检索结果-南通市图书馆

Journal of Cancer Therapy 2021年第3期12卷 146-156页

作者： Raiza Ruiz-Lorente Sayly Alfonso Eduardo Santiesteban Yamilka Sánchez Kirenia Camacho Erasmo Mendoza Carmen Elena Viada Ramón Ortiz Ihosvannys Carreño Mayelin Troche Meylan Cepeda Ana Rosa Vals Leticia Cabrera Annia Gorte Delmis Batista Milagros Domenech Yanela Santiesteban Yuliannis Santiesteban Daymys Estevez Jessica García-Viamontes conrado ramos mico Mayra ramos-Suzarte González Coro Hospital La Habana Cuba Celestino Hernández Robau Hospital Villa Clara Cuba Jose Ramón Lopez Tabranes Hospital Matanzas Cuba III Congreso Hospital Pinar del Río Cuba Faustino Perez Hospital Matanzas Cuba Center of Molecular Immunology Havana Cuba

Cervical uterine cancer represents the fourth most common malignant neoplasm worldwide in the female sex in terms of incidence, principally from epithelial origen. The high expression of EGFR in this tumor leads to the search for therapeutic alternatives. An Expanded Access Clinical Program was carried out in parallel groups, randomized, multicenter and prospective study, to evaluate the survival of patients with advanced cervical carcinoma, without therapeutic alternative, who would be treated with the therapeutic vaccine CIMAvax-EGF®, the humanized mAb nimotuzumab or the combination of both products, which targeted EGF and EGFR respectively. The patients were included between 2008 and 2010 with a more than five years follow-up. The results show that the serious adverse events related to the experimental treatments were 0.9%;1.1% and 2.6% and a medi

关键词： CIMAvax-EGF® Nimotuzumab Survival Safety Advanced Cervical Cancer

Trifocal toric intraocular lenses in eyes with low amount of corneal astigmatism

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2020年第10期13卷 1567-1573页

作者： Paz Orts-Vila Salvador Aguilar-Corcoles Cristina Tello-Elordi María ramos-Alzamora Robert Montés-mico Pedro Taná-Rivero Oftalvist Clinic Alicante 03001Spain Optics and Optometry&Vision Sciences Department University of ValenciaBurjassotValencia 46100Spain

AIM:To evaluate the refractive and visual outcomes following cataract surgery and implantation of a trifocal toric intraocular lens(IOL)in eyes with low degrees of corneal ***:Twenty-six eyes of 22 patients who underwent implantation a trifocal toric IOL(FineVision PODFT,PhysIOL s.a.,Liege,Belgium)were *** with femtosecond laser,capsular tension ring insertion and intraoperative aberrometry were performed in all *** IOLs used showed a cylinder power of 1.00 *** outcome measures were refractive error and corrected-distance visual acuity(CDVA)and uncorrected-distance visual acuity(UDVA)*** were evaluated at 4 mo ***:Totally 50%of eyes showed a spherical equivalent(SE)within±0.13 D and all of them within±0.50 *** mean SE and refractive cylinder were-0.02±0.23 and-0.16±0.22 D,*** analysis revealed that 100%of eyes were within±0.50 D for the SE and cylindrical components(J0 and J45).Refractive changes were not correlated with keratometric changes(P>0.05)showing that the reduction in astigmatism comes from the trifocal toric *** 81%and 96%of eyes showed UDVA and CDVA of 20/20,*** postoperative mean values of monocular distance Snellen decimal UDVA and CDVA were 0.97±0.05 and 0.99±0.02(about 20/20),***:Our study suggests that the use of this trifocal toric IOL in patients with low amount of astigmatism provides accurate refractive outcomes and enables them to achieve excellent visual acuity.

关键词： toric trifocal intraocular lens phacoemulsification cataract astigmatism

激光表面熔化对Ti-30Nb-4Sn合金晶体织构、显微组织、弹性模量和硬度的影响

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2020年第2期30卷 392-404页

作者： Leonardo FANTON Nelson Batista de LIMA Emilio Rayon ENCINAS Vicente Amigo BORRAS conrado ramos Moreira AFONSO Joao Batista FOGAGNOLO School of Mechanical Engineering University of CampinasRua Mendeleyev200CEP 13083-860CampinasSPBrazil Instituto de Pesquisas Energéticas e Nucleares Av.Prof.Lineu Prestes2242CEP 05508-000São PauloSPBrazil Institut de Tecnologia de Materials Universitat Politècnica de ValènciaCamino de Veras/nCódigo Postal 46022ValenciaSpain Department of Materials Engineering Federal University of São CarlosRodovia Washington LuísKm 235CEP 13565-905São CarlosSPBrazil

骨科植入物的生物相容性与其弹性模量和表面性能密切相关。本研究的目的是阐明冷轧、再结晶和表面激光熔化(LSM)对双相(α″+β)Ti-30Nb-4Sn合金显微组织和力学性能的影响。对冷轧态基体进行X射线衍射织构分析(XRD)显示有[302]α″//ND... 详细信息

