with intellectual and relational difficulties. This study illustrated the benefits of music therapy for young people living with intellectual disabilities (YLID) in an African context. Methodology: This study investigated six young individuals with intellectual disabilities who had undergone three years of music therapy. They were participants in the inclusive non-academic training program at the National School of Arts in Dakar from 2017 to 2019. Data collection utilized individual interviews with the youths, evaluation grids from teachers and psychiatrists. Guardians provided informed consent along with the assent of the young participants. Results: The six young were aged between 18 and 30 years old, with an average age of 24.6 years. Four of the YLID were male. Three young people with intellectual disabilities had delayed psychomotor development. Observations revealed the beneficial influence of music therapy on the health and well-being of young individuals. Music played a role in alleviating stress and anxiety among youth with intellectual disabilities (YLID), enhancing their mood and mental health. It assisted in navigating challenging situations and heightened alertness among YLID. Additionally, music therapy contributed to improvements in dyslexia, fine and gross motor skills, and memory development among intellectually disabled youth, ultimately facilitating their integration into society. Conclusion: In light of our results, music therapy makes a major contribution to the empowerment of YLID. Engaging in musical activities helps young people connect with others through instrumental expression and a sense of accomplishment. By facilitating music therapy, it becomes possible to combat discrimination and stigmatization, thus promoting the social inclusion of intellectually disabled youth. Therefore, it is important to promote music therapy in Senegal to meet the needs of YLID.

关键词： Music Therapy Young Intellectual Disabilities Senegal

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Study of the Efficiency of Vertical Drains by an FEM Method in Soil Treatment for Road Projects: Case of the Development and Bitumination Works of the ROCADE Porto-Novo in Benin

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Open Journal of Civil Engineering 2024年第3期14卷 435-455页

作者： Cheikh Diallo Diène Vitouley Kossi Ghyslain Joël Mamadou tine Apanda Mbongote Johnny Laboratory of Modelling and Soils Mechanics TRU Engineering Sciences (UFR SI) University Iba Der Thiam Thies Senegal Laboratory of Modelling and Soils Mechanics School of Electrical and Building (ESEBAT) Dakar Senegal

This article aims to study the efficiency of coupled vertical drains for the treatment of long-lasting compressible clay soils for the road project platform of the ring road of Porto Novo, capital of Benin. The experimental data allowed us to estimate a consolidation of 29% in 9 months, justifying the drainage of the soil. In order to study the efficiency of drainage, a FEM model was proposed simulating different scenarios. These include a drainless road, pavements equipped with vertical drains with meshes of 0.5 m 0.5 m, 1 m 1 m and 1.5 m 1.5 m respectively and horizontal drains. The results expressed in terms of variations in vertical stresses, effective stresses and shear deformations revealed significant variations in pavement performance depending on the mesh size of the vertical drains. The configuration with a mesh of 0.5 m 0.5 m showed the least deformations, thus indicating a reduction in deformations and better stress distribution. However, the other mesh configurations showed variable results, underlining the importance of choosing the right mesh for the specific project conditions.

关键词： Pavement Vertical Drains Horizontal Drains Modelling Plaxis2D ROCADE de Porto-Novo

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The Essential Oil of Ocimum americanum from Senegal and Gambia as a Source of Methyleugenol for the Control of Bactrocera dorsalis, Fruit Fly

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Journal of Agricultural Chemistry and Environment 2024年第1期13卷 133-141页

作者： Yoro tine Antonio Alain Coffi Sinzogan Ousmane Ndiaye Cebastiana Sambou Alioune Diallo Ismaila Mbenga Kemo Badji El Hadji Omar Dieng Assa Balayara Jeanne Diatta Cheikhouna Gaye Julien Paolini Jean Costa Alassane Wele Saliou Ngom Laboratoire de Chimie Organique et Thérapeutique Faculté de Médecine Pharmacie et Odontologie Université Cheikh Anta Diop Dakar Sénégal Faculte des Sciences Agronomiques Universite d’Abomey Calavi Cotonou Benin Ecole Nationale Supérieure d’Agriculture (ENSA) Université Iba Der Thiam de Thiès Thiès Sénégal Direction de la Protection des Végétaux Rufisque Sénégal Laboratoire de Chimie des Produits Naturels Université de Corse Corte France National Agricultural Research Institute (NARI) Sere Kunda Gambia Institut Sénégalais de Recherches Agricoles (ISRA) Dakar Sénégal

