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Self-assembly of DNA Nanostructures via Bioinspired Metal Ion Coordination

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Chemical Research in Chinese Universities 2020年第2期36卷 268-273页

作者： WANG congli DI Zhenghan FAN Zetan LI Lele CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190P.R.China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049P.R.China

Despite a growing interest in DNA nanomaterials,their simple synthesis remains a challenge.A simple and general strategy for constructing DNA-based nanomaterials by metal ion coordination is *** me-tal-DNA nanoparticles(NPs)could be synthesized with DNA molecules of diverse sequence and various metal ions of intrinsic property,resulting in multifunctional NPs with the combined advantages of both inorganic and DNA building *** is demonstrated that the hybrid metal-DNA NPs could be engineered for magnetic resonance and luminescence imaging,encapsulation of multifarious nucleic acids with controlled ratio,and co-assembly with small drug ***,because these metal-DNA NPs exhibited enhanced cellular uptake compared to free synthetic DNA,they hold potential for applications in diagnostics and therapeutics.

关键词： DNA nanotechnology Metal ion coordination Self-assembly

4CR模式护理对弥漫大B细胞淋巴瘤化疗患者遵医行为及心理状态的影响

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河南医学研究 2024年第3期33卷 562-565页

作者：刘晓张聪丽张霞郑州大学第一附属医院血液内科河南郑州450000

目的观察延续性护理和随访管理(4CR)模式护理对弥漫大B细胞淋巴瘤(DLBCL)化疗患者遵医行为及心理状态的影响。方法选取2021年12月至2022年12月郑州大学第一附属医院收治的100例DLBCL化疗患者,用随机数表法纳为研究组(50例)与对照组(50... 详细信息

目的观察延续性护理和随访管理(4CR)模式护理对弥漫大B细胞淋巴瘤(DLBCL)化疗患者遵医行为及心理状态的影响。方法选取2021年12月至2022年12月郑州大学第一附属医院收治的100例DLBCL化疗患者,用随机数表法纳为研究组(50例)与对照组(50例),对照组患者接受常规护理,研究组患者则在此基础上接受4CR模式护理。比较两组遵医行为、焦虑量表(SDS)、抑郁量表(SAS)、生活质量测定量表(QLQ-C30)评分,并统计干预期间不良反应的发生情况。结果干预后两组遵医行为、QLQ-C30评分较干预前高,研究组高于对照组;两组SAS、SDS评分较干预前低,研究组低于对照组(P<0.05)。研究组不良反应总发生率为12.00%,低于对照组的28.00%(P<0.05)。结论 4CR模式护理能显著提高DLBCL化疗患者的遵医行为,同时有助于改善患者的心理状态与生活质量,降低化疗相关不良反应发生率。

关键词：延续性护理随访管理弥漫大B细胞淋巴瘤遵医行为心理状态

Dynamic soft sensor development based on Gaussian mixture regression for fermentation processes

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Chinese Journal of Chemical Engineering 2017年第1期25卷 116-122页

作者： congli Mei Yong Su Guohai Liu Yuhan Ding Zhiling Liao School of Electrical and Information Engineering Jiangsu University Zhenjiang 212013 China

The dynamic soft sensor based on a single Gaussian process regression(GPR) model has been developed in fermentation ***,limitations of single regression models,for multiphase/multimode fermentation processes,may result in large prediction errors and complexity of the soft ***,a dynamic soft sensor based on Gaussian mixture regression(GMR) was proposed to overcome the *** structure parameters,the number of Gaussian components and the order of the model,are crucial to the soft sensor *** achieve a simple and effective soft sensor,an iterative strategy was proposed to optimize the two structure parameters *** the aim of comparisons,the proposed dynamic GMR soft sensor and the existing dynamic GPR soft sensor were both investigated to estimate biomass concentration in a Penicillin simulation process and an industrial Erythromycin fermentation *** show that the proposed dynamic GMR soft sensor has higher prediction accuracy and is more suitable for dynamic multiphase/multimode fermentation processes.

关键词： Dynamic modeling Process systems Instrumentation Gaussian mixture regression Fermentation processes

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不同材料修复无髓年轻第一恒磨牙的临床研究

中国冶金工业医学杂志 2024年第3期41卷 255-256页

作者：郭聪莉徐扬宋荣荣陕西汉中市口腔医院陕西汉中723000 西安交通大学第二附属医院(西北医院)

目的探讨无髓年轻第一恒磨牙经不同材料修复的效果差异性。方法选取2019年10月—2021年12月在我院就诊的患者62例,共86颗无髓大面积牙体组织缺损的第一恒牙。依据随机数字表法将其分为参照组31例(41颗)与研究组31例(45颗)。参照组采用... 详细信息