骨科植入物的生物相容性与其弹性模量和表面性能密切相关。本研究的目的是阐明冷轧、再结晶和表面激光熔化(LSM)对双相(α″+β)Ti-30Nb-4Sn合金显微组织和力学性能的影响。对冷轧态基体进行X射线衍射织构分析(XRD)显示有[302]α″//ND织构成分,而对再结晶态基体的分析显示有[302]α″//ND和[110]α″//ND织构成分。XRD不能直接检测出β相织构,但是通过考虑α′′相和β相之间的位向关系可成功预测出[111]β||ND织构的存在。纳米压痕测试结果表明,冷轧态基体的弹性模量(63 GPa)低于再结晶态基体(74 GPa)。根据已有文献和本文研究结果,认为这种差异是由冷变形过程中晶体缺陷的引入造成的。纳米压痕/EBSD分析表明,纳米压痕结果不受晶体取向的影响。LSM对变形合金硬度、弹性模量和晶体织构产生的变化类似于再结晶热处理产生的变化,均在表面和基体之间产生刚度梯度。

关键词：钛合金冷轧激光表面熔化再结晶晶体织构刚度梯度材料

Novel TINF2 gene mutation in dyskeratosis congenita with extremely short telomeres:A case report

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第33期10卷 12440-12446页

作者： Verónica Judith Picos-Cárdenas Saúl Armando Beltrán-Ontiveros JoséAlfonso Cruz-ramos JoséAlfredo Contreras-Gutiérrez Eliakym Arámbula-Meraz Carla Angulo-Rojo Alma Marlene Guadrón-Llanos Emir Adolfo Leal-León Dora María Cedano-Prieto Juan Pablo Meza-Espinoza Laboratorio de Genética Facultad de MedicinaUniversidad Autónoma de SinaloaCuliacán 80018SinaloaMexico Centro de Investigación y Docencia en Ciencias de la Salud Hospital Civil de CuliacánUniversidad Autónoma de SinaloaCuliacán 80030SinaloaMexico Departamento de Clínicas Médicas Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Facultad de Medicina Universidad Autónoma de SinaloaCuliacán 80018SinaloaMexico Laboratorio de Genética y Biología Molecular Facultad de Ciencias Químico-BiológicasUniversidad Autónoma de SinaloaCuliacán 80010SinaloaMexico Laboratorio de Neurociencias Facultad de MedicinaUniversidad Autónoma de SinaloaCuliacán 80018SinaloaMexico Laboratorio de Diabetes y Comorbilidades Facultad de MedicinaUniversidad Autónoma de SinaloaCuliacán 80018SinaloaMexico Facultad de Medicina Universidad Autónoma de TamaulipasMatamoros 87349TamaulipasMexico

BACKGROUND Dyskeratosis congenita is a rare disease characterized by bone marrow failure and a clinical triad of oral leukoplakia,nail dystrophy,and abnormal skin *** genetics of dyskeratosis congenita include mutations in genes involved in telomere maintenance,including *** SUMMARY Here,we report a female patient who presented thrombocytopenia,anemia,reticulate hyperpigmentation,dystrophy in fingernails and toenails,and leukoplakia on the tongue.A histopathological study of the skin showed dyskeratocytes;however,a bone marrow biopsy revealed normal cell *** patient was diagnosed with dyskeratosis congenita,but her family history did not reveal significant ***-exome sequencing showed a novel heterozygous punctual mutation in exon 6 from the TINF2 gene,namely,NM_001099274.1:-c.854delp.(Val285-Alafs*32).An analysis of telomere length showed short telomeres relative to the patient’s *** The disease in this patient was caused by a germline novel mutation of TINF2 in one of her parents.

关键词： Dyskeratosis congenita TINF2 Germline mutation Novel mutation Short telomeres Case report

ApoB-100, ApoE and CYP7A1 gene polymorphisms in Mexican patients with cholesterol gallstone disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第37期16卷 4685-4690页

作者： Sánchez-Cuén Jaime Aguilar-Medina Maribel Arámbula-Meraz Eliakym Romero-Navarro José Granados Julio Sicairos-Medina Laura ramos-Payán Rosalío División de Gastroenterología Hospital Regional ISSSTE Facultad de Ciencias Químico Biológicas Doctorado en Biotecnología y Maestría en Ciencias Biomédicas Universidad Autónoma de Sinaloa División de Inmunogenética Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

AIM: To determine the possible association of the ApoB100 (Xba Ⅰ ), ApoE (Hha Ⅰ ) and CYP7A1 (Bsa Ⅰ ) gene polymorphisms, with the development of cholesterol gallstone disease (GD) in a Mexican population. METHODS: The polymorphisms were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism, in two groups matched by ethnicity, age and sex: patients with GD (n = 101) and stone-free control subjects (n = 101). RESULTS: Allelic frequencies in patients and controls were: 34.16% vs 41.58% (P = 0.124) for X+of ApoB-100; 4.46% vs 5.94% (P = 0.501) for E2, 85.64% vs 78.22% (P = 0.052) for E3, 9.90% vs 15.84% (P = 0.075) for E4 of ApoE; and 25.74% vs 27.72% (P = 0.653) for C of CYP7A1. Differences in genotypic frequencies between the studied groups were not significant (P < 0.05). CONCLUSION: These results demonstrated that no association exists between the studied polymorphisms and cholelithiasis in this high prevalent population.

