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Innate immune responses in RNA viral infection

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Frontiers of Medicine 2021年第3期15卷 333-346页

作者： Qian Xu Yuting Tang gang huang Divisions of Pathology and Experimental Hematology and Cancer Biology Cincinnati Children’s Hospital Medical CenterCincinnatiOH 45229USA Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

RNA viruses cause a multitude of human diseases,including several pandemic events in the past *** viral invasion,the innate immune system responds rapidly and plays a key role in activating the adaptive immune *** the innate immune system,the interactions between pathogen-associated molecular patterns and host pattern recognition receptors activate multiple signaling pathways in immune cells and induce the production of pro-inflammatory cytokines and interferons to elicit antiviral ***,dendritic cells,and natural killer cells are the principal innate immune components that exert antiviral *** this review,the current understanding of innate immunity contributing to the restriction of RNA viral infections was briefly *** the main role of immune cells in combating viral infection,the intercellular transfer of pathogen and host-derived materials and their epigenetic and metabolic interactions associated with innate immunity was *** knowledge provides an enhanced understanding of the innate immune response to RNA viral infections in general and aids in the preparation for the existing and next emerging viral infections.

关键词： innate immune viral infection intercellular signaling metabolic changes epigenetic changes

Photoinduced radical sulfur dioxide insertion with asymmetric cyclization of alkenes: accessing β-chiral sulfones bearing S-stereocentric cyclic sulfinamides

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Science China Chemistry 2025年第01期 257-263页

作者： Jiapian huang Chenxin Wang Xu Wang Xiaoyu Zhou Wei Xiao Jie Wu School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies Taizhou University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences School of Chemistry and Chemical Engineering Henan Normal University

The generation of various β-chiral sulfones bearing chiral cyclic sulfinamides through photoredox-catalyzed sulfur dioxide insertion with asymmetric radical cyclization is described. This method features a broad substrate scope and excellent stereospecificity. Computational studies reveal that the dispersion interaction between sulfinyl group and CH2SO2Ph group plays a crucial role in the stereoselectivity control.

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Water Storage of Water-Based Enhanced Geothermal System Based on a 3D Thermal-Hydrologic-Mechanical Model

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Journal of Thermal Science 2022年第3期31卷 946-957页

作者： WANG Changlong huang Xinjie TANG gang ZHONG Dan School of Civil Engineering and Architecture Anhui University of TechnologyMa’anshan243002China Zhuhai Da Hengqin Science and Technology Development Co. LtdZhuhai519000China School of Safety Engineering China University of Mining and TechnologyXuzhou221116China

The thermal-hydrologic-mechanical(THM)coupled processes in water-based enhanced geothermal system(EGS)greatly influence the heat extraction performance of *** THM models have been proposed,however,there is a lack of detailed analysis of water storage,which is caused by the increments of reservoir porosity and water density,and the influence of water storage on the heat extraction performance needs to be *** this paper,a 3D THM model is established to simulate the water storage amount and heat extraction rate for a water-based *** 3D THM model is verified against an analytical ***,the influences of water storage are investigated,and comparisons between the THM and thermal-hydrologic(TH)processes are made for different initial reservoir *** results show that the increment of reservoir porosity has a larger influence on water storage than that of water *** ignoring water storage,the injection flow rate would be underestimated,while the production flow rate and heat extraction rate would be overestimated,and the reservoir would be cooled a little *** with the TH processes,the THM processes show larger cumulative water storage amount,higher steady-state heat extraction rate and higher cooling rate of reservoir,indicating that mechanical process has important influences on EGS *** higher initial reservoir porosity,the cumulative water storage amount is *** can be inferred that the water storage amount is related to the cooling rate of *** results of this paper show that water storage has a certain influence on the heat extraction rate,and that the mechanical process and initial reservoir porosity have important effects on the water storage amount,which should be simulated based on a THM model.

关键词： enhanced geothermal system thermal-hydrologic-mechanical model heat extraction water storage

Unsupervised social network embedding via adaptive specific mappings

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Frontiers of Computer Science 2024年第3期18卷 61-71页

作者： Youming GE cong huang Yubao LIU Sen ZHANG Weiyang KONG School of Computer Science and Engineering Sun Yat-Sen UniversityGuangzhou 510275China Guangdong Key Laboratory of Big Data Analysis and Processing Guangzhou 510006China

In this paper,we address the problem of unsuperised social network embedding,which aims to embed network nodes,including node attributes,into a latent low dimensional *** recent methods,the fusion mechanism of node attributes and network structure has been proposed for the problem and achieved impressive prediction ***,the non-linear property of node attributes and network structure is not efficiently fused in existing methods,which is potentially helpful in learning a better network *** this end,in this paper,we propose a novel model called ASM(Adaptive Specific Mapping)based on encoder-decoder *** encoder,we use the kernel mapping to capture the non-linear property of both node attributes and network *** particular,we adopt two feature mapping functions,namely an untrainable function for node attributes and a trainable function for network *** the mapping functions,we obtain the low dimensional feature vectors for node attributes and network structure,***,we design an attention layer to combine the learning of both feature vectors and adaptively learn the node *** encoder,we adopt the component of reconstruction for the training process of learning node attributes and network *** conducted a set of experiments on seven real-world social network *** experimental results verify the effectiveness and efficiency of our method in comparison with state-of-the-art baselines.

