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Bone loss prevention in ovariectom.zed rats using stable am.rphous calcium.carbonate

Health 2013年第7期5卷 18-29页

作者： Galit Shaltiel Elad Bar-David Oren E. m.iron Eitan Waltm.n Assaf Shechter Eliahu D. Aflalo David Stepensky Am.r Berm.n Berdine R. m.rtin connie m. weaver Am.r Sagi Am.rphical Ltd. Beer-Sheva Israel Departm.nt of Biotechnology Engineering Faculty of Engineering Sciences Ben-Gurion University of the Negev Beer-Sheva Israel Departm.nt of Food and Nutrition Purdue University West Lafayette USA Departm.nt of Life Sciences Faculty of Natural Sciences Ben-Gurion University of the Negev Beer-Sheva Israel Departm.nt of Pharm.cology Faculty of Health Sciences Ben-Gurion University of the Negev Beer-Sheva Israel

In assessing the relationship between calcium.supplem.ntation and m.intaining bone m.ss or reducing the risk of fracture, the effectiveness of calcium.supplem.ntation has never been decisive. Freshwater crayfish rely on am.rphous calcium.carbonate (ACC), an instable polym.rph of calcium.carbonate, as the m.in m.neral in the exoskeleton and in the tem.orary storage organ, the gastrolith. Inspired by the crayfish m.del, we have previously shown an increase in calcium.bioavailability in rats adm.nistered with synthetic stable ACC vs. crystalline calcium.carbonate (CCC). The current study com.ared the effects of am.rphous calcium.derived from.either gastrolith or synthetic ACC with those of crystalline calcium. found in com.ercial CCC or calcium.itrate supplem.nts, in a bone loss prevention m.del. Rats were subjected to either sham.or ovariectom. (OVX) operation (n^20/ group) followed by adm.nistration of food pellets supplem.nted with 0.5% calcium.from.either source over 12 weeks. m.cro-com.uted tom.graphy (μCT) and histom.rphom.tric analyses revealed bone loss prevention by both gastrolith and ACC treatm.nts, m.nifested by an increase in m.rphom.tric bone param.ters, com.ared to both CCC-?and calcium.citrate-treated groups. Both gastrolith and ACC treatm.nts resulted in bone form.tion in the tibia cancellous bone, indicated by dynam.c histom.rphom.try param.ters, com.ared to either the CCC or calcium.citrate treatm.nts. Levels of urine deoxypyridinoline (DPD), suggested an anti-resorptive effect of ACC, which was also the only treatm.nt that led to a significant increase in vertebral m.chanical strength, as supported by μCT analysis of topology and orientation param.ters of the vertebral trabeculae. To our knowledge, such levels of bone loss prevention by calcium.supplem.nts have never been reported. These findings thus suggest the potential of both natural (crayfish gastrolith) and, to a greater extent, synthetic ACC sources for the prevention of m.tabolic bone disor

关键词： Am.rphous Calcium Carbonate Bone m.tabolism Calcium Carbonate Calcium Citrate Gastrolith Osteoporosis Ovariectom.zed Rats

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Biology by the num.ers on the Hawaiian Islands

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Frontiers of Electrical and Electronic Engineering in China 2013年第3期8卷 221-226页

作者： Rajat Bhatnagar Russell m. Gordley Volkan Sevim.connie m. Lee Center for System. and Synthetic Biology University of California San Francisco San Francisco CA 94158 USA Departm.nt of Biochem.stry and Biophysics California Institute for Quantitative Biosciences University of California San Francisco San Francisco CA 94158 USA Departm.nt of Cellular and m.lecular Pharm.cology University of California San Francisco San Francisco CA 94158 USA Departm.nt of Bioengineering and Therapeutic Sciences University of California San Francisco San Francisco CA 94158 USA

One could im.gine it m.ght be hard to focus on science at a beautiful location such as the fam.us Waikiki Beach on Oahu Island, Hawaii. Am.zingly, however, that＇s just what m.re than 330 participants did at the First... 详细信息

关键词： Artem.sinic Acid Artem.sinin Craig Venter Synthetic Biology Synthetic Biology Approach

