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Anemia and risk of periprocedural cerebral injury detected by diffusion-weighted magnetic resonance imaging in patients undergoing transcatheter aortic valve replacement

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World Journal of Emergency Medicine 2022年第1期13卷 32-39页

作者： Stella ng Qi-feng Zhu Ju-bo Jiang Chun-hui Liu Jia-qi Fan Ye-ming Xu Xian-bao Liu Jian-an Wang Department of Cardiology the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Zhejiang University School of Medicine Hangzhou 310058China

BACKGROUND: Anemia is prevalent in patients undergoing transcatheter aortic valve replacement(TAVR) and has been linked to impaired outcomes after the procedure. Few studies have evaluated the impact of anemia and new ischemic lesions post ***: We prospectively enrolled 158 patients who received TAVR in our center. Anemia was defined according to the World Health Organization criteria as hemoglobin ng(DW-MRI) procedure before and within 4–7 days after TAVR. RESULTS: Anemia was present in 85(53.8%) patients who underwent TAVR, and 126(79.7%) patients had 718 new DW-MRI positive lesions with a mean of 4.54±5.26 lesions per patient. The incidence of new ischemic lesions was 81.2% in patients with anemia versus 78.1% in patients without anemia(P=0.629). Moreover, anemic patients had bigger total volume/lesions in the anterior cerebral artery/middle cerebral artery(ACA/MCA) and MCA regions compared to the non-anemic patients(31.89±55.78 mm^(3) vs. 17.08±37.39 mm^(3), P=0.049;and 54.54±74.72 mm^(3) vs. 33.75±46.03 mm^(3), P=0.034). Anemia was independently associated with the volume/lesion in the ACA/MCA(β=16.796, 95% confidence interval [95% CI] 2.001 to 31.591, P=0.026) and in the MCA zone(β=0.020, 95% CI 0.001 to 0.040, P=0.041). CONCLUSIONS: Patients with pre-procedural anemia may have bigger total volume/lesions in the ACA/MCA and MCA regions compared to the non-anemic patients. Whether the consequences of bigger total volume/lesions impact neurological and cognitive outcomes remains to be investigated.

关键词： Aortic stenosis Anemia Cerebral ischemic lesions Transcatheter aortic valve replacement

A guide to use fluorinated aromatic bulky cations for stable and high-performance 2D/3D perovskite solar cells:The more fluorination the better?

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Journal of Energy Chemistry 2022年第1期31卷 179-189,I0006页

作者： Lei Wang Qin Zhou Zilong Zhang Wenbo Li Xiaobing Wang Qi ng Tian Xiaoyan Yu Ting Sun Jihuai Wu bao Zhang Peng Gao School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002FujianChina Laboratory for Advanced Functional Materials.Xiamen Institute of Rare Earth Materials Haixi InstituteChinese Academy of SciencesXiamen 361021FujianChina College of Materials Science and Engineering Huaqiao University361021 XiamenFujianChina

While serious stability issues impede the commercialization of perovskite solar cells(PSCs),two-dime nsional(2D)perovskites based on fluorinated bulky cations have emerged as more intrinsically stable ***,the influence of fluorination degree of the bulky aromatic cation on the per-formance of resulting PSCs has not been ***,2D perovskites(FxPEA)_(2)PbI_(4)(x=1,2,3,5)are grown in situ on the surface of the three-dime nsion al(3D)perovskite and dem on strate effective passivation of the surface defects of 3D *** power conversion efficiency(PCE)of the optimized devices were boosted from 20.75%for the control device to 21.09%,22.06%,22.74%and 21.86%for 2D/3D devices treated with 4-fluorophenethylamine iodide,3,5-difluorophenylethylamine iodide,2,4,5-trifluoroethylphenylethylamine iodide,and 1,2,3,4,5-pentafluorophenylethylamine iodide,*** firstly reported two unexplored RP-type layered perovskites with F_(2)PEAI and F_(3)PEAI as bulky *** combined experimental and theoretical analysis revealed the reasons behind the various morphology,device performances,dynamic behavior,and humidity *** best performing F_(5)PEAI-treated device retaining 95.0%of its initial PCE under ambient atmosphere(with RH of 60%±5%)without encapsulation for 300 h *** work provides useful guidance for selecting fluorinated bulky cations with different molecular electronic properties,which will play an essential role in further improving the performance/stability of PSCs for the sake of further commercialization.

