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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： conglin wang Fangyuan Cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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Serum procalcitonin levels are associated with rhabdomyolysis following exertional heatstroke: an over 10-year intensive care survey

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World Journal of Emergency Medicine 2024年第1期15卷 23-27页

作者： Li Zhong Feifei Shuai conglin wang Lipeng Han Zhifeng Liu Ming Wu Department of Traditional Chinese Medicine the First Affi liated HospitalGuizhou University of Chinese MedicineGuiyang 550001China Department of Medical Critical Care Medicine General Hospital of Southern Theatre Command of People’s Liberation ArmyGuangzhou 510010China Department of Infection and Critical Care Medicine Shenzhen Second People’s Hospital&First Affi liated Hospital of Shenzhen UniversityHealth Science CenterShenzhen 518035China Department of Nosocomial Infection Prevention and Control Shenzhen Second People’s HospitalShenzhen 518035China Key Laboratory of Hot Zone Trauma Care and Tissue Repair of People's Liberation Army General Hospital of Southern Theatre Command of People's Liberation ArmyGuangzhou 510010China

BACKGROUND:Heatstroke has become a common emergency event in ***(PCT)is used as a biomarker of infection in the emergency department(ED),but its role in rhabdomyolysis(RM)following exertional heatstroke(EHS)remains ***:A retrospective cohort study enrolled patients with EHS from the intensive care unit(ICU).We collected RM biomarkers,inflammation markers,critical disease scores at admission,24 h,48 h,and discharge,and 90-day *** analysis,linear regression and curve fi tting were used to identify the relationship between PCT and ***:A total of 162 patients were recruited and divided into RM(n=56)and non-RM(n=106)*** was positively correlated with myoglobin(Mb),acute hepatic injury,disseminated intravascular coagulation(DIC),Sequential Organ Failure Assessment(SOFA)score,and Acute Physiology and Chronic Health Evaluation II(APACHE II)score,with correlation coefficients of 0.214,0.237,0.285,0.454,and 0.368,respectively(all P<0.05).Interestingly,the results of curve fi tting revealed a nonlinear relationship between PCT and RM,and a two-piecewise linear regression model showed that PCT was related to RM with an odds ratio of 1.3 and a cut-off of<4.6 ng/*** analysis revealed that RM was associated with higher mortality compared to non-RM cases(P=0.0093).CONCLUSION:High serum PCT concentrations are associated with RM after EHS in critically ill *** PCT concentrations should be interpreted cautiously in patients with EHS in the ED.

关键词： Procalcitonin Myoglobin Rhabdomyolysis Exertional heatstroke

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Characteristics and Outcome of Exertional Heatstroke Patients Complicated by Acute Hepatic Injury:A Cohort Study

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Journal of Clinical and Translational Hepatology 2021年第5期9卷 655-660页

作者： Jingjing Ji Jinghua Gao conglin wang Leifang Ouyang Zheying Liu Zhifeng Liu Department of Critical Care Medicine General Hospital of Southern Theater Command of PLAGuangzhouGuangdongChina Key Laboratory of Hot Zone Trauma Care and Tissue Repair of PLA General Hospital of Southern Theater Command of PLAGuangzhouGuangdongChina

Background and Aims:Exertional heatstroke(EHS)is associated with strenuous physical activity in hot *** present study aimed to investigate dynamic changes of hepatic function indices in EHS patients and determine risk factors for ***:This single-center retrospective cohort study considered all patients with EHS admitted to the intensive care unit at the General Hospital of Southern Theater Command of PLA from October 2008 to May *** on general characteristics,organ function parameters,and the 90-day outcome of enrolled patients were *** indices were collected dynamically,and patients with acute hepatic injury(AHI)were identified by plasma total bilirubin(TBIL)≥34.2μmol/L and an international normalized ratio≥1.5,or with any grade of hepatic ***:In patients who survived,TBIL,alanine aminotransferase and aspartate aminotransferase were increased at 24 h,peaked at 2–3 days,and began to decrease at 5 *** non-survivors,TBIL continuously increased *** area under the receiver operating characteristic curve for the prediction of mortality based on sequential organ failure assessment(SOFA)scores was 89.8%,and the optimal cutoff value was *** injury and infection were identified as independent risk factors for death in EHS patients with ***:In EHS patients,hepatic dysfunction usually occurred within 24 *** with AHI had more severe clinical conditions,and significantly increased 90-day mortality *** scores over 7.5,complicated with myocardial injury or infection,were found to be risk factors for death in EHS patients with AHI.

