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Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jing CHEN,Yan-Yan WEI,cong-qing zhan,Jing HUANG,Ya-Yun WANG,Sheng-Xi WU~* Department of Human Anatomy,Histology and Embryology and K.K.Leung Brain Research Centre,Fourth Military Medical University,Xi''an 710032

＜正＞Objective To characterize green fluorescent protein（GFP） expression in the retina of the preproenkephalin -green fluorescent protein（PPE-GFP） transgenic *** Fluorescent in situ hybridization（FISH） and immunofluorescence（IF） were first employed to confirm the successful transgenic manipulation and its application in showing retinal ENKergic *** the GFP expression was characterized using IF with antibodies to Fluorogold （FG）,glial fibrillary acidic protein（GFAP） and syntaxin 1（HPC-1）.Double labeling with other retina cell markers was then performed to further clarify the neurochemical properties of GFP-expressing amacrine ***（1） The FISH and IF showed a good consistency of the expressions of PPE mRNA and *** mRNA signals were present preferentially in somata of the inner margin of the inner nuclear layer（INL）,while GFP immunoreactivities were present in fibers in the inner plexiform layer（IPL） in addition to the positive somata in the INL.（2） Double immunofluorescence suggested that none of the GFP-positive cells were FG-positive ganglion cells or GFAP-positive astrocytes,while about 94%of the GFP-positive cells were HPC-1 -positive amacrine cells in the INL.（3） The colocalization of GFP with several retina cell markers,such as GlyT1,GAD67,ChAT,CB and vGluT3 indicated that the GFP-positive cells in the INL were different subtypes of the amacrine cell population.（4） No GFP and PV,CR, vGluT1 or vGluT2 double-labeled neurons were observed,although the distributions of some cells were similar to the distribution of *** The present results indicate the layer specific expression pattern of GFP-positive ENKergic neurons in the retina and also provided morphological evidence for further functional *** conclusion, the PPE-GFP mouse line can be highly useful for the study of specific retina amacrine cell population.

关键词： enkephalin amacrine cells green fluorescent protein transgenic mouse

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao zhang Li Jia Xiu-Jun zhan Charity Ngina qing-Rui zhang Xiao-Ge Li Qi-Bao Jiang Shi Bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

Ta-W/Hf合金的结构稳定性及力学性质的第一性原理计算

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原子与分子物理学报 2025年第1期42卷 135-144页

作者：周少兰李忠盛丛大龙韦禹詹青青赵子鹏冉旭东西南技术工程研究所重庆400039

Ta-W/Hf合金具有高熔点、高密度、高延展性等性质,在核电、武器装备等关键零部件中发挥着重要作用,本研究基于密度泛函理论的第一性原理方法,构建不同掺杂含量下的Ta-W/Hf合金模型,计算Ta-W/Hf的晶格常数、结合能、弹性常数、弹性模量... 详细信息

Ta-W/Hf合金具有高熔点、高密度、高延展性等性质,在核电、武器装备等关键零部件中发挥着重要作用,本研究基于密度泛函理论的第一性原理方法,构建不同掺杂含量下的Ta-W/Hf合金模型,计算Ta-W/Hf的晶格常数、结合能、弹性常数、弹性模量、泊松比、维氏硬度、电子态密度等性质参数,分析W、Hf掺杂元素对Ta合金稳定性及力学性能的影响.结果表明:Ta-W合金的晶格常数、弹性常数、体模量、杨氏模量、剪切模量均随着W含量的增加而增加;然而Ta-Hf合金的相关性质参数变化趋势则相反.同时,结合能及电子态密度结果表明Ta-W合金的稳定性与W含量呈正相关;Ta-Hf合金的稳定性随着Hf含量的增加而降低,但Hf的添加对Ta合金的各向异性趋势变化影响显著,且Hf可以明显提高Ta合金的韧性.