关键词： 2D perovskite Fluorinated spacer cation Perovskite solar cells Passivation Stability

Ascending aortic dilatation rate after transcatheter aortic valve replacement in patients with bicuspid and tricuspid aortic stenosis: A multidetector computed tomography follow-up study

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World Journal of Emergency Medicine 2019年第4期10卷 197-204页

作者： Yu-xin He Jia-qi Fan Qi-feng Zhu Qi-jing Zhou Ju-bo Jiang Li-han Wang Stella ng Xian-bao Liu Jian-an Wang Department of Cardiology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Radiology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

BACKGROUND: Current data is lacking about the progression of ascending aortic dilatation after transcatheter aortic valve replacement(TAVR) in aortic stenosis(AS) patients with bicuspid aortic valve(BAV) and tricuspid aortic valve(TAV). This study aims to assess the ascending aortic dilatation rate(mm/year) after TAVR in patients with BAV versus TAV using a multidetector computed tomography(MDCT) fol ow-up and to determine the predictors of ascending aortic dilatation ***: Severe AS patients undergoing TAVR from March 2013 to March 2018 at our center with MDCT follow-ups were included. BAV and TAV were identified using baseline MDCT. Baseline and follow-up MDCT images were analyzed,and the diameters of ascending aorta were measured. Study end point is ascending aortic dilatation rate(mm/year). Furthermore,factors predicting ascending aortic dilatation rate were also ***: Two hundred and eight patients were included,comprised of 86 BAV and 122 TAV patients. Five,4,3,2,and 1-year MDCT follow-ups were achieved in 7,9,30,46,and 116 patients. The ascending aortic diameter was significantly increased after TAVR in both BAV group(43.7±4.4 mm vs. 44.0±4.5 mm;Png aortic dilatation rate was found between BAV and TAV group(0.2±0.8 mm/year vs. 0.3±0.8 mm/year,P=0.592). Multivariate linear regression revealed paravalvular leakage(PVL) grade was independently associated with ascending aortic dilatation rate in the whole population and BAV group,but not TAV group. No aortic events occurred during ***: Ascending aortic size continues to grow after TAVR in BAV patients,but the dilatation rate is mild and comparable to that of TAV patients. PVL grade is associated with ascending aortic dilatation rate in BAV patients post-TAVR.

关键词： Transcatheter aortic valve replacement Aortic dilatation Bicuspid aortic valve

Effect of TiO2 on reduction behavior of Cr2O3 in CaO-SiO2-Al2O3-MgO-TiO2-Cr2O3 by carbon from Fe-C melt

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Journal of Iron and Steel Research International 2020年第10期27卷 1145-1152页

作者： Jun-yi Xiang Gui-shang Pei Wei Lv bao-hua Li Gui-bao Qiu Xue-wei Lv College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and Advanced Materials Chongqing UniversityChongqing 400044China

The chromium-bearing titanomagnetite ore will turn to be the important raw material for blast furnace process in Panxi area,*** reduction behavior of Cr2O3 between CaO-SiO2-Al2O3-TiO2-Cr2O3 and Fe-C systems was *** effect of TiO2 content in the slag system on the reduction of Cr2O3,TiO2,and SiO2 and the con sumption of C in hot metal was investigated by both theoretical calculation and physical *** theoretical calculation results reveal that higher reduction temperature promotes the reduction of Cr and Ti,while high basicity and TiO2 content have little influence on the reduction of chromium but significantly influence the reduction of *** smelting reduction experiment results show that the content of Cr in hot metal significantly in creases with extendi ng the reduction time and decreases with the increase in TiO2 ***,the content of Ti in hot metal significantly increases as the TiO2 increases,reaching 0.073,0.085,0.107,and 0.121 wt.%for 5,10,15,and 20 wt.%of TiO2 input,*** studies proved that the reduction of Cr2O3 was a first-order *** addition of TiO2 inhibited the reduction of Cr2O3 and resulted in the decrease in reaction rate constant.

