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Inhibition of LOX-1 alleviates the proinflammatory effects of high-mobility group box 1 in Aspergillus fumigatus keratitis

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International Journal of Ophthalmology(English edition) 2019年第6期12卷 898-903页

作者： Jia-Qian Jiang cui Li cong-xian cui Yu-Na Ma Gui-Qiu Zhao Xu-Dong Peng Qiang Xu Qian Wang Guo-Qiang Zhu Chen-Yu Li Department of Ophthalmology the Affiliated Hospital of Qingdao University

AIM: To investigate the inflammatory amplification effect of high-mobility group box 1(HMGB1) in Aspergillus fumigatus(A. fumigatus) keratitis and the relationship between lectin-like oxidized low-density lipoprotein receptor 1(LOX-1) and HMGB1 in keratitis immune ***: Phosphate buffer saline(PBS), and Boxb were injected into BALB/c mice subconjunctivally before the corneas were infected with A. fumigatus. RAW264.7 macrophages and neutrophils were pretreated with PBS and Boxb to determine the HMGB1 inflammatory amplification effects. Abdominal cavity extracted macrophages were pretreated with Boxb and Poly(I)(a LOX-1 inhibitor) before A. fumigatus hyphae stimulation to prove the the relationship between the two molecules. LOX-1, interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α), macrophage inflammatory protein-2(MIP-2) and IL-10 were assessed by polymerase chain reaction and Western ***: Pretreatment with Boxb exacerbated corneal inflammation. In macrophages and neutrophils, A. fumigatus induced LOX-1, IL-1β, TNF-α and MIP-2 expression in Boxb group was higher than those in PBS group. Poly(I) treatments before infection alleviated the proinflammatory effects of Boxb in abdominal cavity extracted macrophages. Pretreatment with Boxb did not influence Dectin-1 mRNA levels in macrophages and ***: In fungal keratitis, HMGB1 is a proinflammatory factor in the first line of immune response. HMGB1 mainly stimulates neutrophils and macrophages to produce inflammatory cytokines and chemokines during the immune response. LOX-1 participates in HMGB1 induced inflammatory exacerbation in A. fumigatus keratitis.

关键词： Aspergillus fumigatus keratitis high-mobility group box 1 LOX-1

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Density fluctuations in intermediate-energy heavy-ion collisions

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Nuclear Science and Techniques 2022年第5期33卷 1-7页

作者： cong Liu xian-Gai Deng Yu-Gang Ma Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China

Within the framework of the isospin-dependent quantum molecular dynamics model,we simulate^(129)Xe+^(119)Sn collisions in an incident energy range of 20 to 190MeV/nucleon and discuss the liquid-gas phase transition with density *** comparison,we also extract the effective Fisher parameter τ_(eff),multiplicity of intermediate-mass fragments(IMFs),and information *** is found that the Fisher parameter and maximum information entropy of collisions have peak values at E_(beam)=50-80 MeV/*** addition,the maximum multiplicity of IMFs has a plateau around 70 MeV/*** higher-order density moments in a larger central region of[-5,5]^(3) fm^(3) in the collision system,a maximum plateau also appears as function of beam energy at energies exceeding 70 MeV/*** observables,which are consistent with each other,indicate a liquid-gas phase transition around 70 MeV/nucleon for the^(129)Xe+^(119)Sn system.

关键词： Heavy-ioncollisions Liquid-gasphase transition IQMD Density moment Intermediatemass fragment Informationentropy Fisher-lawparameter

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Morphology Engineering for Covalent Organic Frameworks (COFs) by Surfactant Mediation and Acid Adjustment

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Chinese Journal of Polymer Science 2022年第4期40卷 338-344页

作者： Guang-Hui Yang Zhe Zhang cong-cong Yin xian-Song Shi Yong Wang State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China