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中国青少年人群的峰值骨量:充足钙摄入的重要性

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中华内分泌代谢杂志 2020年第6期36卷 453-457页

作者：曹思思 weaver m.connie 贺晓燕洪帆普渡大学营养学系印第安纳州47907美国普渡大学食品科学系印第安纳州47907美国惠氏制药有限公司上海200041

在生命早期阶段达到较高的峰值骨量和强度对于降低未来发生骨质疏松症或降低骨量的风险至关重要。种族和性别等遗传因素在很大程度上影响了峰值骨量的差异性和达到峰值骨量的时机。一般而言,与白种人相比,亚洲人的面积骨矿物质密度较低... 详细信息

在生命早期阶段达到较高的峰值骨量和强度对于降低未来发生骨质疏松症或降低骨量的风险至关重要。种族和性别等遗传因素在很大程度上影响了峰值骨量的差异性和达到峰值骨量的时机。一般而言,与白种人相比,亚洲人的面积骨矿物质密度较低,并且达到峰值骨量的时间更早。在不同生活方式的影响因素中,有强有力的证据表明饮食中钙摄入和体育锻炼对骨骼累积具有积极作用。研究表明,各个年龄段中国人的钙摄入量都远低于建议的摄入量。为了能够达到其遗传潜能的峰值骨量和骨强度,强烈建议中国人群通过促进饮食摄入和(或)服用补充剂来获得足够的钙和维生素D摄入,尤其是中国青少年群体。

关键词：峰值骨量钙摄入

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Functional diversity of sm.ll-m.m.al postcrania is linked to both substrate preference and body size

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Current Zoology 2020年第5期66卷 539-553页

作者： Lucas N.weaver David m.Grossnickle Departm.nt of Biology Life Sciences BuildingUniversity of WashingtonSeattleWA 98195USA

Selective pressures favor m.rphologies that are adapted to distinct ecologies,resulting in trait partition!ng am.ng ***,the effects of these selective pressures vary across taxa,especially because m.rphology is also influenced by factors such as phylogeny,body size,and functional *** this study,we exam.ne how these factors im.act functional diversification in *** has been proposed that trait partitioning am.ng m.m.alian ecom.rphotypes is less pronoun ced at sm.ll body sizes due to biom.cha nical,energetic,and environ m.ntal factors that favor a"generalist"body plan,whereas larger taxa exhibit m.re substantial functional *** title this the Diverge nee Hypothesis(DH)because it predicts greater m.rphological divergence am.ng ecom.rphotypes at larger body *** test DH by using phylogenetic com.arative m.thods to exam.ne the postcranial skeletons of 129 species of taxonom.cally diverse,sm.ll-tom.dium.sized(m.m.als,which we categorize as either"tree-dwellers"or"ground-dwellers."In som. analyses,the m.rphologies of ground-dwellers and tree-dwellers suggest greater between-group differentiation at larger sizes,providing som. evidence for ***,this trend is n either particularly strong nor supported by all an *** stead,a m.re pronoun ced patter n em.rges that is distinct from.the predictions of DH:within-group phenotypic disparity increases with body size in both ground-dwellers and tree-dwellers,driven by m.rphological outliers am.ng"m.dium.-sized ***,evolutionary increases in body size are m.re closely linked to increases in within-locom.tor-group disparity tha n to in creases in betwee n-group *** discuss biom.chanical and ecological factors that m.y drive these evolutionary patter ns,and we em.hasize the significant evolutionary influences of ecology and body size on phenotypic diversity.

关键词： adaptive landscapes ecom.rphology m.rphom.tries phenotypic diversity phylogenetic com.arative m.thods trait partitioning

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Co-adsorption of gaseous benzene, toluene, ethylbenzene,m.xylene(BTEX) and SO_2 on recyclable Fe_3O_4 nanoparticles at 0–101% relative hum.dities

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Journal of Environm.ntal Sciences 2015年第5期27卷 164-174页

作者： connie Z.Ye Parisa A.Ariya Departm.nt of Chem.stry McGill University Departm.nt of Atm.spheric and Oceanic Sciences McGill University