The fruit fly, Bactrocera dorsalis (Diptera: Tephritidae) is one of the most important pests in all mango-producing areas, particularly in West Africa. In Senegal, O. americanum leaves have been used for several years to control this fly. However, to our knowledge, no chemical studies have been carried out. Thus, the aim of this study is to determine the chemical composition of the essential oil of O. americanum leaves collected in Senegal and Gambia. The essential oil obtained by hydrodistillation of these leaves is analyzed by GC/FID and GC/MS. Yields of essential oils from O. americanum leaves are 3.84% and 2.13%, respectively. Analysis of these essential oils by GC/FID and GC/MS allowed the identification of 23 compounds representing almost 100% of the total compositions. These essential oils are mainly dominated by methyleugenol (72.0% and 75.8%, respectively). Other components in significant percent are trans-β-caryophyllene (13.9% and 13.0%, respectively), germacrene D (4.1% and 3.7%, respectively), β-elemene (3.3% and 0.9%, respectively). Due to the high methyleugenol content, this study explains the attractive potential of O. americanum towards B. dorsalis. In perspective, we plan to evaluate the attractive effect of the essential oil and leaf powder of O. americanum against B. dorsalis, a real pest of mango orchards in Senegal.

关键词： Ocimum americanum Essential Oils Methyleugenol Bactrocera dorsalis GC/MS

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Activity of a lipid synthesis inhibitor(spiromesifen) in Culiseta longiareolata(Diptera:Culicidae)

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Asian Pacific Journal of Tropical Biomedicine 2017年第12期7卷 1120-1124页

作者： Hayette Bouabida Fouzia tine-djebbar Samir tine Noureddine Soltani University of Larbi Tebessi TebessaAlgeria Laboratory of Applied Animal Biology University Badji MokhtarAnnabaAlgeria

Objective: To evaluate the activity of spiromesifen against the most abundant and investigated mosquito species, Culiseta longiareolata Aitken, 1954(Diptera, Culicidae).Methods: Culiseta longiareolata larvae were collected from untreated areas located at Te′bessa(Northeast Algeria). A commercial formulation of spiromesifen(Oberon?240 SC) was tested at different concentrations ranging between 238 and 1 428 mg/L on newly molted fourth-instar larvae under standard laboratory conditions according to Word Health Organization recommendations. The effects were examined on the mortality, the morphometric measurements, two biomarkers(catalase and malondialdehyde), and the biochemical composition of larvae, ***: The compound exhibited insecticidal activity. Moreover, it disturbed growth and several morphological aberrations were observed. It also affected body volume,biomarkers and contents of carbohydrates, lipids and proteins. A marked effect on lipids and malondialdehyde was noted, confirming its primary mode of action on lipid ***: Spiromesifen appears less potent than other insecticides tested such as the insect growth disruptors.

关键词： Culiseta longiareolata Spiromesifen Toxicity Biochemical composition Biomarkers

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Has the risk of colorectal cancer in inflammatory bowel disease decreased?

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World Journal of Gastroenterology 2013年第43期19卷 7561-7568页

作者： Nynne Nyboe Andersen tine Jess Department of Epidemiology Research Statens Serum InstitutDK-2300 CopenhagenDenmark

The association between inflammatory bowel disease(IBD)and colorectal cancer(CRC)has been acknowledged for almost a century and is assumedly promoted by a chronic inflammation-driven carcinogenic process in the intestine in combination with a genetic *** magnitude of the risk of CRC in IBD remains a continuing subject of *** early,high risk estimates for CRC in IBD were most likely overestimated due to selected patient populations originating from tertiary referral centers with a disproportional high percentage of patients with severe *** population-based studies calculating risk estimates from a broad spectrum of IBD patients have found the risk to be significantly *** present,there is evidence that IBD patients with longstanding and extensive disease with uncontrolled inflammation are those at increased ***,other recognized risk factors include early age at onset,family history of CRC,and concomitant primary sclerosing cholangitis.A significant amount of effort is put into identifying potential preventive factors of CRC in IBD,including surveillance programs and chemopreventive agents but the individual effect of these remains ***,recent studies have reported a decline in risk of CRC over *** programs and the new treatment strategies,particular biological treatment might be part of the reason for the observed decline in risk of CRC in IBD over time but future studies will have investigate this assumption.

