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Brain circuits for retching-like behavior

National Science Review 2024年第1期11卷 145-160页

作者： Lifang Huo Zhimin Ye Meiling Liu Ziqing He Meizhu Huang Dapeng Li Qian Wu Qian Wang Xiaoqun Wang Peng Cao Ji Dong congping shang School of Basic Medical Sciences Guangzhou National Laboratory The Fifth Afflliated Hospital Guangzhou Medical University Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Department of Neurobiology School of Basic Medical Sciences Beijing Key Laboratory of Neural Regeneration and Repair Advanced Innovation Center for Human Brain Protection Capital Medical University State Key Laboratory of Cognitive Neuroscience and Learning IDG/McGovern Institute for Brain Research Beijing Normal University Changping Life Science Laboratory National Institute of Biological Sciences

Nausea and vomiting are important defensive responses to cope with pathogens and toxins that invade the body. The nucleus of the solitary tract(NTS) is important for initiating these responses. However, the molecular heterogeneities and cellular diversities of the NTS occlude a better understanding of these defensive responses. Here, we constructed the single-nucleus transcriptomic atlas of NTS cells and found multiple populations of NTS neurons that may be involved in these defensive responses. Among these, we identified Calbindin1-positive(Calb1+) NTS neurons that are molecularly distinct from Tac1+*** Calb1+neurons are critical for nausea and retching induced by cereulide; an emetic toxin secreted by Bacillus Cereus. Strikingly, we found that cereulide can directly modulate vagal sensory neurons that innervate Calb1+NTS neurons, a novel mechanism distinct from that for nausea and retching induced by Staphylococcal enterotoxin A. Together, our transcriptomic atlas of NTS neurons and the functional analyses revealed the neural mechanism for cereulide-induced retching-like behavior. These results demonstrate the molecular and cellular complexities in the brain that underlie defensive responses to the diversities of pathogens and toxins.

关键词： vomiting nausea nucleus of the solitary tract Calbindin1 neural circuits

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Brainstem opioid peptidergic neurons regulate cough reflexes in mice

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The Innovation 2024年第6期5卷 50-61页

作者： Haicheng Lu Guoqing Chen Miao Zhao Huating Gu Wenxuan Zheng Xiating Li Meizhu Huang Dandan Geng Minhui Yu Xuyan Guan Li Zhang Huimeng Song Yaning Li Menghua Wu Fan Zhang Dapeng Li Qingfeng Wu congping shang Zhiyong Xie Peng Cao National Institute of Biological Sciences Beijing 102206China Tsinghua Institute of Multidisciplinary Biomedical Research Tsinghua UniversityBeijing 100084China Peking University-Tsinghua University-NIBS Joint Graduate Program School of Life SciencesTsinghua UniversityBeijing 100084China Department of Neurobiology School of Basic Medical SciencesBeijing Key Laboratory of Neural Regeneration and RepairAdvanced Innovation Center for Human Brain ProtectionCapital Medical UniversityBeijing 100069China Key Laboratory of Neural and Vascular Biology Ministry of EducationDepartment of Biochemistry and Molecular BiologyHebei Medical UniversityShijiazhuang 050011China Graduate School of Peking Union Medical College Chinese Academy of Medical SciencesBeijing 100005China State Key Laboratory of Molecular Development Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China School of Basic Medical Sciences Guangzhou National LaboratoryFifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510799China Department of Psychological Medicine Zhongshan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical NeurobiologyFudan UniversityShanghai 200433China

Cough is a vital defensive reflex for expelling harmful substances from the *** sensory afferents for the cough reflex have been intensively ***,the brain mechanisms underlying the cough reflex remain poorly ***,we developed a paradigm to quantitatively measure cough-like reflexes in *** this paradigm,we found that prodynorphin-expressing(Pdyn+)neurons in the nucleus of the solitary tract(NTS)are critical for capsaicin-induced cough-like *** neurons receive cough-related neural signals from Trpv1+vagal sensory *** activation of Pdyn+NTS neurons triggered respiratory responses resembling cough-like *** the divergent projections of Pdyn+NTS neurons,a glutamatergic pathway projecting to the caudal ventral respiratory group(cVRG),the canonical cough center,was necessary and sufficient for capsaicin-induced cough-like *** results reveal that Pdyn+NTS neurons,as a key neuronal population at the entry point of the vagus nerve to the brainstem,initiate cough-like reflexes in mice.