关键词： Ta-W/Hf合金第一性原理结构稳定力学性质

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Upgrade of nickel and iron from low-grade nickel laterite by improving direct reduction-magnetic separation process

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Journal of Iron and Steel Research International 2022年第8期29卷 1164-1175页

作者： Hong-yu Tian Zheng-qi Guo Ruo-ning zhan Jian Pan De-qing Zhu cong-cong Yang Liao-ting Pan Xue-zhong Huang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina Beibu Gulf New Materials Co. Ltd.Beihai 536000GuangxiChina

Low-grade saprolite nickel laterite,characterized by complicated minerals composition and fine-grained and complex dissemination,was commonly treated with a low recovery efficiency of Ni and Fe by conventional ***,an improved direct reduction and magnetic separation process was ***,the mechanisms on the enhanced growth of the Ni-Fe particles and the phase transformation in the nickel laterite pellets were *** low-nickel concentrates as a nucleating agent can obviously decrease the activation energy for growth of Ni-Fe alloy particles during the improved direct reduction process from 197.10 to 154.81 kJ/mol when the low-nickel concentrates were added from 0 to 20%.Hence,it is able to decrease nucleation barrier,induce the growth of Fe-Ni alloy particles and increase their average *** a result,the size of Ni-Fe particles in the pellets from less than 10 lm grew to more than 20 lm,which is beneficial for the full liberation and recovery of Ni and Fe in subsequent magnetic separation ***,the preferable Ni-Fe alloy concentrates with 6.44%Ni and 82.48%Fe can be prepared with corresponding recovery rates of 96.90%and 95.92%,respectively,when adding 20%low-nickel concentrates.

关键词： Nickel laterite Low-nickel concentrate Nucleating agent Growth kinetics Ni-Fe alloy Direct reduction Magnetic separation

Influence of Mechanical Activation on Acid Leaching Dephosphorization of High-phosphorus Iron Ore Concentrates

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Journal of Iron and Steel Research International 2016年第7期23卷 661-668页

作者： De-qing ZHU Hao WANG Jian PAN cong-cong YANG School of Minerals Processing and Bioengineering Central South University

High pressure roll grinding（HPRG）and ball milling were compared to investigate the influence of mechanical activation on the acid leaching dephosphorization of a high-phosphorus iron ore concentrate,which was manufactured through magnetizing roasting-magnetic separation of high-phosphorus oolitic iron *** results indicated that when high-phosphorus iron ore concentrates containing 54.92 mass% iron and 0.76 mass% phosphorus were directly processed through acid leaching,iron ore concentrates containing 55.74mass%iron and 0.33mass%phosphorus with an iron recovery of 84.64%and dephosphorization of 63.79% were *** high-phosphorus iron ore concentrates activated by ball milling were processed by acid leaching,iron ore concentrates containing56.03mass%iron and 0.21mass% phosphorus with an iron recovery of 85.65% and dephosphorization of 77.49%were ***,when high-phosphorus iron ore concentrates activated by HPRG were processed by acid leaching,iron ore concentrates containing 58.02mass%iron and 0.10mass% phosphorus were obtained,with the iron recovery reaching 88.42% and the dephosphorization rate reaching 88.99%.Mechanistic studies demonstrated that ball milling can reduce the particle size,demonstrating aprominent reunion *** contrast,HPRG pretreatment contributes to the formation of more cracks within the particles and selective dissociation of iron and P bearing minerals,which can provide the favorable kinetic conditions to accelerate the solid-liquid reaction *** such,the crystal structure is destroyed and the surface energy of mineral particles is strengthened by mechanical activation,further strengthening the dephosphorization.

关键词： high-phosphorus iron ore concentrate high pressure roll grinding ball milling selective dissociation sulfuric acid leaching dephosphorization iron recovery

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Some basic properties of granules from ore blends consisting of ultrafine magnetite and hematite ores

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International Journal of Minerals,Metallurgy and Materials 2019年第8期26卷 953-962页

作者： cong-cong Yang De-qing Zhu Jian Pan Yue Shi School of Minerals Processing and Bioengineering Central South University

Some basic properties of granules,including the granule size distribution,packed-bed permeability,and chemical composition of the adhering layer,were investigated in this study for four iron ore blends consisting of 5wt%,25wt%,and 45wt%ultrafine magnetite and 25wt%ultrafine hematite *** effects of varying the sinter basicity(CaO/SiO2 mass ratio=1.4 to 2.2)and adding ultrafine concentrates on the variation of the adhering-layer composition and granule microstructure were ***,the effect of adhering-layer compositional changes on sintering reactions was discussed in combination with pot sintering results of ore *** sinter basicity led to an increase in the basicities of both the adhering layer and the fine part of the sinter mix,which were higher than the overall sinter *** the sinter chemistry was fixed and fine Si-bearing materials(e.g.,quartz sand)were used,increasing the amount of ultrafine ores in the ore blends tended to reduce the adhering-layer basicity and increase the SiO2 content in both the adhering layer and the fine part of the sinter mix,which will induce the formation of low-strength bonding phases and the deterioration of sinter *** adhering-layer composition in granules can be estimated in advance from the compositions of the-1 mm fractions of the raw materials.

