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Roles of THEM4 in the Akt pathway:a double-edged sword

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 541-556页

作者： Wen XIE Weidong LIU Lei WANG Bin ZHU cong ZHAO Ziling LIAO Yihan LI Xingjun jiang Jie LIU Caiping REN NHC Key Laboratory of Carcinogenesis Department of NeurosurgeryXiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China The Key Laboratory of Carcinogenesis and Cancer Invasion of the Ministry of Education Cancer Research InstituteSchool of Basic Medical ScienceCentral South UniversityChangsha 410078China Department of Critical Care Medicine Hainan Hospital of Chinese PLA General HospitalHainan Province Clinical Medical CenterSanya 572013China

The protein kinase B(Akt)pathway can regulate the growth,proliferation,and metabolism of tumor cells and stem cells through the activation of multiple downstream target genes,thus affecting the development and treatment of a range of *** superfamily member 4(THEM4),a member of the thioesterase superfamily,is one of the Akt kinase-binding *** studies on the mechanism of cancers and other diseases have shown that THEM4 binds to Akt to regulate its ***,THEM4 was considered an endogenous inhibitor of Akt,which can inhibit the phosphorylation of Akt in diseases such as lung cancer,pancreatic cancer,and liver cancer,but subsequently,THEM4 was shown to promote the proliferation of tumor cells by positively regulating Akt activity in breast cancer and nasopharyngeal carcinoma,which contradicts previous *** these two distinct views,this review summarizes the important roles of THEM4 in the Akt pathway,focusing on THEM4 as an Akt-binding protein and its regulatory relationship with Akt phosphorylation in various diseases,especially *** work provides a better understanding of the roles of THEM4 combined with Akt in the treatment of diseases.

关键词： Protein kinase B(Akt) Thioesterase superfamily member 4(THEM4) Tumor proliferation Tumor metastasis

Navigating the future:Embracing resilience and interoperability in the industrial internet

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Fundamental Research 2024年第1期4卷 1-2页

作者： Chaojie Gu Chunxiao jiang Jiming Chen Yang cong Bin Xiao College of Control Science and Engineering Zhejiang UniversityHangzhou 310027China Beijing National Research Center for Information Science and Technology Tsinghua UniversityBeijing 100084China School of Automation Science and Engineering South China University of TechnologyGuangzhou 510641China Division II Department of Information SciencesNational Natural Science Foundation of ChinaBeijing 100085China Chongqing Key Laboratory of Image Cognition School of Computer Science and TechnologyChongqing University of Posts and TelecommunicationsChongqing 400065China

In the midst of the fourth industrial revolution,the convergence of the digital,physical,and biological realms is propelling industrial innovation to new *** the heart of this transformative era lies the Industrial In... 详细信息

关键词： internet network shaping

Elaborately engineering of lipid nanoparticle for targeting delivery of siRNA and suppressing acute liver injury

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Chinese Chemical Letters 2024年第2期35卷 323-328页

作者： Qiu Wang Qikun jiang Dan Li Zimeng Yang Lin Gao Fan Liu Chang Li Yao Feng Zhonggui He cong Luo Jin Sun Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Kangya of Ningxia Pharmaceutical Co.Ltd. Yinchuan 750000China

Small interfering RNA(siRNA)-based gene silencing has been considered as a potential therapy modality against inflammatory ***,the effective delivery of siRNA to desired destination still remains challenging due to poor stability,high molecular weight and negative ***,ionizable lipid nanoparticle(LNP)has been extensively used as vector for effective delivery of ***,we report a mannose-modified LNP(M-MC_(3) LNP@TNFα)loading tumor necrosis factorα(TNFα)siRNA for targeting liver macrophages,achieving effectively inhibit acute liver *** M-MC_(3) LNP@TNFαnot only increases the internalization of LNP by macrophages,but also enhances the gene silencing efficiency of TNFαin ***,the M-MC_(3) LNP@TNFαexhibits higher accumulation in liver of healthy mice than that of MC_(3) LNP@TNFα(un-modified LNP)owing to the targeting effect of *** expected,the M-MC_(3) LNP@TNFαsignificantly suppresses the expression of TNFαand ameliorates liver damage in acute liver injury *** a LNP targeting siRNA delivery holds great potential for the treatment of diseases associated with liver in the future.

