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A Scd1-mediated metabolic alteration participates in liver responses to low-dose bavachin

Journal of Pharmaceutical Analysis 2023年第7期13卷 806-816页

作者： Pan Shen Zhi-Jie Bai Lei Zhou Ning-Ning Wang Zhe-Xin Ni De-Zhi Sun cong-shu huang Yang-Yi Hu Cheng-Rong Xiao Wei Zhou Bo-Li Zhang Yue Gao Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing100850China State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin301617China

Hepatotoxicity induced by bioactive constituents in traditional Chinese medicines or herbs,such as bavachin(BV)in Fructus Psoraleae,has a prolonged latency to overt drug-induced liver injury in the *** studies have described BV-induced liver damage and underlying toxicity mechanisms,but little attention has been paid to the deciphering of organisms or cellular responses to BV at no-observed-adverse-effect level,and the underlying molecular mechanisms and specific indicators are also lacking during the asymptomatic phase,making it much harder for early recognition of ***,we treated mice with BV for 7 days and did not detect any abnormalities in biochemical tests,but found subtle steatosis in BV-treated *** then profiled the gene expression of hepatocytes and non-parenchymal cells at single-cell resolution and discovered three types of hepatocyte subsets in the BV-treated *** these,the hepa3 subtype suffered from a vast alteration in lipid metabolism,which was characterized by enhanced expression of apolipoproteins,carboxylesterases,and stearoyl-CoA desaturase 1(Scd1).In particular,increased Scd1 promoted monounsaturated fatty acids(MUFAs)synthesis and was considered to be related to BV-induced steatosis and polyunsaturated fatty acids(PUFAs)generation,which participates in the initiation of ***,we demonstrated that multiple intrinsic transcription factors,including Srebf1 and Hnf4a,and extrinsic signals from niche cells may regulate the above-mentioned molecular events in BV-treated ***,our study deciphered the features of hepatocytes in response to BV insult,decoded the underlying molecular mechanisms,and suggested that Scd1 could be a hub molecule for the prediction of hepatotoxicity at an early stage.

关键词： Bavachin Hepatotoxicity Scd1 Lipid metabolism Single-cell RNA-Seq

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Exploring the performance of large language models on hepatitis B infection-related questions:A comparative study

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World Journal of Gastroenterology 2025年第3期31卷 103-112页

作者： Yu Li Chen-Kai huang Yi Hu Xiao-Dong Zhou cong He Jia-Wei Zhong Department of Gastroenterology Jiangxi Provincial Key Laboratory of Digestive DiseasesJiangxi Clinical Research Center for GastroenterologyDigestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina HuanKui Academy Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Patients with hepatitis B virus(HBV)infection require chronic and personalized care to improve *** language models(LLMs)can potentially provide medical information for *** To examine the performance of three LLMs,ChatGPT-3.5,ChatGPT-4.0,and Google Gemini,in answering HBV-related *** LLMs’responses to HBV-related questions were independently graded by two medical professionals using a four-point accuracy scale,and disagreements were resolved by a third *** question was run three times using three *** was assessed via the Gunning Fog index and Flesch-Kincaid grade *** Overall,all three LLM chatbots achieved high average accuracy scores for subjective questions(ChatGPT-3.5:3.50;ChatGPT-4.0:3.69;Google Gemini:3.53,out of a maximum score of 4).With respect to objective questions,ChatGPT-4.0 achieved an 80.8%accuracy rate,compared with 62.9%for ChatGPT-3.5 and 73.1%for Google *** the six domains,ChatGPT-4.0 performed better in terms of diagnosis,whereas Google Gemini demonstrated excellent clinical ***,in the readability analysis,the mean Gunning Fog index and Flesch-Kincaid grade level scores of the three LLM chatbots were significantly higher than the standard level eight,far exceeding the reading level of the normal *** Our results highlight the potential of LLMs,especially ChatGPT-4.0,for delivering responses to HBV-related *** may be an adjunctive informational tool for patients and physicians to improve ***,current LLMs should not replace personalized treatment recommendations from physicians in the management of HBV infection.

关键词： ChatGPT-3.5 ChatGPT-4.0 Google Gemini Hepatitis B infection Accuracy

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Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer

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World Journal of Gastroenterology 2025年第3期31卷 29-41页

作者： Ruo-Yu Guan Jia-Wei Wu Zi-Yun Yuan Zhi-Yuan Liu Zi-Zhu Liu Zhi-cong Xiao Jing-Hui Li Cheng-Zhi huang Jun-Jiang Wang Xue-Qing Yao Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina Shantou University Medical College Shantou 515041Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Gannan Medical University Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Type II diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with *** effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage III CC who receive curative resection remain *** To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage III *** This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage III CC from 2018 to *** on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic ***,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk *** Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage III CC.

