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Branchio-oculo-facial综合征新的眼部表现

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世界核心医学期刊文摘（眼科学分册） 2005年第7期1卷 17-18页

作者： Demirci H. shields C.L. shields j.A. 王永强 Oncology Service Wills Eye Hospital 840 Walnut StreetPhiladelphia PA 19107 United States

Purpose: To report new ocular manifestations of branchio- oculo- facial (BOF) syndrome. Design: Case report. Methods: A 10- year- old girl with known BOF syndrome was referred because of a fundus lesion in her left eye. Results: She had undergone excision of a left orbital dermoid cyst at age 18 months and a branchial cleft fistula from the right side of neck at age 4 years. Examination disclosed openings of sinus tracts on each side of the nose connecting the lacrimal sac to skin. In the right eye, an iris pigment epithelial cyst was confirmed with ultrasound biomicroscopy. In the left eye, there was a combined hamartoma of the retina and retina pigment epithelium. Conclusion: BOF syndrome can display mild to severe craniofacial, auricular, oral, and ophthalmic anomalies. In this case, the ophthalmic manifestations included lacrimal sac fistula, orbital dermoid cyst, iris pigment epithelial cyst, and combined hamartoma of the retina and retinal pigment epithelium.

关键词： facial 视网膜色素上皮泪囊瘘超声生物显微镜眼底损害眼眶皮样囊肿错构瘤鳃裂瘘眼部异常上皮囊肿

115例视盘黑色素细胞瘤的病例报道:2004年Samuel johnson纪念讲座第一部分

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 55-56页

作者： shields j.A. Demirci H. Mashayekhi A. shields C.L. 黎黎 Oncology Service Wills Eye Hospital Thomas Jefferson University Philadelphia PA Uni ted States Dr.

Purpose To report clinical variations and the natural course of melanocytoma o f the optic disc. Patients and methods A retrospective study was conducted on a consecutive series of patients with melanocytoma of the optic disc who were evaluated at the Ocular Oncology Service at Wills Eye Hospital. Demographic information and variations i n appearance and size of the tumor and local ocular complications were noted. Fr equency of tumor growth and malignant transformation was recorded. Clinical fact ors, including patient data and tumor features, were analyzed for their impact o n visual acuity loss of 2 or more Snellen lines and the tumor growth, using Cox proportional hazards regression models. Kaplan-Meier survival estimates of prob ability of visual acuity loss of 2 or more Snellen lines and probability of tumo r growth were performed as a function of time from the initial examination. Main outcome measures Visual acuity loss of 2 or more Snellen lines, tumor growth, a nd malignant transformation of the tumor. Results There were 115 patients (116 e yes) with melanocytoma of the optic disc. The mean age at diagnosis was 50 years ; 38%of patients were male and 62%of patients were female; 65%of patients wer e white, 29%of patients were African American, and 6%of patients were Asian, H ispanic, Indian, or Arabic. The lesion was unilateral in 99%of patients. Visual symptoms that seemed to be related to the melanocytoma were present in 24%of p atients, and an afferent pupillary defect was noted in 9%of patients. Associate d ocular abnormalities included ocular melanocytosis (8%), racial melanosis (7 %), optic nerve hypoplasia (2%), and retinitis pigmentosa (1%). The melanocyt oma was dark brown to black in 100%of patients. The mean tumor diameter was 2 m m and the mean thickness was 1 mm. Associated findings included a choroidal comp onent (54%), retinal component (30%), optic disc edema (25%), retinal edema ( 16%), localized subretinal fluid (14%), retinal exudation (12

关键词： Samuel johnson 色素细胞瘤视网膜出血视网膜色素变性视网膜静脉阻塞视盘水肿眼底血管造影视网膜水肿视力损害荧光素

1643例黑色素细胞结膜肿瘤和非黑色素细胞结膜肿瘤的临床调查

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 56-57页

作者： shields C.L. Demirci H. Karatza E. shields j.A. 黎黎 Ocular Onco logy Service Wills Eye Hospital Thomas Jefferson University Philadelphia PA United States Dr.