关键词： iron ore granule adhering layer magnetite concentrate sinter basicity

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Internal Conversion Process of Chlorophyll a in Solvents in Femtosecond Pump-Probe Laser Fields

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Chinese Journal of Chemical Physics 2008年第3期21卷 211-216页

作者： Kai Niu Li-qing Dong Shu-lin cong Department of Physics Dalian University of Technology Dalian 116024 China

The internal conversion （IC） processes of chlorophyll a （chl-a） in solvents are studied based on the reduced density matrix theory. The IC times can be obtained by simulating the experimental fluorescence depletion spectra （FDS）. The calculated IC times of chl-a in ethyl acetate, tetrahydrofuran and dimethyl formamide are 141, 147, and 241 fs, respectively. The oscillation feature of the FDS results from the forward and backward transfer of the population between coupled electronic states. The effects of diabatic coupling between two electronic states on the IC time and the FDS are described. The influence of molecule-reservoir coupling on the IC time is also investigated.

关键词： Fluorescence depletion spectrum Internal conversion Reduced density matrix

Prediction of temperature field in machined workpiece surface during the cutting of Inconel 718 coated with surface-active media

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Advances in Manufacturing 2023年第3期11卷 378-389页

作者： qing-An Yin zhan-Qiang Liu Bing Wang School of Mechanical Engineering Shandong UniversityJinan 250061People's Republic of China Key National Demonstration Center for Experimental Mechanical Engineering Education/Key Laboratory of High Efficiency and Clean Mechanical Manufacture of MQE Jinan 250061People's Republic of China

The heat generated and accumulated on the machined surface of an Inconel 718 workpiece causes thermal damage during the cutting ***-active media with high thermal conductivity coated on the workpiece to be machined may have the potential to reduce the generation of cutting *** this study,a theoretical model for predicting the instantaneous machined surface temperature field is proposed for surface-active thermal conductive medium(SACM)-assisted cutting based on the finite element and Fourier heat transfer *** cutting experiments were performed to verify the results predicted using the proposed surface-temperature field *** SACMs with various thermal conductivities were used to coat Inconel 718 surface to be *** embedded into the workpiece were used to measure the cutting temperature at different points on the machined workpiece surface during the cutting *** experimental results were in agreement with the predicted temperatures,and the maximum error between the experimental results and predicted temperatures was approximately 9.5%.The cutting temperature on the machined surface decreased with an increase in the thermal conductivity of the *** graphene SACM with high thermal conductivity can effectively reduce the temperature from 542℃ to 402℃,which corresponds to a reduction of approximately 26%.The temperature reduction due to SACM decreases with an increase in the distance between the temperature prediction point and machined workpiece *** conclusion,the cutting temperatures on the machined workpiece surface can be reduced by coating with SACM.

关键词： Surface-active thermal conductive media(SACM) Finite element model Cutting heat Cutting temperature Inconel 718

A Possible Generalized Form of Jarzynski Equality

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Communications in Theoretical Physics 2006年第5X期46卷 886-890页

作者： TU zhan-Chun ZHOU Zi-cong Department of Physics Tamkang University Tamsui 25137 Taiwan China Physics Division National Center for Theoretical Sciences at Taipei National Taiwan University Taipei 10617 Taiwan China

The crucial condition in the derivation of the Jarzynski equality （JE） from the fluctuation theorem is that the time integral of the phase space contraction factor can be exactly expressed as the entropy production resulting from the heat absorbed by the system from the thermal bath. For the system violating this condition, a more general form of JE may exist. This existence is verified by three Gedanken experiments and numerical simulations, and may be confirmed by the real experiment in the nanoscale.

关键词： Jarzynski equality fluctuation theorem entropy production

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