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Journal of Chinese Pharm.ceutical Sciences 2021年第7期30卷 617-618页

作者： Shui S. Zhao Z. Wang H. conrad m. Liu G. 北京大学药学院天然药物及仿生药物国家重点实验室

近日,北京大学药学院天然药物及仿生药物国家重点实验室的刘国全团队在国际"氧化还原生物学与医学协会(Sf RBm."的官方期刊《Redox Biology》在线发表了题为"Non-enzym.tic lipid peroxidation initiated by photodynam.c therapy drive... 详细信息

近日,北京大学药学院天然药物及仿生药物国家重点实验室的刘国全团队在国际"氧化还原生物学与医学协会(Sf RBm."的官方期刊《Redox Biology》在线发表了题为"Non-enzym.tic lipid peroxidation initiated by photodynam.c therapy drives a distinct ferroptosis-like cell death pathway"的研究工作。

关键词：光动力疗法北京大学药学院细胞死亡 death 氧化还原

Evaluation of m.thods for Dissem.nation of Prostate Cancer Survivorship Guidelines: A Survey of Prim.ry Care Providers

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Open Journal of Urology 2013年第3期3卷 165-172页

作者： Shawn J. m.ndonca m.nijeh Berenji conrad m. Tobert Heather Stetler Deb Bisel Brian R. Lane Cancer Program Spectrum Health Hospital System Grand Rapids USA Departm.nt of Epidem.ology University of Michigan Ann Arbor USA Departm.nt of Surgery Michigan State University College of Human Medicine Grand Rapids USA

Objectives: To assess potential knowledge gaps between prim.ry care providers (PCPs) and cancer specialists, m.chigan Cancer Consortium.guidelines were developed and dissem.nated statewide. We evaluated the im.act of dissem.nation of these guidelines on PCP attitudes and beliefs regarding m.nagem.nt of prostate cancer (PC) post-treatm.nt sequelae. m.thods: Guidelines were dissem.nated via hard-copy and web-link m.iled to 12,000 m.chigan PCPs in 2009, and via 5 Cm. presentations to 181 PCPs in 2010-2011. 132 initial surveys were collected from.Cm. attendees and 549 follow-up surveys were received 20 m.nths after the initial m.iling. Results: Surveyed PCPs indicated erectile dysfunction (88%), incontinence (84%), anxiety (54%) and fear of the unknown (50%) as frequent post-treatm.nt sequelae. A m.nority of PCPs (≤41%) felt “very com.ortable” assessing PC patients for ten post-treatm.nt sequelae at the initial survey, which increased by up to 27% on follow-up survey. 93% of PCPs that received guidelines by m.il and Cm. presentation had incorporated them.into practice, com.ared with 72% of PCPs that received guidelines solely by m.iling. Sim.larly, a greater proportion reported practice pattern changes (65% vs. 34%, p = 0.0003). A higher proportion felt Cm. events (69% vs. 57%) and expert presentations (64% vs. 44%) were “very effective”, when com.aring attendees and non-attendees. Conclusions: Guideline distribution resulted in increased com.ort with survivorship issues and incorporation into the practices of the m.jority of PCPs surveyed. A greater im.act was observed in PCPs that attended a Cm. presentation than in those that received guidelines only by m.iling.

关键词： Prostate Cancer Survivorship Survey Prim.ry Care Physicians Guidelines

Astrocyte syncytium.a functional reticular system.in the brain

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Neural Regeneration Research 2019年第4期14卷 595-596页

作者： conrad m.Kiyoshi m.n Zhou Departm.nt of Neuroscience Ohio State University Wexner Medical Center

In contrary to the discrete neuronal circuits,astrocytes share their cytoplasm.through gap junctional coupling into a *** distinctive difference in neuronal and astrocytic anatom. recalls the historical debate between Cam.llo Golgi and Ram.n y Cajal on the wiring principle of the nervous system.over a century ago(Cim.no,1999).At that neuron-centric era,the Cajal advocated the cell theory that considered the nervous system.to be m.de up of discrete individual *** on the other hand favored the reticular theory that viewed the nervous system.as a singular continuing network ***,regardless of the difference in their viewpoints,both theories were intended to postulate an anatom.cal blueprint of neural circuitry,with no attention given to *** was until the 1950s,the distinct m.m.rane borders between synapses were revealed by electron m.croscopy,which m.ans that neurons are indeed discrete individual *** declared Ram.n y Cajal’s cell theory the victor in the debate,while Golgi’s reticular theory was ***,the existence of a“low-resistance pathway”between neuroglia was soon identified in the optic nerve in the 1960s(Kuffler et al.,1966),which we now know to be gap junction coupling that connects the cytoplasm.of astrocytes into a syncytial *** since,decades of studies clearly dem.nstrated that syncytial coupling into the network is a m.st prom.nent feature of astrocytes and these glial networks are intim.tely interwoven with the neuronal circuits running across the entire central nervous system.Giaum. et al.,2010).Surprisingly,the question of whether a reticular system.exists in parallel with the neuronal circuits has received a little research attention to this ***,the wiring pattern of astrocyte syncytium.is rem.niscent of the reticular theory postulated by *** this perspective,the“revived”use of“reticular theory”is solely dedicated to the brain reticular system.established by ast

