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Imaging assessment after SBRT for hepatocellular carcinoma

Hepatoma Research 2020年第7期6卷 78-85页

作者： connie yip Tiffany Priyanthi Hennedige Gary JRCook Vicky Goh Radiation Oncology National Cancer Centre SingaporeSingapore 169610Singapore Oncologic Imaging National Cancer Centre SingaporeSingapore 169610Singapore Cancer Imaging King’s College LondonLondon WC2R 2LSUnited Kingdom

The use of stereotactic body radiotherapy(SBRT)in hepatocellular carcinoma(HCC)has increased over the past few ***,accurate evaluation of post-SBRT treatment response is essential to avoid over-treatment of responders as well as missing the opportunity to salvage *** are some intricate imaging differences after liver SBRT compared to those observed after conventional fractionated radiotherapy and other locoregional *** aim to review the imaging changes that occur following SBRT for HCC and their potential clinical implications.

关键词： Imaging liver stereotactic body radiotherapy hepatocellular carcinoma

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Feasibility and long-term outcomes of post-chemotherapy-based consolidation radiotherapy in extensive stage small-cell lung cancer

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Journal of the National Cancer Center 2023年第3期3卷 161-166页

作者： Chen Jie Yeshan Chen Yong Yang Rumeng Li Bin Yang connie yip Jing Yu Department of Radiation and Medical Oncology Hubei Key Laboratory of Tumor Biological BehaviorsHubei Cancer Clinical Study CenterZhongnan Hospital of Wuhan UniversityWuhanChina Institute of Radiation Oncology&Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Radiation Oncology Fujian Medical University Union HospitalFuzhouChina Department of Thoracic Oncology Hubei Cancer HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Head&Neck and Thoracic Division of Radiation OncologyNational Cancer Centre SingaporeSingapore

Background:The target definition of consolidation radiotherapy(RT)for extensive stage small-cell lung cancer(ES-SCLC)has not been *** study aimed to demonstrate the feasibility of post-chemotherapy based consolidation RT in ***:All ES-SCLC patients without initial brain metastases who completed≥4 cycles of systemic therapy at Department of Radiation and Medical Oncology,Zhongnan Hospital of Wuhan University from 2012 to 2021 were included in this retrospective *** correlated the site of first recurrence to the post-chemotherapy-based radiation volume(small-field).Relapse pattern,progression-free survival(PFS)and overall survival(OS)were compared between those received and did not receive consolidation ***:A total of 152 patients were followed up for a median of 31.7 months(interquartile range[IQR],23.9-39.6 months).The median PFS and OS of the cohort were 8.3 months(IQR,6.1-11.2 months)and 16.2 months(IQR,9.9-24.9 months),*** consolidation RT served not only as an independent prognostic factor for improved PFS in the entire cohort,but also significantly prolonged OS in the subgroup without syn-chronous liver ***-field consolidation RT markedly reduced in-field recurrences(hazard ratio[HR],0.28[95%CI,0.12-0.38];P<0.001)without increasing out-of-field recurrences(HR,0.40[95%CI,0.13-1.16];P=0.080).No relapse was observed at the margin of the ***-related toxicities were moderate,with grade 3 acute radiation pneumonia,radiation esophagitis,and bone marrow suppression rates of 8.3%,3.1%,and 12.5%,*** grade 5 toxicity ***:Small-field consolidation RT based on post-chemotherapy volume is safe and can significantly im-prove local control in ES-SCLC.

关键词： Small cell lung cancer Extensive stage Consolidation radiotherapy Post-chemotherapy based target Long-term outcomes

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