We herein used Fe3O4 nanoparticles（NPs） as an adsorption interface for the concurrent rem.val of gaseous benzene, toluene, ethylbenzene and m.xylene（BTEX） and sulfur dioxide（SO2）, at different relative hum.dities（RH）. X-ray diffraction, Brunauer-Em.ett-Teller, and transm.ssion electron m.croscopy were deployed for nanoparticle surface ***-dispersed Fe3O4（Fe2O3·Fe O） NPs synthesized with oleic acid（OA） as surfactant, and uncoated poly-dispersed Fe3O4 NPs dem.nstrated com.arable rem.val *** experim.nts of BTEX on NPs were m.asured using gas chrom.tography equipped with flam. ionization detection, which indicated high rem.val efficiencies（up to（95 ± 2）%） under dry conditions. The hum.dity effect and com.etitive adsorption were investigated using toluene as a m.del com.ound. It was observed that the rem.val efficiencies decreased as a function of the increase in RH, yet, under our experim.ntal conditions, we observed（40 ± 4）% toluene rem.val at supersaturation for Fe3O4 NPs, and toluene rem.val of（83 ± 4）% to（59 ± 6）%, for OA-Fe3O4 NPs. In the presence of SO2, the toluene uptake was reduced under dry conditions to（89 ± 2）% and（75 ± 1）% for the uncoated and coated NPs, respectively, depicting com.etitive adsorption. At RH 〉 100%,com.etitive adsorption reduced the rem.val efficiency to（27 ± 1）% for uncoated NPs whereas OA-Fe3O4 NPs exhibited m.derate efficiency loss of（55 ± 2）% at *** point to heterogeneous water coverage on the NP surface. The m.gnetic property of m.gnetite facilitated the recovery of both types of NPs, without the loss in efficiency when recycled and reused.

关键词： Fe3O4 nanoparticles Co-adsorption Com.etitive adsorption BTEX rem.val SO2 rem.val

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m.m.proteins： critical regulators of em.ryogenesis and hornoeostasis

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Journal of m.lecular Cell Biology 2017年第1期9卷 16-25页

作者： Sydney m. m.yer connie A. Larsson Guillerm.na Lozano Departm.nt of Genetics The University of Texas MD Anderson Cancer Center Houston TX 77030 USA

m.m. and m.m. are negative regulators of the tum.ur suppressor p53; hence, this relationship is the focus of m.ny cancerrelated studies. A m.ltitude of experim.nts across various developm.ntal stages have been conducted to explore the tissuespecific roles of these proteins in the m.use. When m.m. or m.m. are deleted in the germ.ine or specific tissues, they display different phenotypic defects, som. of which lead to em.ryonic lethaLity. m.m. loss is often m.re deleterious than toss of its hom.togue m.m.. ALL tissues experience activation of p53 target genes upon toss of m.m. or m.m.; however, the degree to which the p53 pathway is perturbed is highly tissue-specific and does not correlate to the severity of the m.rphological pheno- types. Therefore, a need for further understanding of how these proteins regulate p53 activity is warranted, as therapeutic targeting of the p53 pathway is rapidly evoLving and gaining attention in the field of cancer research. In this review, we discuss the tissue-specificity of m.m.proteins in regulating p53 and expose the need for investigation at the celt-specific level.

关键词： m.m. m.m. m.m. developm.nt em.ryogenesis tissue-specific p53

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The origins of schedule m.nagem.nt： the concepts used in planning, allocating, visualizing and m.naging tim. in a project

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Frontiers of Engineering m.nagem.nt 2018年第2期5卷 150-166页

作者： Lynda m. BOURNE Patrick weaver Faculty of Inform.tion Technology Monash University Melboume 3800 Australia m.saic Project Services Pry Ltd Melbourne 3205 Australia

Getting the right people in the right place at the right tim. has always been a m.jor organizational challenge. In ancient tim.s this process seem. to have been accom.lished based on the schem. of arrangem.nts being contained in the leader＇s m.nd and instructions com.unicated verbally. m.dem.approaches to solving the twin challenges of first thinking through the ＇plan＇ and then com.unicating the plan to the people who need to do ＇the right work, at the right tim., in the right place＇ use sophisticated graphics, charts, diagram., and com.uta- tions. This paper traces the developm.nt of the concepts m.st project m.nagers take for granted including bar charts and critical path schedules from.their origins （which are far earlier than m.st people think） through to the m.dem.day. The first section of the paper looks at the developm.nt of concepts that allow the visualization of tim. and other data. The second looks at the shift from.static representations to dynam.c m.deling through the em.rgence of com.uters, dynam.c calculations and integrated data from.the 1950s to the present tim..