关键词： Smelting reduction Titanomagnetite Blast furnace slag Chromium oxide Titanium oxide

Batroxobin inhibits astrocyte activation following nigrostriatal pathway injury

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Neural Regeneration Research 2021年第4期16卷 721-726页

作者： Zhuo Zhang Xue bao Dan Li Department of Human Anatomy College of Basic Medical SciencesChina Medical UniversityShenyangLiaoning ProvinceChina

Batroxobin is a thrombin-like serine protease from the venom of the Bothrops atrox and Bothrops moojeni snake *** 1(Sirt1)has been shown to play an important role in neuroprotection after traumatic brain ***,its underlying mechanism of action remains poorly *** purpose of this study was to investigate whether the mechanism by which batroxobin participates in the activation of astrocytes is associated with *** models of nigrostriatal pathway injury were *** after modeling,mice were intraperitoneally administered 39 U/kg *** significantly reduced the expression of cleaved caspase-3 in both the substantia nigra and striatum,inhibited neuronal apoptosis,and promoted the recovery of rat locomotor *** changes coincided with a remarkable reduction in astrocyte *** also reduced Sirt1 expression and extracellular signal-regulated kinase activation in brain *** administration of the Sirt1-specific inhibitor EX527(5 mg/kg)30 minutes prior to injury could inhibit the abovementioned *** mouse astrocyte cultures,1 ng/mL batroxobin attenuated interleukin-1β-induced activation of astrocytes and extracellular signal-regulated ***527 could also inhibit the effects of *** findings suggest that batroxobin inhibits astrocyte activation after nigrostriatal pathway injury through the Sirt1 *** study was approved by the Animal Ethics Committee of China Medical University,China(approval ***2020037)on July 19,2015.

关键词： astrocyte brain central nervous system factor injury pathway

Promoting catalytic ozonation of phenol over graphene through nitrogenation and Co_3O_4 compositing

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Journal of Environmental Sciences 2016年第12期28卷 38-48页

作者： Qi bao Kwan San Hui Jenq Gong Duh Department of Materials Science and Engineering Taiwan Tsing Hua University Department of Systems Engineering & Engineering Management City University of Hong Kong Department of Mechanical Engineering Hanyang University

Catalytic ozonation is progressively becoming an attractive technique for quick water purification but efficient and stable catalysts remains elusive. Here we solvothermally synthesized highly-dispersed Co3O4 nanocrystals over microscale nitrogen-doping graphene （ng） nanosheets and tested it as a synthetic catalyst in the ozonation of phenol in aqueous solutions. Transmission electron microscopy, powder X-ray diffraction, Fourier transform infrared spectra and X-ray photoelectron spectroscopy were used to determine its morphology, crystallinity, elemental composition and molecular bonds, respectively. The comparative experiments confirmed the highest catalytic activity and oxidation degree （AOSC） of Co3O4/ng among four nanocomposites （G, ng, Co3O4/G, and Co3OJng）. Co3O4/ng also has exhibited the highest degradation rate： complete conversion of a near-saturated concentration of phenol （941.1 mg/L） was achieved within 30 min under ambient conditions with only a small dosage of Co3O4/ng （50 mg/L） and ozone （4 mg/L, flow rate： 0.5 L/min）. It also resulted in 34.6% chemical oxygen demand （CODcr） and 24.2% total organic carbon （TOC） reduction. In this work, graphene nanosheets not only functioned as a support for Co3O4 nanocrystals but also functioned as a co-catalyst for the enhancement in phenol removal efficiency. The surface nitridation and Co3O4 modification treatment further improved the removal rate of the phenol pollutants and brought in the higher oxidation degree. Our finding may open new perspectives for pursuing exceptional activity for catalytic ozonation reaction.