关键词： Colon cancer Chemoresistance Diabetes mellitus Prognosis Type II diabetes mellitus

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Hierarchical Porous Carbon Counter Electrode for Dye-Sensitized Solar Cells

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Chinese Physics Letters 2011年第3期28卷 224-227页

作者： WANG Gui-Qiang huang cong-cong XING Wei ZHUO shu-Ping College of Chemical Engineering Shandong University of TechnologyZibo 255049

Hierarchical porous carbon is prepared by a combination of self-organization and chemical activation and explored as counter electrode for dye-sensitized solar *** structure analysis shows that micropores generated within the mesopore wall and the pristine mesopore structure of mesoporous carbon are preserved during KOH *** impedance spectroscopy studies demonstrate a relatively high electrocatalytic activity of hierarchical porous carbon electrode for triiodide reduction,as compared with a pristine mesoporous carbon *** enhanced electrocatalytic activity is beneficial for improving the photovoltaic performance of dyesensitized solar *** overall conversion efficiency of dye-sensitized solar cells with the hierarchical porous carbon electrode increased by 11.5%compared with that of the cell with a pristine mesoporous carbon electrode.

关键词： electrode Solar dye

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广西壮族人群与汉族人群白细胞介素-12家族基因多态性分布与差异比较

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广东医学 2018年第18期39卷 2741-2745页

作者：卢建勇黄信顺薛焱杨子聪张舒黄瑛施莹广西壮族自治区人民医院心血管内科广西南宁530021 广西壮族自治区人民医院超声科广西南宁530021

目的分析白细胞介素-12(interleukin-12,IL-12)家族细胞因子单核苷酸基因多态性(single nucleotide polymorphisms,SNP)位点在壮族及汉族间的分布差异,为IL-12家族基因多态性相关疾病的地域性关联研究提供一定的理论依据。方法共纳入25... 详细信息

目的分析白细胞介素-12(interleukin-12,IL-12)家族细胞因子单核苷酸基因多态性(single nucleotide polymorphisms,SNP)位点在壮族及汉族间的分布差异,为IL-12家族基因多态性相关疾病的地域性关联研究提供一定的理论依据。方法共纳入254例壮族健康人群及429例汉族健康人群进行分析。使用Puregene DNA提取试剂盒提取DNA,使用Sequenom MassArray系统对基因进行分型。结果 IL-12家族细胞因子IL-27p28基因上rs17855750、rs181206、rs40837位点,EBi3基因rs428253、rs393581位点、IL-12p35基因rs2243115、rs568408、rs582054、rs583911位点,IL-12p40基因rs3212227、rs56167332位点等位基因分布频率在两个民族间分布差异无统计学意义(P> 0. 05),EBi3 rs4740位点等位基因在两个民族间分布存在统计学差异,壮族人群中AA基因型分布频率明显高于汉族人群(26. 8%vs. 18. 9%,P=0. 034),壮族人群A等位基因分布频率明显高于汉族人群(51. 8%vs. 44. 9%,P=0. 014)。结论 EBi3 rs4740位点等位基因在两个民族间分布存在统计学差异,壮族人群中AA基因型分布频率明显高于汉族人群,这种差异可能是广西某些区域性疾病或疾病区域性特点的基因遗传原因之一。

关键词： IL-12家族基因多态性分布特点壮族人群

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Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders:Present trends and future directions

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World Journal of Psychiatry 2025年第1期15卷 153-167页

作者： Bo-Fan Chen Li Liu Fang-Zhen Lin Hai-Min Zeng Hai-Qiang huang Chun-Fang Zhang cong-cong Liu Xiang Chen Jie Peng Yun-Fa Wang Zhi-Lin Wang Bin Chen De-Le Liu Yun Liu Zheng-Zheng Li Xin-Xing Zeng The Second Affiliated Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Second Clinical Medical College Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Rehabilitation Medicine The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Provincial People’s Hospital The First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006Jiangxi ProvinceChina Department of Psychiatry Jiangxi Mental HospitalHospital of Nanchang UniversityNanchang UniversityNanchang 330029Jiangxi ProvinceChina

BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood *** drug treatment modalities are crucial for managing *** To analyze the current status and future trends of global research on BD drug treatment over the last *** The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were *** visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration *** University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this *** Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited *** This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future *** study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.