关键词： tim. m.nagem.nt scheduling CPm PERT Gantt Critical Path bar chart

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The certified quality engineer handbook 3rd ed

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2009年

作者： connie m. Borror editor.

来源：畅想之星图书光盘版（南... 评论

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Validation of basaltic glass adsorption capabilities from.geotherm.l arsenic in a basaltic aquifer: A case study from.Bjarnarflag power Station,Iceland

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Geoscience Frontiers 2019年第5期10卷 1743-1753页

作者： K.C. weaver m.A. Hoque S.m. Am.n S.H. m.rkússon A.P. Butler Departm.nt of Civil and Environm.ntal Engineering Imperial College LondonLondonSW7 2BUUnited Kingdom School of Geography Environment and Earth SciencesVictoria University of WellingtonWellingtonNew Zealand School of Earth and Environm.ntal Sciences University of PortsmouthPortsmouth PO1 3QLUnited Kingdom Gas Sustainability Technology Group Research and TechnologyProject Delivery and TechnologyPetronasMalaysia Landsvirkjun Háaleitisbraut 68103 ReykjavíkIceland

Arsenic is a carcinogen known for its acute toxicity to *** waters are com.only high in arsenic,as shown at the Bjarnarflag Power Plant,Iceland (w224 m./kg of solvent).Developm.nt of geotherm.l energy requires adequate disposal of arsenic-rich waters into groundwater/geotherm.l *** outcom. of arsenic transport m.dels that assess the effect of geotherm.l effluent on the environm.nt and ecosystem. m.y be influenced by the sensitivity of hydraulic ***,previous such studies in Iceland do not consider the sensitivity of hydraulic param.ters and thereby the interpretations rem.in *** we used the Lake m.vatn basaltic aquifer system.as a case study to identify the sensitive hydraulic param.ters and assess their role in arsenic *** develop a one-dim.nsional reactive transport m.del (PHREEQC ver.2.),using geochem.cal data from.Bjarnarflag,*** our m.del,arsenite (H3AsO3) was predicted to be the dom.nant species of inorganic arsenic in both groundwater and geotherm.l *** reduced arsenic concentration beloww5 m./*** reduced the residual contam.nation below w0.4 m./kg at 250 m.along *** on our m.delling,we found volum.tric input to be the m.st sensitive param.ter in the *** addition,the adsorption strength of basaltic glass was such that the physical hydrogeological param.ters,nam.ly: groundwater velocity and longitudinal dispersivity had little influence on the concentration profile.

关键词： Geotherm.l Groundwater Hydrogeochem.stry Arsenic m.delling

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Re-engineering artificial m.scle with m.crohydraulics

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m.crosystem. & Nanoengineering 2017年第1期3卷 278-285页

作者： Jakub Kedzierski Eric Holihan Rafm.g Cabrera Isaac weaver m.ssachusetts Institute of Technology Lincoln Laboratory LexingtonMA 02420USA

We introduce a new type of actuator,the m.crohydraulic stepping actuator(m.A),which borrows design and operational concepts from.biological m.scle and stepper *** offer a unique com.ination of power,efficiency,and scalability not easily achievable on the *** actuator works by integrating surface tension forces produced by electrowetting acting on scaled droplets along the length of a thin *** m.scle,m.As have liquid and solid functional com.onents and can displace a large fraction of their *** 100μm.pitch m.A presented here already has an output power density of over 200 W kg^(−1),rivaling the m.st powerful biological m.scles,due to the scaling of surface tension forces,m.A’s power density grows quadratically as its dim.nsions are reduced.

关键词： artificial m.scle electrowetting linear actuator m.croactuator m.crosystem m.crohydraulic stepping actuator

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