关键词： Lipid nanoparticle Targeting siRNA delivery Acute liver injury Gene silencing Tumor necrosis factorα

Divergent driving mechanisms of community temporal stability in China's drylands

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Environmental Science and Ecotechnology 2024年第4期20卷 237-246页

作者： Kai Wang cong Wang Bojie Fu Jianbei Huang Fangli Wei Xuejing Leng Xiaoming Feng Zongshan Li Wei jiang State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing100049China Max Planck Institute for Biogeochemistry Hans-Kn€oll-Str.1007745JenaGermany Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing100101China Shaanxi Yan'an Forest Ecosystem National Observation and Research Station Beijing100085China National Observation and Research Station of Earth Critical Zone on the Loess Plateau in Shaanxi Xi'an710061China

Climate change and anthropogenic activities are reshaping dryland ecosystems globally at an unprecedented pace,jeopardizing their *** stability of these ecosystems is crucial for maintaining ecological balance and supporting local ***,the mechanisms governing their stability are poorly understood,largely due to the scarcity of comprehensive field *** we show the patterns of community temporal stability and its determinants across an aridity spectrum by integrating a transect survey across China's drylands with remote *** results revealed a U-shaped relationship between community temporal stability and aridity,with a pivotal shift occurring around an aridity level of *** less arid areas(aridity level below 0.88),enhanced precipitation and biodiversity were associated with increased community productivity and ***,in more arid zones(aridity level above 0.88),elevated soil organic carbon and biodiversity were linked to greater fluctuations in community productivity and reduced *** study identifies a critical aridity threshold that precipitates significant changes in community stability in China's drylands,underscoring the importance of distinct mechanisms driving ecosystem stability in varying aridity *** insights are pivotal for developing informed ecosystem management and policy strategies tailored to the unique challenges of dryland conservation.

关键词： Dryland ecosystems Community stability Ecosystem management Species richness Aridity threshold

Spatiotemporal drivers of Nature's contributions to people:A countylevel study

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Environmental Science and Ecotechnology 2024年第4期20卷 323-332页

作者： Wei jiang Bojie Fu Zhongguo Shu Yihe Lv Guangyao Gao Xiaoming Feng Stefan Schüler Xing Wu cong Wang State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesNo.18 Shuangqing Road100085BeijingChina Functional Agrobiodiversity Georg-August-Universit€at G€ottingenGrisebachstraße 637077G€ottingenGermany

Nature's contributions to people(NCP)encompass both the beneficial and detrimental effects of living nature on human quality of life,including regulatory,material,and non-material ***,vital NCPs have been deteriorating,accelerated by changes in both natural and anthropogenic drivers over recent *** the often inevitable trade-offs between NCPs due to their spatially and temporally uneven distributions,few studies have quantitatively assessed the impacts of different drivers on the spatial and temporal changes in multiple NCPs and their *** we evaluate the effects of precipitation,temperature,population,gross domestic product,vegetation restoration,and urban expansion on four key regulatory NCPs-habitat maintenance,climate regulation,water quantity regulation,and soil protection-in Nei Mongol at the county *** observe increasing trends in climate regulation and soil protection from 2000 to 2019,contrasted with declining trends in habitat maintenance and water quantity *** have identified the dominant positive and negative drivers influencing each NCP across individual counties,finding that natural drivers predominantly overpowered anthropogenic ***,we discover significant spatial disparities in the tradeoff or synergy relationships between NCPs across the *** findings illustrate how the impacts of various drivers on NCPs and their interrelationships can be quantitatively evaluated,offering significant potential for application in various spatial *** an understanding of trade-offs and scale effects,these insights are expected to support and inform policymaking at both county and provincial levels.