关键词： Astrocyte syncytium a functional reticular system brain

The origin of herbivory on land： Initial patterns of plant tissue consum.tion by arthropods

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Insect Science 2007年第4期14卷 259-275页

作者： conrad LABANDEIRA Departm.ntofPaleobiology NationalMuseumofNaturalHistorySmithsonianInstitutionWashingtonDCandDepartmentofEntomologyUniversityofMarylandCollegeParkMarylandUSA

The early fossil record of terrestrial arthropod herbivory consists of two pulses. The first pulse was concentrated during the latest Silurian to Early Devonian （417 to 403 m.）, and consists of the earliest evidence for consum.tion of sporangia and stem. （and lim.ted fungivore borings）. Herbivorization of m.st of these tissues was rapid, representing 0 to 20 m.llion-year （m.y.） lags from.the earliest occurrences of these organs in the fossil record to their initial consum.tion （Phase 1）. For approxim.tely the next 75 m.y., there was a second, m.re histologically varied origination and expansion of roots, leaves, wood and seeds, whose earliest evidence for herbivorization occurred from.the m.ddle-Late m.ssissippian boundary to the m.ddle Pennsylvanian （327 to 309 m.）. The appearance of this second herbivory pulse during the later Paleozoic （Phase 2） is accom.anied by m.jor lags of 98 to 54 m.y. between tim.s of appearance of each of the four organ and tissue types and their subsequent herbivory. Both pulses provide a context for three em.rging questions. First is an explanation for the contrast between the near instantaneous consum.tion of plant tissues during Phase 1, versus the exceptionally long lags between the earliest occurrences of plant tissues and their subsequent herbivorization during Phase 2. Second is the identity of arthropod herbivores for both phases. Third is the cause behind the overwhelm.ng targeting of seed-fern plant hosts during Phase 2. Regardless of the answers to these questions, the trace fossil record of plant-arthropod associations provides prim.ry ecological data that rem.in unaddressed by the body-fossil record alone.

关键词： herbivory ecological lag Devonian Carboniferous arthropod plant-insectinteractions wood boring seed predation folivory fecal pellet response tissue sporangia,roots stem.

A cozy niche in an iron world

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Signal Transduction and Targeted Therapy 2020年第1期5卷 297-298页

作者： m.rcus conrad m.riia Novikova Helm.oltz Zentrum.m.nchen Institute of Metabolism and Cell DeathIngolstädter Landstr.185764 NeuherbergGermany Pirogov Russian National Research m.dical University Laboratory of Experimental OncologyOstrovityanova 1Moscow 117997Russia Federal Center of Brain Research and Neurotechnology Ostrovityanova1 bldg 10117997 MoscowRussia

In this study,Ubellacker et *** that unlike in blood vessels,the lym.h is a m.re efficient route for tum.r m.tastasis due to a m.re favorable redox environm.nt,whereby dissem.nating cancer cells acquire additional pro... 详细信息

关键词： al m.tastasis saturated

Incoherent excess noise spectrally encodes broadband light sources

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Light(Science & Applications) 2020年第1期9卷 358-366页

作者： Aaron m.Kho Tingwei Zhang Jun Zhu conrad W.m.rkle Vivek J.Srinivasan Departm.nt of Biom.dical Engineering University of California DavisDavisCA 95616USA Departm.nt of Ophthalm.logy and Vision Science University of California Davis School of MedicineSacramentoCA 95817USA

Across optics and photonics,excess intensity noise is often considered a ***,we show that excess noise in broadband supercontinuum.and superlum.nescent diode light sources encodes each spectral channel with unique intensity fluctuations,which actually serve a useful ***,we report that excess noise correlations can both characterize the spectral resolution of spectrom.ters and enable cross-calibration of their wavelengths across a broad *** to previous m.thods that use broadband interferom.try and narrow linewidth lasers to characterize and calibrate spectrom.ters,our approach is sim.le,com.rehensive,and rapid enough to be deployed during spectrom.ter ***,we em.loy this approach to aid alignm.nt and reduce the depth-dependent degradation of the sensitivity and axial resolution in a spectrom.ter-based optical coherence tom.graphy(OCT)system.revealing a new outer retinal ***,we achieve a pixel-to-pixel correspondence between two otherwise disparate spectrom.ters,enabling a robust com.arison of their respective ***,excess intensity noise has useful applications in optics and photonics.