目的探讨无髓年轻第一恒磨牙经不同材料修复的效果差异性。方法选取2019年10月—2021年12月在我院就诊的患者62例,共86颗无髓大面积牙体组织缺损的第一恒牙。依据随机数字表法将其分为参照组31例(41颗)与研究组31例(45颗)。参照组采用复合树脂充填治疗,研究组接受IPS *** CAD瓷块高嵌体治疗,比较两组的修复效果。结果研究组的修复成功率高于参照组;修复后6个月,研究组的菌斑指数、龈沟出血指数、探诊深度、牙周附着丧失结果均低于参照组,组间比较差异均有统计学意义(χ^(2)=5.895,t=3.701、2.757、6.359、7.877,均P<0.05)。结论嵌体修复第一恒磨牙缺损的临床效果优于复合树脂直接充填术,具有较高的临床推广价值。

关键词：年轻第一恒磨牙大面积缺损树脂填充高嵌体修复

An Information Management System for FCC Units in Petrochemical Plants

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An Information Management System for FCC Units in Petrochemi...

Metabolism, signaling, and transport of jasmonates

第26届中国控制与决策会议

作者： Xu hongxia Cheng congli College of Electronic Information and Control Engineering Beijing University of Technology Research Institute of Petroleum Processing Beijing

ISBN: (纸本)9781479937066

Parameters management and analysis are the basis for units running and revamping. They also provide scientific guidance for studying chemistries and dynamics of catalytic cracking reactions. So far, each FCC unit is in the status under dispersing management and lack of specified collection and management of parameters. Therefore, the parameters resource could not be shared among each other so as to bring much trouble in establishing a precise model. Based on these reasons, a management system of comprehensive parameters has been developed for FCC units. The system is able to manage parameters for all FCC units during different periods. It supports users to input, edit, search data, and also has the function of data statistics, data analysis, form and graph output. The system helps users to make decisions properly.

关键词： FCC units information management relation database visual software development

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Plant Communications 2021年第5期2卷 78-91页

作者： Mengya Li Guanghui Yu congli Cao Pei Liu Department of Ecology College of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100193P.R.China These authors contributed equally to this article

Biosynthesis/metabolism,perception/signaling,and transport are three essential aspects of the actions of ***(JAs),including jasmonic acid(JA)and related oxylipins,are implicated in the regulation of a range of ecological interactions,as well as developmental programs to integrate these ***-isoleucine(JA-Ile)is the most bioactive JAs,and perception of JA-Ile by its coreceptor,the Skp1-Cullin1-F-box-type(SCF)protein ubiquitin ligase complex SCF^(COI1)-JAZ,in the nucleus derepresses the transcriptional repression of target *** biosynthesis and metabolism of JAs occur in the plastid,peroxisome,cytosol,endoplasmic reticulum,and vacuole,whereas sensing of JA-Ile levels occurs in the *** is increasingly apparent that a number of transporters,particularly members of the jasmonates transporter(JAT)family,located at endomembranes as well as the plasma membrane,constitute a network for modulating and coordinating the metabolic flux and signaling of *** this review,we discuss recent advances in the metabolism,signaling,and especially the transport of JAs,focusing on intracellular compartmentation of these *** roles of transporter-mediated cell-cell transport in driving long-distance transport and signaling of JAs are also discussed.

关键词： jasmonates metabolism signaling transport cellular compartmentation

P53、P16及Ki-67与早期食管癌患者ESD术后复发的关系分析

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分子诊断与治疗杂志 2024年第5期16卷 812-816页

作者：党叶川李聪丽王瑞雪三门峡市中心医院消化内科河南三门峡472000

目的分析研究抑制蛋白基因P53(P53)、抑制蛋白基因P16(P16)及细胞增殖核抗原Ki-67(Ki-67)与早期食管癌患者内镜黏膜下剥离术(ESD)术后复发的关系。方法选取2019年1月至2023年1月三门峡市中心医院收治80例的早期食管癌患者作为研究对象... 详细信息

