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Methotrexate ameliorates pristane-induced arthritis by decreasing IFN-γ and IL-17A expressions

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第1期12卷 40-46页

作者： Wei-kun HOU Lie-su MENG Fang ZHENG Yu-rong WEN Wen-hua ZHU cong-shan jiang Xiao-jing HE Yan ZHOU She-min LU Department of Genetics and Molecular Biology School of Medicine Xi "an Jiaotong University Xi 'an 710061 China Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education Xi 'an Jiaotong University Xi 'an 710061 China Department of Dermatology and Venereology the First Affiliated Hospital School of Medicine Xi 'an Jiaotong University Xi 'an 710061 China Department of Epidemiology and Health Statistics School of Public Health Xi 'an Jiaotong University Xi 'an 710061 China

Objective: This study was carried out to test the effects of methotrexate (MTX) and black seed oil (BSO) on pristane-induced arthritis (PIA) in ***: Inbred dark agouti (DA) rats were induced by a single subcutaneous injection of pristane,and then treated with MTX or *** severity was evaluated macroscopically and *** nitric oxide (NO) concentration was determined by the Griess method and cytokine mRNA expression in the spleen was detected by the real-time reverse transcription-polymerase chain reaction (RT-PCR).Results: The clinical arthritis severity was decreased after MTX treatment,while the BSO groups did not show significant changes compared with the disease *** plasma NO level of the MTX group was significantly decreased compared with the disease group,but the BSO groups showed no difference from the disease group in plasma NO *** interferon-γ (IFN-γ) and interleukin-17A (IL-17A) mRNA expressions in the spleens were significantly decreased in the MTX group,but only showed a declining trend in the BSO groups compared with the disease *** MTX nor BSO had an effect on the mRNA expressions of IL-4,transforming growth factor β (TGF-β),and tumor necrosis factor-α (TNF-α) in the ***: MTX,but not BSO,can reduce the arthritis severity and decrease the mRNA expressions of IFN-γ and IL-17A in pristane-induced arthritis of rats.

关键词： Methotrexate (MTX) Black seed oil (BSO) Pristane-induced arthritis (PIA) Interferon-γ (IFN-γ) Interleukin-17A (IL-17A)

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Surface micro-arrays enhancing electromagnetic interference shielding of polydimethylsiloxane/multiwalled carbon nanotubes nanocomposites

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Nano Research 2025年第1期18卷 508-519页

作者： Ke jiang Zhi Chen Ji Yu Chen Zheng shan Huang Ming Wang Chongqing Key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing

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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： shan Ping Yu Emily Choi Michael Qjiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： cong Geng Kuanxiang Zhang Changhua Wang Chung Hsien Wu Jiwen jiang Fei Long Liyuan Han Qifeng Han Yi‑Bing Cheng Yong Peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

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Toll Like Receptor 3 Plays an Important Role in the Initiation and Development of Pristane Induced Arthritis Model in Rats

Toll Like Receptor 3 Plays an Important Role in the Initiati...

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2008年全国生物化学与分子生物学学术大会

作者： Lie-su Meng Wen-hua Zhu cong-shan jiang Fu-jun Zhang Yan Han Qi-lan Ning She-min Lu (Department of Genetics and Molecular Biology,Xi’an Jiaotong University School of Medicine,Xian 710061,China)

Rheumatoid arthritis (RA) is a chronic immuno-inflammation disease that afflicts the synovium of diarthrodial *** pathogenic mechanisms inciting this disease are not fully *** like receptors (TLRs) may participate in ...

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Stability of 12 Housekeeping Genes in PIA and AIPI Rat Models

Stability of 12 Housekeeping Genes in PIA and AIPI Rat Model...

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2008年全国生物化学与分子生物学学术大会

作者： cong-shan jiang Wen-hua Zhu Lie-su Meng Xiao-jing He Fang Zheng Qi-lan Ning Yan Han She-min Lu (Department of Genetics and Molecular Biology,Xi’an Jiaotong University School of Medicine,Xian 710061,China)

Inflammation may affect the expression level of housekeeping *** is thus evident that normalizing expression of the interest gene to stably expressed reference genes is critical when performing gene expression studies...

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家蚕狭胸(narrow breast,nb)突变性状观察及基因的精细定位

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蚕学通讯 2019年第1期39卷 1-8页

作者：刘品彦刘茹凤丛江珊刘春家蚕基因组生物学国家重点实验室农业农村部蚕桑生物学与遗传育种重点实验室重庆400716

狭胸(narrow breast,nb)是家蚕少数几个体型突变种之一,其表型为胸部狭小,位于19号染色体的31.2位点,该突变为自然隐性突变。到目前为止,其突变基因还未被分离克隆,突变机理未知。为了分离克隆nb的突变基因,阐释其突变机理,本研究首先... 详细信息