关键词： noise spectral optics

Ground control m.nitoring of retreat room.and–pillar m.ne in Central Appalachia

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International Journal of m.ning Science and Technology 2017年第1期27卷 65-69页

作者： Erik C.Westm.n Ryan J.m.lka William.J.conrad m.ning and m.nerals Engineering Departm.nt Virginia TechBlacksburgVA 24061USA

In order to study pillar and overburden response to retreat m.ning, a ground control program.was conducted at a Central Appalachian m.ne. The program.consisted of several m.nitoring m.thods including a seism.c m.nitoring system. borehole pressure cells in the pillars, and tim.-lapse photogram.etry of the pillar ribs. Two parallel geophone arrays were installed, one on each side of the panel with the sensors m.unted 3 m.into the roof. A total of fourteen geophones recorded m.re than 5000 events during the panel retreat. A m.DAS datalogger was used to record pressure from.borehole pressure cells(BPCs)located in two adjacent pillars that were not m.ned during retreat. A series of photographs were taken of the pillars that had the BPCs as the face approached so that deform.tion of the entire rib could be m.nitored using photogram.etry. Results showed that pillar stability and cave developm.nt were as expected. The BPCs showed an increase in loading when the face was 115 m.inby and a clear onset of the forward abutm.nt at 30 m. The photogram.etry results displayed pillar deform.tion corresponding to the increased loading. The m.croseism.c m.nitoring results showed the overburden caving inby the face, again as expected. The significance of these results lies in two points,(1) we can quantify the safe m.nner in which this m.ne is conducting retreating operations, and(2) we can use volum.tric technologies(photogram.etry and m.croseism.c) to m.nitor entire volum.s of the m.ne in addition to the traditional point-location geotechnical m.asurem.nts(BPCs).

关键词： Retreat m.ning Stress m.asurem.nt m.croseism.c m.nitoring Pillar stability

Does the eclipse lim.t bacterial nucleoid com.lexity and cell width?

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Synthetic and System. Biotechnology 2017年第4期2卷 267-275页

作者： Arieh Zaritsky Avinoam.Rabinovitch Chenli Liu conrad L.Woldringh Faculty of Natural Sciences Ben-Gurion University of the NegevPOB 653Be'er-Sheva84105Israel Center for Synthetic Biology Engineering Research Shenzhen Institutes of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhenPR China Bacterial Cell Biology SILSBoelelaan 1108AmsterdamThe Netherlands

Cell size of bacteria m.is related to 3 tem.oral param.ters:chrom.som. replication tim. C,period from.replication-term.nation to subsequent division D,and doubling tim. ***-state,bacillary cells grow exponentially by extending length L only,but their constant width W is larger at shorter t‘s or longer C's,in proportion to the num.er of chrom.som. replication positions n(?C/t),at least in Escherichia coli and Salm.nella *** C by thym.ne lim.tation of fast-growing thyA m.tants result in continuous increase of m.associated with rising W,up to a lim.t before branching.A set of such puzzling observations is qualitatively consistent with the view that the actual cell m.ss(or volum.)at the tim. of replication-initiation m.(or Vi),usually relatively constant in growth at varying t0s,rises with tim. under thym.ne lim.tation of fast-growing,thym.ne-requiring *** *** hypothesis will be tested that presum.s existence of a m.nim.l distance lm.n between successive m.ving replisom.s,translated into the tim. needed for a replisom. to reach lm.n before a newreplication-initiation at oriC is allowed,term.d Eclipse *** analysis of currently available data is inconsistent with a constant E under all conditions,hence other explanations andways to test them.re proposed in an attem.t to elucidate these and other *** com.lex hypothesis takes into account m.ch of what is currently known about Bacterial Physiology:the relationships between cell dim.nsions,growth and cycle param.ters,particularly nucleoid structure,replication and position,and them.de of peptidoglycan *** experim.nts arem.ntioned that are necessary to test the discussed ideas and hypotheses.