关键词： respiratory opioid cough

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社交学习时嗅觉记忆中僧帽细胞依赖胰岛素样生长因子的突触可塑性

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科学新闻 2018年第4期 97-97页

作者： Zhihui Liu Zijun Chen congping shang Fei Yan Yingchao Shi Jiajing Zhang Baole Qu Hailin Han Yanying Wang Dapeng Li Thomas C.Südhof 曹鹏北京生命科学研究所

工作与资助文章简介在食物偏好的社交传递(STFP)中,小鼠能对社交伙伴带来的食物气味形成长时程记忆。传统观点认为,记忆的形成和维持发生在海马和大脑皮层。课题组应用分子遗传学和膜片钳电生理技术,发现小鼠的社交学习记忆依赖于嗅觉... 详细信息

工作与资助文章简介在食物偏好的社交传递(STFP)中,小鼠能对社交伙伴带来的食物气味形成长时程记忆。传统观点认为,记忆的形成和维持发生在海马和大脑皮层。课题组应用分子遗传学和膜片钳电生理技术,发现小鼠的社交学习记忆依赖于嗅觉神经元释放的类胰岛素生长因子(IGF1)。实验表明,在STFP中的气

关键词：僧帽细胞 LTP 胰岛素样生长因子

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Watermelon domestication was shaped by stepwise selection and regulation of the metabolome

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Science China(Life Sciences) 2023年第3期66卷 579-594页

作者： Pingli Yuan congping Xu Nan He Xuqiang Lu Xingping Zhang Jianli shang Hongju Zhu Chengsheng Gong Hanhui Kuang Tang Tang Yong Xu Shuangwu Ma Dexi Sun Weiqin Zhang Muhammad J.Umer Jian Shi Alisdair R.Fernie Wenge Liu Jie Luo Henan Joint International Research Laboratory of South Asian Fruits and Cucurbits Zhengzhou Fruit Research InstituteChinese Academy of Agricultural SciencesZhengzhou 450009China Hainan Yazhou Bay Seed Laboratory Sanya Nanfan Research Institute of Hainan UniversitySanya 572025China Peking University Institute of Advanced Agricultural Sciences Weifang 261325China College of Horticulture and Forestry Sciences Huazhong Agricultural UniversityWuhan 430070China Wuhan Metware Biotechnology Co. Ltd.Wuhan 430070China National Watermelon and Melon Improvement Center Beijing Academy of Agricultural and Forestry SciencesBeijing 100097China Max-Planck-Institute of Molecular Plant Physiology Potsdam-Golm 144776Germany College of Tropical Crops Hainan UniversityHaikou 572208China

Although crop domestication has greatly aided human civilization,the sequential domestication and regulation of most quality traits remain poorly ***,we report the stepwise selection and regulation of major fruit quality traits that occurred during watermelon *** levels of fruit cucurbitacins and flavonoids were negatively selected during speciation,whereas sugar and carotenoid contents were positively selected during ***,fruit malic acid and citric acid showed the opposite selection trends during the *** identified a novel gene cluster(CGC1,cucurbitacin gene cluster on chromosome 1)containing both regulatory and structural genes involved in cucurbitacin biosynthesis,which revealed a cascade of transcriptional regulation operating *** the CGC1,an allele caused a single nucleotide change in Cl ERF1 binding sites(GCC-box)in the promoter of Cl Bh1,which resulted in reduced expression of Cl Bh1 and inhibition of cucurbitacin synthesis in cultivated *** analysis revealed that a rare insertion of 244 amino acids,which arose in *** and became fixed in sweet watermelon,in Cl OSC(oxidosqualene cyclase)was critical for the negative selection of cucurbitacins during watermelon *** research provides an important resource for metabolomics-assisted breeding in watermelon and for exploring metabolic pathway regulation mechanisms.

关键词： metabolome mGWAS gene cluster domestication cucurbitacin biosynthesis

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