狭胸(narrow breast,nb)是家蚕少数几个体型突变种之一,其表型为胸部狭小,位于19号染色体的31.2位点,该突变为自然隐性突变。到目前为止,其突变基因还未被分离克隆,突变机理未知。为了分离克隆nb的突变基因,阐释其突变机理,本研究首先对nb蚕的突变性状进行观察。发现3龄时,nb狭胸表型开始明显,并维持到蛹期。5龄期的nb与野生型的体重没有明显差异,但nb体长明显的比正常表型短。5龄5d解剖观察发现nb和野生型个体前肠存在差异,nb前肠在食道处收缩,而正常个体是逐渐变大且呈漏斗状。同时,本研究还采用大造和nb为亲本构建BC_1群体,通过筛选合适的SNP标记对nb突变基因进行了精细定位,其结果为:利用10 SNP个标记和92个BC_1代个体进行连锁分析,将nb突变相关基因位于标记3和8之间的区域内,遗传距离为7.8cM,物理距离约为1.7Mb。利用13个可用于定位的标记和1794个BC_1代个体,nb突变基因位于标记31和38之间区域内,该区域物理跨度约为1Mb,基因预测结果显示定位区域内含有44个基因。本研究为nb突变基因的定位及机理的阐释提供了参考信息。

关键词： nb 性状观察定位克隆连锁图谱精细定位

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健康中国视域下本科医学教育阶段的全科医学教育探讨

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中国全科医学 2025年第4期28卷 427-431页

作者：杨珊王璁王留义河南省人民医院(郑州大学人民医院)全科医学科河南省郑州市450003

《“健康中国2030”规划纲要》提出“共享共建、全民健康”。作为居民健康的“守门人”,全科医生的教育与培养至关重要。本科教育是医学院校临床教育的根本,也是后续医学人才储备的核心,其教学质量和效果对我国临床医学事业的发展和规... 详细信息

《“健康中国2030”规划纲要》提出“共享共建、全民健康”。作为居民健康的“守门人”,全科医生的教育与培养至关重要。本科教育是医学院校临床教育的根本,也是后续医学人才储备的核心,其教学质量和效果对我国临床医学事业的发展和规模颇有影响。本文通过对比国内外本科医学教育阶段的全科医学教育情况,发现目前我国高校虽设置有全科医学课程,但课程设置与内容体系仍不健全。构建全科医学课程群,加强医学人文与课程思政教育,创新教学方式,完善教学评价对推动我国全科医学教育可能有益,有助于推动我国的全民健康事业。

关键词：全科医学教育医学本科健康中国

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Surface Enhanced Raman Scattering Revealed by Interfacial Charge-Transfer Transitions

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The Innovation 2020年第3期1卷 92-113页

作者： shan cong Xiaohong Liu Yuxiao jiang Wei Zhang Zhigang Zhao Key Lab of Nanodevices and Applications Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of Sciences(CAS)Suzhou 215123China Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714China

Surface enhanced Raman scattering(SERS)is a fingerprint spectral technique whose performance is highly dependent on the physicochemical properties of the substrate *** addition to the traditional plasmonic metal substrates that feature prominent electromagnetic enhancements,boosted SERS activities have been reported recently for various categories of non-metal materials,including graphene,MXenes,transition-metal chalcogens/oxides,and conjugated organic *** the structural compositions of these semiconducting substrates vary,chemical enhancements induced by interfacial charge transfer are often the major contributors to the overall SERS behavior,which is distinct from that of the traditional SERS based on plasmonic *** charge-transfer-induced SERS enhancements,this short review introduces the basic concepts underlying the SERS enhancements,the most recent semiconducting substrates that use novel manipulation strategies,and the extended applications of these versatile substrates.

关键词： SERS CHARGE TRANSFER SEMICONDUCTOR CHEMICAL MECHANISM DEFECT ENGINEERING

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Preparation of Thermosensitive Hollow Imprinted Microspheres via Combining Distillation Precipitation Polymerization and Thiol-ene Click Chemistry

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Chinese Journal of Chemistry 2015年第2期33卷 225-234页

作者： cong Guo Bing Wang Juanjuan shan State Key Laboratory of Hollow Fiber Membrane Materials and Processes Tianjin Polytechnic UniversityTianjin 300387China Tianjin Industry University for the Textile Auxiliaries CO. LTD.Tianjin 300270China

Hollow molecular imprinted polymer microspheres were prepared by distillation precipitation polymerization with(S)-(+)-ibuprofen(S-IBF)as template molecule and acrylamide(AM)as functional *** the silicon dioxide(SiO_(2),180 nm)modified by 3-(trimethoxysilyl)propyl methacrylate(MPS)as the template micro-spheres,the molecular imprinted shells were coated on successfully(SiO_(2)@MIPs).The thermosensitive SiO_(2)@MIPs-PNIPAM core-shell microspheres were subsequently prepared by grafting the PNIPAM chains(M_(n)=1.21×10^(4)g/mol,polydispersity index=1.30),which were prepared by reversible addition-fragmentation chain transfer(RAFT)polymerization,on the surface of SiO_(2)@MIPs microspheres via the thiol-ene click *** grafting density of PNIPAM brushes on the SiO_(2)@MIPs microspheres was about 0.18 chains/nm^(2).After HF etching,the hollow imprinted microspheres were finally *** thermosensitivity analysis,the phase transition temperatures of multifunctional nanoparticles were measured by DSL at 25℃and 45℃respectively,and the sizes of the microspheres changed by about 35 *** modified microspheres presented excellent controlled release property to S-IBF,moreover about half amount of the adsorptions passed into acetonitrile-water solution through the specific holes of imprinted shell at 25℃under vibration.

关键词： molecular imprinted polymer microspheres thermosensitive ibuprofen hollow structure controlled release

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