关键词： network embedding specific kernel mapping attention mechanism

Grain-size effect on dislocation source-limited hardening and ductilization in bulk pure Ni

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Journal of Materials Science & Technology 2023年第23期154卷 9-21页

作者： Kai Hu Jun Yi Bo huang gang Wang Institute of Materials School of Materials Science and Engineering Shanghai University Shanghai 200444 China

Dislocation source-limited hardening and ductilization is an effective strategy to obtain superior strength-ductility synergy in some engineering structural metals. Recent works demonstrated that the synergy could be enhanced by grain-size reduction. However, the mechanism of grain-size dependence is still a mystery. In this work, bulk pure Ni produced by electrodeposition and subsequent annealing, with grain sizes ranging from ∼20 nm to ∼20 µm, were methodically investigated to unravel the mechanism of the grain-size effect on dislocation source-limited hardening and ductilization. The high-density nano-twinning in the as-electrodeposited nanograined specimens exhibited better thermodynamic stability than the peers with random high-angle grain boundaries, leading to fine recrystallized grains with low-density dislocations. The low dislocation density enabled extra hardening beyond grain boundary strengthening via yield-point behavior with grain sizes ranging from ∼110 nm to ∼10 µm and extra ductilization over ∼500 nm. This work demonstrated that the prerequisite for dislocation source-limited hardening was that the dislocation density of the specimen should be lower than the size-dependent critical value of ((1.1 × 107 /d ) m^(–2), d is the grain size in unit of the meter) where a transition from forest-dominated hardening to dislocation source-limited hardening could occur. On the other hand, dislocation source-limited ductilization only worked when the grain size was comparable to/larger than the theoretical dislocation mean slip distance. Dislocation source-limited ductilization resulted from more room in grains for accumulation of dislocations and deformation nano-stacking faults enabling the higher work hardening rate. This work offered an altogether new avenue to obtain stronger and more ductile metallic materials through utilizing grain-size dependent dislocation source-limited hardening and ductilization.

关键词： Dislocation source-limited hardening Dislocation source-limited ductilization Grain size Yield point Hall-Petch slope

Method for triangular fuzzy multiple attribute decision making based on two-dimensional density operator method

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Journal of Systems Engineering and Electronics 2024年第1期35卷 178-185页

作者： LIN Youliang LI Wu LIU gang huang Dong School of Economics and Management Hunan Institute of Science and TechnologyYueyang 414000China Hunan Vocational College for Nationalities Yueyang 414000China School of Information Science and Engineering Hunan Institute of Science and TechnologyYueyang 414000China

Aiming at the triangular fuzzy(TF)multi-attribute decision making(MADM)problem with a preference for the distribution density of attribute(DDA),a decision making method with TF number two-dimensional density(TFTD)operator is proposed based on the density operator theory for the decision maker(DM).Firstly,a simple TF vector clustering method is proposed,which considers the feature of TF number and the geometric distance of ***,the least deviation sum of squares method is used in the program model to obtain the density weight ***,two TFTD operators are defined,and the MADM method based on the TFTD operator is ***,a numerical example is given to illustrate the superiority of this method,which can not only solve the TF MADM problem with a preference for the DDA but also help the DM make an overall comparison.

关键词： fuzzy decision making clustering density operator multi-attribute decision making(MADM)

Modeling tactile perceived intensity for vibration from a coin eccentric rotating mass motor

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Science China Technological Sciences 2025年

作者： Yun FANG Jingchen huang Yujun WU Jiaqi DONG Weichao GUO Xinjun SHENG State Key Laboratory of Mechanical System and Vibration School of Mechanical Engineering Shanghai Jiao Tong University Meta Robotics Institute Shanghai Jiao Tong University