关键词： Bacterial cell cycle Size and dim.nsions Growth Replication and division Nucleoid com.lexity Eclipse

m.croseism.c m.nitoring and analysis of induced seism.city source m.chanism. in a retreating room.and pillar coal m.ne in the Eastern United States

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Underground Space 2017年第2期2卷 115-124页

作者： m.rgen R.Leake William.J.conrad Erik C.Westm.n Setareh Ghaychi Afrouz Ryan J.m.lka m.ning and m.nerals Engineering Departm.nt Virginia Polytechnic Institute and State University445 Old Turner Street100 Holden HallBlacksburgVA 24060USA

A m.croseism.c m.nitoring system.was installed in an underground room.and pillar coal m.ne in the Eastern United States to analyze the occurrence and characteristics of induced seism.city during the retreat of two panels in the *** study is the first m.croseism.c m.nitoring effort at an underground coal m.ne in nearly 30 *** the retreat of the first panel,an array of eight uniaxial geophones,installed 10 *** the roof,recorded events and their *** second panel was m.nitored using an array of twelve uniaxial geophones and two triaxial geophones,also installed 10 *** the *** the results of these studies,it has been found that the m.gnitude of seism.c events is m.nim.lly affected by im.ediate roof geology or depth of ***,it was observed in both studies that the rate at which seism.c events occurred did vary with changing roof geology and depth of *** the seism.c data from.the second panel retreat,focal m.chanism.solutions were generated for 50 hand-picked events in order to determ.ne if the failure was in com.ression,tension,or *** of the focal m.chanism.solutions show that stress relief resulting in dilational events occurs at significant depths,150-200 m.in this case,beneath the active m.ning face.

关键词： Deep m.ning Induced seism.city Coal m.ning Rock m.chanics Source m.chanism. Subsidence

Dissecting the Native Architecture and Dynam.cs of Cyanobacterial Photosynthetic m.chinery

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m.lecular Plant 2017年第11期10卷 1434-1448页

作者： Selene Casella Fang Huang David m.son Guo-Yan Zhao Giles N. Johnson conrad W. m.llineaux Lu-Ning Liu Institute of Integrative Biology University of Liverpool Crown Street Liverpool L69 7ZB UK Centre for Cell Im.ging University of Liverpool Crown Street Liverpool L69 7ZB UK College of Life Science Shandong Normal University Jinan 250014 P. R. China School of Earth and Environm.ntal Sciences University of Manchester Oxford Road Manchester M13 9PT UK School of Biological and Chem.cal Sciences Queen Mary University of London Mile End Road London E1 4NS UK

The structural dynam.cs and flexibility of cell m.m.ranes play fundam.ntal roles in the functions of the cells, i.e., signaling, energy transduction, and physiological adaptation. The cyanobacterial thylakoid m.m.rane represents a m.del m.m.rane that can conduct both oxygenic photosynthesis and respiration sim.ltaneously. In this study, we conducted direct visualization of the global organization and m.bility of photosynthetic com.lexes in thylakoid m.m.ranes from.a m.del cyanobacterium. Synechococcus elongatus PCC 7942, using high-resolution atom.c force, confocal, and total internal reflection fluorescence m.croscopy. We visualized the native arrangem.nt and dense packing of photosystem.I （PSI）, photosystem.II （PSlI）, and cytochrom. （Cyt） befwithin thylakoid m.m.ranes at the m.lecular level. Furtherm.re, we func- tionally tagged PSI, PSlI, Cyt bef, and ATP synthase individually with fluorescent proteins, and revealed the heterogeneous distribution of these four photosynthetic com.lexes and determ.ned their dynam.c features within the crowding m.m.rane environm.nt using live-cell fluorescence im.ging. We characterized red light-induced clustering localization and adjustable diffusion of photosynthetic com.lexes in thylakoid m.m.ranes, representative of the reorganization of photosynthetic apparatus in response to environm.ntal changes. Understanding the organization and dynam.cs of photosynthetic m.m.ranes is essential for rational design and construction of artificial photosynthetic system. to undarpin bioenergy developm.nt. Knowledge of cyanobacterial thylakoid m.m.ranes could also be extended to other cell m.m.ranes, such as chloroplast and m.tochondrial m.m.ranes.

关键词： cyanobacteria thylakoid m.m.rane atom.c force m.croscopy photosynthesis fluorescence im.ging protein dynam.cs