Two-dimensional covalent organic frameworks(COFs)with specific morphologies including nanofibers and nanoplates are highly desired in both nanoscience research and practical *** far,however,morphology engineering for COFs remains challenging because the mechanism underlying the morphology formation and evolution of COFs is not well ***,we propose a strategy of surfactant mediation coupled with acid adjustment to engineer the morphology of aβ-ketoenamine-linked COF,TpPa,during solvothermal *** surfactants function as stabilizers that can encapsulate monomers and prepolymers to create micelles,enabling the formation of fiber-like and plate-like morphologies of TpPa rather than irregularly shaped *** is also found that acetic acid is important in regulating such morphologies,as the amino groups inside the prepolymers can be precisely protonated by acid adjustment,leading to an inhibited ripening process for the creation of specific *** from the synergistic enhancement of surfactant mediation and acid adjustment,TpPa nanofibers with a diameter down to~20 nm along with a length of up to a few microns and TpPa nanoplates with a thickness of~18 nm are *** work sheds light on the mechanism underlying the morphology formation and evolution of TpPa,providing some guidance for exquisite control over the growth of COFs,which is of great significance for their practical applications.

关键词： Covalent organic frameworks(COFs) Morphology engineering Surfactants Nanofibers Nanoplates

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Antibacterial and pH-responsive Quaternized Hydroxypropyl Cellulose-g-Poly(THF-co-epichlorohydrin)Graft Copolymer:Synthesis,Characterization and Properties

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Chinese Journal of Polymer Science 2020年第7期38卷 704-714,I0005页

作者： Jin-Rui Deng cong-Lei Zhao Yi-xian Wu State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing 100029China

The novel quaternized hydroxypropyl cellulose-g-poly(THF-co-epichlorohydrin)graft copolymers,HPC-g-QCP(THF-co-ECH),have been successfully synthesized to combine the properties from hydrophilic hard HPC biomacromolecular backbone and hydrophobic flexible polyether ***,the P(THF-co-ECH)living chains were synthesized by cationic ring-opening copolymerization of THF with ***,P(THF-co-ECH)living chains were grafted onto HPC backbone by reaction with-OH groups along HPC to produce HPC-g-P(THF-co-ECH)graft ***,the mentioned graft copolymers were quaternized by reaction with ternanyamine to generate functionalized HPC-g-QCP(THF-co-ECH).The HPC-g-QCP(THF-co-ECH)graft copolymers exhibited good antibacterial ability against *** or *** *** ibuprofen(IBU)-loaded microparticles of HPC-g-(QC)P(THF-co-ECH)graft copolymers were prepared by *** in vitro pH-responsive drug-release behavior of IBU reached up to 75%of drug-loaded at pH=*** quaternized graft copolymer was beneficial to solving the problems of a burst effect and fast release of HPC as drug carriers.

关键词： Living cationic ring-opening copolymerization Hydroxypropyl cellulose-graft-polyether Antibacterial ability pH-responsive drug-release

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Exact solutions of non-Hermitian chains with asymmetric long-range hopping under specific boundary conditions

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Chinese Physics B 2022年第1期31卷 81-86页

作者： cui-xian Guo Shu Chen Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Yangtze River Delta Physics Research Center Liyang 213300China

We study the one-dimensional general non-Hermitian models with asymmetric long-range hopping and explore how to analytically solve the systems under some specific boundary *** the introduction of long-range hopping terms prevents us from finding analytical solutions for arbitrary boundary parameters,we identify the existence of exact solutions when the boundary parameters fulfill some constraint relations,which give the specific boundary *** analytical results show that the wave functions take simple forms and are independent of hopping range,while the eigenvalue spectra display rich model-dependent ***,we find the existence of a special point coined as pseudo-periodic boundary condition,for which the eigenvalues are the same as those of the periodical system when the hopping parameters fulfill certain conditions,whereas the eigenstates display the non-Hermitian skin effect.