关键词： Exertional heatstroke Acute hepatic injury Mortality TBIL SOFA

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316NG不锈钢在硼-锂溶液中的电化学腐蚀行为研究

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核动力工程 2018年第5期39卷 63-68页

作者：舒茗王丛林陈勇中国核动力研究设计院反应堆燃料及材料重点实验室成都610213

利用电化学方法获得316NG不锈钢(316NG)在300℃、pH=5～8硼-锂溶液中的极化曲线和交流阻抗(EIS),并绘制相应水化学条件下的电位-pH图。结果表明:碱性条件下钝化区尤其是二次钝化区极化电流急剧减小,pH=7～8时阳极极化表现出3次钝化现象... 详细信息

利用电化学方法获得316NG不锈钢(316NG)在300℃、pH=5～8硼-锂溶液中的极化曲线和交流阻抗(EIS),并绘制相应水化学条件下的电位-pH图。结果表明:碱性条件下钝化区尤其是二次钝化区极化电流急剧减小,pH=7～8时阳极极化表现出3次钝化现象,偏碱性条件极化阻抗显著高于偏酸性和近中性条件,说明碱性条件下316NG表面钝化膜保护效果更佳。pH=5时电化学极化后样品表面主要生成Cr2O3和Fe2O3;碱性条件下(pH=6～8)样品表面氧化膜为分层结构:最外层为Fe3O4,随深度增加开始出现NiFe2O4,内层成分主要为FeCr2O4。随着电导率升高,溶液电阻、电荷传递电阻和钝化膜电阻均显著降低。依据极化曲线绘制的电位-pH图与文献结果相吻合。

关键词：核材料 316NG 电位-pH图极化曲线高温电化学

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组合时效对高强导电Cu-Ti-Fe-Cr合金箔组织与性能的影响

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稀有金属材料与工程 2020年第5期49卷 1689-1693页

作者：董亚光董祥雷王琮琳赵红亮郑州大学材料科学与工程学院河南郑州450002 郑州大学河南郑州450002

采用硬度、导电率测试和OM、SEM观察等方法,研究了组合时效对时效强化型Cu-3Ti-0.2Fe-0.2Cr合金箔组织与性能的影响。结果表明,经过900℃固溶4 h后水冷+50%初冷轧+450℃初时效4 h+95.6%终冷轧+450℃再时效1.5 h后,Cu-3Ti-0.2Fe-0.2Cr合... 详细信息

采用硬度、导电率测试和OM、SEM观察等方法,研究了组合时效对时效强化型Cu-3Ti-0.2Fe-0.2Cr合金箔组织与性能的影响。结果表明,经过900℃固溶4 h后水冷+50%初冷轧+450℃初时效4 h+95.6%终冷轧+450℃再时效1.5 h后,Cu-3Ti-0.2Fe-0.2Cr合金箔的综合性能最优,硬度、抗拉强度、延伸率和导电率分别为3546 MPa、1062 MPa、1.9%和17.1%IACS,与未经初时效样品的峰时效性能相比,其力学性能相近,并具有更高的导电率,该状态下合金箔的断口形貌为扁平面、河流状花样和韧窝组成的混合断裂形貌。

关键词： Cu-Ti合金组合时效显微组织力学性能导电率

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热机械处理对Al-Cu-Mg合金显微组织和力学性能的调控机理

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中国有色金属学报 2024年第1期34卷 50-62页

作者：王琮琳刘辉新郑亚亚王昆陈志国中南大学材料科学与工程学院长沙410083 湖南人文科技学院材料工程系娄底417000

采用X射线衍射仪(XRD)、透射电子显微镜(TEM)、拉伸力学性能测试以及疲劳裂纹扩展速率测试等手段探究热机械处理工艺对Al-Cu-Mg合金显微组织及宏观性能的影响。结果表明:热机械处理工艺可以使Al-Cu-Mg合金获得良好的强塑性配合,其中,采... 详细信息