关键词： Bipolar disorder Drug treatment Bibliometric analysis Visualization Mental disorder

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SDDNet:Infrared small and dim target detection network

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CAAI Transactions on Intelligence Technology 2023年第4期8卷 1226-1236页

作者： Ma Long shu cong huang Shanshan Wei Zoujian Wang Xuhao Wei Yanxi School of Computer Science and Engineering Xi'an Technological UniversityXi'anShaanxiChina State and Local Joint Laboratory of Advanced Network and Monitoring Xi'anShaanxiChina School of Computing University of Kent CanterburyUK

This study focuses on developing deep learning methods for small and dim target *** model infrared images as the union of the target region and background *** on this model,the target detection problem is considered a two‐class segmentation problem that divides an image into the target and ***,a neural network called SDDNet for single‐frame images is *** network yields target extraction results according to the original *** multiframe images,a network called IC‐SDDNet,a combination of SDDNet and an interframe correlation network module is *** and IC‐SDDNet achieve target detection rates close to 1 on typical datasets with very low false positives,thereby performing significantly better than current *** models can be executed end to end,so both are very convenient to use,and their implementation efficiency is very *** speeds of 540+/230+FPS and 170+/60+FPS are achieved with SDDNet and IC‐SDDNet on a single Tesla V100 graphics processing unit and a single Jetson TX2 embedded module ***,neither network needs to use future information,so both networks can be directly used in real‐time *** well‐trained models and codes used in this study are available at https://***/LittlePieces/ObjectDetection.

关键词： deep learning detection of moving objects

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A novel dimeric procyanidin glucoside from Polygonum aviculare

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Chinese Chemical Letters 2012年第7期23卷 820-822页

作者： Hai Jian cong shu Wei Zhang Chong Zhang Yu Jie huang Li Jiang Xuan State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaShanghai Institute for Biological SciencesChinese Academy of SciencesShanghai 201203China

A novel dimeric procyanidin glucoside,catechin 3-O-acetate-（4 α→8）-catechin 3-O-acetate-3＇-O- β-D-glucopyranoside（1）, along with five flavonoids and one lignan were isolated from the aerial parts of Polygonum ... 详细信息

关键词： Polygonum aviculare Polygonaceae Procyanidin glucoside Catechin

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Effects of Self-gravity on Mass-loss of the Post-impact Super-Earths

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Research in Astronomy and Astrophysics 2022年第4期22卷 36-41页

作者： Jiang huang Wei Zhong cong Yu School of Physics and Astronomy Sun Yat-Sen UniversityZhuhai 519082China CSST Science Center for the Guangdong-Hong Kong-Macao Greater Bay Area Zhuhai 519082China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacaoChina

Kepler’s observations show most of the exoplanets are *** formation of a super-Earth is generally related to the atmospheric mass loss that is crucial in the planetary structure and *** shock driven by the giant impact will heat the planet,resulting in the atmosphere *** focus on whether self-gravity changes the efficiency of mass *** self-gravity,if the impactor mass is comparable to the envelope mass,there is a significant *** radiative-convective boundary will shift inward by *** the temperature and envelope mass increase,the situation becomes more prominent,resulting in a heavier ***,the impactor mass will increase to motivate the significant mass loss,as the self-gravity is *** the increase of envelope mass,the self-gravity is particularly important.

关键词： planets and satellites:atmospheres planets and satellites:physical evolution methods:numerical

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Loop Subdivision Surface Based Progressive Interpolation

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Journal of Computer Science & Technology 2009年第1期24卷 39-46页

作者： Fu-Hua (Prank) Cheng Feng-Tao Fan shu-Hua Lai cong-Lin huang Jia-Xi Wang 雍俊海 Department of Computer Science University of Kentucky Lexington KY 40506 U.S.A. Department of Mathematics and Computer Science Virginia State University Petersburg VA 23806 U.S.A. School of Software Tsinghua University Beijing 100084 China

A new method for constructing interpolating Loop subdivision surfaces is presented. The new method is an extension of the progressive interpolation technique for B-splines. Given a triangular mesh M, the idea is to iteratively upgrade the vertices of M to generate a new control mesh M such that limit surface of M would interpolate M. It can be shown that the iterative process is convergent for Loop subdivision surfaces. Hence, the method is well-defined. The new method has the advantages of both a local method and a global method, i.e., it can handle meshes of any size and any topology while generating smooth interpolating subdivision surfaces that faithfully resemble the shape of the given meshes. The meshes considered here can be open or closed.

关键词： geometric modeling Loop subdivision surface progressive interpolation

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