关键词： Water treatment Graphene Nanocatalysts Phenol

Separation and Determination of Methylnaltrexone in Human Plasma Samples After Oral Administration by HPLC Coupled with Electrochemical Detection

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Chemical Research in Chinese Universities 2005年第3期21卷 268-273页

作者： WAngAn-bao JosephF.Foss YUANChun-su JoachimOsinski DepartmentofAnesthesiaandCriticalCare TheUniversityofChicagoChicagoIL60637USA DepartmentofAnesthesiaandCriticalCare TheUniversityofChicagoChicagoIL60637USA／／ShanghaiInstituteofCeramicsChineseAcademyofSciencesShanghai200050P.R.China

A high performance liquid chromatography(HPLC) method coupled with electrochemical detection and solid phase extraction is described for the separation and determination of methylnaltrexone(MNTX), a quaternary opioid antagonist, in human clinical plasma samples after oral administration. Linearity of the standard curve for MNTX was found in the range of 4.0_150 ng/mL and was statistically conformed. The correlation coefficient(r2) and calibration equation obtained from linear regression analysis are 0.9999 and Y=54.27X-0.22, where Y and X represent the peak area and concentration of MNTX, respectively. The detection limit of MNTX under the present experimental conditions is 2.0 ng/mL by estimating at a ratio of 3 of signal to noise. The mean recovery of MNTX in human plasma is higher than 97%. The analytical method was applied to the pharmacokinetic determination of MNTX after single dose oral administration. These data demonstrate that the change of MNTX plasma concentration versus time is obvious. MNTX level of plasma reaches to a plateau between 45 to 120 minutes and then falls slowly. The content of MNTX in plasma sample maintains at an obviously detectable level after twelve hours of oral administration. The pharmacokinetic parameters for a single dose of 19.2 mg/kg in plasma are c_~max =206.42(±16.53) ng/mL and t_~max =60 min.

关键词： Liquid chromatography Electrochemical detection Methylnaltrexone Pharmaceutical Serum Biological analysis

Traditional Chinese Medicine in Malaysia:A Brief Historical Overview of the Interactions between China and Malay Peninsula

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Chinese Medicine and Culture 2018年第2期1卷 60-63页

作者： Wen Tien Tan Hon Foong Wong Shih Chau ng Si Woei Goh Jun Liu bao Ling Hoo Chyong En Chai Xun Lin Department of Golden Cabinet International Education CollegeShanghai University of Traditional Chinese MedicineShanghaiChina Department of Chinese Medicine Centre for Complementary and Alternative MedicineInternational Medical UniversityKuala LumpurMalaysia

Chinese Medicine was introduced to the Malay Peninsula during the colonial era circa 18th to 19th *** British imported Chinese immigrants mainly for tin *** early Chinese settlers had brought with them the knowledge of Traditional Chinese Medicine(TCM)to *** time goes by,TCM becomes one of the popular traditional medicines that are accepted by other *** has thus contributed to the welfare of *** 2016,a Traditional and Complementary Medicine(T and CM)Act was passed by the Malaysia *** is one of the T and CM practices that fall under the *** services are now offered in Malaysia’s public hospitals in addition to private *** article aims to provide a brief overview on the development of TCM in the precolonial and postindependent Malaysia.

关键词： Development history Malaysia Traditional Chinese Medicine

The first two cases of transcatheter mitral valve repair with ARTO system in Asia

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World Journal of Emergency Medicine 2020年第1期11卷 33-36页

作者： Kai-da Ren Zhao-xia Pu Lei Yu Feng Gao Li-han Wang Stella ng Ju-bo Jiang Hua-jun Li Yong Xu Wei He Min Yan Xian-bao Liu Jian-an Wang Cardiovascular Department the Second Affiliated Hospital Zhejiang University School of Medicine

BACKGROUND:MAVERIC(Mitral Valve Repair Clinical Trial)validates the safety and effi cacy of the ARTO *** here report the fi rst two successful cases of utilizing the ARTO system in patients with symptomatic heart failure(HF)with functional mitral regurgitation(FMR)in ***:Two patients,aged 70 and 63,had severe HF with *** echocardiography confirmed that the left ventricular ejection fractions were less than 50%with severe mitral regurgitation(MR)in both *** drug treatment could not mitigate their ***,we used the ARTO system to repair the mitral valve for these patients on March 5 and 6,2019,***:Mitral valve repairs using the ARTO system were successfully performed under general anaesthesia for these two *** was decreased immediately after the procedures in both *** 30-day and 3-month transthoracic echocardiography(TTE)revealed a moderate to severe MR in both patients,and the New York Heart Association(NYHA)scales were also partially ***:The first two cases in Asia indicate that the ARTO system is feasible for patients with heart failure with FMR,and the patient selection appears to be crucial.

关键词： Mitral regurgitation Mitral valve repair ARTO system