Objective To report the spectrum and frequency of melanocytic and nonmelanocyt ic conjunctival tumors in an ocular oncology practice. Design Retrospective noninterventional case series. Participants One thousand six hundred forty-three consecutive patients with a c onjunctival mass evaluated at an ocular oncology department. Methods A chart rev iew was conducted to obtain the clinical features of the patient and tumor and t o tabulate and categorize the diagnoses. Main outcome measures Tumor diagnosis o verall and relative to patient age, race, and gender and relative to tumor locat ion and laterality. Results In 1643 consecutive patients, the tumor was classifi ed as melanocytic in 872 cases (53%) and nonmelanocytic in 771 cases (47%). Th e nonmelanocytic categories included congenital choristomatous (n=40 2%), epi thelial (n=219 13%), vascular (n=63 4%), fibrous (n=7 60. Of the 219 patients with e pithelial tumors, 80%occurred inmales, whereas the incidence of melanocytic les ions was equal in males and females. African-American patients represented only 7%of epithelial tumors,junctival tumors were of melanocytic origin in 53%of cases and nonmelanocy tic origin in 47%. Overall, melanocytic tumors, epithelial tumors, and lymphoid tumors acco

关键词：黑色素细胞临床调查黑色素沉着病牙瘤黏液瘤瘤样病变上皮型黄色瘤血管瘤黑素瘤

CONTROL OF GULLY EROSION USING STIFF GRASSES

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International journal of Sediment Research 2005年第4期20卷 319-332页

作者： F. D. shields, jr. S. M. DABNEY E. j. LANGENDOEN D. M. TEMPLE Research Hydraulic Engineer USDA-ARS National Sedimentation Laboratory Oxford Mississippi Research Argonomist USDA-ARS National Sedimentation Laboratory Oxford Mississippis Research Hydraulic Engineer USDA-ARS National Sedimentation Laboratory Oxford Mississippi USDA-ARS Hydraulic Engineering Research Unit Stillwater

Concentrated flow can cause gully formation on sloping lands and in riparian zones. Current practice for riparian gully erosion control involves blocking the gully with a structure comprised of an earthen embankment and a metal or plastic pipe. Measures involving native vegetation would be more attractive for habitat recovery and economic reasons. To test the hypothesis that switchgrass (Panicum virgatum L.) hedges planted at 0.5-m vertical intervals within a gully would control erosion, a series of hedges was established in four concentrated flow channels. Two of the channels were previously eroded trapezoidal channels cut into compacted fill in an outdoor laboratory. The other two channels were natural gullies located at the edge of floodplain fields adjacent to an incised stream. While vegetation was dormant, artificial runoff events were created in the two laboratory gullies and one of the natural gullies using synthetic trapezoidal-shaped hydrographs with peak discharge rates of approximately 0.03, 0.07, and 0.16 m3/s. During these tests flow depth, velocity, turbidity, and soil pore water pressures were monitored. The fourth gully was subjected to a series of natural runoff events over a five-month period with peaks up to 0.09 m3/s. Flow depths in all tests were generally 1 for step heights 1 m, consistent with the experimental observations.

关键词： Erosion Gully Grass hedges Buffers

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化学减容法治疗视网膜母细胞瘤的远期视力

世界核心医学期刊文摘(眼科学分册) 2006年第3期 21-22页

作者： Demirci H shields C.L Meadows A.T shields j.A. 陈立军 Ocular Oncology Service Wills Eye Hospital Thomas Jefferson University 840 Walnut St Philadelphia PA 19107 United StatesDr.

Objective: To evaluate long-term visual outcome following chemoreduction. Design: Interventional case series evaluating 54 eyes of 40 children with retinoblastoma successfully treated with chemoreduction, consisting of a combination of intravenous carboplatin, etoposide phosphate, and vincristine sulfate plus focal therapy without external beam radiotherapy or enucleation. All patients were followed up for at least 5 years. Patient and tumor data were analyzed for their effect on the main outcome measures (final visual acuities of 20/40 or better and of 20/200 or better) using univariate and multivariate regression models. Patien ts who failed chemoreduction were excluded. Results: There were 4 eyes in Reese -Ellsworth group I, 7 in group II, 3 in group III, 15 in group IV, and 25 in gr oup V. The mean distance from the posterior tumor margin to the optic disc was 2 mm, and from the tumor margin to the foveola it was 3 mm. After a mean follow- up of 68 months, 27 eyes (50%) had a final visual acuity of 20/40 or better, an d 36 eyes (67%) had final visual acuity of 20/200 or better. Of 33 eyes with ma cular tumor, only 8 (24%) had a final visual acuity of 20/40 or better, and 15 (45%) had a final visual acuity of 20/200 or better. Of 21 eyes with extramacul ar tumor, 19 (90%) had a final visual acuity of 20/40 or better, and all (100% ) had a final visual acuity of 20/200 or better. Conclusion: The clinical factor s that predicted visual acuity of 20/40 or better were a tumor margin at least 3 mm from the foveola and optic disc and an absence of sub-retinal fluid.