关键词： Inflammatory bowel disease Colorectal cancer Risk Ulcerative colitis Crohn’s disease

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Risk of infections associated with biological treatment in inflammatory bowel disease

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World Journal of Gastroenterology 2014年第43期20卷 16014-16019页

作者： Nynne Nyboe Andersen tine Jess Department of Epidemiology Research Statens Serum InstitutDK-2300 CopenhagenDenmark

Tumor necrosis factor-α (TNF-α) inhibitors are biological agents introduced in the late 1990s for the treatment of different immune-mediated diseases as inflammatory bowel disease, rheumatoid arthritis and psoriasis. The most commonly used TNF-α antagonists are infliximab, adalimumab, and certolizumab pegol, and though highly effective in lowering inflammation, the efficacy must be weighed against the potential for adverse events. The treatment-induced immunosuppression is suspected to increase the risk of infections, including the risk of reactivation of latent tuberculosis, as the TNF-α cytokine plays an important role in the immune function. In this topic highlight a short overview of the infection risk associated with TNF-α inhibiter therapy is outlined with a focus on the overall risk of serious infections, mycobacterial infection and latent viral infections.

关键词： Inflammatory bowel disease Biological treatment Tumor necrosis factor-α inhibitors Risk Infections Ulcerative colitis Crohn’ s disease

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The Role of Music Therapy in Supporting Intellectually Disabled Youth in Senegal

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Health（健康） 2024年第5期 521页

作者： Raymond Birane Youm kadidiatou Diarra Mathias Pouye Jean Augustin Diégane tine

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Immune checkpoint inhibitor resistance in soft tissue sarcoma

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Cancer Drug Resistance 2022年第2期5卷 328-338页

作者： Vanessa Eulo Brian A.Van tine Division of Medical Oncology University of Alabama at BirminghamBirminghamAL35233USA. Division of Medical Oncology Washington University in St.LouisSt.LouisMO63110USA. Division of Pediatric Hematology/Oncology Washington University in St.LouisSt.LouisMO63110USA. Siteman Cancer Center St.LouisMO 63110USA.

The emergence of immunotherapy as a cancer therapy has dramatically changed the treatment paradigm of systemic cancer *** have been several trials evaluating immune checkpoint blockade(ICI)in soft tissue *** there is generally a limited response in sarcoma,a subset of patients has durable responses to *** is attributable to a variety of factors including histologic subtype,tumor-infiltrating lymphocytes,and the tumor microenvironment among *** is ongoing translational and clinical research evaluating ICI resistance in sarcoma and identifying therapeutic strategies to overcome this ***,we provide a review of the current data,proposed mechanisms of resistance,and potential approaches to overcome this resistance.

关键词： Sarcoma soft tissue sarcoma checkpoint inhibitor immunotherapy resistance

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Innate and adaptive resistance mechanisms to arginine deprivation therapies in sarcoma and other cancers

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Cancer Drug Resistance 2019年第3期2卷 516-526页

作者： Leonard C.Rogers Brian A.Van tine Division of Medical Oncology Washington University in St.LouisSt.LouisMO 63110USA Alvin J Siteman Cancer Center Washington University School of MedicineSt.LouisMO 63110USA

Many cancers lack functional expression of the enzyme argininosuccinate synthetase 1(ASS1)that is necessary for synthesis of *** cancers must import arginine for survival and growth,and this reliance can be targeted by arginine-degrading extracellular enzymatic drugs,most commonly PEGylated arginine *** enzymes can become targets of the immune system,reducing their effectiveness,but PEGylation improves the in vivo *** deprivation causes cell death in some cancers,but others gain resistance by expressing ASS1 after a starvation response is *** resistance mechanisms are possible and explored,but these have not been observed specifically in response to arginine *** studies,especially focusing on the mechanisms of ASS1 upregulation and metabolic adaptations,may yield insights into preventing or taking advantage of resistance adaptations to make arginine deprivation therapy more effective.

关键词： PEGylated arginine deiminase argininosuccinate synthetase 1 resistance metabolism arginine

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