Establishing the relationship between vibrotactile parameters and perceived intensity（PI） is of great significance in the regulation of desired sensations, which contribute to haptic interfaces in practical applications. Coin eccentric rotating mass（ERM） motors are routinely utilized due to their lightweight design and efficient ability to evoke strong tactile sensations. By adjusting input voltages, ERMs can yield different stimuli, but the effects of their physical properties on PI remain ***, we developed the physical model of the ERM-skin system and optimized the parameters affecting PI. Moreover, the relationship between stimulus and perception was derived based on Fechner?s law. Three experiments were conducted on fifteen subjects（ten males and five females, aged 24.40 ± 2.87 years） to identify the vibration parameters and corresponding PI to verify the proposed PI model. ERMs in this study were attached to phantom skin/forearm with slim adhesive tape to minimize the interference. Experiment 1 performed vibration calibration with ERM attached to the skin phantom to simulate the actual configuration. Then, the relative and absolute PI of subjects on specific stimuli were acquired in Experiments 2 and *** fitting reliability of the proposed PI model was evaluated on fifteen subjects with R2of 0.73 ± 0.07 and root mean squared error（RMSE） of 1.35 ± 0.28. Overall, the proposed PI model established the quantitative relationship between stimulus parameters（vibration parameters and physical parameters） and subjective PI, which provided theoretical support for ERM optimization and vibrotactile modulation.

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Estimation of the unfrozen water content of saturated sandstones by ultrasonic velocity

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International Journal of Mining Science and Technology 2023年第6期33卷 733-746页

作者： Shibing huang Fei Liu gang Liu Shilin Yu School of Resources and Environmental Engineering Wuhan University of Science and TechnologyWuhan 430081China Hubei Key Laboratory for Efficient Utilization and Agglomeration of Metallurgic Mineral Resources Wuhan 430081China

The unfrozen water content(UWC)of rocks at low temperature is an important index for evaluating the stability of the rock engineering in cold regions and artificial freezing *** study addresses a new method to estimate the UWC of saturated sandstones at low temperature by using the ultrasonic *** velocity variations can be divided into the normal temperature stage(20 to 0℃),quick phase transition stage(0 to-5℃)and slow phase transition stage(-5 to-25℃).Most increment of ultrasonic velocity is completed in the quick phase transition stage and then turns to be almost a constant in the slow phase transition *** addition,the UWC is also measured by using nuclear magnetic resonance(NMR)*** is validated that the ultrasonic velocity and UWC have a similar change law against freezing and thawing *** WE(weighted equation)model is appropriate to estimate the UWC of saturated sandstones,in which the parameters have been accurately determined rather than by data *** addition,a linear relationship between UWC and ultrasonic velocity is built based on pore ice crystallization *** is evidenced that this linear function can be adopted to estimate the UWC at any freezing temperature by using P-wave velocity,which is simple,practical,and accurate enough compared with the WE model.

关键词： Ultrasonic velocity Freeze-thaw cycles Unfrozen water content Prediction function Hysteresis effect

Systematic Acupuncture Explains Acupuncture at Baihui(GV20) and Fengchi(GB20) Targeting the Inflammatory Response to Regulate Migraine

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Journal of Traditional Chinese Medicine 2025年

作者： MIN Yu ZHENG Meifeng SUN Ju PENG Zetong CAO Zhixian huang Xiaohua Medical College of Acu-Moxi and Rehabilitation， Guangzhou University of Chinese Medicine Department of Rehabilitation Medicine， the Affiliated Panyu Central Hospital of Guangzhou Medical University

Objective: To take Baihui (GV20) and Fengchi (GB20) targeting inflammatory response to regulate migraine as an example to describe a new method for studying the mechanism of stimulating ***: The target information of Baihui (GV20) and Fengchi (GB20) was retrieved， and after intersection with migraine， Kyoto Encyclopedia of Genes and Genomes (KEGG)， Reactome， and UniProt Keywords were used for functional enrichment. After selecting the main pathway， rats were selected and nitroglycerin was used for modeling， and the behavioral scores， inflammatory factors， heme oxygenase 1 (HMOX1)， protein kinase B (AKT1)， signal transducer and activator of transcription 3 (STAT3)， phosphorylated extracellular signal-regulated kinase 1/2 (P-ERK1/ERK2) and other states of the rats in the acupuncture， twisting， and electroacupuncture groups were ***: A total of 135 Baihui (GV20) targets and 27 Fengchi (GB20) targets were collected. A total of 73 target information were obtained after the intersection of these targets in migraine. These 73 targets have three main pathways: hypoxia-inducible factor 1 (HIF-1) signaling pathway， signaling by interleukins and inflammatory response. The main targets in the pathway were verified and found that interleukin-1 beta (IL-1β)， interleukin-6 (IL-6)， tumor necrosis factor-alpha (TNF-α) and HMOX1， AKT1， STAT3， P-ERK1/ERK2 can be regulated by Baihui (GV20) and Fengchi (GB20).Conclusion: Baihui (GV20) and Fengchi (GB20) can regulate migraine by regulating inflammatory factors and HMOX1， AKT1， STAT3， P-ERK1/ERK2 and other changes in HIF-1 signaling pathway， Signaling by Interleukins and Inflammatory response pathways. Based on systems biology and network pharmacology， and with the model of "acupoint-target-disease"， explore the research methods of systematic acupuncture and moxibustion. We believe this is a usable research direction for exploring the mechanism of acupuncture stimulation.

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