关键词：视网膜母细胞瘤视力减容

ELISA夹心法中抗体质量的重要性——评价选用的商品试剂

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微生物学免疫学进展 1988年第1期 50-52页

作者： shields j G Turner M W ,范亚民

ELISA的许多特性中以其能有效地检测各种生物液或细胞培养上清液中低浓度的免疫球蛋白类或亚类为最。虽然对抗血清的选择很严格,但对试验取得成功所需之纯度还缺少深入研究。最近,几家公司介绍的高

关键词：抗体 IgG 绵羊试剂夹心法 ELISA 商品

C-reactive protein and radiographic findings of lower respiratory tract infection in infants

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World journal of Radiology 2017年第4期9卷 206-211页

作者： Maria Twomey Hannah Fleming Fiachra Moloney Kevin P Murphy Lee Crush Siobhan B O’Neill Oisin Flanagan Karl james conor Bogue Owen j O’Connor Michael M Maher Department of Radiology Cork University HospitalWiltonT12 DC4A CorkIreland

AIM To evaluate the association between C-reactive protein(CRP) and radiological evidence of lower respiratory tract infection(LRTI) in *** All patients aged less than 4 years who presented with suspected lower respiratory tract infection,who received a peri-presentation chest radiograph and CRP blood measurement over an 18-mo period were included in the ***,gender,source of referral,CRP,white cell count,neutrophil count along with the patients' symptoms and radiologist's report were *** Three hundred and eleven patients met the *** chest radiographs were more common in patients with elevated CRP levels(P < 0.01).Radiologic signs of LRTI were identified in 73.7% of chest radiographs when a patient had a CRP level between 50-99 mg/*** levels were a better predictor of positive chest radiograph findings for those aged greater than I year compared to those 1 year or *** CRP may be used in patients with suspected LRTI diagnosis to select those who are likely to have positive findings on chest radiograph,thus reducing unnecessary chest radiographs.

关键词： Chest radiograph C-reactive protein Chest infection Respiratory infection Pediatric

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可持续发展对采矿部门的挑战

产业与环境 2001年第S1期23卷 16-19页

作者： Deborah j.shields Slavko V.Solar 温官 USDA Forest Service-Researeh asd Development Rocky Mountain Research station Geological survey of Slovenia

支撑实际上所有可持续能力定义的基本原理现在已经应用于采矿部门，然而，它们的应用仍然具有明显和潜在的障碍障碍包括原理本身以及它们在一些情况下与当前运作的社会和经济系统不一致这一事实．我们作出如下结论：由于有许多途径来... 详细信息

支撑实际上所有可持续能力定义的基本原理现在已经应用于采矿部门，然而，它们的应用仍然具有明显和潜在的障碍障碍包括原理本身以及它们在一些情况下与当前运作的社会和经济系统不一致这一事实．我们作出如下结论：由于有许多途径来定义和实施可持续发展，引用它的原理可能带来不同的可能结果．这井不降低解决公开问题的可能性，而且它更可能为适合每一种特定矿物操作或活动的特殊条件的平衡的解决方法，以及每一个国家的独特处境带来机遇．

关键词：可持续能力利益攸关者自然资本国际条约矿物资源社会资本矿物开采预防原理政策和法律公众参与

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肿瘤相关的色素上皮钱币状缺失

世界核心医学期刊文摘（眼科学分册） 2005年第9期1卷 24-25页

作者： Slakter j.S. shields j.A. Spaide R.F. 韩静 Vitreous Retina Macula Consult. N. 460 Park Avenue New York NY 10021 United States Dr.

PURPOSE: To report a case of bilateral diffuse uveal melanocytic proliferation (BDUMP) that had areas of retinal pigment epithelial loss. DESIGN: Observational case report. METHODS: A 67-year-old woman with a history of uterine cancer presented with 4 months of bilateral visual loss. RESULTS: Although B-scan ultrasonography revealed both small shallow serous retinal and choroidal detachments in the periphery, the choroid was normal in thickness. Fluorescein angiography revealed numerous nummular-shaped areas of transmission defects suggesting retinal pigment epithelium loss. Autofluorescence photography showed complete absence of autofluorescence in these nummular areas, and optical co-herence tomography showed segmental areas with lack of any signal from affected areas of the retinal pigment epithelium, suggesting complete loss of retinal pigment epithelium cells. CONCLUSIONS: Although the fundus findings in BDUMPhave been attributed to the proliferation of uveal melanocytic cells in the outer choroid in previous papers, our patient had nummular areas of loss of the retinal pigment epithelium as the apparent reason for visual decline.

关键词：色素上皮钱币状自发荧光荧光血管造影脉络膜脱离葡萄膜黑色素细胞观察性膜厚度弥漫性