目的分析研究抑制蛋白基因P53(P53)、抑制蛋白基因P16(P16)及细胞增殖核抗原Ki-67(Ki-67)与早期食管癌患者内镜黏膜下剥离术(ESD)术后复发的关系。方法选取2019年1月至2023年1月三门峡市中心医院收治80例的早期食管癌患者作为研究对象,均进行ESD治疗。比较所有患者癌组织与癌旁组织(距肿瘤边缘>3 cm,镜下未见肿瘤组织或不典型增生组织)P53、P16、Ki-67蛋白表达。ESD术后对患者随访1年,根据有无术后复发食管癌,将患者分为复发组(n=20)与无复发组(n=60)。比较两组癌组织P53、P16、Ki-67蛋白表达。采用多因素Logistic回归分析早期食管癌患者ESD术后复发的影响因素,并绘制ROC曲线分析P53、P16、Ki-67蛋白表达与早期食管癌患者ESD术后复发。结果与癌旁组织相比,癌组织P53、Ki-67蛋白表达升高,P16蛋白表达降低(t=9.276、13.987、10.595,均P<0.05);复发组的癌组织P53、Ki-67蛋白表达均高于无复发组,P16蛋白表达低于无复发组(t=5.086、4.648、5.139,均P<0.05);多因素Logistic回归分析显示,肿瘤低分化(OR=1.870)、肿瘤浸润侵犯黏膜下层(OR=1.808)、有淋巴结转移(OR=2.089)、P53蛋白高表达(OR=2.046)、P16蛋白低表达(OR=1.988)及Ki-67蛋白高表达(OR=1.761)均是早期食管癌患者ESD术后复发的独立危险因素(P<0.05);ROC曲线分析显示,P53、P16、Ki-67蛋白表达及联合检测的曲线下面积(AUC)分别为0.803、0.828、0.834、0.942,联合检测优于单一检测(P<0.05)。结论 P53、P16及Ki-67蛋白与早期食管癌患者ESD术后复发情况相关,可以作为辅助预测的相关诊断指标。

关键词：早期食管癌内镜黏膜下剥离术抑制蛋白基因P53 抑制蛋白基因P16 细胞增殖核抗原Ki-67

Revealing structural degradation in layered structure oxides cathode of lithium ion batteries via in-situ transmission electron microscopy

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Journal of Materials Science & Technology 2023年第23期154卷 189-201页

作者： Fanjie Xia Weihao Zeng Haoyang Peng Hong Wang congli Sun Ji Zou Jinsong Wu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and Engineering Wuhan University of Technology Wuhan 430070 China Nanostructural Research Center (NRC) Wuhan University of Technology Wuhan 430070 China Hubei Longzhong Laboratory Xiangyang 441000 China

Transition metal oxides with layered structure have been widely used as cathode materials for lithium-ion batteries(LIBs)which have relatively high energy density,large capacity and long ***,in the long-term electrochemical cycle,the inevitable degradation of performance of LIBs due to structural degradation in cathodes severely restricts their large-scale practical *** the underlying mechanism of structural degradation is the most critical scientific ***,in situ transmission electron microscopy(TEM)has become a useful tool to study the structural and compositional evolutions at atomic scale in electrochemical reactions,which provided a unique and in-depth understanding of the structural *** this review,we discuss the recent advances in the in situ TEM,focusing on its role in revealing the structural degradation mechanisms in the four key places:(1)the interface between the cathodes and electrolyte;(2)the cathode surface;(3)the particle interior and(4)those induced by thermal *** insight gained by the in-situ TEM which is still developing at its fast pace is unique and expected to provide guidance for designing better layered cathode materials.

关键词： Li-ion battery Layered cathodes Structural degradations Electron microscopy In-situ

Rapid identification of diarrheagenic Escherichia coli based on barcoded magnetic bead hybridization

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Chinese Chemical Letters 2020年第7期31卷 1812-1816页

作者： Hongming Dong congli Tang Ziyu he Hongmei Liu Yuyue Xu Hao Huang Gaojian Yang Ziqi Xiao Song Li Yan Deng Zhu Chen Hui Chen Zuodong Qin Yasser Perera Negrin Nongyue he Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of TechnologyZhuzhou 412007China State Key Laboratory of Bioelectronics Southeast UniversityNanjing 210096China Hunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources Hunan University of Science and EngineeringYongzhou 425199China China-Cuba Biotechnology Joint Innovation Center(CCBJIC) Yongzhou Zhong Gu Biotechnology Co.Yongzhou 425000China

Diarrhea,as a global public health problem,causes a large number of infections and deaths every *** Escherichia coli(***)is one of the normal flo ra microorganisms in the human intestinal tract,it has five pathogenic bacteria types that can cause human diarrhea,known as diarrheagenic *** people are infected,rapid and accurate diagnosis,along with timely treatment,are especially ***,we introduce a new method to identify and analyze a large number of pathogenic strains in *** by multiplex PCR and barcoded magnetic bead *** show that the detection sensitivities of enterohemorrhagic ***,enterotoxigenic ***,enteropathogenic ***,enteroinvasive *** and enteroaggregative *** were 1.3×10^3 CFU/mL,2×10^4 CFU/mL,4×10^4 CFU/mL,7.2×10^4 CFU/mL and 1.7 CFU/mL *** method has strong specificity and high sensitivity and detects multiple target sequences in one *** with other methods,BMB array has great application potential.

关键词： Diarrheagenic E.coli Rapid detection Multiplex PCR Barcoded magnetic bead Detect multiple target