关键词： non-Hermitian physics exact solution topological physics long-range hopping

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Disinfection byproduct formation from algal organic matters after ozonation or ozone combined with activated carbon treatment with subsequent chlorination

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Journal of Environmental Sciences 2021年第6期33卷 233-241页

作者： Qiufeng Lin Feilong Dong cong Li Junkui cui School of Environment and Architecture University of Shanghai for Science and TechnologyShanghai200433China Department of Earth and Environmental Studies Montclair State UniversityMontclairNew Jersey 07043United States College of Environment Zhejiang University of TechnologyHangzhou310032China

Algal organic matter(AOM),including extracellular organic matter(EOM)and intracellular organic matter(IOM)from algal blooms,is widely accepted as essential precursors of disinfection byproducts(DBPs).This study evaluated the effect of ozonation or ozone combined with activated carbon(O_(3)-AC)treatment on characteristic alternation and DBP formation with subsequent chlorination of Chlorella sp..The effects of p H and bromide concentration on DBP formation by ozonation or O_(3)-AC treatment were also *** showed that the potential formation of DBPs might be attributed to ozonation,but these DBP precursors could be further removed by activated carbon(AC)***,the formation of target DBPs was controlled at acidic pH by alleviating the reactions between chlorine and ***,the bromide substitution factor(BSF)value of trihalomethanes(THMs)from EOM and IOM remained constant after AC ***,THM precursors could be significantly decreased by AC *** above results indicated that O_(3)-AC was a feasible treatment method for algal-impacted water.

关键词： Ozone combined with activated carbon treatment Chlorella sp. Disinfection byproducts PH Bromide substitution factor

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Ultrasound-guided needle release plus corticosteroid injection of superficial radial nerve:A case report

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World Journal of Clinical Cases 2022年第4期10卷 1320-1325页

作者： Zeng Zeng cong-xian Chen Department of Ultrasound Zhejiang Provincial People's HospitalHangzhou 310000Zhejiang ProvinceChina

BACKGROUND The radial nerve(RN)splits into two main branches at the elbow:The superficial branch of RN(SBRN)and the deep branch of *** SBRN can be easily damaged in acute trauma due to its superficial *** SUMMARY A 55-year-old male patient injured his right wrist 10 mo ***,suturing and bandaging were performed in the emergency *** months after the scar had healed,he felt numbness and tingling in the dorsal surface of the thumb of the right *** the surgery of resection and SBRN anastomosis were *** pathological findings showed it as traumatic *** months after surgery,the patient felt numbness and tingling in the right dorsal surface of the thumb *** tenderness was marked in the operated *** indicated that the SBRN was adhered to the surrounding *** patient refused further surgical treatment and underwent ultrasound-guided needle release plus corticosteroid injection of the *** weeks later,the tenderness in the surgical area was reduced by 70%,the numbness in the dorsal surface of the thumb of the right hand was reduced by 40%and the nerve swelling evaluated by ultrasound was *** months passed,he did not feel any numbness or tingling sensation of his right *** is the first report of ultrasound-guided needle release plus corticosteroid injection of the *** Ultrasound can evaluate the condition of the RN,and the relationship with surrounding ***-guided needle release plus corticosteroid injection is an effective and safe treatment for SBRN adhesion.

关键词： Ultrasound-guided Needle release Superficial radial nerve Traumatic neuroma Corticosteroid injection Case report

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Hashtag Recommendation Based on Multi-Features of Microblogs

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Journal of Computer Science & Technology 2018年第4期33卷 711-726页

作者： Fei-Fei Kou Jun-Ping Du cong-xian Yang Yan-Song Shi Wan-Qiu cui Mei-Yu Liang Yue Geng Beijing Key Laboratory of Intelligent Telecommunication Software and Multimedia School of Computer Science Beijing University of Posts and Telecommunications Beijing 100876 China

Hashtag recommendation for microblogs is a very hot research topic that is useful to many applications involving microblogs. However, since short text in microblogs and low utilization rate of hashtags will lead to the data sparsity problem, it is difficult for typical hashtag recommendation methods to achieve accurate recommendation. In light of this, we propose HRMF, a hashtag recommendation method based on multi-features of microblogs in this article. First, our HRMF expands short text into long text, and then it simultaneously models multi-features （i.e., user, hashtag, text） of microblogs by designing a new topic model. To further alleviate the data sparsity problem, HRMF exploits hashtags of both similar users and similar microblogs as the candidate hashtags. In particular, to find similar users, HRMF combines the designed topic model with typical user-based collaborative filtering method. Finally, we realize hashtag recommendation by calculating the recommended score of each hashtag based on the generated topical representations of multi-features. Experimental results on a real-world dataset crawled from Sina Weibo demonstrate the effectiveness of our HRMF for hashtag recommendation.