采用X射线衍射仪(XRD)、透射电子显微镜(TEM)、拉伸力学性能测试以及疲劳裂纹扩展速率测试等手段探究热机械处理工艺对Al-Cu-Mg合金显微组织及宏观性能的影响。结果表明:热机械处理工艺可以使Al-Cu-Mg合金获得良好的强塑性配合,其中,采用25%变形量的固溶热轧+30%变形量的深冷非对称轧制(1.2异速比)+100℃、6 h的人工时效处理时,Al-Cu-Mg合金的伸长率可达10.1%;抗拉强度和屈服强度达到了517.2和448.3 MPa,分别比常规T6态的Al-Cu-Mg合金高74.8和98.6 MPa。热机械处理工艺使合金中出现大量位错缠结及细小S析出相,高强度的Goss织构和大量剪切织构通过影响疲劳裂纹的偏折提升合金的疲劳性能。

关键词： Al-Cu-Mg合金热机械处理拉伸力学性能显微组织疲劳裂纹扩展速率

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先进核能技术发展及展望

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核动力工程 2023年第5期44卷 1-5页

作者：王丛林柴晓明杨博李仲春中国核动力研究设计院核反应堆系统设计技术重点实验室成都610213

“碳达峰、碳中和”目标的提出对我国未来能源体系发展具有深远影响。核能作为稳定的清洁能源,对于“碳达峰、碳中和”目标实现能够发挥更大作用,在发电、供热、制氢等领域均有着巨大的应用前景和需求。经过60余年发展,核能建立了完善... 详细信息

“碳达峰、碳中和”目标的提出对我国未来能源体系发展具有深远影响。核能作为稳定的清洁能源,对于“碳达峰、碳中和”目标实现能够发挥更大作用,在发电、供热、制氢等领域均有着巨大的应用前景和需求。经过60余年发展,核能建立了完善的产业链,研发形成了“华龙一号”等具有完全自主知识产权的第三代大型商业压水堆核电技术品牌,研发了具有国际先进水平的多用途模块式小型堆“玲龙一号”,积极探索了钠冷快堆、超高温气冷堆、熔盐堆等第四代先进核能技术,持续开展聚变核能利用。同时我国核能发展也面临一些挑战,先进核能技术亟需突破。本文提出了先进核能技术的发展思路和路径,从在役核电厂智能化运行管理、三代核电批量化部署、固有安全快堆技术研发、积极研发满足高效制氢需求的超高温气冷堆、积极探索能够满足工业供热和平台供电的模块式小型堆技术、国内国际合作发展先进核能关键技术等6个方面进行了展望,为我国先进核能技术的发展给出了具体的研究目标与方向。

关键词：第四代先进核能技术发展思路技术路径发展展望

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黄河“几”字弯都市圈交通基础设施投资效率的空间溢出效应研究

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铁道运输与经济 2024年第10期46卷 166-177页

作者：王伟王聪琳巩亮胡倩北方民族大学商学院宁夏银川750021 兰州交通大学交通运输学院甘肃兰州730070 银川能源学院商学院宁夏银川750001

经济发展水平、人口流动规模等对交通基础设施投资效率的影响日益凸显,而这种影响的空间效应强度、范围以及时空过程的规律性亟待深入研究。以黄河“几”字弯都市圈15个城市为研究单元,运用超效率SBM模型测算2011—2021年基础设施投资效... 详细信息

经济发展水平、人口流动规模等对交通基础设施投资效率的影响日益凸显,而这种影响的空间效应强度、范围以及时空过程的规律性亟待深入研究。以黄河“几”字弯都市圈15个城市为研究单元,运用超效率SBM模型测算2011—2021年基础设施投资效率,同时采用空间杜宾模型(SDM)揭示其空间溢出效应及其衰减边界,并对导致非线性影响关系的中间机制进行探讨。研究发现:黄河“几”字弯都市圈交通基础设施投资效率大体上呈现“U”字型变化,随着经济水平的发展,交通基础设施的投资效率也会随之提高,但经济发展水平对投资效率呈现出负的空间溢出效应,会降低邻近地区的交通基础设施投资效率。

关键词：交通基础设施投资效率超效率SBM模型空间杜宾模型空间溢出效应

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