关键词： Apolipoprotein CYP7A1 Gallstones Mexicans Polymorphisms

Dynamics in the emergence of dormant and non-dormant herbaceous species from the soil seed bank from a Brazilian dry forest

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Plant Ecology 2020年第3期13卷 256-265页

作者： José Djalma de Souza Bruno Ayron de Souza Aguiar Danielle Melo dos Santos Vanessa Kelly Rodrigues de Araujo Júlia Arruda Simões Juliana ramos de Andrade Elcida de Lima Araújo Departamento de Biologia Universidade Federal Rural de PernambucoRecifePernambucoBrazil2Universidade Federal de Pernambuco-Centro Acadêmico de VitóriaPernambucoBrazil

在干旱的热带森林中,草本植物可能具有休眠机制,并在土壤中形成持续和短暂的种子库。这一由进化而获得的机制对草本植物的建植和生存,特别是在气候不可预测的森林生态系统中,具有重要生态适应意义。因此,本研究的目的是验证草本植物是... 详细信息

在干旱的热带森林中,草本植物可能具有休眠机制,并在土壤中形成持续和短暂的种子库。这一由进化而获得的机制对草本植物的建植和生存,特别是在气候不可预测的森林生态系统中,具有重要生态适应意义。因此,本研究的目的是验证草本植物是否具备物理休眠机制,以及这些植物是如何克服这些自然屏障的,并最终理解巴西干旱热带森林土壤种子库中种子萌发时间动态。本研究选择巴西Caatinga森林中的5种本地草本植物的种子,经过发芽前处理来验证是否存在物理休眠。连续4年在雨季和旱季收集土壤样品,并监测这些草本植物种子在温室中的萌发动态。利用广义线性模型验证种子萌发和出苗率的差异。研究结果表明Caatinga森林中的草本植物种子存在着物理休眠和非物理休眠;而且草本植物从土壤种子库中出苗的种内和种间存在着年份和季节的差异。对于多年生草本植物,不同季节和年份频繁出现不出苗的现象,这可能与物理休眠机制和克服种皮障碍所需的环境条件有关。在这些物种中,种子的二态性和休眠可能给它们的生存带来额外的优势。此外,在一年生植物中出现中等水平的物理休眠可能是对降雨不可预测性的进化调整。相比之下,我们发现没有休眠的一年生草本植物对季节和年际气候变化更敏感,这可以从土壤种子库中其出苗率的增加和显著减少得到证明。这些通过进化获得的种子休眠差异有利于那些分布在气候变化无常的半干旱地区草本植物种群的建立。

关键词：草本植物半干旱种子萌发植株建立物理休眠

拉丁美洲的新韦伯主义国家和新发展主义战略:以乌拉圭为例

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际行政科学评论（中文版） 2020年第2期 63-81页

作者：康拉多·拉莫斯亚历杭德罗·米兰尼斯胡轶俊(译) 王秋蕾(审校) 德国法兰克福大学乌拉圭共和国大学政治学系乌拉圭共和国大学新西兰惠灵顿维多利亚大学不详

本文试图将新韦伯主义公共行政学置于拉丁美洲的背景下进行研究,以期为发展该理论做贡献。我们认为,这种在欧洲大陆国家中发生的公共行政改革模式,在一些遵循新发展主义经济发展模式的拉美国家中也开始有所呈现。新韦伯主义的政治战略... 详细信息

本文试图将新韦伯主义公共行政学置于拉丁美洲的背景下进行研究,以期为发展该理论做贡献。我们认为,这种在欧洲大陆国家中发生的公共行政改革模式,在一些遵循新发展主义经济发展模式的拉美国家中也开始有所呈现。新韦伯主义的政治战略推动了公共部门的现代化,这一改革增强了公共部门的控制和协调能力,从而有效落实了新发展主义观,即重塑国家在引领经济增长和增强社会凝聚力方面的核心地位。然而,由于这些国家的体制缺陷和难以提出清晰的改革方案,因此,他们引入的公共管理模式类似于"不完美"的新韦伯主义。在乌拉圭广泛阵线(Frente Amplio)政党联盟推行改革的背景下,我们通过解析其公共管理模式的要点来展现这种联系。

关键词：拉丁美洲新韦伯主义公共行政国家乌拉圭