关键词： Potential regulating contributions Natural and anthropogenic drivers Path analysis Trade-off or synergy relationship China

Flexible and multifunctional triboelectric nanogenerator based on liquid metal/polyvinyl alcohol hydrogel for energy harvesting and self-powered wearable human-machine interaction

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Rare Metals 2024年第3期43卷 1186-1196页

作者： Hou-Wang Zhou cong Zhao Ze-Yu Zhao Jun-Chen jiang Hui-Le Jin Shun Wang Shuang Pan Min-Yi Xu Yi-Huang Chen Hai-Ming Jin Department of Orthopaedics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou325027China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou325035China Dalian Key Laboratory of Marine Micro/Nano Energy and Self-Powered Systems Marine Engineering CollegeDalian Maritime UniversityDalian116026China

Hydrogel-based triboelectric nanoge nerator(TENG)has a promising applied prospect in wearable electronic ***,its low performance,poor stability,insufficient recyclability and inferior self-healing seriously hinder its ***,we report a robust route to a liquid metal(LM)/polyvinyl alcohol(PVA)hydrogel-based TENG(LP-TENG).Owing to the intrinsically liquid feature of conductive LM within the flexible PVA hydrogel,the as-prepared LP-TENG exhibited comprehensiye advantages of adaptability,biocompatibility,outstanding electrical performance,superior stability,recyclability and diverse applications,which were unattainable by traditional ***,the LP-TENG delivered appealing open circuit voltage of 250 V,short circuit current of 4μA and transferred charge of 120 nC with high stability,outperforming most advanced TENG *** LP-TENG was successfully employed for versatile applications with multifunctionality,including human motion detection,handwriting recognition,energy collection,message transmission and human-machine *** work presents significant prospects for crafting advanced materials and devices in the fields of wearable electronics,flexible skin and smart robots.

关键词： Liquid metal Hydrogel Wearable TENG Multifunctionality Human-machine interaction

Bazi Bushen alleviates reproductive aging in aged male mice

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Chinese Journal of Natural Medicines 2024年第5期22卷 416-425页

作者： MA Kun LI Mengnan SONG Yahui MAO Xinjing ZHANG Shaolan ZHANG Yaping jiang Yuning JI Chuanyuan NIU Kunxu LI Hongrong HOU Yunlong WEI cong Graduate School Hebei University of Chinese MedicineShijiazhuang 050091China State Key Laboratory for Innovation and Transformation of Luobing Theory Shijiazhuang 050035China Key Laboratory of State Administration of TCM(Cardio-Cerebral Vessel Collateral Disease) Shijiazhuang 050035China College of Traditional Chinese Medicine·College of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210023China Hebei Provincial Key Laboratory of Luobing Shijiazhuang 050035China Key Disciplines of State Administration of TCM for Luobing Shijiazhuang 050035China

Bazi Bushen(BZBS),a traditional Chinese medicine(TCM),has demonstrated therapeutic efficacy in testicular dysfunction within D-galactose and NaNO_(2)mouse *** study aimed to ascertain if BZBS could also mitigate the decline in testicular function associated with natural ***,male aged mice were employed to evaluate the preventive effects of BZBS on male reproductive *** was achieved by assessing sex hormone production,testicular histomorphology,and *** to the untreated aged control group,BZBS administration elevated the levels of sex hormones and spermatocyte populations and preserved normal testicular structure in aged ***,spermatogenesis was *** analyses,including malondialdehyde(MDA)assays and real-time PCR,indicated that BZBS diminished testicular oxidative stress and the inflammatory *** these findings,mice treated with BZBS exhibited reductions in the populations of senescent and apoptotic cells within the seminiferous tubules,suggesting alleviated cellular *** contrast,we observed that rapamycin,a drug known for its longevity benefits,induced excessive testicular apoptosis and did not decrease lipid ***,our results highlight BZBS’s promising clinical potential in counteracting male reproductive aging,underlining its mechanisms of action.