关键词： hashtag recommendation topic model collaborative filtering method microblog

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Impurity effects of theΛhyperon in the hypernuclear systems^(25)ΛMg and(29)ΛSi

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Communications in Theoretical Physics 2021年第11期73卷 116-121页

作者： Ji-Wei cui xian-Rong Zhou School of Physics and Optoelectronic Engineering Xidian UniversityXi'an 710071China Department of Physics East China Normal UniversityShanghai 200241China

Based on the beyond-mean-field Skyrme-Hartree-Fock model,impurity effects of theΛhyperon in the hypernuclear systems^(25)ΛMg and^(29)ΛSi are investigated,*** cases,in which theΛhyperon occupies the single-particle orbitals L[000]1+/2,L[110]1-/2,L[101]3-/2 and L[101]1-/2,are *** each case,the potential energy surface and the energy curves projected on certain angular momenta are employed to show the influence of theΛhyperon on the nuclear *** the shrinkage effect that is induced by theΛhyperon occupying the sΛorbital,it is found that theΛhyperon on the pΛorbital,L[110]1-/2,drives the nuclear core toward a prolate shape,while the ones on the other two pΛorbitals,L[101]3-/2 and L[101]1-/2,drive the nuclear core toward an oblate *** energy spectra and the corresponding intra-band E2 transition rates for the rotational bands are given as a prediction for future experiments.

关键词： Λhypernuclei Skyrme-Hartree-Fock model angular momentum projection generator coordinate method

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轻度认知障碍老人与认知正常老人在不同单双任务下姿势控制能力的差异性

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中国组织工程研究 2025年第8期29卷 1643-1649页

作者：张雨馨于聪张翠丁建军陈岩山东体育学院山东省济南市250102 山东省体育科学研究中心山东省济南市250102 山东体育学院运动与健康学院山东省济南市250102

背景:老年人由于轻度认知障碍而引起姿势控制能力下降,导致跌倒风险增高。双任务是在接近真实生活场景下评估认知与姿势控制能力关系的主要研究范式,站立时足底压力中心位移样本熵可代表姿势控制的复杂程度。目的:基于压力中心位移样本... 详细信息

背景:老年人由于轻度认知障碍而引起姿势控制能力下降,导致跌倒风险增高。双任务是在接近真实生活场景下评估认知与姿势控制能力关系的主要研究范式,站立时足底压力中心位移样本熵可代表姿势控制的复杂程度。目的:基于压力中心位移样本熵分析轻度认知障碍老年人与认知正常老年人在姿势控制-空间工作记忆任务中姿势稳定性特征及控制策略的差异,探究认知功能损伤对站立姿势控制能力影响。方法:筛选出符合条件的16名轻度认知障碍老年人和17名认知正常老年人为研究对象,老年人分别完成5种测试任务,包括空间工作记忆、双脚平衡站立、Romberg站立、双脚平衡站立-空间工作记忆双任务、Romberg站立-空间工作记忆双任务,每个任务有效完成3次。使用Kistler三维测力台采集足底压力中心数据,测试指标包括认知行为学指标(认知得分与反应时长)、动力学指标(压力中心位移及样本熵)。结果与结论:①轻度认知障碍老年人在执行空间工作记忆任务时认知得分最大、反应时间最短,双脚平衡站立-空间工作记忆双任务居中,Romberg站立-空间工作记忆双任务认知得分最小、反应时长最长,任务间比较差异均有显著性意义(P0.05);在两种双任务下,与认知正常老年人相比,轻度认知障碍老年人的认知得分更小、反应时长更长(P<0.05),同时轻度认知障碍老年人压力中心前后、内外方向位移更大,压力中心前后、内外方向位移样本熵值更小(P<0.05);④结果表明:与认知正常老年人相比,轻度认知障碍老年人在执行双任务时姿势控制复杂度降低,系统适应性较差,自动调控能力下降,更容易受到空间工作记忆干扰,跌倒风险增大。

关键词：轻度认知障碍老年人空间工作记忆姿势控制双任务样本熵

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