关键词： Traditional Chinese medicine Male reproductive aging Spermatogenic cells Cell senescence Apoptosis

Comprehensive reutilization of herbal waste:Coproduction of magnolol,honokiol,and β-amyrin from Magnolia officinalis residue

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Green Energy & Environment 2024年第2期9卷 403-412页

作者： Lukun Xiao Anyi Zhao Jie Qiu An Liu Sha Chen Jinzhu jiang Jun Zhang cong Guo Jipeng Di Jintang Cheng Chang Chen Kangxin Hou Aiping Zhang Yan Liu Caixia Wang Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing100700China School of Pharmacy Shanxi Medical UniversityTaiyuan030001China

Herbal extraction residues(HERs)cause serious environmental pollution and resource *** this study,a novel green route was designed for the comprehensive reutilization of all components in HERs,taking Magnolia officinalis residues(MOR)as an *** reluctant structure of MOR was first destroyed by alkali pretreatment to release the functional ingredients(magnolol and honokiol)originally remaining in MOR and to make MOR more accessible for hydrolysis.A metal–organic frame material MIL-101(Cr)with a maximum absorption capacity of 255.64 mg g^(-1)was synthesized to absorb the released honokiol and magnolol from the pretreated MOR solutions,and 40 g L^(-1)reducing sugars were obtained with 81.8%enzymatic hydrolysis rate at 10%MOR solid ***,382 mg L-1β-amyrin was produced from MOR hydrolysates by an engineered yeast *** total,1 kg honokiol,8 kg magnolol,and 7.64 kg β-amyrin could produce from 1 ton MOR by this cleaner process with a total economic output of 170,700 RMB.

关键词： Magnolia officinalis residues(MOR) Comprehensive utilization Metal-organic frame material Biosynthesis

Rethinking development and major research plans of Industrial Internet in China

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Fundamental Research 2024年第1期4卷 3-7页

作者： Chunxiao jiang Yang cong Jiming Chen Chenghong Wang Guozheng Wu Ruizhen Zhao Zhiheng Wang Bin Xiao Ting Chen Beijing National Research Center for Information Science and Technology Tsinghua UniversityBeijing 100084China Tsinghua Space Center Tsinghua UniversityBeijing 100084China State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016China College of Control Science and Engineering Zhejiang UniversityHangzhou 310027China Division III Department of Information SciencesNational Natural Science Foundation of ChinaBeijing 100085China Division II Department of Information SciencesNational Natural Science Foundation of ChinaBeijing 100085China Chongqing Key Laboratory of Image Cognition School of Computer Science and TechnologyChongqing University of Posts and TelecommunicationsChongqing 400065China University of Electronic Science and Technology of China Chengdu 611731China

This paper gives a definition of the Industrial Internet and expounds on the academic connotation of the future Industrial *** this foundation,we outline the development and current status of the Industrial Internet in China and ***,we detail the avant-garde paradigms encompassed within the National Natural Science Foundation of China(NSFC)’s“Future Industrial Internet Fundamental Theory and Key Technologies”research plan and its corresponding management *** research initiative endeavors to enhance interdisciplinary collaborations,aiming for a synergistic alignment of industry,academia,research,and practical *** primary focus of the research plan is on the pivotal scientific challenges inherent to the future industrial *** is poised to traverse the“first mile”,encompassing foundational research and pioneering innovations specific to the industrial internet,and seamlessly bridges to the“last mile”,ensuring the effective commercialization of scientific and technological breakthroughs into tangible industrial market *** anticipated contributions from this initiative are projected to solidify both the theoretical and practical scaffolding essential for the cultivation of a globally competitive industrial internet infrastructure in China.

关键词： Industrial Internet Academic connotation Major research plan Scientific problem Policy advice